thiotepa has been researched along with Anemia, Cooley's in 6 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty-four children with beta-thalassemia major received abatacept at a dose of 10 mg/kg intravenously on days -1, +5, +14, and +28 after HSCT in addition to calcineurin inhibitors and methylprednisolone." | 8.02 | Graft-versus-host Disease Prophylaxis With Abatacept Reduces Severe Acute Graft-versus-host Disease in Allogeneic Hematopoietic Stem Cell Transplant for Beta-thalassemia Major With Busulfan, Fludarabine, and Thiotepa. ( Dandoy, CE; Davies, SM; El-Bietar, J; Grimley, MS; Khandelwal, P; Lane, A; Yeh, RF; Yu, L, 2021) |
| "Twenty-four children with beta-thalassemia major received abatacept at a dose of 10 mg/kg intravenously on days -1, +5, +14, and +28 after HSCT in addition to calcineurin inhibitors and methylprednisolone." | 4.02 | Graft-versus-host Disease Prophylaxis With Abatacept Reduces Severe Acute Graft-versus-host Disease in Allogeneic Hematopoietic Stem Cell Transplant for Beta-thalassemia Major With Busulfan, Fludarabine, and Thiotepa. ( Dandoy, CE; Davies, SM; El-Bietar, J; Grimley, MS; Khandelwal, P; Lane, A; Yeh, RF; Yu, L, 2021) |
| " This treosulfan-based preparation proved to be safe and effective for thalassemia patients given allogeneic HSCT." | 2.77 | Allogeneic hematopoietic stem cell transplantation in thalassemia major: results of a reduced-toxicity conditioning regimen based on the use of treosulfan. ( Bernardo, ME; Bertaina, A; Caocci, G; Contoli, B; Giorgiani, G; La Nasa, G; Locatelli, F; Mastronuzzi, A; Pagliara, D; Pinto, RM; Piras, E; Vacca, A; Zecca, M, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Kulkarni, UP | 1 |
| Pai, AA | 1 |
| Kavitha, ML | 1 |
| Selvarajan, S | 1 |
| Lionel, S | 1 |
| Devasia, AJ | 1 |
| Korula, A | 1 |
| Fouzia, NA | 1 |
| Sindhuvi, E | 1 |
| Abraham, A | 1 |
| Srivastava, A | 1 |
| Mathews, V | 1 |
| George, B | 1 |
| Balasubramanian, P | 1 |
| Khandelwal, P | 1 |
| Yeh, RF | 1 |
| Yu, L | 1 |
| Lane, A | 1 |
| Dandoy, CE | 1 |
| El-Bietar, J | 1 |
| Davies, SM | 1 |
| Grimley, MS | 1 |
| Bernardo, ME | 2 |
| Zecca, M | 2 |
| Piras, E | 2 |
| Vacca, A | 2 |
| Giorgiani, G | 2 |
| Cugno, C | 1 |
| Caocci, G | 2 |
| Comoli, P | 1 |
| Mastronuzzi, A | 2 |
| Merli, P | 1 |
| La Nasa, G | 2 |
| Locatelli, F | 3 |
| Bertaina, A | 1 |
| Pagliara, D | 1 |
| Contoli, B | 1 |
| Pinto, RM | 1 |
| Choudhary, D | 1 |
| Sharma, SK | 1 |
| Gupta, N | 1 |
| Kharya, G | 1 |
| Pavecha, P | 1 |
| Handoo, A | 1 |
| Setia, R | 1 |
| Katewa, S | 1 |
| Miniero, R | 1 |
| Rocha, V | 1 |
| Saracco, P | 1 |
| Brichard, B | 1 |
| Nagler, A | 1 |
| Roberts, I | 1 |
| Yaniv, I | 1 |
| Beksac, M | 1 |
| Bernaudin, F | 1 |
| Gluckman, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Multicentre, Randomized, Controlled Open-label Study on the Use of Anti-thymocyte Globulin and Rituximab for Immunomodulation of Graft-versus-host Disease in Allogeneic Matched Transplants for Non Malignancies[NCT01810926] | Phase 2 | 130 participants (Anticipated) | Interventional | 2011-09-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for thiotepa and Anemia, Cooley's
| Article | Year |
|---|---|
Treosulfan-based conditioning regimen for allogeneic haematopoietic stem cell transplantation in patients with thalassaemia major.
Topics: Adolescent; Adult; beta-Thalassemia; Busulfan; Child; Child, Preschool; Drug Therapy, Combination; F | 2008 |
Allogeneic hematopoietic stem cell transplantation in thalassemia major: results of a reduced-toxicity conditioning regimen based on the use of treosulfan.
Topics: Adolescent; Adult; beta-Thalassemia; Busulfan; Child; Child, Preschool; Cohort Studies; Female; Graf | 2012 |
Cord blood transplantation (CBT) in hemoglobinopathies. Eurocord.
Topics: Anemia, Sickle Cell; Antineoplastic Agents, Alkylating; beta-Thalassemia; Child; Child, Preschool; C | 1998 |
3 other studies available for thiotepa and Anemia, Cooley's