Compounds > thiotepa
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thiotepa and Abnormalities, Autosome

thiotepa has been researched along with Abnormalities, Autosome in 85 studies

Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).

Research Excerpts

ExcerptRelevanceReference
"From June 1997 to November 1999, 28 SRCT patients (median age, 26 years; 14 peripheral primitive neuroectodermal tumors [pPNETs], seven rhabdomyosarcomas [RMSs], and seven desmoplastic small round-cell tumors [DSRCTs]) received induction chemotherapy with ifosfamide, epirubicin, and vincristine followed by HD-CT."5.10High-dose chemotherapy in poor-prognosis adult small round-cell tumors: clinical and molecular results from a prospective study. ( Alloisio, M; Balzarotti, M; Bertuzzi, A; Castagna, L; Compasso, S; Nozza, A; Quagliuolo, V; Santoro, A; Siracusano, L; Soto Parra, H, 2002)
"Chromosomal aberrations were quantitated using traditional Giemsa stain."1.33The extent of chromosomal aberrations induced by chemotherapy in non-human primates depends on the schedule of administration. ( Balis, F; Bates, S; Cole, D; Egorin, MJ; Flynn, BM; Fojo, T; Knutsen, T; Langham, G; Rao, VK; Ried, T; Steinberg, SM; Wangsa, D, 2005)
"It was observed, that the rate of chromosome aberrations and SCE increased within a matter of first 6 hours."1.27[Changes in the occurrence of cytogenetic effects after mutagenic exposure in vivo]. ( Chebotarev, AN; Stukalov, SV, 1983)
"Caffeine was found to potentiate the frequency of chromatid aberrations induced by all 3 S-dependent agents tested; the most striking enhancement being obtained when caffeine was present during the last 1."1.27Influence of caffeine and 3-aminobenzamide in G2 on the frequency of chromosomal aberrations induced by thiotepa, mitomycin C and N-methyl-N-nitro-N'-nitrosoguanidine in human lymphocytes. ( Hansson, K; Kihlman, BA; Palitti, F; Tanzarella, C, 1984)
"Styrene oxide proved also to be a very potent inducer of sister chromatid exchanges (SCE) within the concentration range 5 X 10(-6) to 1 X 10(-3) mol."1.27Cytogenetic analysis of human peripheral blood lymphocytes in culture exposed in vitro to styrene and styrene oxide. ( Pohlová, H; Rössner, P; Srám, RJ, 1984)
" It was shown that the dose-response relationships and corresponding regression coefficients were similar when the in vivo and in vitro results were compared."1.27[Quantitative comparison of the cytogenetic effect of thiophosphamide during in vivo and in vitro action on monkey lymphocytes]. ( Kuzin, SM; Popandopulo, PG; Stukalov, SV, 1987)
"The frequency of chromosome aberrations in the initial period somewhat increases and then keeps to a certain constant level independently on the duration of action of thiophosphamide."1.26[Effect of long-term exposure to thiophosphamide on the frequency of chromosome aberrations in Chinese hamster cell cultures]. ( Chebotarev, AN; Ressner, P; Selezneva, TG, 1980)
"Chromosome aberrations were studied in cells of embryo liver of 101/H and CBA mice following mutagenic treatment with the alkylating agent--thiophosphamide."1.26[101/H line mice, a possible model of human chromosomal instability diseases]. ( Korogodina, IuV; S'iakste, TG, 1981)
"In C57BL/6 mice the level of induced chromosome aberrations was found to be age-independent."1.26[Spontaneous and induced chromosome aberrations in the bone marrow cells of different strains of mice during aging]. ( Korogodina, IuV; Lil'p, IG, 1981)
"Chromosomal aberrations were studied in cells of embryonic liver and bone marrow of A/He and C57BL/6 mice following mutagenic treatment by the alkylating agent thiophosphamide in g1-S periods of the cell cycle."1.26[Thiophosphamide-induced chromosome aberrations in embryonal liver and bone marrow cells of A/He and C57BL/L mice]. ( Gordeeva, EV; Korogodina, IuV; Lil'p, IG, 1979)
"Griseofulvin was studied for its ability to induce structural chromosomal aberrations in germ and somatic cells of the male mouse."1.26Mutagenicity tests with griseofulvin. ( Carbonelle, E; Fabry, L; Grutman, G; Léonard, A; Poncelet, F, 1979)
"The contribution of induced chromosomal aberrations to preimplantation embryonic death was studied."1.26[Estimation of the contribution of thiophosphamide-induced chromosomal aberrations to perimplantation embryonic mortality in mice]. ( Malashenko, AM; Semenov, KhKh, 1979)
"Types of chromosome aberrations were studied in human lymphocyte cultures in combined action of different concentrations of thiophosphamide and dipine in different proportions."1.26[Analysis of the types of chromosome aberrations in the combined action of chemical mutagens]. ( Nazarenko, SA, 1978)
"Structure chromosome aberrations were found in the cells of such embryos."1.26[Mutagenic effect of chemical compounds on laboratory mice]. ( Malashenko, AM; Selezneva, GP; Semenov, KhKh; Surkova, NI, 1978)
"ThioTEPA was injected intraperitoneally once a week in a dose of 40 mg."1.25[Chromosomal aberrations induced by thio-TEPA in cells of malignant ovarian tumors in humans]. ( Aĭnbinder, NM; Gnilevskaia, ZU; Neĭshtadt, EL, 1975)
"The rate of induced chromosome aberrations was correlated with the level of spontaneous chromosome damages in bone marrow cells (r=+/-0,893+/-0,02)."1.25[The mutagenic effect of thioTEPA in laboratory mice. IV. The influence of genotype and sex on the frequency of induced chromosome aberrations in bone marrow cells]. ( Malashenko, AM; Surkova, NI, 1975)

Research

Studies (85)

TimeframeStudies, this research(%)All Research%
pre-199074 (87.06)18.7374
1990's7 (8.24)18.2507
2000's3 (3.53)29.6817
2010's1 (1.18)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Riethdorf, S1
Pantel, K1
MOORE, JG1
VANCAMPENHOUT, JL1
BRANDKAMP, WW1
Rao, VK1
Knutsen, T1
Ried, T1
Wangsa, D1
Flynn, BM1
Langham, G1
Egorin, MJ1
Cole, D1
Balis, F1
Steinberg, SM1
Bates, S1
Fojo, T1
Hansson, K3
Hartley-Asp, B2
Murphy, WM1
Stukalov, SV6
Chebotarev, AN9
Shcheglova, EG2
Kihlman, BA2
Tanzarella, C1
Palitti, F1
Pohlová, H1
Rössner, P1
Srám, RJ2
Ivanova, IuE1
Bochkov, NP8
Iakovenko, KN4
Ressner, P1
Selezneva, TG2
Devi, KR1
Reddy, PP1
Korogodina, IuV3
S'iakste, TG1
Lil'p, IG2
Malashenko, AM15
Kryshkina, VP1
Surkova, NI8
Yakovenko, KN3
Voskoboiynik, NI1
Beskova, TB3
Salikhova, RA1
Poroshenko, GG1
Goncharova, RI1
Kuzhir, TD1
Dalivelia, OV1
Dubur, GIa1
Uldrikis, IaR1
Ignat'eva, EL1
Bertuzzi, A1
Castagna, L1
Nozza, A1
Quagliuolo, V1
Siracusano, L1
Balzarotti, M1
Compasso, S1
Alloisio, M1
Soto Parra, H1
Santoro, A1
Maier, P1
Schmid, W1
Littlefield, LG1
Colyer, SP1
Sayer, AM1
Dufrain, RJ1
Gordeeva, EV1
Léonard, A1
Poncelet, F1
Grutman, G1
Carbonelle, E1
Fabry, L1
Semenov, KhKh3
Wolff, S1
Arutyunyan, R1
Sturelid, S2
Nazarenko, SA1
Selezneva, GP1
Neĭshtadt, EL1
Gnilevskaia, ZU1
Aĭnbinder, NM1
Kirichenko, OP1
Iakovenko, KI1
Tarusina, TO2
Kuleshov, NP4
Lunga, IN1
Lyon, MF1
Glenister, PH1
Renner, HW2
Semenov, VV1
Kuzin, SM2
Viktorov, VV1
Dzhemilev, ZA1
Popandopulo, PG2
Tulina, AN3
Fingert, HJ1
Chang, JD1
Pardee, AB1
Sato, S1
Kitajima, H1
Konishi, S1
Takizawa, H1
Inui, N1
Sarkisian, TF1
Movsesian, ES1
Arutiunian, RM1
Zasukhina, GD1
Vasil'eva, SV1
Funes-Cravioto, F1
Yakovienko, KN1
Zhurkov, VS2
Andreesu, M1
Matefsu, C1
Mogos, I1
Mudric, V1
Dubinina, LG2
Arutyunyan, RM1
Funes Cravioto, F1
Cravioto, FF1
Korman, NP1
Azhaev, SA2
Shevchenko, VV1
Protopopova, EM1
Grigor'eva, GA1
Bolotova, TK1
Fickers, M1
Speck, B1
Voĭtovitskiĭ, VK2
Edygenova, AK2
Kabiev, OK2
Gol'dberg, ED1
Gol'dberg, DI1
Golubev, IV1
Bournique, CP1
Deysson, G1
Smirnov, AD1

Reviews

2 reviews available for thiotepa and Abnormalities, Autosome

ArticleYear
Current topics in the pathology of bladder cancer.
    Pathology annual, 1983, Volume: 18 Pt 1

    Topics: Carcinoma in Situ; Carcinoma, Transitional Cell; Chromosome Aberrations; Chromosomes, Human, 1-3; Cy

1983
[Chemical mutagenesis patterns in experimental mammals].
    Vestnik Akademii meditsinskikh nauk SSSR, 1982, Issue:6

    Topics: Animals; Bone Marrow; Chromosome Aberrations; DNA Repair; Female; Genes; Genes, Dominant; Genes, Let

1982

Trials

1 trial available for thiotepa and Abnormalities, Autosome

ArticleYear
High-dose chemotherapy in poor-prognosis adult small round-cell tumors: clinical and molecular results from a prospective study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Apr-15, Volume: 20, Issue:8

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Chromosome Aberrations; Cyclophos

2002

Other Studies

82 other studies available for thiotepa and Abnormalities, Autosome

ArticleYear
Advancing personalized cancer therapy by detection and characterization of circulating carcinoma cells.
    Annals of the New York Academy of Sciences, 2010, Volume: 1210

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Breast Neoplasms; Carboplatin; Chromoso

2010
EFFECTS OF IONIZING IRRADIATION AND CHEMOTHERAPEUTIC AGENTS ON HUMAN CHROMOSOMES.
    American journal of obstetrics and gynecology, 1964, Apr-15, Volume: 88

    Topics: Antineoplastic Agents; Biomedical Research; Chlorambucil; Choriocarcinoma; Chromosome Aberrations; C

1964
The extent of chromosomal aberrations induced by chemotherapy in non-human primates depends on the schedule of administration.
    Mutation research, 2005, Jun-06, Volume: 583, Issue:2

    Topics: Animals; Area Under Curve; Azure Stains; Bone Marrow Cells; Chromosome Aberrations; Chromosome Paint

2005
Potentiation by hydroxyurea in G2-prophase of thiotepa- and bleomycin-induced chromosomal aberrations in Chinese hamster cells.
    Hereditas, 1981, Volume: 94, Issue:1

    Topics: Animals; Bleomycin; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Drug Synergism; Hydro

1981
[Changes in the occurrence of cytogenetic effects after mutagenic exposure in vivo].
    Biulleten' eksperimental'noi biologii i meditsiny, 1983, Volume: 96, Issue:11

    Topics: Animals; Chromosome Aberrations; Crossing Over, Genetic; Dose-Response Relationship, Drug; Lymphocyt

1983
[Comparison of the levels of chromosome aberration and sister chromatid exchange induced by chemical mutagens in vitro].
    Biulleten' eksperimental'noi biologii i meditsiny, 1983, Volume: 96, Issue:11

    Topics: Aziridines; Cells, Cultured; Chromosome Aberrations; Crossing Over, Genetic; Dose-Response Relations

1983
[Correlation of the sister chromatid exchange level with chromosome aberrations induced by chemical mutagens in vivo].
    Biulleten' eksperimental'noi biologii i meditsiny, 1983, Volume: 96, Issue:12

    Topics: Alkylating Agents; Animals; Antineoplastic Agents; Aziridines; Bone Marrow; Chromosome Aberrations;

1983
Influence of caffeine and 3-aminobenzamide in G2 on the frequency of chromosomal aberrations induced by thiotepa, mitomycin C and N-methyl-N-nitro-N'-nitrosoguanidine in human lymphocytes.
    Mutation research, 1984, Volume: 126, Issue:3

    Topics: Benzamides; Caffeine; Cell Cycle; Cells, Cultured; Chromosome Aberrations; DNA Repair; Drug Synergis

1984
Cytogenetic analysis of human peripheral blood lymphocytes in culture exposed in vitro to styrene and styrene oxide.
    Journal of hygiene, epidemiology, microbiology, and immunology, 1984, Volume: 29, Issue:3

    Topics: Adult; Cells, Cultured; Chromosome Aberrations; Dose-Response Relationship, Drug; Epoxy Compounds; E

1984
[Effect of thiophosphamide on the frequency of chromosome aberrations in cells heterozygous for ataxia-telangiectasia].
    Biulleten' eksperimental'noi biologii i meditsiny, 1980, Volume: 89, Issue:7

    Topics: Ataxia Telangiectasia; Cells, Cultured; Chromosome Aberrations; Heterozygote; Humans; Lymphocytes; T

1980
[Effect of long-term exposure to thiophosphamide on the frequency of chromosome aberrations in Chinese hamster cell cultures].
    Genetika, 1980, Volume: 16, Issue:7

    Topics: Animals; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; Dose-Response Relationship

1980
Evaluation of thiotepa for genetic damage in mice.
    Indian journal of experimental biology, 1980, Volume: 18, Issue:8

    Topics: Animals; Chromosome Aberrations; Male; Metaphase; Mice; Mutagens; Thiotepa; Translocation, Genetic

1980
[101/H line mice, a possible model of human chromosomal instability diseases].
    Genetika, 1981, Volume: 17, Issue:5

    Topics: Animals; Chromosome Aberrations; Chromosome Disorders; Disease Models, Animal; Female; Fetal Death;

1981
[Spontaneous and induced chromosome aberrations in the bone marrow cells of different strains of mice during aging].
    Tsitologiia, 1981, Volume: 23, Issue:10

    Topics: Aging; Animals; Bone Marrow; Chromosome Aberrations; Gamma Rays; Genotype; Male; Mice; Mice, Inbred

1981
[Influence of selection on the sensitivity of laboratory mice to the cytogenetic effect oof thioTEPA].
    Genetika, 1982, Volume: 18, Issue:2

    Topics: Animals; Chromosome Aberrations; Crosses, Genetic; Genetic Variation; Genotype; Inbreeding; Male; Mi

1982
Dose and concentration dependence of chromosome aberrations in human cells and the combined action of radiation and chemical mutagens.
    Cytogenetics and cell genetics, 1982, Volume: 33, Issue:1-2

    Topics: Chromosome Aberrations; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Gam

1982
[Comparison of the frequency of chromosome aberrations induced by thiophosphamide in rabbit lymphocytes in vitro and in vivo].
    Biulleten' eksperimental'noi biologii i meditsiny, 1982, Volume: 94, Issue:8

    Topics: Animals; Chromosome Aberrations; Dose-Response Relationship, Drug; In Vitro Techniques; Lymphocytes;

1982
[Interlineage differences in murine sensitivity to thiotepa: an experiment with recombinant strains].
    Genetika, 1995, Volume: 31, Issue:7

    Topics: Animals; Chromosome Aberrations; Crosses, Genetic; Female; Male; Mice; Mice, Inbred C3H; Mutagens; R

1995
[Antimutagenic properties of Angelica archangelica L].
    Vestnik Rossiiskoi akademii meditsinskikh nauk, 1995, Issue:1

    Topics: Animals; Antimutagenic Agents; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Mice; Micronu

1995
[1,4-dihydroisonicotinic acid (1,4-DHINA) derivatives, inhibitors of chemical mutagenesis].
    Vestnik Rossiiskoi akademii meditsinskikh nauk, 1995, Issue:1

    Topics: Animals; Antimutagenic Agents; Bone Marrow; Cells, Cultured; Chromosome Aberrations; Drosophila mela

1995
[Modeling the periodically-changing predictable response to mutagen exposure in CBA/LacY mice in a successive inbred generations].
    Genetika, 2001, Volume: 37, Issue:10

    Topics: Animals; Benzo(a)pyrene; Chromosome Aberrations; Inbreeding; Mice; Mice, Inbred CBA; Mutagens; Thiot

2001
Ten model mutagens evaluated by the micronucleus test.
    Mutation research, 1976, Volume: 40, Issue:4

    Topics: Animals; Bleomycin; Bone Marrow; Bone Marrow Cells; Cell Line; Cell Nucleus; Chromosome Aberrations;

1976
Relationship between acute and chronic exposures in mutagenicity studies in mice.
    Mutation research, 1976, Nov-01, Volume: 41, Issue:1 spel. no

    Topics: Animals; Arsenic; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Cyclophosphamide; Dose-Res

1976
Sister-chromatid exchanges in human lymphocytes exposed during Go to four classes of DNA-damaging chemicals.
    Mutation research, 1979, Volume: 67, Issue:3

    Topics: Bleomycin; Cell Cycle; Chlorambucil; Chromatids; Chromosome Aberrations; Cytarabine; DNA; Humans; Ly

1979
Caffeine enhancement of chromosomal aberrations induced by thiotepa in bone marrow cells of mice.
    Hereditas, 1978, Volume: 89, Issue:1

    Topics: Animals; Bone Marrow; Caffeine; Chromosome Aberrations; Chromosomes; Drug Synergism; Male; Mice; Thi

1978
[Thiophosphamide-induced chromosome aberrations in embryonal liver and bone marrow cells of A/He and C57BL/L mice].
    Biulleten' eksperimental'noi biologii i meditsiny, 1979, Volume: 88, Issue:10

    Topics: Animals; Bone Marrow; Chromosome Aberrations; Embryo, Mammalian; Female; Liver; Male; Mice; Mice, In

1979
Mutagenicity tests with griseofulvin.
    Mutation research, 1979, Volume: 68, Issue:3

    Topics: Animals; Bone Marrow; Chromosome Aberrations; Corpus Luteum; Dose-Response Relationship, Drug; Embry

1979
[Estimation of the contribution of thiophosphamide-induced chromosomal aberrations to perimplantation embryonic mortality in mice].
    Biulleten' eksperimental'noi biologii i meditsiny, 1979, Volume: 88, Issue:9

    Topics: Animals; Chromosome Aberrations; Embryo, Mammalian; Embryonic Development; Female; Fetal Death; Kary

1979
The apparent decrease in thiotepa-induced chromosome aberrations in human lymphocytes caused by an effect of WR2721 on the cell cycle as found by the definitively determined division method.
    Environmental mutagenesis, 1979, Volume: 1, Issue:1

    Topics: Amifostine; Cell Cycle; Cells, Cultured; Chromosome Aberrations; Chromosomes, Human; Humans; Lymphoc

1979
Enhancement by caffeine of cell killing and chromosome damage in Chinese hamster cells treated with thiotepa.
    Hereditas, 1977, Feb-03, Volume: 84, Issue:2

    Topics: Animals; Caffeine; Cell Line; Cell Survival; Chromosome Aberrations; Chromosomes; Clone Cells; Crice

1977
[Genetic control of mutability in laboratory mice. I. Genetic analysis of the sensitivity of mice of strains 101/H and C57BL/6 to the mutagenic effect of thio-TEPA].
    Genetika, 1977, Volume: 13, Issue:9

    Topics: Animals; Bone Marrow; Chromosome Aberrations; Chromosomes; Mice; Mice, Inbred C57BL; Mice, Inbred St

1977
[Analysis of the types of chromosome aberrations in the combined action of chemical mutagens].
    Biulleten' eksperimental'noi biologii i meditsiny, 1978, Volume: 85, Issue:1

    Topics: Aziridines; Cells, Cultured; Chromatids; Chromosome Aberrations; Dose-Response Relationship, Drug; D

1978
[Mutagenic effect of chemical compounds on laboratory mice].
    Genetika, 1978, Volume: 14, Issue:1

    Topics: Animals; Chromosome Aberrations; Embryonic Development; Female; Genes, Dominant; Genes, Lethal; Male

1978
Enhancement by methylated oxypurines of the frequency of induced chromosomal aberrations.
    Hereditas, 1975, Volume: 79, Issue:1

    Topics: Animals; Caffeine; Cell Line; Cells, Cultured; Chromosome Aberrations; Chromosomes; Cricetinae; Drug

1975
[Chromosomal aberrations induced by thio-TEPA in cells of malignant ovarian tumors in humans].
    Voprosy onkologii, 1975, Volume: 21, Issue:7

    Topics: Chromosome Aberrations; Female; Humans; Ovarian Neoplasms; Thiotepa

1975
[Mathematical modeling of the relationship between the cytogenetic effect and the concentration of the mutagen].
    Genetika, 1975, Volume: 10, Issue:8

    Topics: Cells, Cultured; Chromosome Aberrations; Dose-Response Relationship, Drug; Humans; Lymphocytes; Math

1975
[The mutagenic effect of thio-TEPA in laboratory mice. III. A comparison of the effect of different doses in the generative and somatic cells of male mice].
    Genetika, 1975, Volume: 10, Issue:8

    Topics: Aneuploidy; Animals; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Genes, Dominant; Genes,

1975
[The relationship between the cytogenetic action of thiophosphamide and the duration of human cell treatment].
    Genetika, 1975, Volume: 10, Issue:9

    Topics: Chromatids; Chromosome Aberrations; Chromosomes; Humans; Lymphocytes; Mutagens; Thiotepa; Time Facto

1975
[The mutagenic effect of thioTEPA in laboratory mice. IV. The influence of genotype and sex on the frequency of induced chromosome aberrations in bone marrow cells].
    Genetika, 1975, Volume: 11, Issue:1

    Topics: Animals; Bone Marrow Cells; Chromosome Aberrations; Female; Genotype; Male; Mice; Mice, Inbred AKR;

1975
[The mutagenic effect of thioTEPA in laboratory mice. V. The influence of female genotype on the realization of dominant lethal mutations induced in male spermatids].
    Genetika, 1975, Volume: 11, Issue:2

    Topics: Animals; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Female; Genes, Dominant; Genes, Let

1975
[Cytological study of early embryonic mortality in laboratory mice].
    Biulleten' eksperimental'noi biologii i meditsiny, 1975, Volume: 80, Issue:10

    Topics: Animals; Animals, Laboratory; Chromosome Aberrations; Embryo Loss; Embryonic Development; Female; Fe

1975
Enhancement by methylated oxypurines of the frequency of induced chromosomal aberrations. IV. The dependence of the potentiation on the type of material.
    Hereditas, 1976, Volume: 83, Issue:2

    Topics: Caffeine; Cell Line; Chromosome Aberrations; Drug Synergism; Maleic Hydrazide; Mitomycins; Plants; T

1976
[Mutation process in man].
    Vestnik Akademii meditsinskikh nauk SSSR, 1976, Issue:7

    Topics: Chromosome Aberrations; Chromosomes; Genetic Diseases, Inborn; Humans; Mutagens; Mutation; Thiotepa

1976
[Individual variations in the frequency of chromosome aberrations following exposure to chemical mutagens. II. Interindividual variation in the frequency of chromosome aberrations in the presence of different mutagen concentrations].
    Genetika, 1976, Volume: 12, Issue:12

    Topics: Chromosome Aberrations; Chromosomes; Dose-Response Relationship, Drug; Genetic Variation; Humans; Mu

1976
[Individual variations in the frequency of chromosome aberrations following exposure to chemical mutagens. III. Interindividual differences at different stages of the cell cycle].
    Genetika, 1976, Volume: 12, Issue:12

    Topics: Aziridines; Azirines; Cells, Cultured; Chromosome Aberrations; Chromosomes; Cytarabine; Genetic Vari

1976
[Cytogenetic damage and the degree of reparative synthesis in the lymphocytes of chemical industry workers].
    Gigiena i sanitariia, 1991, Issue:12

    Topics: Adult; Air Pollutants, Occupational; Cells, Cultured; Chemical Industry; Chromosome Aberrations; Cul

1991
A search for strain differences in response of mice to mutagenesis by thio-TEPA.
    Mutation research, 1991, Volume: 249, Issue:2

    Topics: Animals; Bone Marrow; Chromosome Aberrations; Genes, Dominant; Genes, Lethal; Injections, Intraperit

1991
In vivo effects of single or combined dietary antimutagens on mutagen-induced chromosomal aberrations.
    Mutation research, 1990, Volume: 244, Issue:2

    Topics: Animals; beta Carotene; Carotenoids; Chlorophyll; Chlorophyllides; Chromosome Aberrations; Cricetina

1990
[Mutagenic activity of antineoplastic agents under conditions of normal and artificial modification].
    Genetika, 1990, Volume: 26, Issue:11

    Topics: Antineoplastic Agents; Aziridines; Chromosome Aberrations; Interphase; Melphalan; Mutagens; Plants;

1990
[The induction and elimination of cytogenetic disorders in monkey lymphocytes following thiophosphamide action].
    Biulleten' eksperimental'noi biologii i meditsiny, 1989, Volume: 107, Issue:6

    Topics: Animals; Cells, Cultured; Chromosome Aberrations; Lymphocytes; Macaca mulatta; Male; Mathematics; Mo

1989
[Interchangeability of mutagens during fractionated effects of unequal concentrations of alkylating agents].
    Biulleten' eksperimental'noi biologii i meditsiny, 1989, Volume: 108, Issue:7

    Topics: Alkylating Agents; Aziridines; Cells, Cultured; Chromatids; Chromosome Aberrations; Humans; Lymphocy

1989
[Effects of exposure time using preliminary concentrations on the mutagenic effect of the basic action of one-center and dual-center mutagens].
    Biulleten' eksperimental'noi biologii i meditsiny, 1989, Volume: 108, Issue:10

    Topics: Alkylating Agents; Antineoplastic Agents; Aziridines; Cells, Cultured; Chromosome Aberrations; Cultu

1989
[The effect of fractionated exposure to unequal concentrations of chemical mutagens].
    Biulleten' eksperimental'noi biologii i meditsiny, 1989, Volume: 108, Issue:9

    Topics: Aziridines; Cells, Cultured; Chromosome Aberrations; Dose-Response Relationship, Drug; Humans; Lymph

1989
Cytotoxic, cell cycle, and chromosomal effects of methylxanthines in human tumor cells treated with alkylating agents.
    Cancer research, 1986, Volume: 46, Issue:5

    Topics: Alkylating Agents; Caffeine; Cell Cycle; Cell Line; Cell Survival; Chromosome Aberrations; Chromosom

1986
[Quantitative comparison of the cytogenetic effect of thiophosphamide during in vivo and in vitro action on monkey lymphocytes].
    Biulleten' eksperimental'noi biologii i meditsiny, 1987, Volume: 103, Issue:3

    Topics: Animals; Chromosome Aberrations; Dose-Response Relationship, Drug; In Vitro Techniques; Lymphocytes;

1987
Mouse strain differences in the induction of micronuclei by polycyclic aromatic hydrocarbons.
    Mutation research, 1987, Volume: 192, Issue:3

    Topics: Animals; Biotransformation; Bone Marrow; Cell Nucleus; Chromosome Aberrations; Cyclophosphamide; Mic

1987
[Thiophosphamide induction of chromosome disorders in the spermatogonia of 101/HY, TPS/Y and CBA/LacY inbred mouse strains].
    Genetika, 1988, Volume: 24, Issue:3

    Topics: Animals; Bone Marrow; Chromosome Aberrations; Chromosomes; Diploidy; Dose-Response Relationship, Dru

1988
[Dynamics of the frequencies of sister chromatid exchange and chromosome aberrations in vivo].
    Biulleten' eksperimental'noi biologii i meditsiny, 1988, Volume: 106, Issue:8

    Topics: Animals; Chromosome Aberrations; Dose-Response Relationship, Drug; Metaphase; Mutagenicity Tests; Ra

1988
[Effect of interferon on the number of cytogenetic disorders occurring in human cultured lymphocytes treated with thio-TEPA and fotrin].
    Tsitologiia, 1988, Volume: 30, Issue:12

    Topics: Aziridines; Azirines; Cells, Cultured; Chromosome Aberrations; Drug Interactions; Humans; Interferon

1988
[Modification of the genetic effect of N-nitrosoethylurea in inbred mice by para-aminobenzoic acid].
    Genetika, 1985, Volume: 21, Issue:4

    Topics: 4-Aminobenzoic Acid; Aminobenzoates; Animals; Bone Marrow; Chromosome Aberrations; Drug Interactions

1985
Anticlastogenic effect of beta-carotene in Chinese hamsters. Time and dose response studies with different mutagens.
    Mutation research, 1985, Volume: 144, Issue:4

    Topics: Alkylating Agents; Animals; beta Carotene; Bone Marrow Cells; Busulfan; Carotenoids; Chromosome Aber

1985
[Problems of mutagenesis in man].
    Vestnik Akademii meditsinskikh nauk SSSR, 1973, Volume: 28, Issue:1

    Topics: Adult; Age Factors; Chromosome Aberrations; Fetus; Genetics, Medical; Humans; Infant, Newborn; Infan

1973
Localization of chemically induced breaks in chromosomes of human leucocytes.
    Mutation research, 1974, Volume: 23, Issue:1

    Topics: Cells, Cultured; Chromosome Aberrations; Chromosome Mapping; Chromosomes; Female; Humans; In Vitro T

1974
[Chromosomal studies in correlation with other biologic constants in neoplasms treated by chemotherapy].
    Minerva medica, 1974, May-05, Volume: 65, Issue:34

    Topics: Adult; Antibody Formation; Bone Marrow; Cell Division; Chromosome Aberrations; Female; Fluorouracil;

1974
[Chromosome mutations in human leukocytes and the test-system problem in the analysis of the mutagenicity of biosphere factors].
    Doklady Akademii nauk SSSR, 1974, Aug-01, Volume: 217, Issue:4

    Topics: Autoradiography; Chromosome Aberrations; Chromosomes; Humans; In Vitro Techniques; Leukocytes; Mitos

1974
Modifying effect of cysteine on the induction of chromosomal aberrations by thioTEP in a culture of human leukocytes.
    Soviet genetics, 1974, May-15, Volume: 8, Issue:4

    Topics: Cells, Cultured; Chromosome Aberrations; Cysteine; Humans; In Vitro Techniques; Leukocytes; Mutagens

1974
Localization of breaks in human chromosomes induced by thio-TEPA in peripheral blood lymphocyte cultures at different times.
    Soviet genetics, 1974, Jul-01, Volume: 8, Issue:6

    Topics: Cells, Cultured; Chromosome Aberrations; Chromosome Mapping; Chromosomes; Humans; In Vitro Technique

1974
Intensity of chemical mutagenesis in human cells as a function of age and sex.
    Soviet genetics, 1973, Volume: 7, Issue:3

    Topics: Adult; Age Factors; Aged; Cells, Cultured; Chromatids; Chromosome Aberrations; Chromosomes, Human, 1

1973
Distribution of defective chromosomes in human cells after treatment with chemical mutagens in vitro and in vivo.
    Soviet genetics, 1974, Nov-01, Volume: 8, Issue:12

    Topics: Cells, Cultured; Chromatids; Chromosome Aberrations; Chromosomes; Dose-Response Relationship, Drug;

1974
[Mutagenic effect of thio-TEPA in laboratory mice. I. Chromosome aberrations in somatic and germ cells of male mice].
    Genetika, 1974, Volume: 10, Issue:1

    Topics: Aneuploidy; Animals; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Genes, Dominant; Genes,

1974
[Mutagenic effect of thio-TEPA in laboratory mice. II. Cytogenetic analysis of damage to bone marrow cells].
    Genetika, 1974, Volume: 10, Issue:2

    Topics: Animals; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Dose-Response Relationship, Drug; M

1974
[Analysis of somatic cell chromosomes in patients treated with antineoplastic agents].
    Genetika, 1973, Volume: 9, Issue:12

    Topics: Adult; Aged; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Cyclopho

1973
[Cytogenetic effect of ethylenimine derivatives in cultures of human lymphocytes. I. Experimental findings and mathematical verification of quantitative patterns].
    Genetika, 1974, Volume: 10, Issue:10

    Topics: Aziridines; Azirines; Cells, Cultured; Chromosome Aberrations; Chromosomes; Cyclic P-Oxides; Dimetho

1974
[Prolonged mutagenesis in a culture of human leukocytes].
    Genetika, 1974, Volume: 10, Issue:11

    Topics: Aziridines; Cells, Cultured; Chromosome Aberrations; Chromosomes; Cyclic P-Oxides; DNA; Drug Interac

1974
[Cytogenetic effect of ethylenimine derivatives in human lymphocyte cultures. III. An analysis of the types of chromosome aberrations].
    Genetika, 1974, Volume: 10, Issue:12

    Topics: Aziridines; Azirines; Cells, Cultured; Chromosome Aberrations; Chromosomes; Cyclic P-Oxides; Humans;

1974
Change in the activity of chemical mutagens during their interaction with seed metabolites.
    Soviet genetics, 1971, Volume: 7, Issue:4

    Topics: Chromosome Aberrations; Dimethoate; Ethylenes; Hydrazines; Imines; Maleates; Mechlorethamine; Mesyla

1971
Thrombocythaemia. Familial occurrence and transition into blastic crisis.
    Acta haematologica, 1974, Volume: 51, Issue:5

    Topics: Alkaline Phosphatase; Anemia, Aplastic; Blood Coagulation Tests; Bone Marrow Examination; Busulfan;

1974
[Chromosome characteristics of tumors during changes in drug resistance (experimental study)].
    Voprosy onkologii, 1973, Volume: 19, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Line; Chromosome Aberrations; Drug Resistance; Female; Melphala

1973
[Disturbances of mitotic activity in hemohistoblasts of the bone marrow during acute radiation injury and under the effects of chemical mutagenic agents].
    Arkhiv patologii, 1967, Volume: 29, Issue:2

    Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Division; Cell Nucleus; Chromosome Aberrations; Cyclop

1967
[Distribution of chromosomal fragments induced by methoxy-9 ellipticin lactate in human diploid cells cultivated in vitro].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1971, Jun-21, Volume: 272, Issue:25

    Topics: Alkaloids; Chromosome Aberrations; Chromosomes; Culture Techniques; Diploidy; Fibroblasts; Humans; L

1971
[Modifying effect of cystamine in some mutagenic influences on the human organism].
    Doklady Akademii nauk SSSR, 1971, Volume: 199, Issue:4

    Topics: Bone Marrow; Bone Marrow Cells; Bronchial Neoplasms; Chromosome Aberrations; Cystamine; Humans; Male

1971
[Chromosome aberrations in cells of a thiophosphamide-resistant tumor arising during a single treatment with alkylating preparations and x-rays].
    Tsitologiia, 1971, Volume: 13, Issue:10

    Topics: Animals; Cell Line; Chromosome Aberrations; Culture Techniques; Female; Melphalan; Neoplasms, Experi

1971