Page last updated: 2024-10-20

thiosulfates and Skin Ulcer

thiosulfates has been researched along with Skin Ulcer in 14 studies

Thiosulfates: Inorganic salts of thiosulfuric acid possessing the general formula R2S2O3.
thiosulfate(2-) : A divalent inorganic anion obtained by removal of both protons from thiosulfuric acid.

Skin Ulcer: An ULCER of the skin and underlying tissues.

Research Excerpts

ExcerptRelevanceReference
"We report the successful use of abatacept and sodium thiosulfate in a patient with severe recalcitrant juvenile dermatomyositis complicated by ulcerative skin disease and progressive calcinosis."7.78Abatacept and sodium thiosulfate for treatment of recalcitrant juvenile dermatomyositis complicated by ulceration and calcinosis. ( Arabshahi, B; Jones, OY; Rider, LG; Silverman, RA, 2012)
" The skin ulcers drastically improved within 6 months after the initiation of hemodialysis, aggressive wound care, the control of a mineral and bone disorder, and the administration of sodium thiosulfate and hyperbaric oxygen therapy."3.83The Successful Treatment of Calciphylaxis with Sodium Thiosulfate and Hyperbaric Oxygen in a Non-dialyzed Patient with Chronic Kidney Disease. ( Aihara, S; Arase, H; Higashi, H; Kitazono, T; Nakano, T; Taniguchi, M; Tsuchimoto, A; Tsuruya, K; Uchida, Y; Yamada, S, 2016)
"We report the successful use of abatacept and sodium thiosulfate in a patient with severe recalcitrant juvenile dermatomyositis complicated by ulcerative skin disease and progressive calcinosis."3.78Abatacept and sodium thiosulfate for treatment of recalcitrant juvenile dermatomyositis complicated by ulceration and calcinosis. ( Arabshahi, B; Jones, OY; Rider, LG; Silverman, RA, 2012)
"A 66-year-old man with renal failure due to diabetic nephropathy was on peritoneal dialysis alone for 1 year, followed by peritoneal dialysis combined with hemodialysis for 3 years."1.48Penile calciphylaxis in a patient on combined peritoneal dialysis and hemodialysis. ( Fujii, K; Itoh, H; Kasai, T; Morimoto, K; Muraoka, H; Shinozuka, K; Tokuyama, H; Uchiyama, K; Wakino, S; Washida, N, 2018)
"Sodium thiosulfate (STS) is used to treat calciphylaxis and cyanide poisoning, but can lead to a serious anion-gap acidosis."1.40Falsely increased chloride and missed anion gap elevation during treatment with sodium thiosulfate. ( Bachmann, LM; Boyd, JC; Bruns, DE; Haverstick, DM; Heady, TN; Scott, MG; Wendroth, SM, 2014)
"Calciphylaxis is a rare life-threatening form of skin necrosis."1.39Warfarin-induced calciphylaxis successfully treated with sodium thiosulphate. ( Brais, R; Deegan, P; Hafiji, J; Norris, P, 2013)
" Although many recent case reports have shown exceptional results and healing with the use of sodium thiosulphate, we did not experience any change in the poor prognosis of our patients with the use of this drug, at a dosage of 5 g thrice weekly endovenously."1.39Calciphylaxis in dialysis patients, a severe disease poorly responding to therapies: report of 4 cases. ( Aldi, M; Cantelli, S; Gaddoni, G; Misciali, C; Odorici, G; Patrizi, A; Savoia, F; Tampieri, E; Tampieri, G, 2013)
" Thiosulfate dosing studies showed that a molar excess of at least 200:1 (Na2S2O3:HN2) was required for significant antidotal activity."1.27Efficacy of sodium thiosulfate as a local antidote to mechlorethamine skin toxicity in the mouse. ( Alberts, DS; Dorr, RT; Soble, M, 1988)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.14)18.7374
1990's1 (7.14)18.2507
2000's1 (7.14)29.6817
2010's11 (78.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fiel, DC1
Margarido Malvar, HB1
Dias Silva, RA1
Kasai, T1
Washida, N1
Muraoka, H1
Fujii, K1
Uchiyama, K1
Shinozuka, K1
Morimoto, K1
Tokuyama, H1
Wakino, S1
Itoh, H1
Ishikawa, M1
Motegi, SI1
Toki, S1
Endo, Y1
Yasuda, M1
Ishikawa, O1
Rodelo-Haad, C1
Esquivias-Motta, E1
Amaral-Neiva, F1
Martin-Malo, A1
Aljama, P1
Rodriguez, M1
Hafiji, J1
Deegan, P1
Brais, R1
Norris, P1
Savoia, F1
Gaddoni, G1
Patrizi, A1
Misciali, C1
Odorici, G1
Tampieri, G1
Tampieri, E1
Cantelli, S1
Aldi, M1
Wendroth, SM1
Heady, TN1
Haverstick, DM1
Bachmann, LM1
Scott, MG1
Boyd, JC1
Bruns, DE1
Ossorio-García, L1
Jiménez-Gallo, D1
Arjona-Aguilera, C1
Linares-Barrios, M1
Aihara, S1
Yamada, S1
Uchida, Y1
Arase, H1
Tsuchimoto, A1
Nakano, T1
Taniguchi, M1
Higashi, H1
Kitazono, T1
Tsuruya, K1
Scola, N1
Gäckler, D1
Stücker, M1
Kreuter, A1
Arabshahi, B1
Silverman, RA1
Jones, OY1
Rider, LG1
Tokashiki, K1
Ishida, A1
Kouchi, M1
Ishihara, S1
Tomiyama, N1
Kohagura, K1
Iseki, K1
Takishita, S1
Bertelli, G1
Dorr, RT1
Soble, M1
Alberts, DS1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Controlled Pilot Trial to Evaluate the Efficacy and Safety of Subcutaneous Abatacept in Treating Interstitial Lung Disease Associated With the Anti-synthetase Syndrome[NCT03215927]Phase 220 participants (Actual)Interventional2017-06-01Active, not recruiting
Abatacept for the Treatment of Refractory Juvenile Dermatomyositis[NCT02594735]Phase 410 participants (Actual)Interventional2015-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Corticosteroid Dose for Steroid-sparing Benefit From Baseline to Week 24

"Patients who have achieved Definition of Improvement (DOI) at week 6 (visit 2) or at any point thereafter and is rated by their study physician as at least minimally improved, then tapering of corticosteroids may commence using a precise dose reduction schedule as follows:~For patients taking 40 to 60 mg daily, prednisone will be tapered by 10 mg ,For patients taking 20 to 35 mg daily, prednisone will be tapered by 5 mg. For patients taking 7.5 to 15 mg daily, prednisone will be tapered by 2.5 mg. For patients taking 1 to 5 mg daily, prednisone will be tapered by 1 mg For patients receiving intravenous pulse methylprednisolone therapy, they may alternatively reduce the dose of IV therapy, instead of oral by a decrease of 25%" (NCT02594735)
Timeframe: week 0 to week 24

Interventionmg (Mean)
Week 0 (Baseline)16.7
Week 2410.2

Improvement in Childhood Health Assessment Questionnaire (CHAQ) From Baseline to Week 24

Physical function will be measured by using the Stanford HAQ/CHAQ: Childhood Health Assessment Questionnaire: The Stanford HAQ is a brief self-report questionnaire assessing physical function pertaining to activities of daily living in a variety of domains. The CHAQ was adapted directly from the HAQ and it has also been successfully applied to patients with juvenile myositis, with scores ranging from 0 to 3. Lower scores indicate less physical disability. (NCT02594735)
Timeframe: week 0 to 24

Interventionunits on a scale (Mean)
Week 0 (Baseline)1.84
Week 240.88

Improvement in Cutaneous Disease Activity From Baseline to Week 24

Cutaneous disease activity will be measured using the Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI). CDASI is a clinician-scored instrument that separately measures activity and damage in the skin of dermatomyositis patients for use in clinical practice or clinical/therapeutic studies. Cutaneous disease activity was measured via the activity sub-score of CDASI, ranging from 0-100. Higher scores indicate more disease activity. (NCT02594735)
Timeframe: week 0 to week 24

Interventionscore on a scale (Mean)
Week 0 (Baseline)21.4
Week 2414.0

Improvement in Extramuscular Activity From Baseline to Week 24

The extramuscular activity will be measured by using the Myositis Disease Activity Assessment Tool (MDAAT). This validated tool measures the degree of disease activity of extra-muscular organ systems and muscle on a 0 - 10 cm visual analogue scale (VAS). Extramuscular activity ranges between 0 and 10 via VAS. Lower scores indicate lower disease activity. (NCT02594735)
Timeframe: week 0 to 24

Interventionunits on a scale (Mean)
Week 0 (Baseline)4.1
Week 242.4

Improvement in Manual Muscle Testing (MMT8) From Baseline to Week 24

Muscle strength will be measured using an abbreviated Manual Muscle Testing (MMT) in 8 muscles (MMT8) ranging between 0 and 10 for each muscle bilaterally (with the exception of neck flexors, for a total of 15 muscles) with a total score ranging between 0 and 150. Higher scores indicate higher muscle strength. (NCT02594735)
Timeframe: week 0 to week 24

Interventionunits on a scale (Mean)
Week 0 (Baseline)121.8
Week 24137.2

Improvement in Muscle Enzymes From Baseline to Week 24

"The muscle enzymes include creatine kinase (CK), aldolase, lactate dehydrogenase (LDH), alanine aminotransferase (ALT) and aspartate aminotransferase (AST). If more than one muscle enzyme is identified as being elevated (a minimum level of 1.3 x the upper limit of normal), then the most abnormal will be selected and this enzyme will be the target enzyme followed to evaluate disease improvement or worsening.~In order to standardize the change in muscle enzymes selected as most abnormal across patients, the outcome measurement was calculated as the most abnormal enzyme level measured via bloodwork divided by the upper limit normal of the healthy reference range (i.e percentage of the upper limit normal for the respective muscle enzyme). Higher percentages indicate higher muscle enzyme levels." (NCT02594735)
Timeframe: week 0 to 24

Interventionpercentage of upper limit normal (Mean)
Week 0 (Baseline)1.52
Week 241.52

Improvement in Parent/Patient Global Activity From Baseline to Week 24

This tool measures the global evaluation y the patient, or by the parent if the patient is a minor, of the patient's overall disease activity at the time of assessment using a 10 cm. visual analogue scale (VAS). Parent/Patient Global Activity ranges between 0 and 10 via VAS. Lower scores indicate less disease activity. (NCT02594735)
Timeframe: week 0 to 24

Interventionunits on a scale (Mean)
Week 0 (Baseline)5.3
Week 242.3

Improvement in Physician Global Activity From Baseline to Week 24

This tool measures the global evaluation by the treating physician of the overall disease activity of the patient at the time of assessment using a 10 cm visual analogue scale (VAS). Physician global activity ranges between 0 and 10 via VAS. Lower scores indicate less disease activity. (NCT02594735)
Timeframe: week 0 to week 24

Interventionunits on a scale (Mean)
Week 0 (Baseline)5.0
Week 242.6

Improvement in Total Muscle Edema by MRI From Baseline to Week 24

Axial STIR and T1 MRI images of bilateral thighs and pelvis were obtained at baseline and week 24. Images were coded and reviewed independently by two musculoskeletal radiologists who had comparable inter-observer variability and were blinded to any subject data, including visit number. MRI scoring was performed utilizing a 4-point scale (0-normal, 1-mild, 2-moderate, 3-severe) for muscle edema for each of the muscle groups examined, i.e. gluteal, adductors, hamstrings, and quadriceps, resulting in an aggregate score between 0 to 12. (NCT02594735)
Timeframe: week 0 to week 24

Interventionscore on a scale (Mean)
Week 0 (Baseline)5.3
Week 242.3

Total Improvement Score by IMACS Core Set Measures at Week 24

"The ACR-EULAR Response Criteria use a continuous total improvement score from baseline (range 0-100) based on the sum of the absolute percent change in the 6 core domains (weighted) used in the IMACS DOI (International Myositis Assessment and Clinical Studies definition of improvement)~IMACS core measures are: Physician Global Assessment of Disease Activity (PGA), Patient (Subject) Global Assessment of Disease Activity (SGA), Manual Muscle Test (MMT-8), Health Assessment Questionnaire-Disability Index (HAQ-DI), Muscle Enzyme levels, Myositis Disease Activity Assessment Tool (MDAAT) Extramuscular Global Activity.~In children, the total improvement score ranges between 0 and 100 percent corresponds to the degree of improvement, with higher scores corresponding to a greater degree of improvement ( >/= 30 represents minimal improvement, a score of >/= 45 represents moderate improvement, and a score of >/= 75 represents major improvement)." (NCT02594735)
Timeframe: week 0 to week 24

Interventionscore on a scale (Mean)
Open Label (One Arm)53.8

Number of Treatment-emergent Adverse Events

Safety will be assessed by review of adverse events using NCI Common Terminology criteria v5.0 November 2017. Particular attention to serious adverse events and infections will be given. An adverse event diary will be maintained throughout the study. Patient evaluations will include: vital sign measurement, physical examination, and laboratory parameters for hematology and routine chemistries (NCT02594735)
Timeframe: week 0 to week 24

Interventionevents (Number)
Worsening of interstitial lung diseaseCompression fractureRight knee contracture worseningWorsening calcinosisLipoatrophy, focalFebrile episodesSkin-infectionE. coli diarrhea
Open Label (One Arm)11121211

Reviews

1 review available for thiosulfates and Skin Ulcer

ArticleYear
Prevention and management of extravasation of cytotoxic drugs.
    Drug safety, 1995, Volume: 12, Issue:4

    Topics: Adrenal Cortex Hormones; Animals; Antidotes; Combined Modality Therapy; Dimethyl Sulfoxide; Extravas

1995

Other Studies

13 other studies available for thiosulfates and Skin Ulcer

ArticleYear
The role of mammography in calcific uremic arteriolopathy.
    Kidney international, 2017, Volume: 92, Issue:3

    Topics: Aged; Arterioles; Biopsy; Calcinosis; Debridement; Diabetes Mellitus, Type 2; Diabetic Nephropathies

2017
Penile calciphylaxis in a patient on combined peritoneal dialysis and hemodialysis.
    CEN case reports, 2018, Volume: 7, Issue:2

    Topics: Aged; Buffers; Calciphylaxis; Dialysis Solutions; Humans; Lactates; Male; Penile Diseases; Penis; Pe

2018
Calciphylaxis and nephrogenic fibrosing dermopathy with pseudoxanthoma elasticum-like changes: Successful treatment with sodium thiosulfate.
    The Journal of dermatology, 2019, Volume: 46, Issue:7

    Topics: Aged; Calciphylaxis; Chelating Agents; Humans; Kidney Failure, Chronic; Male; Microscopy, Electron;

2019
Reversing extraosseous calcifications. A case of breast uremic calcific arteriolopathy.
    The breast journal, 2019, Volume: 25, Issue:5

    Topics: Arterioles; Breast Diseases; Calcinosis; Ergocalciferols; Female; Humans; Kidney Failure, Chronic; M

2019
Warfarin-induced calciphylaxis successfully treated with sodium thiosulphate.
    The Australasian journal of dermatology, 2013, Volume: 54, Issue:2

    Topics: Anticoagulants; Antioxidants; Calciphylaxis; Drug Eruptions; Humans; Male; Middle Aged; Skin Ulcer;

2013
Calciphylaxis in dialysis patients, a severe disease poorly responding to therapies: report of 4 cases.
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 2013, Volume: 148, Issue:5

    Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Biopsy; Calciphylaxis; Cinacalcet; Combined Modality

2013
Falsely increased chloride and missed anion gap elevation during treatment with sodium thiosulfate.
    Clinica chimica acta; international journal of clinical chemistry, 2014, Apr-20, Volume: 431

    Topics: Acid-Base Equilibrium; Adult; Calciphylaxis; Chlorides; Electrodes; False Positive Reactions; Female

2014
Multimodal Treatment of Calciphylaxis With Sodium Thiosulfate, Alprostadil, and Hyperbaric Oxygen Therapy.
    Actas dermo-sifiliograficas, 2016, Volume: 107, Issue:8

    Topics: Alprostadil; Calciphylaxis; Combined Modality Therapy; Female; Humans; Hyperbaric Oxygenation; Hyper

2016
The Successful Treatment of Calciphylaxis with Sodium Thiosulfate and Hyperbaric Oxygen in a Non-dialyzed Patient with Chronic Kidney Disease.
    Internal medicine (Tokyo, Japan), 2016, Volume: 55, Issue:14

    Topics: alpha-2-HS-Glycoprotein; C-Reactive Protein; Calciphylaxis; Female; Humans; Hyperbaric Oxygenation;

2016
Complete clearance of calciphylaxis following combined treatment with cinacalcet and sodium thiosulfate.
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2011, Volume: 9, Issue:12

    Topics: Calciphylaxis; Cinacalcet; Drug Therapy, Combination; Female; Humans; Middle Aged; Naphthalenes; Ski

2011
Abatacept and sodium thiosulfate for treatment of recalcitrant juvenile dermatomyositis complicated by ulceration and calcinosis.
    The Journal of pediatrics, 2012, Volume: 160, Issue:3

    Topics: Abatacept; Adolescent; Anti-Inflammatory Agents; Antioxidants; Calcinosis; Chelating Agents; Dermato

2012
Abatacept and sodium thiosulfate for treatment of recalcitrant juvenile dermatomyositis complicated by ulceration and calcinosis.
    The Journal of pediatrics, 2012, Volume: 160, Issue:3

    Topics: Abatacept; Adolescent; Anti-Inflammatory Agents; Antioxidants; Calcinosis; Chelating Agents; Dermato

2012
Abatacept and sodium thiosulfate for treatment of recalcitrant juvenile dermatomyositis complicated by ulceration and calcinosis.
    The Journal of pediatrics, 2012, Volume: 160, Issue:3

    Topics: Abatacept; Adolescent; Anti-Inflammatory Agents; Antioxidants; Calcinosis; Chelating Agents; Dermato

2012
Abatacept and sodium thiosulfate for treatment of recalcitrant juvenile dermatomyositis complicated by ulceration and calcinosis.
    The Journal of pediatrics, 2012, Volume: 160, Issue:3

    Topics: Abatacept; Adolescent; Anti-Inflammatory Agents; Antioxidants; Calcinosis; Chelating Agents; Dermato

2012
Successful management of critical limb ischemia with intravenous sodium thiosulfate in a chronic hemodialysis patient.
    Clinical nephrology, 2006, Volume: 66, Issue:2

    Topics: Calcinosis; Calciphylaxis; Fingers; Humans; Infusions, Intravenous; Ischemia; Male; Middle Aged; Ren

2006
Efficacy of sodium thiosulfate as a local antidote to mechlorethamine skin toxicity in the mouse.
    Cancer chemotherapy and pharmacology, 1988, Volume: 22, Issue:4

    Topics: Animals; Dose-Response Relationship, Drug; Female; Mechlorethamine; Mice; Mice, Inbred BALB C; Skin;

1988