thiotepa has been researched along with Bone Marrow Diseases in 18 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Bone Marrow Diseases: Diseases involving the BONE MARROW.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study was to evaluate the activity and toxicity of the combination of vinorelbine and thiotepa as second-line treatment in patients with metastatic breast cancer." | 9.08 | A phase II trial of vinorelbine and thiotepa in metastatic breast cancer. ( Cirulli, S; Cognetti, F; Conte, E; Fabi, A; Savarese, A; Tomao, S; Tonachella, R, 1995) |
| " The aim of this study was to evaluate the activity and toxicity of the combination of vinorelbine and thiotepa as second-line treatment in patients with metastatic breast cancer." | 5.08 | A phase II trial of vinorelbine and thiotepa in metastatic breast cancer. ( Cirulli, S; Cognetti, F; Conte, E; Fabi, A; Savarese, A; Tomao, S; Tonachella, R, 1995) |
| "Twenty-seven percent of responding metastatic breast cancer patients remain progression-free a median 29 months following one intensification course of cyclophosphamide (6,000 mg/m2), thiotepa (500 mg/m2), and carboplatin (800 mg/m2) (CTCb) with autologous bone marrow transplantation (ABMT)." | 3.69 | Double dose-intensive chemotherapy with autologous marrow and peripheral-blood progenitor-cell support for metastatic breast cancer: a feasibility study. ( Ayash, LJ; Elias, A; Gonin, R; Lynch, C; Mazanet, R; Reich, E; Schwartz, G; Tepler, I; Warren, D; Wheeler, C, 1994) |
| " Linear regression analyses of pharmacokinetic parameters versus myelosuppression revealed statistically significant correlations between thio-TEPA pharmacokinetics and the percentage of reductions in leukocytes and platelets at their mean nadirs." | 1.28 | Pharmacokinetics of thio-TEPA and TEPA in the conventional dose-range and its correlation to myelosuppressive effects. ( Hagen, B, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (33.33) | 18.7374 |
| 1990's | 11 (61.11) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| BRIDGES, JB | 1 |
| BRIDGES, JM | 1 |
| EDELSTYN, GJ | 1 |
| LYONS, AR | 1 |
| Ayash, LJ | 2 |
| Elias, A | 3 |
| Wheeler, C | 3 |
| Reich, E | 1 |
| Schwartz, G | 3 |
| Mazanet, R | 2 |
| Tepler, I | 3 |
| Warren, D | 1 |
| Lynch, C | 1 |
| Gonin, R | 1 |
| Williams, SF | 1 |
| Zimmerman, T | 1 |
| Grad, G | 1 |
| Mick, R | 1 |
| Antman, K | 2 |
| Ayash, L | 1 |
| Schnipper, LE | 1 |
| Frei, E | 2 |
| Fabi, A | 1 |
| Tonachella, R | 1 |
| Savarese, A | 1 |
| Cirulli, S | 1 |
| Tomao, S | 1 |
| Conte, E | 1 |
| Cognetti, F | 1 |
| Schnipper, L | 1 |
| Alexanian, R | 1 |
| Dimopoulos, MA | 1 |
| Hester, J | 1 |
| Delasalle, K | 1 |
| Champlin, R | 2 |
| Bacigalupo, A | 1 |
| Van Lint, MT | 1 |
| Valbonesi, M | 1 |
| Lercari, G | 1 |
| Carlier, P | 1 |
| Lamparelli, T | 1 |
| Gualandi, F | 1 |
| Occhini, D | 1 |
| Bregante, S | 1 |
| Valeriani, A | 1 |
| Piaggio, G | 1 |
| Pitto, A | 1 |
| Benvenuto, F | 1 |
| Figari, O | 1 |
| De Stefano, G | 1 |
| Caimo, A | 1 |
| Sessarego, M | 1 |
| Deisseroth, AB | 1 |
| Holmes, F | 1 |
| Hortobagyi, G | 1 |
| Meisenberg, BR | 1 |
| Miller, WE | 1 |
| McMillan, R | 1 |
| Cairncross, G | 1 |
| Swinnen, L | 1 |
| Bayer, R | 1 |
| Rosenfeld, S | 1 |
| Salzman, D | 1 |
| Paleologos, N | 1 |
| Kaminer, L | 1 |
| Forsyth, P | 1 |
| Stewart, D | 1 |
| Peterson, K | 1 |
| Hu, W | 1 |
| Macdonald, D | 1 |
| Ramsay, D | 1 |
| Smith, A | 1 |
| Donfrancesco, A | 1 |
| Deb, G | 1 |
| Dominici, C | 1 |
| Angioni, A | 1 |
| Caniglia, M | 1 |
| De Sio, L | 1 |
| Fidani, P | 1 |
| Amici, A | 1 |
| Helson, L | 1 |
| Hagen, B | 1 |
| Garfield, DH | 1 |
| Arthur, K | 1 |
| Kottmeier, HL | 1 |
| Edgren, B | 1 |
| Forsgren, L | 1 |
| Boström, H | 1 |
| Ansfield, FJ | 1 |
| Carter, AC | 1 |
| Goldenberg, IS | 1 |
| Segaloff, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A National, Open-Label, Multicenter, Randomized, Comparative Phase III Study of Induction Treatment With VBMCP-VBAD/Velcade Versus Thalidomide / Dexamethasone Versus Velcade / Thalidomide / Dexamethasone Followed by High Dose Intensive Therapy With Autolo[NCT00461747] | Phase 3 | 390 participants (Anticipated) | Interventional | 2006-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for thiotepa and Bone Marrow Diseases
| Article | Year |
|---|---|
Source of stem cell rescue: bone marrow versus peripheral blood progenitors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blood Cells; Blood Transfusion, Autologous; Bone Mar | 1993 |
High-dose chemotherapy with autologous stem cell support for breast cancer: a review of the Dana-Farber Cancer Institute/Beth Israel Hospital experience.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blood Transfusion, Auto | 1993 |
Treatment of ovarian cancer with thiotepa.
Topics: Bone Marrow Diseases; Female; Humans; Infections; Injections, Intravenous; Ovarian Neoplasms; Pallia | 1968 |
3 trials available for thiotepa and Bone Marrow Diseases
| Article | Year |
|---|---|
High-dose cyclophosphamide, thiotepa, and carboplatin with autologous marrow support in women with measurable advanced breast cancer responding to standard-dose therapy: analysis by age.
Topics: Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Bone Marro | 1994 |
A phase II trial of vinorelbine and thiotepa in metastatic breast cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Breast Neoplasms; Drug | 1995 |
Thiotepa cyclophosphamide followed by granulocyte colony-stimulating factor mobilized allogeneic peripheral blood cells in adults with advanced leukemia.
Topics: Actuarial Analysis; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone M | 1996 |
12 other studies available for thiotepa and Bone Marrow Diseases
| Article | Year |
|---|---|
FEOTAL LIVER SUSPENSIONS IN THE TREATMENT OF MARROW APLASIA.
Topics: Anemia; Anemia, Aplastic; Antineoplastic Agents; Bone Marrow; Bone Marrow Diseases; Fetus; Hemoglobi | 1965 |
Double dose-intensive chemotherapy with autologous marrow and peripheral-blood progenitor-cell support for metastatic breast cancer: a feasibility study.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Bone Marrow Transplanta | 1994 |
Early myeloablative therapy for multiple myeloma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Bone Marrow Transplanta | 1994 |
Use of safety-modified retroviruses to introduce chemotherapy resistance sequences into normal hematopoietic cells for chemoprotection during the therapy of breast cancer: a pilot trial.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B | 1996 |
Mobilized peripheral blood progenitor cells (PBPC) in support of tandem cycles of high-dose chemotherapy (HDC).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Bone Marrow Trans | 1996 |
Myeloablative chemotherapy for recurrent aggressive oligodendroglioma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Bone Marrow Transplanta | 2000 |
Deferoxamine, cyclophosphamide, etoposide, carboplatin, and thiotepa (D-CECaT): a new cytoreductive chelation-chemotherapy regimen in patients with advanced neuroblastoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Carboplatin; Chelation Therapy | 1992 |
Pharmacokinetics of thio-TEPA and TEPA in the conventional dose-range and its correlation to myelosuppressive effects.
Topics: Aged; Aged, 80 and over; Bilirubin; Bone Marrow Diseases; Creatinine; Female; Humans; Leukocyte Coun | 1991 |
Acute erythromegakaryocytic leukaemia after treatment with cytostatic agents.
Topics: Adenocarcinoma; Aged; Bone Marrow Diseases; Erythrocytes; Humans; Leukemia; Lung Neoplasms; Male; Me | 1970 |
Some aspects of chemotherapy in breast carcinomatosis.
Topics: Adrenalectomy; Bone Marrow Diseases; Breast Neoplasms; Carcinoma; Cyclophosphamide; Female; Humans; | 1968 |
[Severe bone marrow damage after instillation of thio tepa into the bladder].
Topics: Aged; Bone Marrow Diseases; Humans; Male; Papilloma; Thiotepa; Urinary Bladder; Urinary Bladder Neop | 1966 |
Phase I study of phenesterin (NSC-104469).
Topics: Administration, Oral; Adult; Aged; Androgens; Antineoplastic Agents; Blood Cell Count; Blood Platele | 1971 |