thiosulfates has been researched along with Skin Ulcer in 14 studies
Thiosulfates: Inorganic salts of thiosulfuric acid possessing the general formula R2S2O3.
thiosulfate(2-) : A divalent inorganic anion obtained by removal of both protons from thiosulfuric acid.
Skin Ulcer: An ULCER of the skin and underlying tissues.
Excerpt | Relevance | Reference |
---|---|---|
"We report the successful use of abatacept and sodium thiosulfate in a patient with severe recalcitrant juvenile dermatomyositis complicated by ulcerative skin disease and progressive calcinosis." | 7.78 | Abatacept and sodium thiosulfate for treatment of recalcitrant juvenile dermatomyositis complicated by ulceration and calcinosis. ( Arabshahi, B; Jones, OY; Rider, LG; Silverman, RA, 2012) |
" The skin ulcers drastically improved within 6 months after the initiation of hemodialysis, aggressive wound care, the control of a mineral and bone disorder, and the administration of sodium thiosulfate and hyperbaric oxygen therapy." | 3.83 | The Successful Treatment of Calciphylaxis with Sodium Thiosulfate and Hyperbaric Oxygen in a Non-dialyzed Patient with Chronic Kidney Disease. ( Aihara, S; Arase, H; Higashi, H; Kitazono, T; Nakano, T; Taniguchi, M; Tsuchimoto, A; Tsuruya, K; Uchida, Y; Yamada, S, 2016) |
"We report the successful use of abatacept and sodium thiosulfate in a patient with severe recalcitrant juvenile dermatomyositis complicated by ulcerative skin disease and progressive calcinosis." | 3.78 | Abatacept and sodium thiosulfate for treatment of recalcitrant juvenile dermatomyositis complicated by ulceration and calcinosis. ( Arabshahi, B; Jones, OY; Rider, LG; Silverman, RA, 2012) |
"A 66-year-old man with renal failure due to diabetic nephropathy was on peritoneal dialysis alone for 1 year, followed by peritoneal dialysis combined with hemodialysis for 3 years." | 1.48 | Penile calciphylaxis in a patient on combined peritoneal dialysis and hemodialysis. ( Fujii, K; Itoh, H; Kasai, T; Morimoto, K; Muraoka, H; Shinozuka, K; Tokuyama, H; Uchiyama, K; Wakino, S; Washida, N, 2018) |
"Sodium thiosulfate (STS) is used to treat calciphylaxis and cyanide poisoning, but can lead to a serious anion-gap acidosis." | 1.40 | Falsely increased chloride and missed anion gap elevation during treatment with sodium thiosulfate. ( Bachmann, LM; Boyd, JC; Bruns, DE; Haverstick, DM; Heady, TN; Scott, MG; Wendroth, SM, 2014) |
"Calciphylaxis is a rare life-threatening form of skin necrosis." | 1.39 | Warfarin-induced calciphylaxis successfully treated with sodium thiosulphate. ( Brais, R; Deegan, P; Hafiji, J; Norris, P, 2013) |
" Although many recent case reports have shown exceptional results and healing with the use of sodium thiosulphate, we did not experience any change in the poor prognosis of our patients with the use of this drug, at a dosage of 5 g thrice weekly endovenously." | 1.39 | Calciphylaxis in dialysis patients, a severe disease poorly responding to therapies: report of 4 cases. ( Aldi, M; Cantelli, S; Gaddoni, G; Misciali, C; Odorici, G; Patrizi, A; Savoia, F; Tampieri, E; Tampieri, G, 2013) |
" Thiosulfate dosing studies showed that a molar excess of at least 200:1 (Na2S2O3:HN2) was required for significant antidotal activity." | 1.27 | Efficacy of sodium thiosulfate as a local antidote to mechlorethamine skin toxicity in the mouse. ( Alberts, DS; Dorr, RT; Soble, M, 1988) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (7.14) | 18.7374 |
1990's | 1 (7.14) | 18.2507 |
2000's | 1 (7.14) | 29.6817 |
2010's | 11 (78.57) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Fiel, DC | 1 |
Margarido Malvar, HB | 1 |
Dias Silva, RA | 1 |
Kasai, T | 1 |
Washida, N | 1 |
Muraoka, H | 1 |
Fujii, K | 1 |
Uchiyama, K | 1 |
Shinozuka, K | 1 |
Morimoto, K | 1 |
Tokuyama, H | 1 |
Wakino, S | 1 |
Itoh, H | 1 |
Ishikawa, M | 1 |
Motegi, SI | 1 |
Toki, S | 1 |
Endo, Y | 1 |
Yasuda, M | 1 |
Ishikawa, O | 1 |
Rodelo-Haad, C | 1 |
Esquivias-Motta, E | 1 |
Amaral-Neiva, F | 1 |
Martin-Malo, A | 1 |
Aljama, P | 1 |
Rodriguez, M | 1 |
Hafiji, J | 1 |
Deegan, P | 1 |
Brais, R | 1 |
Norris, P | 1 |
Savoia, F | 1 |
Gaddoni, G | 1 |
Patrizi, A | 1 |
Misciali, C | 1 |
Odorici, G | 1 |
Tampieri, G | 1 |
Tampieri, E | 1 |
Cantelli, S | 1 |
Aldi, M | 1 |
Wendroth, SM | 1 |
Heady, TN | 1 |
Haverstick, DM | 1 |
Bachmann, LM | 1 |
Scott, MG | 1 |
Boyd, JC | 1 |
Bruns, DE | 1 |
Ossorio-García, L | 1 |
Jiménez-Gallo, D | 1 |
Arjona-Aguilera, C | 1 |
Linares-Barrios, M | 1 |
Aihara, S | 1 |
Yamada, S | 1 |
Uchida, Y | 1 |
Arase, H | 1 |
Tsuchimoto, A | 1 |
Nakano, T | 1 |
Taniguchi, M | 1 |
Higashi, H | 1 |
Kitazono, T | 1 |
Tsuruya, K | 1 |
Scola, N | 1 |
Gäckler, D | 1 |
Stücker, M | 1 |
Kreuter, A | 1 |
Arabshahi, B | 1 |
Silverman, RA | 1 |
Jones, OY | 1 |
Rider, LG | 1 |
Tokashiki, K | 1 |
Ishida, A | 1 |
Kouchi, M | 1 |
Ishihara, S | 1 |
Tomiyama, N | 1 |
Kohagura, K | 1 |
Iseki, K | 1 |
Takishita, S | 1 |
Bertelli, G | 1 |
Dorr, RT | 1 |
Soble, M | 1 |
Alberts, DS | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Randomized, Controlled Pilot Trial to Evaluate the Efficacy and Safety of Subcutaneous Abatacept in Treating Interstitial Lung Disease Associated With the Anti-synthetase Syndrome[NCT03215927] | Phase 2 | 20 participants (Actual) | Interventional | 2017-06-01 | Active, not recruiting | ||
Abatacept for the Treatment of Refractory Juvenile Dermatomyositis[NCT02594735] | Phase 4 | 10 participants (Actual) | Interventional | 2015-11-30 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
"Patients who have achieved Definition of Improvement (DOI) at week 6 (visit 2) or at any point thereafter and is rated by their study physician as at least minimally improved, then tapering of corticosteroids may commence using a precise dose reduction schedule as follows:~For patients taking 40 to 60 mg daily, prednisone will be tapered by 10 mg ,For patients taking 20 to 35 mg daily, prednisone will be tapered by 5 mg. For patients taking 7.5 to 15 mg daily, prednisone will be tapered by 2.5 mg. For patients taking 1 to 5 mg daily, prednisone will be tapered by 1 mg For patients receiving intravenous pulse methylprednisolone therapy, they may alternatively reduce the dose of IV therapy, instead of oral by a decrease of 25%" (NCT02594735)
Timeframe: week 0 to week 24
Intervention | mg (Mean) |
---|---|
Week 0 (Baseline) | 16.7 |
Week 24 | 10.2 |
Physical function will be measured by using the Stanford HAQ/CHAQ: Childhood Health Assessment Questionnaire: The Stanford HAQ is a brief self-report questionnaire assessing physical function pertaining to activities of daily living in a variety of domains. The CHAQ was adapted directly from the HAQ and it has also been successfully applied to patients with juvenile myositis, with scores ranging from 0 to 3. Lower scores indicate less physical disability. (NCT02594735)
Timeframe: week 0 to 24
Intervention | units on a scale (Mean) |
---|---|
Week 0 (Baseline) | 1.84 |
Week 24 | 0.88 |
Cutaneous disease activity will be measured using the Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI). CDASI is a clinician-scored instrument that separately measures activity and damage in the skin of dermatomyositis patients for use in clinical practice or clinical/therapeutic studies. Cutaneous disease activity was measured via the activity sub-score of CDASI, ranging from 0-100. Higher scores indicate more disease activity. (NCT02594735)
Timeframe: week 0 to week 24
Intervention | score on a scale (Mean) |
---|---|
Week 0 (Baseline) | 21.4 |
Week 24 | 14.0 |
The extramuscular activity will be measured by using the Myositis Disease Activity Assessment Tool (MDAAT). This validated tool measures the degree of disease activity of extra-muscular organ systems and muscle on a 0 - 10 cm visual analogue scale (VAS). Extramuscular activity ranges between 0 and 10 via VAS. Lower scores indicate lower disease activity. (NCT02594735)
Timeframe: week 0 to 24
Intervention | units on a scale (Mean) |
---|---|
Week 0 (Baseline) | 4.1 |
Week 24 | 2.4 |
Muscle strength will be measured using an abbreviated Manual Muscle Testing (MMT) in 8 muscles (MMT8) ranging between 0 and 10 for each muscle bilaterally (with the exception of neck flexors, for a total of 15 muscles) with a total score ranging between 0 and 150. Higher scores indicate higher muscle strength. (NCT02594735)
Timeframe: week 0 to week 24
Intervention | units on a scale (Mean) |
---|---|
Week 0 (Baseline) | 121.8 |
Week 24 | 137.2 |
"The muscle enzymes include creatine kinase (CK), aldolase, lactate dehydrogenase (LDH), alanine aminotransferase (ALT) and aspartate aminotransferase (AST). If more than one muscle enzyme is identified as being elevated (a minimum level of 1.3 x the upper limit of normal), then the most abnormal will be selected and this enzyme will be the target enzyme followed to evaluate disease improvement or worsening.~In order to standardize the change in muscle enzymes selected as most abnormal across patients, the outcome measurement was calculated as the most abnormal enzyme level measured via bloodwork divided by the upper limit normal of the healthy reference range (i.e percentage of the upper limit normal for the respective muscle enzyme). Higher percentages indicate higher muscle enzyme levels." (NCT02594735)
Timeframe: week 0 to 24
Intervention | percentage of upper limit normal (Mean) |
---|---|
Week 0 (Baseline) | 1.52 |
Week 24 | 1.52 |
This tool measures the global evaluation y the patient, or by the parent if the patient is a minor, of the patient's overall disease activity at the time of assessment using a 10 cm. visual analogue scale (VAS). Parent/Patient Global Activity ranges between 0 and 10 via VAS. Lower scores indicate less disease activity. (NCT02594735)
Timeframe: week 0 to 24
Intervention | units on a scale (Mean) |
---|---|
Week 0 (Baseline) | 5.3 |
Week 24 | 2.3 |
This tool measures the global evaluation by the treating physician of the overall disease activity of the patient at the time of assessment using a 10 cm visual analogue scale (VAS). Physician global activity ranges between 0 and 10 via VAS. Lower scores indicate less disease activity. (NCT02594735)
Timeframe: week 0 to week 24
Intervention | units on a scale (Mean) |
---|---|
Week 0 (Baseline) | 5.0 |
Week 24 | 2.6 |
Axial STIR and T1 MRI images of bilateral thighs and pelvis were obtained at baseline and week 24. Images were coded and reviewed independently by two musculoskeletal radiologists who had comparable inter-observer variability and were blinded to any subject data, including visit number. MRI scoring was performed utilizing a 4-point scale (0-normal, 1-mild, 2-moderate, 3-severe) for muscle edema for each of the muscle groups examined, i.e. gluteal, adductors, hamstrings, and quadriceps, resulting in an aggregate score between 0 to 12. (NCT02594735)
Timeframe: week 0 to week 24
Intervention | score on a scale (Mean) |
---|---|
Week 0 (Baseline) | 5.3 |
Week 24 | 2.3 |
"The ACR-EULAR Response Criteria use a continuous total improvement score from baseline (range 0-100) based on the sum of the absolute percent change in the 6 core domains (weighted) used in the IMACS DOI (International Myositis Assessment and Clinical Studies definition of improvement)~IMACS core measures are: Physician Global Assessment of Disease Activity (PGA), Patient (Subject) Global Assessment of Disease Activity (SGA), Manual Muscle Test (MMT-8), Health Assessment Questionnaire-Disability Index (HAQ-DI), Muscle Enzyme levels, Myositis Disease Activity Assessment Tool (MDAAT) Extramuscular Global Activity.~In children, the total improvement score ranges between 0 and 100 percent corresponds to the degree of improvement, with higher scores corresponding to a greater degree of improvement ( >/= 30 represents minimal improvement, a score of >/= 45 represents moderate improvement, and a score of >/= 75 represents major improvement)." (NCT02594735)
Timeframe: week 0 to week 24
Intervention | score on a scale (Mean) |
---|---|
Open Label (One Arm) | 53.8 |
Safety will be assessed by review of adverse events using NCI Common Terminology criteria v5.0 November 2017. Particular attention to serious adverse events and infections will be given. An adverse event diary will be maintained throughout the study. Patient evaluations will include: vital sign measurement, physical examination, and laboratory parameters for hematology and routine chemistries (NCT02594735)
Timeframe: week 0 to week 24
Intervention | events (Number) | |||||||
---|---|---|---|---|---|---|---|---|
Worsening of interstitial lung disease | Compression fracture | Right knee contracture worsening | Worsening calcinosis | Lipoatrophy, focal | Febrile episodes | Skin-infection | E. coli diarrhea | |
Open Label (One Arm) | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 1 |
1 review available for thiosulfates and Skin Ulcer
Article | Year |
---|---|
Prevention and management of extravasation of cytotoxic drugs.
Topics: Adrenal Cortex Hormones; Animals; Antidotes; Combined Modality Therapy; Dimethyl Sulfoxide; Extravas | 1995 |
13 other studies available for thiosulfates and Skin Ulcer
Article | Year |
---|---|
The role of mammography in calcific uremic arteriolopathy.
Topics: Aged; Arterioles; Biopsy; Calcinosis; Debridement; Diabetes Mellitus, Type 2; Diabetic Nephropathies | 2017 |
Penile calciphylaxis in a patient on combined peritoneal dialysis and hemodialysis.
Topics: Aged; Buffers; Calciphylaxis; Dialysis Solutions; Humans; Lactates; Male; Penile Diseases; Penis; Pe | 2018 |
Calciphylaxis and nephrogenic fibrosing dermopathy with pseudoxanthoma elasticum-like changes: Successful treatment with sodium thiosulfate.
Topics: Aged; Calciphylaxis; Chelating Agents; Humans; Kidney Failure, Chronic; Male; Microscopy, Electron; | 2019 |
Reversing extraosseous calcifications. A case of breast uremic calcific arteriolopathy.
Topics: Arterioles; Breast Diseases; Calcinosis; Ergocalciferols; Female; Humans; Kidney Failure, Chronic; M | 2019 |
Warfarin-induced calciphylaxis successfully treated with sodium thiosulphate.
Topics: Anticoagulants; Antioxidants; Calciphylaxis; Drug Eruptions; Humans; Male; Middle Aged; Skin Ulcer; | 2013 |
Calciphylaxis in dialysis patients, a severe disease poorly responding to therapies: report of 4 cases.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Biopsy; Calciphylaxis; Cinacalcet; Combined Modality | 2013 |
Falsely increased chloride and missed anion gap elevation during treatment with sodium thiosulfate.
Topics: Acid-Base Equilibrium; Adult; Calciphylaxis; Chlorides; Electrodes; False Positive Reactions; Female | 2014 |
Multimodal Treatment of Calciphylaxis With Sodium Thiosulfate, Alprostadil, and Hyperbaric Oxygen Therapy.
Topics: Alprostadil; Calciphylaxis; Combined Modality Therapy; Female; Humans; Hyperbaric Oxygenation; Hyper | 2016 |
The Successful Treatment of Calciphylaxis with Sodium Thiosulfate and Hyperbaric Oxygen in a Non-dialyzed Patient with Chronic Kidney Disease.
Topics: alpha-2-HS-Glycoprotein; C-Reactive Protein; Calciphylaxis; Female; Humans; Hyperbaric Oxygenation; | 2016 |
Complete clearance of calciphylaxis following combined treatment with cinacalcet and sodium thiosulfate.
Topics: Calciphylaxis; Cinacalcet; Drug Therapy, Combination; Female; Humans; Middle Aged; Naphthalenes; Ski | 2011 |
Abatacept and sodium thiosulfate for treatment of recalcitrant juvenile dermatomyositis complicated by ulceration and calcinosis.
Topics: Abatacept; Adolescent; Anti-Inflammatory Agents; Antioxidants; Calcinosis; Chelating Agents; Dermato | 2012 |
Abatacept and sodium thiosulfate for treatment of recalcitrant juvenile dermatomyositis complicated by ulceration and calcinosis.
Topics: Abatacept; Adolescent; Anti-Inflammatory Agents; Antioxidants; Calcinosis; Chelating Agents; Dermato | 2012 |
Abatacept and sodium thiosulfate for treatment of recalcitrant juvenile dermatomyositis complicated by ulceration and calcinosis.
Topics: Abatacept; Adolescent; Anti-Inflammatory Agents; Antioxidants; Calcinosis; Chelating Agents; Dermato | 2012 |
Abatacept and sodium thiosulfate for treatment of recalcitrant juvenile dermatomyositis complicated by ulceration and calcinosis.
Topics: Abatacept; Adolescent; Anti-Inflammatory Agents; Antioxidants; Calcinosis; Chelating Agents; Dermato | 2012 |
Successful management of critical limb ischemia with intravenous sodium thiosulfate in a chronic hemodialysis patient.
Topics: Calcinosis; Calciphylaxis; Fingers; Humans; Infusions, Intravenous; Ischemia; Male; Middle Aged; Ren | 2006 |
Efficacy of sodium thiosulfate as a local antidote to mechlorethamine skin toxicity in the mouse.
Topics: Animals; Dose-Response Relationship, Drug; Female; Mechlorethamine; Mice; Mice, Inbred BALB C; Skin; | 1988 |