thiotepa has been researched along with Astrocytoma in 9 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Between April 1986 and March 1989, ten patients under 21 years of age with histologically confirmed malignant astrocytoma, received marrow-ablative chemotherapy with either thiotepa and Etoposide (five patients) or thiotepa, Etoposide and BCNU (five patients), followed by bone marrow 'rescue'." | 5.06 | High-dose multi-agent chemotherapy followed by bone marrow 'rescue' for malignant astrocytomas of childhood and adolescence. ( August, C; Bayever, E; Finlay, JL; Freid, A; Kamani, N; Kramer, E; Packer, R; Rorke, L; Sutton, L; Zimmerman, R, 1990) |
| "Twenty-seven children and adolescents with malignant astrocytomas [17 glioblastoma multiforme and 10 anaplastic astrocytoma (AA)] following initial tumor progression, received myeloablative chemotherapy followed by autologous marrow rescue with one of three thiotepa and etoposide-based chemotherapy regimens, administered alone (n = 11) or combined with carmustine (n = 5) or carboplatin (n = 11)." | 3.74 | Myeloablative chemotherapy with autologous bone marrow rescue in children and adolescents with recurrent malignant astrocytoma: outcome compared with conventional chemotherapy: a report from the Children's Oncology Group. ( Boyett, JM; Dhall, G; Dunkel, IJ; Finlay, JL; Gardner, SL; Goldman, S; Packer, RJ; Pollack, IF; Rosenblum, MK; Stanley, P; Wallace, D; Yates, AJ; Zimmerman, RA, 2008) |
| "High-dose chemotherapy with thiotepa and carboplatin with concomitant ASCT was used safely to treat patients with malignant astrocytomas and may provide a survival advantage." | 3.72 | Safety and efficacy of high-dose chemotherapy with autologous stem cell transplantation for patients with malignant astrocytomas. ( Ahmed, T; Benzil, DL; Chen, B; Gruber, M; Mannancheril, A, 2004) |
| "Nineteen patients with primary malignant gliomas were treated with thioTEPA." | 3.66 | Phase II evaluation of thioTEPA for treatment of central nervous system tumors. ( Edwards, MS; Levin, VA; Pischer, TL; Seager, ML; Wilson, CB, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Finlay, JL | 3 |
| Dhall, G | 1 |
| Boyett, JM | 1 |
| Dunkel, IJ | 2 |
| Gardner, SL | 1 |
| Goldman, S | 1 |
| Yates, AJ | 1 |
| Rosenblum, MK | 1 |
| Stanley, P | 1 |
| Zimmerman, RA | 1 |
| Wallace, D | 1 |
| Pollack, IF | 1 |
| Packer, RJ | 1 |
| STEVENS, DA | 1 |
| EASTY, GC | 1 |
| AMBROSE, EJ | 1 |
| Chen, B | 1 |
| Ahmed, T | 1 |
| Mannancheril, A | 1 |
| Gruber, M | 1 |
| Benzil, DL | 1 |
| Fagioli, F | 1 |
| Biasin, E | 1 |
| Mastrodicasa, L | 1 |
| Sandri, A | 1 |
| Ferrero, I | 1 |
| Berger, M | 1 |
| Vassallo, E | 1 |
| Madon, E | 1 |
| Mohile, NA | 1 |
| Forsyth, P | 1 |
| Stewart, D | 1 |
| Raizer, JJ | 1 |
| Paleologos, N | 1 |
| Kewalramani, T | 1 |
| Louis, DN | 1 |
| Cairncross, JG | 1 |
| Abrey, LE | 1 |
| O'Malley, B | 1 |
| Edwards, MS | 1 |
| Levin, VA | 1 |
| Seager, ML | 1 |
| Pischer, TL | 1 |
| Wilson, CB | 1 |
| August, C | 1 |
| Packer, R | 1 |
| Zimmerman, R | 1 |
| Sutton, L | 1 |
| Freid, A | 1 |
| Rorke, L | 1 |
| Bayever, E | 1 |
| Kamani, N | 1 |
| Kramer, E | 1 |
| Mahaley, MS | 1 |
| Woodhall, B | 1 |
2 trials available for thiotepa and Astrocytoma
| Article | Year |
|---|---|
A phase II study of intensified chemotherapy alone as initial treatment for newly diagnosed anaplastic oligodendroglioma: an interim analysis.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Busulfan; Combi | 2008 |
High-dose multi-agent chemotherapy followed by bone marrow 'rescue' for malignant astrocytomas of childhood and adolescence.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Bone Marrow Transplantation | 1990 |
7 other studies available for thiotepa and Astrocytoma
| Article | Year |
|---|---|
Myeloablative chemotherapy with autologous bone marrow rescue in children and adolescents with recurrent malignant astrocytoma: outcome compared with conventional chemotherapy: a report from the Children's Oncology Group.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Bone Marrow Transpla | 2008 |
THE ASSAY OF THE EFFECT OF CHEMICAL AGENTS ON TUMOUR INVASION USING CHICK EMBRYOS.
Topics: Animals; Astrocytoma; Biological Assay; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Chick Embry | 1963 |
Safety and efficacy of high-dose chemotherapy with autologous stem cell transplantation for patients with malignant astrocytomas.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carboplatin; Co | 2004 |
High-dose thiotepa and etoposide in children with poor-prognosis brain tumors.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carboplati | 2004 |
Is there a role for high-dose chemotherapy with stem cell rescue for brain stem tumors of childhood?
Topics: Adult; Astrocytoma; Cerebellar Neoplasms; Cerebellopontine Angle; Dose-Response Relationship, Drug; | 1996 |
Phase II evaluation of thioTEPA for treatment of central nervous system tumors.
Topics: Adolescent; Adult; Astrocytoma; Brain Neoplasms; Drug Evaluation; Glioblastoma; Glioma; Humans; Midd | 1979 |
Regional chemotherapeutic perfusion and infusion of brain and face tumors.
Topics: Adenocarcinoma; Ameloblastoma; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carcinoma; Carci | 1967 |