thiotepa and Anemia
thiotepa has been researched along with Anemia in 15 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Anemia: A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thirty-five patients with advanced gynecologic malignancies were entered into a phase I study evaluating thio-TEPA in combination with cisplatin (50 mg/m2) intravenously every 4 weeks." | 1.28 | Phase I evaluation of thio-TEPA in combination with cisplatin for advanced gynecologic malignancies. ( Edwards, CL; Freedman, RS; Kavanagh, J; Raber, MN; Sandles, LG; Scott, WR; Wharton, JT, 1990) |
| "Thiotepa treatments should be limited to 90 mg/mo and protracted therapy avoided in elderly men." | 1.26 | Hematologic effects of intravesicular thiotepa therapy for bladder carcinoma. ( Coleman, M; Hollister, D, 1980) |
Research
Studies (15)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (80.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Ferreri, AJ | 1 |
| Cwynarski, K | 1 |
| Pulczynski, E | 1 |
| Ponzoni, M | 1 |
| Deckert, M | 1 |
| Politi, LS | 1 |
| Torri, V | 1 |
| Fox, CP | 1 |
| Rosée, PL | 1 |
| Schorb, E | 1 |
| Ambrosetti, A | 1 |
| Roth, A | 1 |
| Hemmaway, C | 1 |
| Ferrari, A | 1 |
| Linton, KM | 1 |
| Rudà, R | 1 |
| Binder, M | 1 |
| Pukrop, T | 1 |
| Balzarotti, M | 1 |
| Fabbri, A | 1 |
| Johnson, P | 1 |
| Gørløv, JS | 1 |
| Hess, G | 1 |
| Panse, J | 1 |
| Pisani, F | 1 |
| Tucci, A | 1 |
| Stilgenbauer, S | 1 |
| Hertenstein, B | 1 |
| Keller, U | 1 |
| Krause, SW | 1 |
| Levis, A | 1 |
| Schmoll, HJ | 1 |
| Cavalli, F | 1 |
| Finke, J | 1 |
| Reni, M | 1 |
| Zucca, E | 1 |
| Illerhaus, G | 1 |
| Grodman, H | 1 |
| Wolfe, L | 1 |
| Kretschmar, C | 1 |
| PLAUCHU, M | 2 |
| DALMAIS, J | 2 |
| CHATAING, B | 1 |
| PHILIBERT, S | 1 |
| MATSUOKA, M | 1 |
| MAUER, AM | 1 |
| KRILL, CE | 1 |
| GUINGAND, M | 1 |
| SHMIDT, AA | 1 |
| SOLAZEMNIETSE, GD | 1 |
| LIEPA, VE | 1 |
| BRIDGES, JB | 1 |
| BRIDGES, JM | 1 |
| EDELSTYN, GJ | 1 |
| LYONS, AR | 1 |
| Hollister, D | 1 |
| Coleman, M | 1 |
| Shamberger, RC | 1 |
| Devereux, DF | 1 |
| Brennan, MF | 1 |
| Sandles, LG | 1 |
| Freedman, RS | 1 |
| Raber, MN | 1 |
| Kavanagh, J | 1 |
| Edwards, CL | 1 |
| Scott, WR | 1 |
| Wharton, JT | 1 |
| Archimbaud, JP | 1 |
| Calcat, P | 1 |
| Martel, JP | 1 |
| Frid, IA | 1 |
| Turbina, IL | 1 |
| Chernyĭ, VA | 1 |
| Levin, AO | 1 |
| Volodkovich, HG | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Phase II Trial On Primary Chemotherapy With High-Dose Methotrexate And High-Dose Cytarabine With Or Without Thiotepa, And With Or Without Rituximab, Followed By Brain Irradiation Vs. High-Dose Chemotherapy Supported By Autologous Stem Cells Tra[NCT01011920] | Phase 2 | 126 participants (Actual) | Interventional | 2009-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
1 review available for thiotepa and Anemia
| Article | Year |
|---|---|
The effect of chemotherapeutic agents on wound healing.
Topics: Adrenal Cortex Hormones; Anemia; Animals; Antineoplastic Agents; Azathioprine; Collagen; Cyclophosph | 1981 |
Trials
1 trial available for thiotepa and Anemia
| Article | Year |
|---|---|
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
Topics: Acute Kidney Injury; Anemia; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System | 2016 |
Other Studies
13 other studies available for thiotepa and Anemia
| Article | Year |
|---|---|
Outcome of patients with recurrent medulloblastoma or central nervous system germinoma treated with low dose continuous intravenous etoposide along with dose-intensive chemotherapy followed by autologous hematopoietic stem cell rescue.
Topics: Adolescent; Adult; Anemia; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Central Nerv | 2009 |
[3 cases of bone marrow aplasia, 1 of which is curable, due to triethylene thio-phosphoramide of RP 10, 090].
Topics: Anemia; Anemia, Aplastic; Bone Marrow; Humans; Pancytopenia; Phosphoramides; Thiotepa | 1962 |
[IMPROVEMENT AND EXACERBATION IN LEUKEMIA].
Topics: Aminocaproates; Aminocaproic Acid; Anemia; Antineoplastic Agents; Blood Transfusion; Busulfan; Centr | 1963 |
A STUDY OF THE MECHANISMS OF GRANULOCYTOPENIA.
Topics: Agranulocytosis; Anemia; Anemia, Macrocytic; Carcinoma; Carcinoma, Bronchogenic; Child; Hodgkin Dise | 1964 |
[MEDULLARY APLASIA DURING THE USE OF 4 ANTIMITOTICS: CARYOLYSIN, MYLERAN, THIOTEPA, ENDOXAN (APROPOS OF 32 CASES)].
Topics: Anemia; Anemia, Aplastic; Antimitotic Agents; Busulfan; Cyclophosphamide; Neoplasms; Nitrogen Mustar | 1963 |
[ON THE STIMULATING EFFECT OF TRIETHYLENETHIOPHOSPHRAMIDE (THIO-TEPA) ON SERUM PROTEIN SYNTHESIS IN NORMAL RABBITS].
Topics: Anemia; Animals; Blood Proteins; Erythrocytes; Iron; Lagomorpha; Pharmacology; Proteins; Rabbits; Re | 1963 |
FEOTAL LIVER SUSPENSIONS IN THE TREATMENT OF MARROW APLASIA.
Topics: Anemia; Anemia, Aplastic; Antineoplastic Agents; Bone Marrow; Bone Marrow Diseases; Fetus; Hemoglobi | 1965 |
Hematologic effects of intravesicular thiotepa therapy for bladder carcinoma.
Topics: Adult; Aged; Anemia; Blood Cell Count; Bone Marrow; Female; Hematologic Diseases; Humans; Injections | 1980 |
Phase I evaluation of thio-TEPA in combination with cisplatin for advanced gynecologic malignancies.
Topics: Agranulocytosis; Anemia; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Evaluation; | 1990 |
[Spontaneously cured pancytopenia due to intravesical thio-tepa, apropos of one case].
Topics: Anemia; Female; Herpes Zoster; Humans; Leukopenia; Middle Aged; Mucous Membrane; Papilloma; Thiotepa | 1973 |
[The effect of anesthesia and surgical intervention on hematopoiesis following chemotherapy of malignant ovarian tumors].
Topics: Anemia; Anesthesia, Endotracheal; Cyclophosphamide; Female; Hematopoiesis; Humans; Leukopenia; Ovari | 1972 |
[The morphologic composition of peripheral blood following intra-arterial infusion of 5-fluorouracil and alkylating preparations in stomach cancer patients].
Topics: Anemia; Fluorouracil; Humans; Leukopenia; Melphalan; Nitrogen Mustard Compounds; Stomach Neoplasms; | 1970 |
[Clinico-electrocardiographic changes during perfusion chemotherapy of malignant tumors of the extremities].
Topics: Adolescent; Adult; Aged; Anemia; Cardiomyopathies; Chemotherapy, Cancer, Regional Perfusion; Child; | 1970 |