thiotepa has been researched along with Blood Diseases in 20 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The maximum tolerated dose for a combination chemotherapy regimen of Thiotepa, Mitoxantrone and Methotrexate (TMM) administered intravenously every three weeks to twelve patients with metastatic breast cancer was: Thiotepa: 15mg/m2, Mitoxantrone: 10mg/m2 and Methotrexate: 30mg/m2." | 9.06 | A pilot trial of TMM (thiotepa, mitoxantrone and methotrexate) chemotherapy for metastatic breast cancer. ( Bhardwaj, S; Holland, JF, 1990) |
| "The maximum tolerated dose for a combination chemotherapy regimen of Thiotepa, Mitoxantrone and Methotrexate (TMM) administered intravenously every three weeks to twelve patients with metastatic breast cancer was: Thiotepa: 15mg/m2, Mitoxantrone: 10mg/m2 and Methotrexate: 30mg/m2." | 5.06 | A pilot trial of TMM (thiotepa, mitoxantrone and methotrexate) chemotherapy for metastatic breast cancer. ( Bhardwaj, S; Holland, JF, 1990) |
| "Current treatments for metastatic breast cancer are not associated with significant survival benefits despite response rates of over 50%." | 2.68 | High-dose chemotherapy supported by peripheral blood progenitor cells in poor prognosis metastatic breast cancer--phase I/II study. Edinburgh Breast Group. ( Anderson, E; Anderson, T; Cameron, DA; Chetty, U; Craig, J; Dixon, M; Gabra, H; Hawkins, A; Jack, W; Kunkler, I; Lee, L; Leonard, R; Leonard, RC; MacKay, J; Matheson, L; Miller, W; Parker, AC, 1996) |
| "Stage II patients with breast carcinoma who had undergone lumpectomy." | 1.28 | Adjuvant therapy of stage II breast cancer treated with CMFVP, radiation therapy and VATH following lumpectomy. A pilot trial. ( Allen, S; Bosworth, H; Budman, D; Lehrman, D; Lichtman, SM; Schulman, P; Vinciguerra, V; Weiselberg, L; Weiss, R, 1991) |
| "Thiotepa treatments should be limited to 90 mg/mo and protracted therapy avoided in elderly men." | 1.26 | Hematologic effects of intravesicular thiotepa therapy for bladder carcinoma. ( Coleman, M; Hollister, D, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (40.00) | 18.7374 |
| 1990's | 6 (30.00) | 18.2507 |
| 2000's | 6 (30.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grodman, H | 1 |
| Wolfe, L | 1 |
| Kretschmar, C | 1 |
| Kremens, B | 1 |
| Gruhn, B | 1 |
| Klingebiel, T | 1 |
| Hasan, C | 1 |
| Laws, HJ | 1 |
| Koscielniak, E | 1 |
| Hero, B | 1 |
| Selle, B | 1 |
| Niemeyer, C | 1 |
| Finckenstein, FG | 1 |
| Schulz, A | 1 |
| Wawer, A | 1 |
| Zintl, F | 1 |
| Graf, N | 1 |
| Ferreri, AJ | 1 |
| Dell'Oro, S | 1 |
| Foppoli, M | 1 |
| Bernardi, M | 1 |
| Brandes, AA | 1 |
| Tosoni, A | 1 |
| Montanari, M | 1 |
| Balzarotti, M | 1 |
| Spina, M | 1 |
| Ilariucci, F | 1 |
| Zaja, F | 1 |
| Stelitano, C | 1 |
| Bobbio, F | 1 |
| Corazzelli, G | 1 |
| Baldini, L | 1 |
| Ponzoni, M | 1 |
| Picozzi, P | 1 |
| Caligaris Cappio, F | 1 |
| Reni, M | 1 |
| Hollister, D | 1 |
| Coleman, M | 1 |
| Korochkin, IM | 1 |
| Samoĭlova, LN | 1 |
| Kapustina, GM | 1 |
| Przepiorka, D | 2 |
| Ippoliti, C | 2 |
| Giralt, S | 1 |
| van Beisen, K | 1 |
| Mehra, R | 1 |
| Deisseroth, AB | 1 |
| Andersson, B | 1 |
| Luna, M | 2 |
| Cork, A | 1 |
| Lee, M | 1 |
| Dimopoulos, M | 1 |
| Smith, T | 1 |
| Diener, K | 1 |
| Champlin, RE | 1 |
| Cameron, DA | 1 |
| Craig, J | 1 |
| Gabra, H | 1 |
| Lee, L | 1 |
| MacKay, J | 1 |
| Parker, AC | 1 |
| Leonard, RC | 1 |
| Anderson, E | 1 |
| Anderson, T | 1 |
| Chetty, U | 1 |
| Dixon, M | 1 |
| Hawkins, A | 1 |
| Jack, W | 1 |
| Kunkler, I | 1 |
| Leonard, R | 1 |
| Matheson, L | 1 |
| Miller, W | 1 |
| Papadakis, V | 1 |
| Dunkel, IJ | 1 |
| Cramer, LD | 1 |
| Kramer, E | 1 |
| Papadopoulos, E | 1 |
| Goldman, S | 1 |
| Packer, RJ | 1 |
| Willoughby, M | 1 |
| Baker, D | 1 |
| Garvin, J | 1 |
| Strandjord, S | 1 |
| Coccia, P | 1 |
| Kaplan, AM | 1 |
| Klemperer, M | 1 |
| Finlay, JL | 1 |
| Winer, EP | 1 |
| Burstein, HJ | 1 |
| De Giorgi, U | 1 |
| Rosti, G | 1 |
| Papiani, G | 1 |
| Marangolo, M | 1 |
| Gutin, PH | 1 |
| Levi, JA | 1 |
| Wiernik, PH | 1 |
| Walker, MD | 1 |
| Ransom, DT | 1 |
| Neuberg, D | 1 |
| Loprinzi, CL | 1 |
| Tormey, DC | 1 |
| Blum, RH | 1 |
| Harris, JE | 1 |
| Asbury, RF | 1 |
| Falkson, G | 1 |
| Lichtman, SM | 1 |
| Budman, D | 1 |
| Bosworth, H | 1 |
| Allen, S | 1 |
| Schulman, P | 1 |
| Weiselberg, L | 1 |
| Weiss, R | 1 |
| Lehrman, D | 1 |
| Vinciguerra, V | 1 |
| Bhardwaj, S | 1 |
| Holland, JF | 1 |
| Williams, SF | 1 |
| Bitran, JD | 1 |
| Kaminer, L | 1 |
| Westbrook, C | 1 |
| Jacobs, R | 1 |
| Ashenhurst, J | 1 |
| Robin, E | 1 |
| Purl, S | 1 |
| Beschorner, J | 1 |
| Schroeder, C | 1 |
| Simpson, WG | 1 |
| Tseng, MT | 1 |
| Harty, JI | 1 |
| Antelava, NV | 1 |
| Trapeznikov, NN | 1 |
| Iavorskiĭ, VV | 1 |
| Amcheslavskiĭ, EG | 1 |
| Saslaw, S | 1 |
| Carlisle, HN | 1 |
| Kholodnyi, MD | 1 |
| Mindlin, SS | 1 |
2 reviews available for thiotepa and Blood Diseases
| Article | Year |
|---|---|
New combinations with Herceptin in metastatic breast cancer.
Topics: Anastrozole; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Hormo | 2001 |
The status of high-dose chemotherapy with hematopoietic stem cell transplantation in germ cell tumor patients.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carboplatin; Cisplatin; Clinical T | 2002 |
6 trials available for thiotepa and Blood Diseases
| Article | Year |
|---|---|
MATILDE regimen followed by radiotherapy is an active strategy against primary CNS lymphomas.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neop | 2006 |
A phase I-II study of high-dose thiotepa, busulfan and cyclophosphamide as a preparative regimen for allogeneic marrow transplantation.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Busu | 1994 |
Thiotepa, busulfan, and cyclophosphamide as a preparative regimen for marrow transplantation: risk factors for early regimen-related toxicity.
Topics: Adult; Bone Marrow Transplantation; Busulfan; Cyclophosphamide; Female; Hematologic Diseases; Humans | 1994 |
High-dose chemotherapy supported by peripheral blood progenitor cells in poor prognosis metastatic breast cancer--phase I/II study. Edinburgh Breast Group.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Central Nervous System Neop | 1996 |
Treatment of malignant meningeal disease with intrathecal thioTEPA: a phase II study.
Topics: Clinical Trials as Topic; Drug Evaluation; Hematologic Diseases; Humans; Injections, Spinal; Meninge | 1977 |
A pilot trial of TMM (thiotepa, mitoxantrone and methotrexate) chemotherapy for metastatic breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Hematologic D | 1990 |
12 other studies available for thiotepa and Blood Diseases
| Article | Year |
|---|---|
Outcome of patients with recurrent medulloblastoma or central nervous system germinoma treated with low dose continuous intravenous etoposide along with dose-intensive chemotherapy followed by autologous hematopoietic stem cell rescue.
Topics: Adolescent; Adult; Anemia; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Central Nerv | 2009 |
High-dose chemotherapy with autologous stem cell rescue in children with nephroblastoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Child, Preschool; Combined Modal | 2002 |
Hematologic effects of intravesicular thiotepa therapy for bladder carcinoma.
Topics: Adult; Aged; Anemia; Blood Cell Count; Bone Marrow; Female; Hematologic Diseases; Humans; Injections | 1980 |
[Changes in the blood due to drug-induced disease].
Topics: Anaphylaxis; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Hematologic Dis | 1980 |
High-dose carmustine, thiotepa and etoposide followed by autologous bone marrow rescue for the treatment of high risk central nervous system tumors.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carm | 2000 |
A pilot study of three sequential chemotherapeutic regimens in metastatic breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Dox | 1991 |
Adjuvant therapy of stage II breast cancer treated with CMFVP, radiation therapy and VATH following lumpectomy. A pilot trial.
Topics: Adjuvants, Pharmaceutic; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplas | 1991 |
A phase I-II study of bialkylator chemotherapy, high-dose thiotepa, and cyclophosphamide with autologous bone marrow reinfusion in patients with advanced cancer.
Topics: Adult; Alkylating Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantatio | 1987 |
Systemic influence of intravesical chemotherapy with verapamil.
Topics: Animals; Calcium Channel Blockers; Cardiomyopathies; Doxorubicin; Drug Evaluation, Preclinical; Fema | 1985 |
[Status of the blood after perfusion with various doses of chemopreparations and the efficiency of an artificial ciruclation device in malignant tumors of the extremities].
Topics: Extracorporeal Circulation; Extremities; Hematologic Diseases; Humans; Melphalan; Neoplasms; Perfusi | 1968 |
Nonhuman primates in evaluation of hematotoxicity.
Topics: Animals; Busulfan; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug-Related Side Effects and Adver | 1969 |
[The hypoplastic state of hematopoiesis following chemotherapy with alkylating compounds].
Topics: Adult; Aged; Alkylating Agents; Antineoplastic Agents; Breast Neoplasms; Female; Hematologic Disease | 1969 |