thiotepa has been researched along with Agranulocytosis in 6 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Agranulocytosis: A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thirty-five patients with advanced gynecologic malignancies were entered into a phase I study evaluating thio-TEPA in combination with cisplatin (50 mg/m2) intravenously every 4 weeks." | 1.28 | Phase I evaluation of thio-TEPA in combination with cisplatin for advanced gynecologic malignancies. ( Edwards, CL; Freedman, RS; Kavanagh, J; Raber, MN; Sandles, LG; Scott, WR; Wharton, JT, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| MAUER, AM | 1 |
| KRILL, CE | 1 |
| Hara, J | 1 |
| Osugi, Y | 1 |
| Ohta, H | 1 |
| Matsuda, Y | 1 |
| Nakanishi, K | 1 |
| Takai, K | 1 |
| Fujisaki, H | 1 |
| Tokimasa, S | 1 |
| Fukuzawa, M | 1 |
| Okada, A | 1 |
| Okada, S | 1 |
| Langer, CJ | 1 |
| Nash, S | 1 |
| Catalano, R | 1 |
| Rosenblum, NG | 1 |
| Hogan, WM | 1 |
| Comis, RL | 1 |
| O'Dwyer, PJ | 1 |
| Sandles, LG | 1 |
| Freedman, RS | 1 |
| Raber, MN | 1 |
| Kavanagh, J | 1 |
| Edwards, CL | 1 |
| Scott, WR | 1 |
| Wharton, JT | 1 |
| Vagina, OG | 1 |
| Vasiliev, AK | 1 |
| Kirko, EI | 1 |
| Veshler, VM | 1 |
| Tarasenko, OP | 1 |
1 trial available for thiotepa and Agranulocytosis
| Article | Year |
|---|---|
Phase II trial of thio-TEPA in relapsed and refractory ovarian carcinoma.
Topics: Adenocarcinoma; Adult; Aged; Agranulocytosis; Carcinoma, Squamous Cell; Drug Evaluation; Female; Hum | 1991 |
5 other studies available for thiotepa and Agranulocytosis
| Article | Year |
|---|---|
A STUDY OF THE MECHANISMS OF GRANULOCYTOPENIA.
Topics: Agranulocytosis; Anemia; Anemia, Macrocytic; Carcinoma; Carcinoma, Bronchogenic; Child; Hodgkin Dise | 1964 |
Double-conditioning regimens consisting of thiotepa, melphalan and busulfan with stem cell rescue for the treatment of pediatric solid tumors.
Topics: Adolescent; Adult; Agranulocytosis; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Child; | 1998 |
Phase I evaluation of thio-TEPA in combination with cisplatin for advanced gynecologic malignancies.
Topics: Agranulocytosis; Anemia; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Evaluation; | 1990 |
[A case of agranulocytosis following use of thio-TEPA].
Topics: Adenocarcinoma; Agranulocytosis; Female; Humans; Middle Aged; Thiotepa; Uterine Neoplasms | 1972 |
[Agranulocytic reaction associated with thio-tepa therapy].
Topics: Agranulocytosis; Humans; Thiotepa | 1971 |