thiotepa has been researched along with Acute Lymphoid Leukemia in 20 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diagnoses were AML (n=18), ALL (n=3), multiple myeloma (n=11), lymphoma (n=16) and CML (n=1)." | 2.73 | A fludarabine, thiotepa reduced toxicity conditioning regimen designed specifically for allogeneic second haematopoietic cell transplantation after failure of previous autologous or allogeneic transplantation. ( Bertz, H; Finke, J; Grüllich, C; Müller, CI; Spyridonidis, A, 2008) |
| "Twelve children with high-risk acute lymphoblastic leukemia underwent stem cell transplantation (SCT) with a conditioning regimen consisting of busulfan, cyclophosphamide and thiotepa." | 2.70 | [Hematopoietic stem cell transplantation with busulfanthiotepa-cyclophosphamide conditioning for pediatric patients with high-risk acute lymphoblastic leukemia]. ( Adachi, S; Akiyama, Y; Kubota, M; Lin, YW; Nakahata, T; Umeda, K; Usami, I; Watanabe, K, 2001) |
| "Thiotepa (TTP) is an alkylating agent that has been used mainly in breast and ovarian cancer with 20-50% response rates." | 2.69 | The role of thiotepa in autologous bone marrow transplantation for acute leukemia. ( Finlander, R; Nagler, A; Naparstek, E; Or, R; Slavin, S; Varadi, G, 1998) |
| " CNS relapse and neurotoxicity in patients with acute lymphoblastic leukaemia, especially younger children, may be reduced by using age-related dosing of intrathecal MTX and Ara-C." | 2.41 | Intrathecal chemotherapy with antineoplastic agents in children. ( Biagi, E; Conter, V; Lazzareschi, I; Milani, M; Riccardi, R; Ruggiero, A; Sparano, P, 2001) |
| "For acute lymphoblastic leukemia (ALL) patients, total body irradiation (TBI)- based conditioning regimens are the first choice specially in young population." | 1.91 | Thiotepa, busulfan and fludarabine conditioning-regimen is a promising approach for older adult patients with acute lymphoblastic leukemia treated with allogeneic stem cell transplantation. ( Banet, A; Bazarbachi, A; Belhocine, R; Bonnin, A; Brissot, E; Duléry, R; El-Cheikh, J; Genthon, A; Labopin, M; Ledraa, T; Legrand, O; Malard, F; Memoli, M; Mohty, M; Sestili, S; Stocker, N; Van de Wyngaert, Z, 2023) |
| "Optimal conditioning for adults with acute lymphoblastic leukemia (ALL) treated with haploidentical hematopoietic cell transplantation (haplo-HCT) and post-transplant cyclophosphamide has not been established so far." | 1.72 | Total body irradiation plus fludarabine versus thiotepa, busulfan plus fludarabine as a myeloablative conditioning for adults with acute lymphoblastic leukemia treated with haploidentical hematopoietic cell transplantation. A study by the Acute Leukemia W ( Aljurf, M; Angelucci, E; Arat, M; Bernasconi, P; Giebel, S; Labopin, M; Mohty, M; Nagler, A; Pavlu, J; Peric, Z; Pioltelli, P; Rigacci, L; Risitano, A; Rovira, M; Saccardi, R; Savani, BN; Sica, S; Socié, G; Spyridonidis, A; Swoboda, R; Tischer, J; Van Gorkom, G; Vitek, A, 2022) |
| "Busulfan was administered IV and according to body weight." | 1.62 | Comparison of Total Body Irradiation-based Versus Chemotherapy-based Conditionings for Early Complications of Allogeneic Hematopoietic Stem Cell Transplantation in Children With ALL. ( Bas, EG; Celen, S; Daloglu, H; Hazar, V; Kabakci, C; Karasu, GT; Pashayev, D; Pehlivan, B; Uygun, V; Yalcin, K; Yesilipek, A; Zhumatayev, S, 2021) |
| "Clofarabine was administered at a dose of 30 or 40 mg/m(2)/day over 2 hr for five consecutive days in six patients each." | 1.36 | Remission re-induction chemotherapy with clofarabine, topotecan, thiotepa, and vinorelbine for patients with relapsed or refractory leukemia. ( Kobos, R; Shukla, N; Steinherz, L; Steinherz, PG, 2010) |
| "The load of minimal residual disease prior to transplantation appears to be predictive for outcome in this very poor-prognosis subgroup of ALL." | 1.33 | Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children. ( Escherich, G; Hassenpflug, WA; Horstmann, MA; Janka, G; Kabisch, H; zur Stadt, U, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 7 (35.00) | 29.6817 |
| 2010's | 6 (30.00) | 24.3611 |
| 2020's | 5 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Swoboda, R | 1 |
| Labopin, M | 4 |
| Giebel, S | 3 |
| Angelucci, E | 1 |
| Arat, M | 1 |
| Aljurf, M | 3 |
| Sica, S | 1 |
| Pavlu, J | 1 |
| Socié, G | 3 |
| Bernasconi, P | 1 |
| Rigacci, L | 1 |
| Tischer, J | 1 |
| Risitano, A | 1 |
| Rovira, M | 1 |
| Saccardi, R | 1 |
| Pioltelli, P | 1 |
| Van Gorkom, G | 1 |
| Vitek, A | 1 |
| Savani, BN | 1 |
| Spyridonidis, A | 2 |
| Peric, Z | 1 |
| Nagler, A | 4 |
| Mohty, M | 4 |
| Banet, A | 1 |
| Bazarbachi, A | 1 |
| Stocker, N | 1 |
| Duléry, R | 1 |
| Malard, F | 1 |
| Van de Wyngaert, Z | 1 |
| Genthon, A | 1 |
| Memoli, M | 1 |
| Legrand, O | 1 |
| Bonnin, A | 1 |
| Ledraa, T | 1 |
| Belhocine, R | 1 |
| Sestili, S | 1 |
| El-Cheikh, J | 1 |
| Brissot, E | 1 |
| Chinnabhandar, V | 1 |
| Tran, S | 1 |
| Sutton, R | 1 |
| Shaw, PJ | 2 |
| Mechinaud, F | 1 |
| Cole, C | 1 |
| Tapp, H | 1 |
| Teague, L | 1 |
| Fraser, C | 1 |
| O'Brien, TA | 1 |
| Mitchell, R | 1 |
| Peters, C | 1 |
| Dalle, JH | 1 |
| Locatelli, F | 2 |
| Poetschger, U | 1 |
| Sedlacek, P | 1 |
| Buechner, J | 1 |
| Staciuk, R | 1 |
| Ifversen, M | 1 |
| Pichler, H | 1 |
| Vettenranta, K | 1 |
| Svec, P | 1 |
| Aleinikova, O | 1 |
| Stein, J | 1 |
| Güngör, T | 1 |
| Toporski, J | 1 |
| Truong, TH | 1 |
| Diaz-de-Heredia, C | 1 |
| Bierings, M | 1 |
| Ariffin, H | 1 |
| Essa, M | 1 |
| Burkhardt, B | 1 |
| Schultz, K | 1 |
| Meisel, R | 1 |
| Lankester, A | 1 |
| Ansari, M | 1 |
| Schrappe, M | 1 |
| von Stackelberg, A | 1 |
| Balduzzi, A | 1 |
| Corbacioglu, S | 1 |
| Bader, P | 1 |
| Yalcin, K | 1 |
| Pehlivan, B | 1 |
| Celen, S | 1 |
| Bas, EG | 1 |
| Kabakci, C | 1 |
| Pashayev, D | 1 |
| Daloglu, H | 1 |
| Zhumatayev, S | 1 |
| Uygun, V | 1 |
| Karasu, GT | 1 |
| Hazar, V | 1 |
| Yesilipek, A | 1 |
| Eder, S | 2 |
| Canaani, J | 1 |
| Beohou, E | 2 |
| Sanz, J | 2 |
| Arcese, W | 2 |
| Or, R | 3 |
| Finke, J | 3 |
| Cortelezzi, A | 1 |
| Beelen, D | 1 |
| Passweg, J | 2 |
| Gurman, G | 1 |
| Stelljes, M | 1 |
| Esiashvili, N | 1 |
| Lu, X | 1 |
| Ulin, K | 1 |
| Laurie, F | 1 |
| Kessel, S | 1 |
| Kalapurakal, JA | 1 |
| Merchant, TE | 1 |
| Followill, DS | 1 |
| Sathiaseelan, V | 1 |
| Schmitter, MK | 1 |
| Devidas, M | 1 |
| Chen, Y | 1 |
| Wall, DA | 1 |
| Brown, PA | 1 |
| Hunger, SP | 1 |
| Grupp, SA | 1 |
| Pulsipher, MA | 1 |
| Shukla, N | 2 |
| Kobos, R | 2 |
| Renaud, T | 1 |
| Steinherz, LJ | 1 |
| Steinherz, PG | 2 |
| Srour, SA | 1 |
| Borders, EB | 1 |
| Cherry, MA | 1 |
| Holter, J | 1 |
| Herman, T | 1 |
| Selby, GB | 1 |
| Bonifazi, F | 1 |
| Steinherz, L | 1 |
| Horstmann, MA | 1 |
| Hassenpflug, WA | 1 |
| zur Stadt, U | 1 |
| Escherich, G | 1 |
| Janka, G | 1 |
| Kabisch, H | 1 |
| Beske, F | 1 |
| Modrow, S | 1 |
| Sörensen, J | 1 |
| Schmidt, H | 1 |
| Kriener, S | 1 |
| Allwinn, R | 1 |
| Klingebiel, T | 1 |
| Schwabe, D | 1 |
| Lehrnbecher, T | 1 |
| Grüllich, C | 1 |
| Bertz, H | 1 |
| Müller, CI | 1 |
| Hiwarkar, P | 1 |
| Arkenau, HT | 1 |
| Treleaven, J | 1 |
| Morgan, G | 1 |
| Potter, M | 1 |
| Ethell, M | 1 |
| Finlander, R | 1 |
| Naparstek, E | 1 |
| Varadi, G | 1 |
| Slavin, S | 1 |
| Zecca, M | 1 |
| Pession, A | 1 |
| Messina, C | 1 |
| Bonetti, F | 1 |
| Favre, C | 1 |
| Prete, A | 1 |
| Cesaro, S | 1 |
| Porta, F | 1 |
| Mazzarino, I | 1 |
| Giorgiani, G | 1 |
| Rondelli, R | 1 |
| Bieri, S | 1 |
| Helg, C | 1 |
| Chapuis, B | 1 |
| Miralbell, R | 1 |
| Ruggiero, A | 1 |
| Conter, V | 1 |
| Milani, M | 1 |
| Biagi, E | 1 |
| Lazzareschi, I | 1 |
| Sparano, P | 1 |
| Riccardi, R | 1 |
| Umeda, K | 1 |
| Lin, YW | 1 |
| Watanabe, K | 1 |
| Adachi, S | 1 |
| Usami, I | 1 |
| Akiyama, Y | 1 |
| Kubota, M | 1 |
| Nakahata, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia[NCT01949129] | Phase 2/Phase 3 | 1,000 participants (Anticipated) | Interventional | 2013-04-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for thiotepa and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
Intrathecal chemotherapy with antineoplastic agents in children.
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Blood-Brain Barrier; Cerebellar Neoplasms; Cerebrosp | 2001 |
8 trials available for thiotepa and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
Total Body Irradiation or Chemotherapy Conditioning in Childhood ALL: A Multinational, Randomized, Noninferiority Phase III Study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Chemoradiotherapy; Child; Chil | 2021 |
Higher Reported Lung Dose Received During Total Body Irradiation for Allogeneic Hematopoietic Stem Cell Transplantation in Children With Acute Lymphoblastic Leukemia Is Associated With Inferior Survival: A Report from the Children's Oncology Group.
Topics: Adolescent; Analysis of Variance; Child; Child, Preschool; Cyclophosphamide; Disease-Free Survival; | 2019 |
Phase II trial of clofarabine with topotecan, vinorelbine, and thiotepa in pediatric patients with relapsed or refractory acute leukemia.
Topics: Adenine Nucleotides; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Arabinonucle | 2014 |
Thiotepa-based conditioning for allogeneic stem cell transplantation in acute lymphoblastic leukemia-A survey from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Disease-Free Survival; Female; Graft vs | 2017 |
A fludarabine, thiotepa reduced toxicity conditioning regimen designed specifically for allogeneic second haematopoietic cell transplantation after failure of previous autologous or allogeneic transplantation.
Topics: Adult; Aged; Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neo | 2008 |
The role of thiotepa in autologous bone marrow transplantation for acute leukemia.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Busu | 1998 |
Total body irradiation, thiotepa, and cyclophosphamide as a conditioning regimen for children with acute lymphoblastic leukemia in first or second remission undergoing bone marrow transplantation with HLA-identical siblings.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Child; Chil | 1999 |
[Hematopoietic stem cell transplantation with busulfanthiotepa-cyclophosphamide conditioning for pediatric patients with high-risk acute lymphoblastic leukemia].
Topics: Adolescent; Antineoplastic Agents, Alkylating; Busulfan; Child; Child, Preschool; Cyclophosphamide; | 2001 |
11 other studies available for thiotepa and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
Total body irradiation plus fludarabine versus thiotepa, busulfan plus fludarabine as a myeloablative conditioning for adults with acute lymphoblastic leukemia treated with haploidentical hematopoietic cell transplantation. A study by the Acute Leukemia W
Topics: Adult; Busulfan; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, M | 2022 |
Thiotepa, busulfan and fludarabine conditioning-regimen is a promising approach for older adult patients with acute lymphoblastic leukemia treated with allogeneic stem cell transplantation.
Topics: Adolescent; Adult; Aged; Busulfan; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; H | 2023 |
Addition of Thiotepa to Total Body Irradiation and Cyclophosphamide Conditioning for Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia.
Topics: Child; Cyclophosphamide; Disease-Free Survival; Hematopoietic Stem Cell Transplantation; Humans; Pre | 2020 |
Comparison of Total Body Irradiation-based Versus Chemotherapy-based Conditionings for Early Complications of Allogeneic Hematopoietic Stem Cell Transplantation in Children With ALL.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Child; Child, Preschool; Combi | 2021 |
Thiotepa-based conditioning versus total body irradiation as myeloablative conditioning prior to allogeneic stem cell transplantation for acute lymphoblastic leukemia: A matched-pair analysis from the Acute Leukemia Working Party of the European Society f
Topics: Adolescent; Adult; Cyclophosphamide; Disease-Free Survival; Female; Hematopoietic Stem Cell Transpla | 2017 |
Role of topotecan, vinorelbine, thiotepa and gemcitabine chemotherapy in relapsed/refractory adult acute leukemia.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Deoxycytidine; Dru | 2015 |
Remission re-induction chemotherapy with clofarabine, topotecan, thiotepa, and vinorelbine for patients with relapsed or refractory leukemia.
Topics: Adenine Nucleotides; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Arabinonucle | 2010 |
Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.
Topics: Adolescent; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Comb | 2005 |
Parvovirus B19 pneumonia in a child undergoing allogeneic hematopoietic stem cell transplantation.
Topics: Adolescent; Antineoplastic Agents; Combined Modality Therapy; Erythema Infectiosum; Fatal Outcome; H | 2007 |
The feasibility of using topotecan, vinorelbine, thiotepa and gemcitabine (TVTG) in adult patients with relapsed/refractory acute lymphoblastic leukaemia/lymphoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Feasibility Studie | 2008 |
Total body irradiation before allogeneic bone marrow transplantation: is more dose better?
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Busu | 2001 |