Page last updated: 2024-10-20

thiosulfates and Leg Ulcer

thiosulfates has been researched along with Leg Ulcer in 14 studies

Thiosulfates: Inorganic salts of thiosulfuric acid possessing the general formula R2S2O3.
thiosulfate(2-) : A divalent inorganic anion obtained by removal of both protons from thiosulfuric acid.

Leg Ulcer: Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (VARICOSE ULCER), 5% to arterial disease, and the remaining 5% to other causes.

Research Excerpts

ExcerptRelevanceReference
"Knowledge of advancement in the treatment of calciphylaxis, which was previously a highly fatal disease, is important for physicians and other professionals from various medical fields."2.61Successful treatment of extensive uremic calciphylaxis with intravenous sodium thiosulfate and its potential in treating various diseases of pathologic calcification. ( Breznik, V; Burja, S; Ekart, R; Jovic, A; Miljkovic, J; Piko, N, 2019)
" Careful monitoring for adverse transient side effects is advised."2.50Successful treatment of calciphylaxis with intravenous sodium thiosulfate in a nonuremic patient: case report and review of therapy side effects. ( Fernandes, C; Hanna, D; Maynard, B, 2014)
"Sodium thiosulfate therapy has proven to be effective and tolerated."1.51Multifaceted approach to a rare clinical case of calciphylaxis in a renal transplant recipient. ( Bellasi, A; Feriozzi, S; Gomes, V; Massimetti, C; Modoni, A, 2019)
"Non-uremic calciphylaxis is a rare, life-threatening condition characterized clinically by cutaneous necrosis and histologically by calcium deposition in small vessel walls."1.51Non-uremic calciphylaxis in a patient with multiple rheumatologic diseases. ( Cotter, D; Hinds, B; Kusari, A; Paravar, T, 2019)
"Treatment with sodium thiosulfate was given for 8 patients, and was beneficial for all after a mean duration of 3."1.40[Incidence and characteristics of calciphylaxis in Martinique (2006-2012)]. ( Aoun, A; Banydeen, R; Baubion, E; Derancourt, C; Djiconkpode, I; Dueymes, JM; Ekindi, N; Quist, D; Riaux, A; Sadreux, T; Ureña-Torres, P, 2014)
" Although many recent case reports have shown exceptional results and healing with the use of sodium thiosulphate, we did not experience any change in the poor prognosis of our patients with the use of this drug, at a dosage of 5 g thrice weekly endovenously."1.39Calciphylaxis in dialysis patients, a severe disease poorly responding to therapies: report of 4 cases. ( Aldi, M; Cantelli, S; Gaddoni, G; Misciali, C; Odorici, G; Patrizi, A; Savoia, F; Tampieri, E; Tampieri, G, 2013)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (21.43)29.6817
2010's11 (78.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Massimetti, C1
Bellasi, A1
Modoni, A1
Gomes, V1
Feriozzi, S1
Isoherranen, K1
Bouchard, L1
Kluger, N1
Deverapalli, SC1
Jacob, J1
Santoro, F1
Devey, S1
Valois, A1
Cazajous, G1
Beaume, J1
Abed, S1
Okhremchuk, I1
Spadoni, S1
Boyé, T1
Morand, JJ1
Kusari, A1
Cotter, D1
Hinds, B1
Paravar, T1
Burja, S1
Jovic, A1
Ekart, R1
Piko, N1
Miljkovic, J1
Breznik, V1
Savoia, F1
Gaddoni, G1
Patrizi, A1
Misciali, C1
Odorici, G1
Tampieri, G1
Tampieri, E1
Cantelli, S1
Aldi, M1
Hawkes, JE1
Karavan, M1
Bowen, AR1
Summers, EM1
Fernandes, C1
Maynard, B1
Hanna, D1
Aoun, A1
Baubion, E1
Banydeen, R1
Djiconkpode, I1
Ekindi, N1
Ureña-Torres, P1
Riaux, A2
Sadreux, T1
Dueymes, JM1
Quist, D1
Derancourt, C2
Wolf, EK1
Smidt, AC1
Laumann, AE1
Ong, S1
Coulson, IH1
Baker, BL1
Fitzgibbons, CA1
Buescher, LS1
Ackermann, F1
Levy, A1
Daugas, E1
Schartz, N1
Urena, P1
Lebbé, C1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Pilot Study to Evaluate Topical Sodium Thiosulfate Therapy for Calcinosis Cutis (STS-CALC)[NCT01918904]Phase 20 participants (Actual)Interventional2013-09-30Withdrawn (stopped due to PI decided not to proceed with this project. No participants were enrolled.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for thiosulfates and Leg Ulcer

ArticleYear
Successful treatment of extensive uremic calciphylaxis with intravenous sodium thiosulfate and its potential in treating various diseases of pathologic calcification.
    Acta dermatovenerologica Alpina, Pannonica, et Adriatica, 2019, Volume: 28, Issue:1

    Topics: Aged; Calciphylaxis; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Kidney Failure, Chro

2019
Successful treatment of calciphylaxis with intravenous sodium thiosulfate in a nonuremic patient: case report and review of therapy side effects.
    Journal of cutaneous medicine and surgery, 2014, Volume: 18, Issue:5

    Topics: Administration, Intravenous; Calciphylaxis; Chelating Agents; Female; Humans; Leg Ulcer; Middle Aged

2014

Other Studies

12 other studies available for thiosulfates and Leg Ulcer

ArticleYear
Multifaceted approach to a rare clinical case of calciphylaxis in a renal transplant recipient.
    Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia, 2019, Sep-24, Volume: 36, Issue:5

    Topics: Aged; Anticoagulants; Bone Density Conservation Agents; Calciphylaxis; Chelating Agents; Combined Mo

2019
Benefits of intralesional injections of sodium thiosulfate in the treatment of calciphylaxis.
    International wound journal, 2017, Volume: 14, Issue:6

    Topics: Aged; Aged, 80 and over; Antidotes; Calciphylaxis; Female; Humans; Injections, Intralesional; Leg Ul

2017
Recalcitrant ulcer on the lower leg.
    Cutis, 2017, Volume: 100, Issue:3

    Topics: Administration, Intravenous; Aged, 80 and over; Antioxidants; Biopsy; Calciphylaxis; Diagnosis, Diff

2017
[Calciphylaxis in hemodialysis patients: 8 cases treated with sodium thiosulfate].
    Annales de dermatologie et de venereologie, 2018, Volume: 145, Issue:4

    Topics: Aged; Aged, 80 and over; Calciphylaxis; Combined Modality Therapy; Diabetes Mellitus, Type 2; Diabet

2018
Non-uremic calciphylaxis in a patient with multiple rheumatologic diseases.
    Dermatology online journal, 2019, Feb-15, Volume: 25, Issue:2

    Topics: Calciphylaxis; Chelating Agents; Female; Humans; Kidney; Leg Ulcer; Lupus Erythematosus, Systemic; M

2019
Calciphylaxis in dialysis patients, a severe disease poorly responding to therapies: report of 4 cases.
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 2013, Volume: 148, Issue:5

    Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Biopsy; Calciphylaxis; Cinacalcet; Combined Modality

2013
Nonuraemic calciphylaxis and pancreatic cancer: a previously unreported association.
    The British journal of dermatology, 2014, Volume: 171, Issue:5

    Topics: Adenocarcinoma; Administration, Oral; Aged; Calciphylaxis; Chelating Agents; Fatal Outcome; Humans;

2014
[Incidence and characteristics of calciphylaxis in Martinique (2006-2012)].
    Annales de dermatologie et de venereologie, 2014, Volume: 141, Issue:12

    Topics: Amputation, Surgical; Calciphylaxis; Female; Humans; Hyperparathyroidism, Secondary; Incidence; Kidn

2014
Topical sodium thiosulfate therapy for leg ulcers with dystrophic calcification.
    Archives of dermatology, 2008, Volume: 144, Issue:12

    Topics: Administration, Topical; Adult; Calcinosis; Female; Humans; Immunosuppressive Agents; Leg Ulcer; Lup

2008
Normo-renal calciphylaxis: response to sodium thiosulfate.
    Journal of the American Academy of Dermatology, 2011, Volume: 64, Issue:5

    Topics: Aged; Calciphylaxis; Chelating Agents; Disease Progression; Female; Humans; Kidney; Leg Ulcer; Thios

2011
Calciphylaxis responding to sodium thiosulfate therapy.
    Archives of dermatology, 2007, Volume: 143, Issue:2

    Topics: Aged; Calciphylaxis; Chelating Agents; Female; Humans; Leg Ulcer; Thiosulfates

2007
Sodium thiosulfate as first-line treatment for calciphylaxis.
    Archives of dermatology, 2007, Volume: 143, Issue:10

    Topics: Calciphylaxis; Diabetes Complications; Female; Humans; Kidney Diseases; Kidney Transplantation; Leg

2007