thiosulfates has been researched along with Ototoxicity in 4 studies
Thiosulfates: Inorganic salts of thiosulfuric acid possessing the general formula R2S2O3.
thiosulfate(2-) : A divalent inorganic anion obtained by removal of both protons from thiosulfuric acid.
Ototoxicity: Damage to the EAR or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the association between concurrent STS and reduced risk of ototoxic effects among patients undergoing platinum-based chemotherapy and to evaluate outcomes, including event-free survival, overall survival, and adverse outcomes." | 2.72 | Association of Sodium Thiosulfate With Risk of Ototoxic Effects From Platinum-Based Chemotherapy: A Systematic Review and Meta-analysis. ( Chang, CY; Chen, CH; Cheng, YF; Huang, CY; Lin, HH; Wang, MC, 2021) |
| "Despite ototoxicity being a prevalent consequence of cisplatin chemotherapy, little guidance exists on interventions to prevent this permanent and progressive adverse event." | 2.66 | Prevention of cisplatin-induced ototoxicity in children and adolescents with cancer: a clinical practice guideline. ( Brock, PR; Cabral, S; Chang, KW; Dupuis, LL; Epelman, S; Freyer, DR; Knight, K; Mills, D; Phillips, R; Potter, E; Risby, D; Robinson, PD; Simpkin, P; Sullivan, M; Sung, L, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 3 (75.00) | 2.80 |
| Authors | Studies |
|---|---|
| Freyer, DR | 2 |
| Brock, PR | 1 |
| Chang, KW | 1 |
| Dupuis, LL | 1 |
| Epelman, S | 1 |
| Knight, K | 2 |
| Mills, D | 1 |
| Phillips, R | 1 |
| Potter, E | 1 |
| Risby, D | 1 |
| Simpkin, P | 1 |
| Sullivan, M | 1 |
| Cabral, S | 2 |
| Robinson, PD | 2 |
| Sung, L | 2 |
| Navarro-Ruiz, NE | 1 |
| Chen, CH | 1 |
| Huang, CY | 1 |
| Lin, HH | 1 |
| Wang, MC | 1 |
| Chang, CY | 1 |
| Cheng, YF | 1 |
| Brock, P | 1 |
| Reaman, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 3 Multi-institutional Study for Treatment of Children With Newly Diagnosed Hepatoblastoma Using a Modified PHITT Strategy Incorporating a Randomized Assessment of Sodium Thiosulfate as Otoprotection for Children With Localized Disease, and Respons[NCT04478292] | Phase 3 | 330 participants (Anticipated) | Interventional | 2021-03-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for thiosulfates and Ototoxicity
| Article | Year |
|---|---|
Prevention of cisplatin-induced ototoxicity in children and adolescents with cancer: a clinical practice guideline.
Topics: Adolescent; Antineoplastic Agents; Child; Cisplatin; Female; Hearing Loss; Humans; Male; Neoplasms; | 2020 |
Prevention of Platinum-Induced Hearing Loss in Children with Cancer.
Topics: Amifostine; Humans; Neoplasms; Ototoxicity; Platinum; Practice Guidelines as Topic; Thiosulfates | 2020 |
Association of Sodium Thiosulfate With Risk of Ototoxic Effects From Platinum-Based Chemotherapy: A Systematic Review and Meta-analysis.
Topics: Adolescent; Adult; Antineoplastic Agents; Child; Clinical Trials as Topic; Female; Humans; Male; Oto | 2021 |
Interventions for cisplatin-induced hearing loss in children and adolescents with cancer.
Topics: Acetylcysteine; Adolescent; Amifostine; Anti-Inflammatory Agents; Antineoplastic Agents; Chelating A | 2019 |