thiotepa has been researched along with Benign Cerebellar Neoplasms in 16 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the study is to evaluate the outcome of young children with high risk localized medulloblastomas (newly diagnosed classical or incompletely resected) treated by high-dose busulfan-thiotepa with autologous stem cell rescue (ASCT) followed by focal radiation therapy (RT)." | 7.80 | High-dose busulfan-thiotepa with autologous stem cell transplantation followed by posterior fossa irradiation in young children with classical or incompletely resected medulloblastoma. ( Bergthold, G; Dhermain, F; Dufour, C; El Kababri, M; Goma, G; Grill, J; Kieffer, V; Raquin, MA; Sainte-Rose, C; Valteau-Couanet, D; Varlet, P, 2014) |
| "Recurrent medulloblastoma is highly lethal in previously irradiated patients." | 6.75 | High-dose carboplatin, thiotepa, and etoposide with autologous stem cell rescue for patients with previously irradiated recurrent medulloblastoma. ( Dunkel, IJ; Finlay, JL; Gardner, SL; Garvin, JH; Goldman, S; Shi, W, 2010) |
| "Medulloblastoma is a highly lethal disease when it recurs." | 5.30 | High-dose carboplatin, thiotepa, and etoposide with autologous stem-cell rescue for patients with recurrent medulloblastoma. Children's Cancer Group. ( Allen, JC; Bostrom, BC; Boyett, JM; Dunkel, IJ; Finlay, JL; Gardner, SL; Garvin, JH; Goldman, S; Li, H; Rosenblum, M; Sender, LS; Yates, A, 1998) |
| "By conventional Phase II criteria, thiotepa appears to have activity in medulloblastoma." | 5.07 | A phase II evaluation of thiotepa in pediatric central nervous system malignancies. ( Allen, JC; Balis, FM; Gillespie, A; Heideman, RL; Horowitz, ME; Kovnar, EH; Lange, B; Packer, RJ; Reaman, GH; Steinberg, SM, 1993) |
| "The aim of the study is to evaluate the outcome of young children with high risk localized medulloblastomas (newly diagnosed classical or incompletely resected) treated by high-dose busulfan-thiotepa with autologous stem cell rescue (ASCT) followed by focal radiation therapy (RT)." | 3.80 | High-dose busulfan-thiotepa with autologous stem cell transplantation followed by posterior fossa irradiation in young children with classical or incompletely resected medulloblastoma. ( Bergthold, G; Dhermain, F; Dufour, C; El Kababri, M; Goma, G; Grill, J; Kieffer, V; Raquin, MA; Sainte-Rose, C; Valteau-Couanet, D; Varlet, P, 2014) |
| "Recurrent medulloblastoma is highly lethal in previously irradiated patients." | 2.75 | High-dose carboplatin, thiotepa, and etoposide with autologous stem cell rescue for patients with previously irradiated recurrent medulloblastoma. ( Dunkel, IJ; Finlay, JL; Gardner, SL; Garvin, JH; Goldman, S; Shi, W, 2010) |
| " CNS relapse and neurotoxicity in patients with acute lymphoblastic leukaemia, especially younger children, may be reduced by using age-related dosing of intrathecal MTX and Ara-C." | 2.41 | Intrathecal chemotherapy with antineoplastic agents in children. ( Biagi, E; Conter, V; Lazzareschi, I; Milani, M; Riccardi, R; Ruggiero, A; Sparano, P, 2001) |
| "Primitive neuroectodermal tumors (PNET) originating within the spinal cord are extraordinarily rare." | 1.37 | Intramedullary PNET of the spine: long-term survival after combined modality therapy and subsequent relapse. ( Anson, J; Gollard, RP; Khoury, J; Mason, J; Rosen, L, 2011) |
| "Medulloblastoma is a highly lethal disease when it recurs." | 1.30 | High-dose carboplatin, thiotepa, and etoposide with autologous stem-cell rescue for patients with recurrent medulloblastoma. Children's Cancer Group. ( Allen, JC; Bostrom, BC; Boyett, JM; Dunkel, IJ; Finlay, JL; Gardner, SL; Garvin, JH; Goldman, S; Li, H; Rosenblum, M; Sender, LS; Yates, A, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 6 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Van Schandevyl, G | 1 |
| Bauters, T | 1 |
| Bergthold, G | 1 |
| El Kababri, M | 1 |
| Varlet, P | 1 |
| Dhermain, F | 1 |
| Sainte-Rose, C | 2 |
| Raquin, MA | 2 |
| Kieffer, V | 1 |
| Goma, G | 1 |
| Grill, J | 2 |
| Valteau-Couanet, D | 2 |
| Dufour, C | 1 |
| Pezuk, JA | 1 |
| Valera, ET | 1 |
| Delsin, LE | 1 |
| Scrideli, CA | 1 |
| Tone, LG | 1 |
| Brassesco, MS | 1 |
| Massimino, M | 1 |
| Gandola, L | 1 |
| Spreafico, F | 1 |
| Biassoni, V | 1 |
| Luksch, R | 1 |
| Collini, P | 1 |
| Solero, CN | 1 |
| Simonetti, F | 1 |
| Pignoli, E | 1 |
| Cefalo, G | 1 |
| Poggi, G | 1 |
| Modena, P | 1 |
| Mariani, L | 1 |
| Potepan, P | 1 |
| Podda, M | 1 |
| Casanova, M | 1 |
| Pecori, E | 1 |
| Acerno, S | 1 |
| Ferrari, A | 1 |
| Terenziani, M | 1 |
| Meazza, C | 1 |
| Polastri, D | 1 |
| Ravagnani, F | 1 |
| Fossati-Bellani, F | 1 |
| Dunkel, IJ | 3 |
| Gardner, SL | 2 |
| Garvin, JH | 2 |
| Goldman, S | 2 |
| Shi, W | 1 |
| Finlay, JL | 3 |
| Gollard, RP | 1 |
| Rosen, L | 1 |
| Anson, J | 1 |
| Mason, J | 1 |
| Khoury, J | 1 |
| Sung, KW | 1 |
| Lim, DH | 1 |
| Son, MH | 1 |
| Lee, SH | 1 |
| Yoo, KH | 1 |
| Koo, HH | 1 |
| Kim, JH | 1 |
| Suh, YL | 1 |
| Joung, YS | 1 |
| Shin, HJ | 1 |
| Pérez-Martínez, A | 1 |
| Lassaletta, A | 1 |
| González-Vicent, M | 1 |
| Sevilla, J | 1 |
| Díaz, MA | 1 |
| Madero, L | 1 |
| Ridola, V | 1 |
| Doz, F | 2 |
| Gentet, JC | 1 |
| Frappaz, D | 1 |
| Habrand, JL | 1 |
| Kalifa, C | 2 |
| Edwards, MS | 1 |
| Levin, VA | 1 |
| Seager, ML | 1 |
| Wilson, CB | 1 |
| Heideman, RL | 1 |
| Packer, RJ | 1 |
| Reaman, GH | 1 |
| Allen, JC | 2 |
| Lange, B | 1 |
| Horowitz, ME | 1 |
| Steinberg, SM | 1 |
| Gillespie, A | 1 |
| Kovnar, EH | 1 |
| Balis, FM | 1 |
| O'Malley, B | 1 |
| Dupuis-Girod, S | 1 |
| Hartmann, O | 1 |
| Benhamou, E | 1 |
| Mechinaud, F | 1 |
| Bouffet, E | 1 |
| Coze, C | 1 |
| Boyett, JM | 1 |
| Yates, A | 1 |
| Rosenblum, M | 1 |
| Bostrom, BC | 1 |
| Sender, LS | 1 |
| Li, H | 1 |
| Foa, C | 1 |
| Magné, N | 1 |
| Bondiau, PY | 1 |
| Otto, J | 1 |
| Thyss, A | 1 |
| Ruggiero, A | 1 |
| Conter, V | 1 |
| Milani, M | 1 |
| Biagi, E | 1 |
| Lazzareschi, I | 1 |
| Sparano, P | 1 |
| Riccardi, R | 1 |
2 reviews available for thiotepa and Benign Cerebellar Neoplasms
| Article | Year |
|---|---|
[High-dose chemotherapy in relapse of medulloblastoma in young children].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Busulfan; Cerebellar Ne | 1997 |
Intrathecal chemotherapy with antineoplastic agents in children.
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Blood-Brain Barrier; Cerebellar Neoplasms; Cerebrosp | 2001 |
3 trials available for thiotepa and Benign Cerebellar Neoplasms
| Article | Year |
|---|---|
High-dose carboplatin, thiotepa, and etoposide with autologous stem cell rescue for patients with previously irradiated recurrent medulloblastoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cerebellar Neoplasms | 2010 |
High-dose chemotherapy with autologous stem cell rescue for children with high risk and recurrent medulloblastoma and supratentorial primitive neuroectodermal tumors.
Topics: Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Cerebel | 2005 |
A phase II evaluation of thiotepa in pediatric central nervous system malignancies.
Topics: Adolescent; Adult; Brain Neoplasms; Cerebellar Neoplasms; Child; Child, Preschool; Drug Administrati | 1993 |
11 other studies available for thiotepa and Benign Cerebellar Neoplasms
| Article | Year |
|---|---|
Thiotepa-induced cutaneous toxicity in pediatric patients: Case report and implementation of preventive care guidelines.
Topics: Adolescent; Cerebellar Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Drug Eruptions | 2019 |
High-dose busulfan-thiotepa with autologous stem cell transplantation followed by posterior fossa irradiation in young children with classical or incompletely resected medulloblastoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Busulfan; Cerebellar Neoplasms; Child, Preschool; Co | 2014 |
The Antiproliferative and Pro-apoptotic Effects of Methoxyamine on Pediatric Medulloblastoma Cell Lines Exposed to Ionizing Radiation and Chemotherapy.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Apoptosis; Caspases; Cell Line, Tumor; Cel | 2015 |
No salvage using high-dose chemotherapy plus/minus reirradiation for relapsing previously irradiated medulloblastoma.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cerebellar Neoplasms; Child | 2009 |
Intramedullary PNET of the spine: long-term survival after combined modality therapy and subsequent relapse.
Topics: Antineoplastic Combined Chemotherapy Protocols; Busulfan; Cerebellar Neoplasms; Chemotherapy, Adjuva | 2011 |
Reduced-dose craniospinal radiotherapy followed by tandem high-dose chemotherapy and autologous stem cell transplantation in patients with high-risk medulloblastoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cerebellar Neoplasms | 2013 |
High-dose chemotherapy with autologous stem cell rescue followed by posterior fossa irradiation for local medulloblastoma recurrence or progression after conventional chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aspergillosis; Busulfan; Cerebellar Neoplasms; Child | 2007 |
Intrathecal chemotherapy for leptomeningeal dissemination of medulloblastoma.
Topics: Adolescent; Antineoplastic Agents; Cerebellar Neoplasms; Child; Cytarabine; Drug Therapy, Combinatio | 1981 |
Is there a role for high-dose chemotherapy with stem cell rescue for brain stem tumors of childhood?
Topics: Adult; Astrocytoma; Cerebellar Neoplasms; Cerebellopontine Angle; Dose-Response Relationship, Drug; | 1996 |
High-dose carboplatin, thiotepa, and etoposide with autologous stem-cell rescue for patients with recurrent medulloblastoma. Children's Cancer Group.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cerebellar Neoplasms | 1998 |
High-dose chemotherapy with autologous stem cell support in an adult with bone marrow relapse of medulloblastoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasms; Busulfan; Carboplatin; | 2000 |