thiotepa has been researched along with Cardiac Failure in 6 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We combined paclitaxel, melphalan and high-dose cyclophosphamide, thiotepa, and carboplatin in a triple sequential high-dose regimen for patients with metastatic breast cancer." | 5.11 | Cardiac toxicity observed in association with high-dose cyclophosphamide-based chemotherapy for metastatic breast cancer. ( Hesdorffer, C; Horwich, T; Jacobson, C; Savage, D; Tiersten, A; Troxel, A; Weitzman, A; Wo, J, 2004) |
| "Thiotepa (TT) has not been reported to cause cardiomyopathy, whereas cyclophosphamide (Cy)-related cardiomyopathy is well characterized." | 1.30 | Thiotepa-associated cardiomyopathy during blood or marrow transplantation: association with the female sex and cardiac risk factors. ( Alidina, A; Anderson, B; Baer, MR; Bambach, B; Barcos, MP; Bernstein, SH; Czuczman, MS; Ford, LA; Lawrence, D; McCarthy, PL; Proulx, GM; Slack, JL; Spangenthal, E; Wetzler, M, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, X | 1 |
| Deng, S | 1 |
| Liu, L | 2 |
| GOLDMAN, BS | 1 |
| PEARSON, FG | 1 |
| Tiersten, A | 1 |
| Wo, J | 1 |
| Jacobson, C | 1 |
| Weitzman, A | 1 |
| Horwich, T | 1 |
| Hesdorffer, C | 1 |
| Savage, D | 1 |
| Troxel, A | 1 |
| Alidina, A | 1 |
| Lawrence, D | 1 |
| Ford, LA | 1 |
| Baer, MR | 1 |
| Bambach, B | 1 |
| Bernstein, SH | 1 |
| Czuczman, MS | 1 |
| Slack, JL | 1 |
| Spangenthal, E | 1 |
| Wetzler, M | 1 |
| Barcos, MP | 1 |
| Proulx, GM | 1 |
| Anderson, B | 1 |
| McCarthy, PL | 1 |
| Fujimaki, K | 1 |
| Maruta, A | 1 |
| Yoshida, M | 1 |
| Sakai, R | 1 |
| Tanabe, J | 1 |
| Koharazawa, H | 1 |
| Kodama, F | 1 |
| Asahina, S | 1 |
| Minamizawa, M | 1 |
| Matsuzaki, M | 1 |
| Fujisawa, S | 1 |
| Kanamori, H | 1 |
| Ishigatsubo, Y | 1 |
| Ellis, ED | 1 |
| Williams, SF | 1 |
| Moormeier, JA | 1 |
| Kaminer, LS | 1 |
| Bitran, JD | 1 |
2 trials available for thiotepa and Cardiac Failure
| Article | Year |
|---|---|
Cardiac toxicity observed in association with high-dose cyclophosphamide-based chemotherapy for metastatic breast cancer.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brea | 2004 |
A phase I-II study of high-dose cyclophosphamide, thiotepa and escalating doses of mitoxantrone with autologous stem cell rescue in patients with refractory malignancies.
Topics: Actuarial Analysis; Chicago; Cyclophosphamide; Drug Evaluation; Heart Failure; Hematopoietic Stem Ce | 1990 |
4 other studies available for thiotepa and Cardiac Failure
| Article | Year |
|---|---|
Sieve estimation in semiparametric modeling of longitudinal data with informative observation times.
Topics: Aged; Computer Simulation; Female; Heart Failure; Humans; Least-Squares Analysis; Longitudinal Studi | 2014 |
MALIGNANT PERICARDIAL EFFUSION. REVIEW OF HOSPITAL EXPERIENCE AND REPORT OF A CASE SUCCESSFULLY TREATED BY TALC POUDRAGE.
Topics: Breast Neoplasms; Cardiac Surgical Procedures; Cardiac Tamponade; Drug Therapy; Exudates and Transud | 1965 |
Thiotepa-associated cardiomyopathy during blood or marrow transplantation: association with the female sex and cardiac risk factors.
Topics: Adult; Animals; Antineoplastic Agents, Alkylating; Blood Transfusion; Bone Marrow Transplantation; C | 1999 |
Severe cardiac toxicity in hematological stem cell transplantation: predictive value of reduced left ventricular ejection fraction.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dose-Response R | 2001 |