thiotepa has been researched along with Bone Cancer in 25 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the efficacy and safety of docetaxel plus thiotepa(TXT/TSPA) and docetaxel plus capecitabine(TXT/CAPE) in patients with metastatic breast cancer." | 9.15 | [Randomized clinical case-control trial for the comparison of docetaxel plus thiotepa versus docetaxel plus capecitabine in patients with metastatic breast cancer]. ( Che, L; DI, Lj; Jia, J; Jiang, Hf; Liang, X; Ren, J; Song, Gh; Wang, Xl; Yang, Hb; Yu, J; Zhang, J; Zhou, Xn; Zhu, Yl, 2011) |
| "To evaluate the efficacy and safety of docetaxel plus thiotepa(TXT/TSPA) and docetaxel plus capecitabine(TXT/CAPE) in patients with metastatic breast cancer." | 5.15 | [Randomized clinical case-control trial for the comparison of docetaxel plus thiotepa versus docetaxel plus capecitabine in patients with metastatic breast cancer]. ( Che, L; DI, Lj; Jia, J; Jiang, Hf; Liang, X; Ren, J; Song, Gh; Wang, Xl; Yang, Hb; Yu, J; Zhang, J; Zhou, Xn; Zhu, Yl, 2011) |
| "ThioTEPA was administered intravenously every three weeks, at a dose of 65 mg/m2." | 2.68 | A phase II study of thioTEPA in children with recurrent solid tumor malignancies: a Children's Cancer Group study. ( Balis, FM; Bleyer, WA; Broxson, E; Geyer, JR; Heideman, R; Krailo, MD; Poplack, D; Sato, JK, 1996) |
| "Melphalan was given i." | 2.68 | High-dose sequential chemotherapy and autologous stem cell reinfusion in advanced pediatric solid tumors. ( Ater, J; Chan, KW; Choroszy, M; Herzog, C; Jaffe, N; Korbling, M; Petropoulos, D, 1997) |
| "A 56-year-old female with breast cancer after left partial mastectomy and subaxillary lymph node dissection was treated with adjuvant chemoradiotherapy." | 1.33 | [A case of recurrent breast cancer complicated with pericardial effusions and cardiac tamponade]. ( Ishiguro, A; Mitobe, S; Munakata, M; Okada, R; Sakata, Y; Shitara, K; Tomioka, R, 2006) |
| "A case of distant metastases of a giant cell tumor of the radius is presented." | 1.27 | Extensive distal subcutaneous metastases of a "benign" giant cell tumor of the radius. ( Muirragui, A; Serra, JM; Tadjalli, H, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (48.00) | 18.7374 |
| 1990's | 4 (16.00) | 18.2507 |
| 2000's | 5 (20.00) | 29.6817 |
| 2010's | 3 (12.00) | 24.3611 |
| 2020's | 1 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Uemura, S | 1 |
| Mori, T | 1 |
| Ishiko, S | 1 |
| Takafuji, S | 1 |
| Nino, N | 1 |
| Yamamoto, N | 1 |
| Hayakawa, A | 1 |
| Nishimura, N | 1 |
| Hara, H | 1 |
| Kawamoto, T | 1 |
| Akisue, T | 1 |
| Iijima, K | 1 |
| Jahnukainen, K | 1 |
| Kallio, P | 1 |
| Koivusalo, A | 1 |
| Saarinen-Pihkala, UM | 1 |
| Cheng, JP | 1 |
| Yan, Y | 1 |
| Wang, XY | 1 |
| Lu, YL | 1 |
| Yuan, YH | 1 |
| Jia, J | 2 |
| Ren, J | 2 |
| Yu, J | 1 |
| DI, Lj | 1 |
| Song, Gh | 1 |
| Che, L | 1 |
| Jiang, Hf | 1 |
| Zhu, Yl | 1 |
| Liang, X | 1 |
| Zhang, J | 1 |
| Yang, Hb | 1 |
| Wang, Xl | 1 |
| Zhou, Xn | 1 |
| YAMAGUCHI, H | 1 |
| TERASHITA, N | 1 |
| TABUCHI, Y | 1 |
| IKEDA, E | 1 |
| FUKUI, S | 1 |
| SVIATUKHINA, OV | 1 |
| PRIEDITE, IJ | 1 |
| DOWD, JE | 1 |
| DIPAOLO, JA | 1 |
| WATNE, AL | 1 |
| BIRINGER, A | 1 |
| HOLAN, J | 1 |
| MEDLA, F | 1 |
| Dillman, RO | 1 |
| Barth, NM | 1 |
| VanderMolen, LA | 1 |
| Allen, K | 1 |
| Beutel, LD | 1 |
| Chico, S | 1 |
| Shitara, K | 1 |
| Munakata, M | 1 |
| Ishiguro, A | 1 |
| Okada, R | 1 |
| Tomioka, R | 1 |
| Mitobe, S | 1 |
| Sakata, Y | 1 |
| Legha, SS | 1 |
| Ajani, JA | 1 |
| Blumenschein, GR | 1 |
| Hortobagyi, GN | 1 |
| Buzdar, AU | 1 |
| Geyer, JR | 1 |
| Balis, FM | 1 |
| Krailo, MD | 1 |
| Heideman, R | 1 |
| Broxson, E | 1 |
| Sato, JK | 1 |
| Poplack, D | 1 |
| Bleyer, WA | 1 |
| Chan, KW | 1 |
| Petropoulos, D | 1 |
| Choroszy, M | 1 |
| Herzog, C | 1 |
| Jaffe, N | 1 |
| Ater, J | 1 |
| Korbling, M | 1 |
| Yonemoto, T | 1 |
| Tatezaki, S | 1 |
| Ishii, T | 1 |
| Satoh, T | 1 |
| Bashey, A | 1 |
| Corringham, S | 1 |
| Garrett, J | 1 |
| Lane, TA | 1 |
| Gilpin, EA | 1 |
| Corringham, RE | 1 |
| Law, P | 1 |
| Ho, AD | 1 |
| Okumura, A | 1 |
| Tokuda, Y | 1 |
| Ohta, M | 1 |
| Suzuki, Y | 1 |
| Saito, Y | 1 |
| Kuge, S | 1 |
| Kubota, M | 1 |
| Makuuchi, H | 1 |
| Tajima, T | 1 |
| Nakamura, Y | 1 |
| Hotta, T | 1 |
| Kushner, BH | 1 |
| Meyers, PA | 1 |
| Hertzberg, H | 1 |
| Kremens, B | 1 |
| Velten, I | 1 |
| Beck, JD | 1 |
| Greil, J | 1 |
| Kutateladze, TO | 1 |
| Moroshkin, IB | 1 |
| Portnoĭ, SM | 1 |
| Rosen, JM | 1 |
| MacLaughlin, WW | 1 |
| Jaffe, RM | 1 |
| Serra, JM | 1 |
| Muirragui, A | 1 |
| Tadjalli, H | 1 |
| Scott, WP | 1 |
| Fisher, B | 1 |
| Ravdin, RG | 1 |
| Ausman, RK | 1 |
| Slack, NH | 1 |
| Moore, GE | 1 |
| Noer, RJ | 1 |
| Boeckl, O | 1 |
| Hell, E | 1 |
| Zimmermann, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessment of MGMT Promoter Methylation and Clinical Benefit From Temozolomide-based Therapy in Ewing Sarcoma Patients[NCT03542097] | 82 participants (Actual) | Observational | 2014-04-15 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for thiotepa and Bone Cancer
| Article | Year |
|---|---|
How effective is dose-intensive/myeloablative therapy against Ewing's sarcoma/primitive neuroectodermal tumor metastatic to bone or bone marrow? The Memorial Sloan-Kettering experience and a literature review.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasms; Bone Neopl | 2001 |
[Regional perfusion therapy of malignant tumors of the extremities].
Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Carcinoma, Squamous Cell; Chemotherapy, Cancer, Regi | 1970 |
7 trials available for thiotepa and Bone Cancer
| Article | Year |
|---|---|
Retrospective analysis of high-dose chemotherapy followed by autologous stem cell transplantation for high-risk pediatric osteosarcoma.
Topics: Adolescent; Bone Neoplasms; Busulfan; Child; Female; Hematopoietic Stem Cell Transplantation; Humans | 2020 |
[Randomized clinical case-control trial for the comparison of docetaxel plus thiotepa versus docetaxel plus capecitabine in patients with metastatic breast cancer].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Capec | 2011 |
High-dose chemotherapy and autologous stem cell rescue for metastatic breast cancer: superior survival for tandem compared with single transplants.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Carbo | 2005 |
A phase II study of thioTEPA in children with recurrent solid tumor malignancies: a Children's Cancer Group study.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Bone Neoplasms; Child; Humans; Neoplasms; Neuroectode | 1996 |
High-dose sequential chemotherapy and autologous stem cell reinfusion in advanced pediatric solid tumors.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; | 1997 |
A phase II study of two cycles of high-dose chemotherapy with autologous stem cell support in patients with metastatic breast cancer who meet eligibility criteria for a single cycle.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Carboplatin | 2000 |
Surgical adjuvant chemotherapy in cancer of the breast: results of a decade of cooperative investigation.
Topics: Adult; Aged; Axilla; Bone Neoplasms; Breast Neoplasms; Clinical Trials as Topic; Female; Fluorouraci | 1968 |
16 other studies available for thiotepa and Bone Cancer
| Article | Year |
|---|---|
High-dose Thiotepa as Consolidation Therapy With Autologous Hematopoietic Stem Cell Transplantation for High-risk Ewing Family Tumors: Single-institution Experience.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bone | 2015 |
MUC1-positive circulating tumor cells and MUC1 protein predict chemotherapeutic efficacy in the treatment of metastatic breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Cell | 2011 |
[Triethylenethiophosphoramide in the treatment of the osteosarcoma and lymphomatosis].
Topics: Antineoplastic Agents; Bone Neoplasms; Humans; Lymphoma; Neoplasms; Osteosarcoma; Thiotepa | 1956 |
HORMONE THERAPY OF PATIENTS WITH ADVANCED CANCER OF THE BREAST.
Topics: Bone Neoplasms; Breast Neoplasms; Castration; Cortisone; Estrogens; Female; Follicle Stimulating Hor | 1964 |
COMPLEX TREATMENT APPLIED IN CASES OF NEGLECTED CANCER OF THE MAMMARY GLAND.
Topics: Bone Neoplasms; Breast Neoplasms; Castration; Cortisone; Female; Humans; Mammary Glands, Human; Meth | 1964 |
INDIVIDUALIZED CHEMOTHERAPY BY IN VITRO DRUG SELECTION.
Topics: Antineoplastic Agents; Bone Neoplasms; Dactinomycin; Female; Floxuridine; Fluorouracil; Genital Neop | 1964 |
OUR EXPERIENCES WITH CYTOSTATIC PERFUSIONS OF THE EXTREMITIES IN THE TREATMENT OF MALIGNANT TUMORS.
Topics: Animals; Bone Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Cyclophosphamide; Dogs; Drug Ther | 1964 |
[A case of recurrent breast cancer complicated with pericardial effusions and cardiac tamponade].
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; B | 2006 |
Combination chemotherapy of metastatic breast carcinoma with cyclophosphamide, adriamycin, and peptichemio.
Topics: Adult; Aged; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone Neoplasms; | 1984 |
[High-dose chemotherapy with autologous peripheral blood stem cell transplantation (PBSCT) for refractory bone and soft tissue sarcomas].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Busulfan; Child; | 1999 |
Autografting with peripheral blood CD34-positive cells following high-dose chemotherapy against breast cancer.
Topics: Adult; Antigens, CD34; Antineoplastic Agents, Alkylating; Bone Neoplasms; Breast Neoplasms; Cyclopho | 1999 |
Recurrent disseminated retinoblastoma in a 7-year-old girl treated successfully by high-dose chemotherapy and CD34-selected autologous peripheral blood stem cell transplantation.
Topics: Antigens, CD34; Antineoplastic Agents; Bone Marrow Neoplasms; Bone Neoplasms; Carboplatin; Child; Cy | 2001 |
[Dynamics of metastasis of breast cancer to the bones].
Topics: Bone Neoplasms; Breast Neoplasms; Female; Humans; Mastectomy, Radical; Neoplasm Staging; Postoperati | 1989 |
Resolution of a photopenic lesion on bone imaging following chemotherapy for metastatic disease.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Carcinoma, Intradu | 1987 |
Extensive distal subcutaneous metastases of a "benign" giant cell tumor of the radius.
Topics: Adult; Bone Neoplasms; Doxorubicin; Female; Giant Cell Tumors; Hand; Humans; Neoplasm Metastasis; Ne | 1985 |
Fluoride therapy for pain in malignant bone disease.
Topics: Adult; Aged; Analgesia; Bone Neoplasms; Breast Neoplasms; Estrogens; Fluorides; Fluoxymesterone; Hum | 1968 |