thiotepa has been researched along with Arachnoidal Cerebellar Sarcoma, Circumscribed in 23 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We previously demonstrated that Busulfan-Thiotepa (Bu-Thio) and ASCT effectively treated patients with locally relapsed medulloblastoma after surgery and conventional chemotherapy." | 9.11 | High-dose busulfan and thiotepa followed by autologous stem cell transplantation (ASCT) in previously irradiated medulloblastoma patients: high toxicity and lack of efficacy. ( Benhamou, E; Couanet, D; Fillipini, B; Grill, J; Habrand, JL; Hartmann, O; Kalifa, C; Valteau-Couanet, D, 2005) |
| "The aim of the study is to evaluate the outcome of young children with high risk localized medulloblastomas (newly diagnosed classical or incompletely resected) treated by high-dose busulfan-thiotepa with autologous stem cell rescue (ASCT) followed by focal radiation therapy (RT)." | 7.80 | High-dose busulfan-thiotepa with autologous stem cell transplantation followed by posterior fossa irradiation in young children with classical or incompletely resected medulloblastoma. ( Bergthold, G; Dhermain, F; Dufour, C; El Kababri, M; Goma, G; Grill, J; Kieffer, V; Raquin, MA; Sainte-Rose, C; Valteau-Couanet, D; Varlet, P, 2014) |
| "Recurrent medulloblastoma is highly lethal in previously irradiated patients." | 6.75 | High-dose carboplatin, thiotepa, and etoposide with autologous stem cell rescue for patients with previously irradiated recurrent medulloblastoma. ( Dunkel, IJ; Finlay, JL; Gardner, SL; Garvin, JH; Goldman, S; Shi, W, 2010) |
| "Medulloblastoma is a highly lethal disease when it recurs." | 5.30 | High-dose carboplatin, thiotepa, and etoposide with autologous stem-cell rescue for patients with recurrent medulloblastoma. Children's Cancer Group. ( Allen, JC; Bostrom, BC; Boyett, JM; Dunkel, IJ; Finlay, JL; Gardner, SL; Garvin, JH; Goldman, S; Li, H; Rosenblum, M; Sender, LS; Yates, A, 1998) |
| "We previously demonstrated that Busulfan-Thiotepa (Bu-Thio) and ASCT effectively treated patients with locally relapsed medulloblastoma after surgery and conventional chemotherapy." | 5.11 | High-dose busulfan and thiotepa followed by autologous stem cell transplantation (ASCT) in previously irradiated medulloblastoma patients: high toxicity and lack of efficacy. ( Benhamou, E; Couanet, D; Fillipini, B; Grill, J; Habrand, JL; Hartmann, O; Kalifa, C; Valteau-Couanet, D, 2005) |
| "By conventional Phase II criteria, thiotepa appears to have activity in medulloblastoma." | 5.07 | A phase II evaluation of thiotepa in pediatric central nervous system malignancies. ( Allen, JC; Balis, FM; Gillespie, A; Heideman, RL; Horowitz, ME; Kovnar, EH; Lange, B; Packer, RJ; Reaman, GH; Steinberg, SM, 1993) |
| "The aim of the study is to evaluate the outcome of young children with high risk localized medulloblastomas (newly diagnosed classical or incompletely resected) treated by high-dose busulfan-thiotepa with autologous stem cell rescue (ASCT) followed by focal radiation therapy (RT)." | 3.80 | High-dose busulfan-thiotepa with autologous stem cell transplantation followed by posterior fossa irradiation in young children with classical or incompletely resected medulloblastoma. ( Bergthold, G; Dhermain, F; Dufour, C; El Kababri, M; Goma, G; Grill, J; Kieffer, V; Raquin, MA; Sainte-Rose, C; Valteau-Couanet, D; Varlet, P, 2014) |
| "Recurrent medulloblastoma is highly lethal in previously irradiated patients." | 2.75 | High-dose carboplatin, thiotepa, and etoposide with autologous stem cell rescue for patients with previously irradiated recurrent medulloblastoma. ( Dunkel, IJ; Finlay, JL; Gardner, SL; Garvin, JH; Goldman, S; Shi, W, 2010) |
| " CNS relapse and neurotoxicity in patients with acute lymphoblastic leukaemia, especially younger children, may be reduced by using age-related dosing of intrathecal MTX and Ara-C." | 2.41 | Intrathecal chemotherapy with antineoplastic agents in children. ( Biagi, E; Conter, V; Lazzareschi, I; Milani, M; Riccardi, R; Ruggiero, A; Sparano, P, 2001) |
| "Treatment for malignant embryonal brain tumors in young children usually employs cycles of standardly dosed cisplatinum followed by high-dose carboplatinum-containing conditioning with single or tandem autologous stem cell rescue (HDC-ASCR)." | 1.56 | Changes in glomerular filtration rate and clinical course after sequential doses of carboplatin in children with embryonal brain tumors undergoing autologous stem cell transplantation. ( Almutereen, M; Elborai, Y; Hafez, H; Lee, MA; Lehmann, L; Maher, OM, 2020) |
| "Four patients with primitive neuroectodermal tumors also had subdural fluid leaks, with meningeal enhancement over the effusion." | 1.35 | Brain magnetic resonance imaging after high-dose chemotherapy and radiotherapy for childhood brain tumors. ( Adduci, A; Biassoni, V; Catania, S; Clerici, CA; Fossati-Bellani, F; Gandola, L; Luksch, R; Marchianò, A; Massimino, M; Meazza, C; Musumeci, R; Poggi, G; Simonetti, F; Spreafico, F; Terenziani, M, 2008) |
| "Medulloblastoma is a highly lethal disease when it recurs." | 1.30 | High-dose carboplatin, thiotepa, and etoposide with autologous stem-cell rescue for patients with recurrent medulloblastoma. Children's Cancer Group. ( Allen, JC; Bostrom, BC; Boyett, JM; Dunkel, IJ; Finlay, JL; Gardner, SL; Garvin, JH; Goldman, S; Li, H; Rosenblum, M; Sender, LS; Yates, A, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 3 (13.04) | 18.2507 |
| 2000's | 12 (52.17) | 29.6817 |
| 2010's | 6 (26.09) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Elborai, Y | 1 |
| Almutereen, M | 1 |
| Maher, OM | 1 |
| Hafez, H | 1 |
| Lee, MA | 1 |
| Lehmann, L | 1 |
| Osorio, DS | 1 |
| Dunkel, IJ | 3 |
| Cervone, KA | 1 |
| Goyal, RK | 1 |
| Steve Lo, KM | 1 |
| Finlay, JL | 4 |
| Gardner, SL | 3 |
| Van Schandevyl, G | 1 |
| Bauters, T | 1 |
| Bergthold, G | 1 |
| El Kababri, M | 1 |
| Varlet, P | 1 |
| Dhermain, F | 1 |
| Sainte-Rose, C | 2 |
| Raquin, MA | 2 |
| Kieffer, V | 1 |
| Goma, G | 1 |
| Grill, J | 3 |
| Valteau-Couanet, D | 3 |
| Dufour, C | 1 |
| Pezuk, JA | 1 |
| Valera, ET | 1 |
| Delsin, LE | 1 |
| Scrideli, CA | 1 |
| Tone, LG | 1 |
| Brassesco, MS | 1 |
| Massimino, M | 2 |
| Gandola, L | 2 |
| Spreafico, F | 2 |
| Biassoni, V | 2 |
| Luksch, R | 2 |
| Collini, P | 1 |
| Solero, CN | 1 |
| Simonetti, F | 2 |
| Pignoli, E | 1 |
| Cefalo, G | 1 |
| Poggi, G | 2 |
| Modena, P | 1 |
| Mariani, L | 1 |
| Potepan, P | 1 |
| Podda, M | 1 |
| Casanova, M | 1 |
| Pecori, E | 1 |
| Acerno, S | 1 |
| Ferrari, A | 1 |
| Terenziani, M | 2 |
| Meazza, C | 2 |
| Polastri, D | 1 |
| Ravagnani, F | 1 |
| Fossati-Bellani, F | 2 |
| Butturini, AM | 1 |
| Jacob, M | 1 |
| Aguajo, J | 1 |
| Vander-Walde, NA | 1 |
| Villablanca, J | 1 |
| Jubran, R | 1 |
| Erdreich-Epstein, A | 1 |
| Marachelian, A | 1 |
| Dhall, G | 1 |
| Garvin, JH | 2 |
| Goldman, S | 2 |
| Shi, W | 1 |
| Sung, KW | 1 |
| Lim, DH | 1 |
| Son, MH | 1 |
| Lee, SH | 1 |
| Yoo, KH | 1 |
| Koo, HH | 1 |
| Kim, JH | 1 |
| Suh, YL | 1 |
| Joung, YS | 1 |
| Shin, HJ | 1 |
| Zia, MI | 1 |
| Forsyth, P | 1 |
| Chaudhry, A | 1 |
| Russell, J | 1 |
| Stewart, DA | 1 |
| Pérez-Martínez, A | 1 |
| Lassaletta, A | 1 |
| González-Vicent, M | 1 |
| Sevilla, J | 1 |
| Díaz, MA | 1 |
| Madero, L | 1 |
| Fillipini, B | 1 |
| Benhamou, E | 2 |
| Kalifa, C | 3 |
| Couanet, D | 1 |
| Habrand, JL | 2 |
| Hartmann, O | 2 |
| Thorarinsdottir, HK | 1 |
| Rood, B | 2 |
| Kamani, N | 2 |
| Lafond, D | 1 |
| Perez-Albuerne, E | 1 |
| Loechelt, B | 1 |
| Packer, RJ | 3 |
| MacDonald, TJ | 2 |
| Ridola, V | 1 |
| Doz, F | 2 |
| Gentet, JC | 1 |
| Frappaz, D | 1 |
| Marchianò, A | 1 |
| Adduci, A | 1 |
| Clerici, CA | 1 |
| Catania, S | 1 |
| Musumeci, R | 1 |
| Choi, LM | 1 |
| La Fond, D | 1 |
| Santi, MR | 1 |
| Gill, P | 1 |
| Litzow, M | 1 |
| Buckner, J | 1 |
| Arndt, C | 1 |
| Moynihan, T | 1 |
| Christianson, T | 1 |
| Ansell, S | 1 |
| Galanis, E | 1 |
| Edwards, MS | 1 |
| Levin, VA | 1 |
| Seager, ML | 1 |
| Wilson, CB | 1 |
| Heideman, RL | 1 |
| Reaman, GH | 1 |
| Allen, JC | 2 |
| Lange, B | 1 |
| Horowitz, ME | 1 |
| Steinberg, SM | 1 |
| Gillespie, A | 1 |
| Kovnar, EH | 1 |
| Balis, FM | 1 |
| Dupuis-Girod, S | 1 |
| Mechinaud, F | 1 |
| Bouffet, E | 1 |
| Coze, C | 1 |
| Boyett, JM | 1 |
| Yates, A | 1 |
| Rosenblum, M | 1 |
| Bostrom, BC | 1 |
| Sender, LS | 1 |
| Li, H | 1 |
| Foa, C | 1 |
| Magné, N | 1 |
| Bondiau, PY | 1 |
| Otto, J | 1 |
| Thyss, A | 1 |
| Ruggiero, A | 1 |
| Conter, V | 1 |
| Milani, M | 1 |
| Biagi, E | 1 |
| Lazzareschi, I | 1 |
| Sparano, P | 1 |
| Riccardi, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-Institutional Pilot Study of Allogeneic Hematopoietic Stem Cell Transplantation for Patients With Malignant Neuro-Epithelial and Other Solid Tumors[NCT02653196] | Early Phase 1 | 1 participants (Actual) | Interventional | 2015-09-30 | Terminated (stopped due to The Principal Investigator left the institution.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for thiotepa and Arachnoidal Cerebellar Sarcoma, Circumscribed
| Article | Year |
|---|---|
[High-dose chemotherapy in relapse of medulloblastoma in young children].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Busulfan; Cerebellar Ne | 1997 |
Intrathecal chemotherapy with antineoplastic agents in children.
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Blood-Brain Barrier; Cerebellar Neoplasms; Cerebrosp | 2001 |
5 trials available for thiotepa and Arachnoidal Cerebellar Sarcoma, Circumscribed
| Article | Year |
|---|---|
Tandem thiotepa with autologous hematopoietic cell rescue in patients with recurrent, refractory, or poor prognosis solid tumor malignancies.
Topics: Adolescent; Adult; Autografts; Brain Neoplasms; Child; Child, Preschool; Disease-Free Survival; Fema | 2018 |
High-dose carboplatin, thiotepa, and etoposide with autologous stem cell rescue for patients with previously irradiated recurrent medulloblastoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cerebellar Neoplasms | 2010 |
High-dose chemotherapy with autologous stem cell rescue for children with high risk and recurrent medulloblastoma and supratentorial primitive neuroectodermal tumors.
Topics: Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Cerebel | 2005 |
High-dose busulfan and thiotepa followed by autologous stem cell transplantation (ASCT) in previously irradiated medulloblastoma patients: high toxicity and lack of efficacy.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Child; Child, Preschool; Combi | 2005 |
A phase II evaluation of thiotepa in pediatric central nervous system malignancies.
Topics: Adolescent; Adult; Brain Neoplasms; Cerebellar Neoplasms; Child; Child, Preschool; Drug Administrati | 1993 |
16 other studies available for thiotepa and Arachnoidal Cerebellar Sarcoma, Circumscribed
| Article | Year |
|---|---|
Changes in glomerular filtration rate and clinical course after sequential doses of carboplatin in children with embryonal brain tumors undergoing autologous stem cell transplantation.
Topics: Acute Kidney Injury; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Ca | 2020 |
Thiotepa-induced cutaneous toxicity in pediatric patients: Case report and implementation of preventive care guidelines.
Topics: Adolescent; Cerebellar Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Drug Eruptions | 2019 |
High-dose busulfan-thiotepa with autologous stem cell transplantation followed by posterior fossa irradiation in young children with classical or incompletely resected medulloblastoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Busulfan; Cerebellar Neoplasms; Child, Preschool; Co | 2014 |
The Antiproliferative and Pro-apoptotic Effects of Methoxyamine on Pediatric Medulloblastoma Cell Lines Exposed to Ionizing Radiation and Chemotherapy.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Apoptosis; Caspases; Cell Line, Tumor; Cel | 2015 |
No salvage using high-dose chemotherapy plus/minus reirradiation for relapsing previously irradiated medulloblastoma.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cerebellar Neoplasms; Child | 2009 |
High-dose chemotherapy and autologous hematopoietic progenitor cell rescue in children with recurrent medulloblastoma and supratentorial primitive neuroectodermal tumors: the impact of prior radiotherapy on outcome.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined | 2009 |
Reduced-dose craniospinal radiotherapy followed by tandem high-dose chemotherapy and autologous stem cell transplantation in patients with high-risk medulloblastoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cerebellar Neoplasms | 2013 |
Possible benefits of high-dose chemotherapy and autologous stem cell transplantation for adults with recurrent medulloblastoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Combined Modality Therapy | 2002 |
Outcome for children <4 years of age with malignant central nervous system tumors treated with high-dose chemotherapy and autologous stem cell rescue.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Child, Preschool; Cisp | 2007 |
High-dose chemotherapy with autologous stem cell rescue followed by posterior fossa irradiation for local medulloblastoma recurrence or progression after conventional chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aspergillosis; Busulfan; Cerebellar Neoplasms; Child | 2007 |
Brain magnetic resonance imaging after high-dose chemotherapy and radiotherapy for childhood brain tumors.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols | 2008 |
Feasibility of metronomic maintenance chemotherapy following high-dose chemotherapy for malignant central nervous system tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Chemotherapy, Adjuvant | 2008 |
High-dose chemotherapy with autologous stem cell transplantation in adults with recurrent embryonal tumors of the central nervous system.
Topics: Adult; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; | 2008 |
Intrathecal chemotherapy for leptomeningeal dissemination of medulloblastoma.
Topics: Adolescent; Antineoplastic Agents; Cerebellar Neoplasms; Child; Cytarabine; Drug Therapy, Combinatio | 1981 |
High-dose carboplatin, thiotepa, and etoposide with autologous stem-cell rescue for patients with recurrent medulloblastoma. Children's Cancer Group.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cerebellar Neoplasms | 1998 |
High-dose chemotherapy with autologous stem cell support in an adult with bone marrow relapse of medulloblastoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasms; Busulfan; Carboplatin; | 2000 |