thiotepa has been researched along with Cancer, Second Primary in 8 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The incidence of secondary myelodysplasia/acute myeloid leukemia (AML) was retrospectively assessed in an international joint study in 305 node-positive breast cancer patients, who received mitoxantrone-based high-dose chemotherapy (HDCT) followed by autologous stem cell support as adjuvant therapy." | 8.82 | Secondary acute leukemia following mitoxantrone-based high-dose chemotherapy for primary breast cancer patients. ( Damon, L; Demirer, T; Derigs, G; Ferrante, P; Kröger, N; Rosti, G; Wandt, H; Zander, AR, 2003) |
| "The incidence of secondary myelodysplasia/acute myeloid leukemia (AML) was retrospectively assessed in an international joint study in 305 node-positive breast cancer patients, who received mitoxantrone-based high-dose chemotherapy (HDCT) followed by autologous stem cell support as adjuvant therapy." | 4.82 | Secondary acute leukemia following mitoxantrone-based high-dose chemotherapy for primary breast cancer patients. ( Damon, L; Demirer, T; Derigs, G; Ferrante, P; Kröger, N; Rosti, G; Wandt, H; Zander, AR, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Puckrin, R | 1 |
| Chua, N | 2 |
| Shafey, M | 1 |
| Stewart, DA | 2 |
| Oh, DH | 1 |
| Street, L | 1 |
| Rodenhuis, S | 1 |
| Bontenbal, M | 1 |
| Beex, LV | 1 |
| Wagstaff, J | 1 |
| Richel, DJ | 1 |
| Nooij, MA | 1 |
| Voest, EE | 1 |
| Hupperets, P | 1 |
| van Tinteren, H | 1 |
| Peterse, HL | 1 |
| TenVergert, EM | 1 |
| de Vries, EG | 1 |
| GRIGALINOVICH, GA | 1 |
| ZIDERMANE, AA | 1 |
| ZHAGATA, MA | 1 |
| Kröger, N | 1 |
| Damon, L | 1 |
| Zander, AR | 1 |
| Wandt, H | 1 |
| Derigs, G | 1 |
| Ferrante, P | 1 |
| Demirer, T | 1 |
| Rosti, G | 2 |
| Bretheau, D | 1 |
| Lechevallier, E | 1 |
| Jean, F | 1 |
| Rampal, M | 1 |
| Coulange, C | 1 |
| De Giorgi, U | 1 |
| Papiani, G | 1 |
| Marangolo, M | 1 |
| Heath, JA | 1 |
| Broxson, EH | 1 |
| Dole, MG | 1 |
| Filippa, DA | 1 |
| George, D | 1 |
| Lyden, D | 1 |
| Dunkel, IJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective Randomized Feasibility and Phase II Adjuvant Breast Cancer Study of the Netherlands Working Party for Autotransplantation in Solid Tumors.[NCT00851110] | Phase 2 | 50 participants (Anticipated) | Interventional | 2004-10-31 | Terminated | ||
| High-dose Chemotherapy With Hematopoietic Stem-cell Rescue for High-risk Breast Cancer: Long-term Follow-up of a Randomized Phase III Study[NCT03087409] | 885 participants (Actual) | Observational | 2016-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for thiotepa and Cancer, Second Primary
| Article | Year |
|---|---|
Secondary acute leukemia following mitoxantrone-based high-dose chemotherapy for primary breast cancer patients.
Topics: Acute Disease; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantat | 2003 |
The status of high-dose chemotherapy with hematopoietic stem cell transplantation in germ cell tumor patients.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carboplatin; Cisplatin; Clinical T | 2002 |
1 trial available for thiotepa and Cancer, Second Primary
| Article | Year |
|---|---|
High-dose chemotherapy with hematopoietic stem-cell rescue for high-risk breast cancer.
Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Breast Neo | 2003 |
High-dose chemotherapy with hematopoietic stem-cell rescue for high-risk breast cancer.
Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Breast Neo | 2003 |
High-dose chemotherapy with hematopoietic stem-cell rescue for high-risk breast cancer.
Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Breast Neo | 2003 |
High-dose chemotherapy with hematopoietic stem-cell rescue for high-risk breast cancer.
Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Breast Neo | 2003 |
5 other studies available for thiotepa and Cancer, Second Primary
| Article | Year |
|---|---|
Improving the outcomes of secondary CNS lymphoma with high-dose thiotepa, busulfan, melphalan, rituximab conditioning and autotransplant.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Autografts; Busulfan; Central Nervous S | 2022 |
Treatment of patients with secondary central nervous system lymphoma with high-dose busulfan/thiotepa-based conditioning and autologous stem cell transplant.
Topics: Antineoplastic Combined Chemotherapy Protocols; Busulfan; Central Nervous System Neoplasms; Combined | 2016 |
[CYCLOPHOSPHANE, ETHOXENE AND THIO-TEPA IN THE PREVENTION OF METASTASES FOLLOWING SURGICAL EXTIRPATION OF TRANSPLANTED TUMORS].
Topics: Antineoplastic Agents; Cyclophosphamide; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimenta | 1963 |
[Tumors of the superior urinary tract and associated bladder tumors: clinical and etiological aspects].
Topics: Aged; Aged, 80 and over; Combined Modality Therapy; Cystectomy; Female; Follow-Up Studies; Humans; I | 1993 |
Epstein-Barr virus-associated lymphoma in a child undergoing an autologous stem cell rescue.
Topics: Acyclovir; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents, Ph | 2002 |