thiosulfates has been researched along with Liver Neoplasms in 20 studies
Thiosulfates: Inorganic salts of thiosulfuric acid possessing the general formula R2S2O3.
thiosulfate(2-) : A divalent inorganic anion obtained by removal of both protons from thiosulfuric acid.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We randomly assigned children older than 1 month and younger than 18 years of age who had standard-risk hepatoblastoma (≤3 involved liver sectors, no metastatic disease, and an alpha-fetoprotein level of >100 ng per milliliter) to receive cisplatin alone (at a dose of 80 mg per square meter of body-surface area, administered over a period of 6 hours) or cisplatin plus sodium thiosulfate (at a dose of 20 g per square meter, administered intravenously over a 15-minute period, 6 hours after the discontinuation of cisplatin) for four preoperative and two postoperative courses." | 9.27 | Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss. ( Ansari, M; Brichard, B; Brock, PR; Brugières, L; Capra, M; Childs, M; Covezzoli, A; Czauderna, P; Dall'Igna, P; Hiyama, E; Laithier, V; Maibach, R; Mateos, ME; Morland, B; Neuwelt, EA; Perilongo, G; Rajput, K; Rangaswami, AA; Rechnitzer, C; Roebuck, D; Ronghe, M; Skeen, J; Sullivan, MJ; Veal, GJ, 2018) |
| "To evaluate the effect of sodium thiosulfate (STS) on cisplatin clearance after transcatheter embolization (TAE) with a lipiodol-platinum suspension (LPS) in patients with hepatocellular carcinoma (HCC)." | 9.14 | Effect of sodium thiosulfate on cisplatin removal after intra-arterial embolization with a lipiodol-platinum suspension for hepatocellular carcinoma. ( Ikeda, O; Iryo, Y; Nakasone, Y; Tamura, Y; Yamashita, Y, 2010) |
| "It was reported that sodium thiosulfate (STS) was contributed to antivomiting effect in 20 transarterial chemotherapic patients." | 7.69 | [Relieving effect of sodium thiosulfate on transarterial chemotherapeutic emesis]. ( Cao, SW; Chen, BH; Wang, GH, 1997) |
| "We randomly assigned children older than 1 month and younger than 18 years of age who had standard-risk hepatoblastoma (≤3 involved liver sectors, no metastatic disease, and an alpha-fetoprotein level of >100 ng per milliliter) to receive cisplatin alone (at a dose of 80 mg per square meter of body-surface area, administered over a period of 6 hours) or cisplatin plus sodium thiosulfate (at a dose of 20 g per square meter, administered intravenously over a 15-minute period, 6 hours after the discontinuation of cisplatin) for four preoperative and two postoperative courses." | 5.27 | Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss. ( Ansari, M; Brichard, B; Brock, PR; Brugières, L; Capra, M; Childs, M; Covezzoli, A; Czauderna, P; Dall'Igna, P; Hiyama, E; Laithier, V; Maibach, R; Mateos, ME; Morland, B; Neuwelt, EA; Perilongo, G; Rajput, K; Rangaswami, AA; Rechnitzer, C; Roebuck, D; Ronghe, M; Skeen, J; Sullivan, MJ; Veal, GJ, 2018) |
| "To evaluate the effect of sodium thiosulfate (STS) on cisplatin clearance after transcatheter embolization (TAE) with a lipiodol-platinum suspension (LPS) in patients with hepatocellular carcinoma (HCC)." | 5.14 | Effect of sodium thiosulfate on cisplatin removal after intra-arterial embolization with a lipiodol-platinum suspension for hepatocellular carcinoma. ( Ikeda, O; Iryo, Y; Nakasone, Y; Tamura, Y; Yamashita, Y, 2010) |
| "It was reported that sodium thiosulfate (STS) was contributed to antivomiting effect in 20 transarterial chemotherapic patients." | 3.69 | [Relieving effect of sodium thiosulfate on transarterial chemotherapeutic emesis]. ( Cao, SW; Chen, BH; Wang, GH, 1997) |
| "Twenty-one cases of unresectable hepatocellular carcinoma (HCC), including 15 cases receiving intravenous infusion of CDDP in addition to transcatheter arterial embolization (TAE), and 6 cases receiving intraarterial infusion of CDDP in combination with sodium thiosulfate rescue (STS rescue) were studied." | 3.67 | [Clinical study of the effect of cisplatin therapy in unresectable hepatocellular carcinoma]. ( Ishii, K; Kokubu, S; Matsuki, S; Nii, S; Okabe, H; Shibata, H; Sugimoto, M; Yamada, N, 1988) |
| "Nine (six male and three female) patients with unresectable liver metastasis of gastrointestinal adenocarcinoma were treated by two-route chemotherapy using cis-diamminedichloroplatinum (CDDP) and sodium thiosulfate (STS)." | 3.67 | [Two-route chemotherapy by CDDP and STS in liver metastasis of gastrointestinal adenocarcinoma]. ( Banno, T; Nakamura, M; Nojiri, O; Tanaka, Y, 1988) |
| "Therefore, rat hepatoma cells (H4IIE) were cultured with 1 to 100 micromol/L of NPTS or 2PTS for 48 hours at 37 degrees C; and the activities and messenger RNA (mRNA) expression levels of phase II enzymes in H4IIE cells were investigated." | 1.36 | Sodium 2-propenyl thiosulfate derived from garlic induces phase II detoxification enzymes in rat hepatoma H4IIE cells. ( Chang, HS; Fujita, S; Hossain, MA; Ishizuka, M; Ko, M; Yabuki, A; Yamato, O, 2010) |
| "Patients with unresectable liver cancer (primary and metastatic) were treated with a newly-devised arterial infusion chemotherapy using Cis-DDP and its antidote Sodium thiosulfate (STS)." | 1.27 | [Intra-arterial infusion through 2 routes in liver (primary and metastatic cancer]. ( Abe, R; Akiyoshi, T; Arinaga, S; Asoh, T; Baba, T; Koba, F; Miyazaki, S; Shirasaka, C; Takeuchi, Y; Tsuii, H; Uchida, I; Wada, T, 1983) |
| "Five of 11 (45%) hepatocellular carcinoma and two of six (33%) metastatic tumors achieved partial response." | 1.27 | 'Two-route chemotherapy' using intra-arterial cisplatin and intravenous sodium thiosulfate, its neutralizing agent, for hepatic malignancies. ( Abe, R; Akiyoshi, T; Baba, T; Koba, F; Tsuji, H, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (55.00) | 18.7374 |
| 1990's | 4 (20.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 3 (15.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brock, PR | 1 |
| Maibach, R | 1 |
| Childs, M | 1 |
| Rajput, K | 1 |
| Roebuck, D | 1 |
| Sullivan, MJ | 2 |
| Laithier, V | 1 |
| Ronghe, M | 1 |
| Dall'Igna, P | 1 |
| Hiyama, E | 1 |
| Brichard, B | 1 |
| Skeen, J | 1 |
| Mateos, ME | 1 |
| Capra, M | 1 |
| Rangaswami, AA | 1 |
| Ansari, M | 1 |
| Rechnitzer, C | 1 |
| Veal, GJ | 1 |
| Covezzoli, A | 1 |
| Brugières, L | 1 |
| Perilongo, G | 1 |
| Czauderna, P | 1 |
| Morland, B | 1 |
| Neuwelt, EA | 1 |
| JAFFE, WG | 1 |
| Tamura, Y | 1 |
| Ikeda, O | 1 |
| Nakasone, Y | 1 |
| Iryo, Y | 1 |
| Yamashita, Y | 1 |
| Chang, HS | 1 |
| Ko, M | 1 |
| Ishizuka, M | 1 |
| Fujita, S | 1 |
| Yabuki, A | 1 |
| Hossain, MA | 1 |
| Yamato, O | 1 |
| LAWRENCE, W | 1 |
| TAYAO, MS | 1 |
| MAHAJAN, RD | 1 |
| PAGE, R | 1 |
| MILLER, DG | 1 |
| CLAPP, P | 1 |
| Sagiyama, K | 2 |
| Uozumi, J | 2 |
| Aoki, K | 3 |
| Baba, T | 7 |
| Onohara, S | 1 |
| Sonoda, T | 1 |
| Oyama, T | 1 |
| Kobayashi, H | 2 |
| Uchiyama, N | 1 |
| Yamaguchi, K | 1 |
| Shinohara, S | 1 |
| Koba, F | 2 |
| Tsuii, H | 1 |
| Abe, R | 3 |
| Asoh, T | 1 |
| Miyazaki, S | 1 |
| Shirasaka, C | 1 |
| Takeuchi, Y | 1 |
| Arinaga, S | 1 |
| Wada, T | 1 |
| Uchida, I | 1 |
| Akiyoshi, T | 3 |
| Taniguchi, S | 2 |
| Iwamoto, Y | 1 |
| Wang, GH | 1 |
| Cao, SW | 1 |
| Chen, BH | 1 |
| Iciek, MB | 1 |
| Rokita, HB | 1 |
| Wlodek, LB | 1 |
| Takada, K | 1 |
| Takashima, S | 1 |
| Nakamura, K | 1 |
| Morimoto, A | 1 |
| Inoue, AM | 1 |
| Fujimoto, K | 1 |
| Murata, K | 1 |
| Usuki, N | 1 |
| Minakuchi, K | 1 |
| Onoyama, Y | 1 |
| Hasuda, K | 1 |
| Hokita, S | 1 |
| Takao, S | 1 |
| Tokushige, M | 1 |
| Maenohara, S | 1 |
| Aikou, T | 1 |
| Shimazu, H | 1 |
| Matsuki, S | 1 |
| Sugimoto, M | 1 |
| Nii, S | 1 |
| Kokubu, S | 1 |
| Yamada, N | 1 |
| Ishii, K | 1 |
| Shibata, H | 1 |
| Okabe, H | 1 |
| Tsuji, H | 1 |
| Nojiri, O | 1 |
| Nakamura, M | 1 |
| Tanaka, Y | 1 |
| Banno, T | 1 |
| Kuroiwa, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 3 Multi-institutional Study for Treatment of Children With Newly Diagnosed Hepatoblastoma Using a Modified PHITT Strategy Incorporating a Randomized Assessment of Sodium Thiosulfate as Otoprotection for Children With Localized Disease, and Respons[NCT04478292] | Phase 3 | 330 participants (Anticipated) | Interventional | 2021-03-01 | Recruiting | ||
| A Multi-centre Open-label Randomised Phase III Trial of the Efficacy of Sodium Thiosulphate in Reducing Ototoxicity in Patients Receiving Cisplatin Chemotherapy for Standard Risk Hepatoblastoma[NCT00652132] | Phase 3 | 116 participants (Actual) | Interventional | 2007-12-15 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for thiosulfates and Liver Neoplasms
| Article | Year |
|---|---|
Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss.
Topics: Adolescent; Child; Child, Preschool; Cisplatin; Doxorubicin; Drug Therapy, Combination; Female; Foll | 2018 |
Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss.
Topics: Adolescent; Child; Child, Preschool; Cisplatin; Doxorubicin; Drug Therapy, Combination; Female; Foll | 2018 |
Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss.
Topics: Adolescent; Child; Child, Preschool; Cisplatin; Doxorubicin; Drug Therapy, Combination; Female; Foll | 2018 |
Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss.
Topics: Adolescent; Child; Child, Preschool; Cisplatin; Doxorubicin; Drug Therapy, Combination; Female; Foll | 2018 |
Effect of sodium thiosulfate on cisplatin removal after intra-arterial embolization with a lipiodol-platinum suspension for hepatocellular carcinoma.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Hepatocellular; Chelating Agents; Chemoem | 2010 |
18 other studies available for thiosulfates and Liver Neoplasms
| Article | Year |
|---|---|
The influence of sodium thiosulfate on experimental tumor induction.
Topics: Adenoma; Animals; Choline; Choline Deficiency; Humans; Liver; Liver Neoplasms; Neoplasms; Neoplasms, | 1948 |
Hepatoblastoma, cisplatin, and ototoxicity: good news on deaf ears.
Topics: Amifostine; Cisplatin; Clinical Trials as Topic; Hearing Loss; Hepatoblastoma; Humans; Infant; Inter | 2009 |
Sodium 2-propenyl thiosulfate derived from garlic induces phase II detoxification enzymes in rat hepatoma H4IIE cells.
Topics: Allyl Compounds; Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Cell Line, T | 2010 |
SYSTEMIC THIOSULFATE PROTECTION DURING FRACTIONATED REGIONAL NITROGEN MUSTARD THERAPY.
Topics: Biomedical Research; Carcinoma; Carcinoma, Squamous Cell; Dogs; Geriatrics; Infusions, Parenteral; I | 1964 |
Efficacy of "two-route chemotherapy" using intra-arterial cisplatin and iv sodium thiosulfate, its antidote, in rat bladder tumor.
Topics: Animals; Antidotes; Body Weight; Carcinoma, Hepatocellular; Carcinoma, Transitional Cell; Cisplatin; | 1983 |
[Two route infusion therapy of cisplatin using balloon catheter for primary liver cancer--with special reference to its provisional effects and side effects].
Topics: Aged; Catheterization; Cisplatin; Female; Follow-Up Studies; Humans; Infusions, Intra-Arterial; Infu | 1984 |
[Intra-arterial infusion through 2 routes in liver (primary and metastatic cancer].
Topics: Adult; Aged; Antidotes; Cisplatin; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasm | 1983 |
"Two route infusion chemotherapy" using cis-Diamminedichloroplatinum (II) and its antidote, sodium thiosulfate, for metastatic liver tumors in rats.
Topics: Animals; Cisplatin; Drug Therapy, Combination; Female; Femoral Vein; Hepatic Artery; Infusions, Intr | 1982 |
[Relieving effect of sodium thiosulfate on transarterial chemotherapeutic emesis].
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antioxidants; Carcinoma, Hepatocellular; Embo | 1997 |
Effects of diallyl disulfide and other donors of sulfane sulfur on the proliferation of human hepatoma cell line (HepG2).
Topics: Allyl Compounds; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Division; Cystamine; Disulfi | 2001 |
[Two routes chemotherapy by CDDP and STS against liver tumor].
Topics: Aged; Carcinoma, Hepatocellular; Catheterization; Cisplatin; Female; Hepatic Artery; Humans; Infusio | 1991 |
Inactivation of cis-diamminedichloroplatinum (II) in blood by sodium thiosulfate.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dogs; Humans; Liver Neoplasms; P | 1990 |
Increased therapeutic effect on metastatic liver tumors in rats of two-route chemotherapy using cis-diamminedichloroplatinum (II) and its antidote, sodium thiosulfate, with temporary clamping of the abdominal aorta.
Topics: Animals; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Aorta, Abdominal; Cisplatin; Con | 1990 |
[Two-route chemotherapy under AT-II induced hypertension using totally implanted injection port system in liver metastases derived from digestive cancers].
Topics: Adult; Aged; Aged, 80 and over; Angiotensin II; Blood Pressure; Cisplatin; Female; Gastrointestinal | 1989 |
[Clinical study of the effect of cisplatin therapy in unresectable hepatocellular carcinoma].
Topics: Aged; Carcinoma, Hepatocellular; Cisplatin; Drug Administration Schedule; Drug Therapy, Combination; | 1988 |
'Two-route chemotherapy' using intra-arterial cisplatin and intravenous sodium thiosulfate, its neutralizing agent, for hepatic malignancies.
Topics: Aged; Carcinoma, Hepatocellular; Cisplatin; Drug Therapy, Combination; Female; Humans; Infusions, In | 1988 |
[Two-route chemotherapy by CDDP and STS in liver metastasis of gastrointestinal adenocarcinoma].
Topics: Adenocarcinoma; Aged; Cisplatin; Drug Administration Schedule; Drug Therapy, Combination; Female; Ga | 1988 |
[Two-route chemotherapy using the anticancer drug cis-diamminedichloroplatinum(II) and its antidote, sodium thiosulfate].
Topics: Animals; Cisplatin; Drug Therapy, Combination; Injections; Liver Neoplasms; Lung Neoplasms; Rats; Th | 1987 |