Page last updated: 2024-10-20

thiosulfates and Kidney Diseases

thiosulfates has been researched along with Kidney Diseases in 46 studies

Thiosulfates: Inorganic salts of thiosulfuric acid possessing the general formula R2S2O3.
thiosulfate(2-) : A divalent inorganic anion obtained by removal of both protons from thiosulfuric acid.

Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the effect of sodium thiosulfate (STS) on cisplatin clearance after transcatheter embolization (TAE) with a lipiodol-platinum suspension (LPS) in patients with hepatocellular carcinoma (HCC)."9.14Effect of sodium thiosulfate on cisplatin removal after intra-arterial embolization with a lipiodol-platinum suspension for hepatocellular carcinoma. ( Ikeda, O; Iryo, Y; Nakasone, Y; Tamura, Y; Yamashita, Y, 2010)
"Calciphylaxis is associated with medial arteriolar vascular calcification and results in ischemic subcutaneous necrosis with vulnerable skin ulcerations and high mortality."6.43Vascular ossification-calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis-calcific uremic arteriolopathy: the emerging role of sodium thiosulfate. ( Hayden, MR; Khanna, R; Kolb, L; Sowers, JR; Tyagi, SC, 2005)
"To evaluate the effect of sodium thiosulfate (STS) on cisplatin clearance after transcatheter embolization (TAE) with a lipiodol-platinum suspension (LPS) in patients with hepatocellular carcinoma (HCC)."5.14Effect of sodium thiosulfate on cisplatin removal after intra-arterial embolization with a lipiodol-platinum suspension for hepatocellular carcinoma. ( Ikeda, O; Iryo, Y; Nakasone, Y; Tamura, Y; Yamashita, Y, 2010)
" After oral application, only 4% of STS was recovered in urine of volunteers, reflecting a low bioavailability of 7."2.76Sodium thiosulfate pharmacokinetics in hemodialysis patients and healthy volunteers. ( Farese, S; Frey, BM; Frey, FJ; Hildebrandt, T; Kalicki, R; Pasch, A; Stauffer, E; Uehlinger, DE, 2011)
"Calciphylaxis is associated with medial arteriolar vascular calcification and results in ischemic subcutaneous necrosis with vulnerable skin ulcerations and high mortality."2.43Vascular ossification-calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis-calcific uremic arteriolopathy: the emerging role of sodium thiosulfate. ( Hayden, MR; Khanna, R; Kolb, L; Sowers, JR; Tyagi, SC, 2005)
"Nephrotoxicity is a relatively common and potentially serious adverse effect of treatment with certain cytotoxic drugs (especially ifosfamide)."2.39Strategies to prevent nephrotoxicity of anticancer drugs. ( Skinner, R, 1995)
"Cisplatin is a nephrotoxic drug; however, agents that may make cisplatin therapy more safe and rewarding will be available in the near future."2.38Newer insights into cisplatin nephrotoxicity. ( Anand, AJ; Bashey, B, 1993)
"Renal dysfunction and urinary disorders are the most troublesome adverse reaction to anticancer agents such as cisplatin (CDDP) and ifosfamide (IFM)."2.38[New treatments for urogenital toxicity of anti-neoplastic chemotherapy]. ( Hirosawa, A; Niitani, H; Shibuya, M, 1990)
" Therapeutic strategies aimed at reducing toxicity and allowing dose escalation of intravenous cisplatin, such as administration in hypertonic saline and pharmacokinetically based dosing schedules, have been partially successful in reducing nephrotoxicity and bone marrow suppression."2.38Cisplatin rescue therapy: experience with sodium thiosulfate, WR2721, and diethyldithiocarbamate. ( DeGregorio, MW; Gandara, DR; Makuch, RW; Perez, EA; Wiebe, VJ, 1990)
"ESRD was secondary to nephronophthisis (n = 1), membranoproliferative glomerulonephritis (n = 1), diabetic nephropathy (n = 1), and thrombotic microangiopathy (n = 1)."1.40Sodium thiosulphate treatment of uraemic tumoral calcinosis. ( Bardin, T; Cohen-Solal, M; Ea, HK; Lioté, F; Malbos, S; Trout, H; Urena-Torres, P, 2014)
"Sodium thiosulfate treatment transiently lowered plasma ionized calcium and induced metabolic acidosis."1.35Sodium thiosulfate prevents vascular calcifications in uremic rats. ( Farese, S; Frey, BM; Frey, FJ; Huynh-Do, U; Pasch, A; Schaffner, T, 2008)
"Sodium thiosulfate is a neutralizing agent for cisplatin that protects against renal damage."1.27High-dose cisplatin with sodium thiosulfate protection. ( Andrews, PA; Felthouse, RD; Howell, SB; Markman, M; Murphy, MP; Pfeifle, CE; Woliver, TB, 1985)
"Sodium thiosulfate was shown to protect renal function, as well as lessen hematologic complications of cisplatin therapy."1.27Experimental and clinical results with intraperitoneal cisplatin. ( Aartsen, E; Dubbelman, R; Franklin, H; McVie, JG; ten Bokkel Huinink, WW, 1985)

Research

Studies (46)

TimeframeStudies, this research(%)All Research%
pre-199019 (41.30)18.7374
1990's12 (26.09)18.2507
2000's10 (21.74)29.6817
2010's5 (10.87)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nigwekar, SU1
Thadhani, R1
Brandenburg, VM1
Malbos, S1
Urena-Torres, P1
Cohen-Solal, M1
Trout, H1
Lioté, F1
Bardin, T1
Ea, HK1
Pasch, A2
Schaffner, T1
Huynh-Do, U1
Frey, BM2
Frey, FJ2
Farese, S2
Rogers, NM1
Coates, PT1
O'Neill, WC2
Tamura, Y1
Ikeda, O1
Nakasone, Y1
Iryo, Y1
Yamashita, Y1
Lomashvili, KA1
Stauffer, E1
Kalicki, R1
Hildebrandt, T1
Uehlinger, DE1
Leitao, DJ1
Blakley, BW2
CASTEX, MR1
ESPOSITO, S1
BLAGMAN, GF1
ESTRIN, EI1
DVORKINA, EB1
MINTS, OI1
Hayden, MR2
Tyagi, SC1
Kolb, L1
Sowers, JR1
Khanna, R1
Viallet, NR1
Begleiter, A1
Leith, MK1
Meissner, M1
Kaufmann, R1
Gille, J1
Ackermann, F1
Levy, A1
Daugas, E1
Schartz, N1
Riaux, A1
Derancourt, C1
Urena, P1
Lebbé, C1
Skinner, R1
Nagai, N1
Hotta, K1
Yamamura, H1
Ogata, H1
Guastalla, JP1
Vermorken, JB1
Wils, JA1
George, M1
Scotto, V1
Nooij, M1
ten Bokkel Huinnink, WW1
Dalesio, O1
Renard, J1
Anand, AJ1
Bashey, B1
Kim, S1
Howell, SB3
McClay, E1
Kirmani, S1
Goel, R1
Plaxe, S1
Braly, P1
Bonetti, A1
Miki, Y1
Iwase, K1
Kamiike, W1
Taniguchi, E1
Sakaguchi, K1
Sumimura, J1
Matsuda, H1
Nagai, I1
Kazama, JJ1
Kutsuwada, K1
Ataka, K1
Maruyama, H1
Gejyo, F1
Bailey, K1
Chow, AY1
Downie, RH1
Pike, RK1
Reichman, B1
Markman, M3
Hakes, T1
Budnick, A1
Rubin, S1
Jones, W1
Almadrones, L1
Lewis, JL1
Hoskins, W1
Brillet, G1
Deray, G1
Bunker, D1
Ben Hmida, M1
Baumelou, A1
Jacobs, C1
Shibuya, M1
Hirosawa, A2
Niitani, H2
Tognella, S1
Gandara, DR1
Wiebe, VJ1
Perez, EA1
Makuch, RW1
DeGregorio, MW1
Saito, D1
Fujii, T1
Yoshida, S1
Ohkura, H1
Oguro, Y1
Nagase, S1
Narita, M1
Aamdal, S1
Fodstad, O1
Pihl, A1
Sakai, S1
Iizuka, K1
Hayashibara, K1
Tsuboi, E1
Cleary, S1
De Broe, ME1
Wedeen, RP1
Pfeifle, CE1
Felthouse, RD1
Woliver, TB1
Andrews, PA1
Murphy, MP1
ten Bokkel Huinink, WW1
Dubbelman, R1
Aartsen, E1
Franklin, H1
McVie, JG1
Ito, T1
Niwa, T1
Matsui, E1
Hosain, F2
Wagner, HN2
Vorburger, C1
Riedwyl, H1
Reubi, F2
Francois, B1
Pozet, N1
Rattanachane, B1
Traeger, J1
James, AE1
DeLand, FH1
Reba, RC1
Anghel, S1
Jahnecke, J1
Sökeland, J1
Schmidt, AW1
Krück, F1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Human Amniotic Mesenchymal Stem Cells (hAMSCs) on Wound Healing in Uremic Calciphylaxis Patients: an Open Label Single Arm Study[NCT04592640]7 participants (Anticipated)Interventional2018-09-17Active, not recruiting
The Pharmacologic Profile of Sodium Thiosulfate in Renal Failure and Healthy[NCT01008631]19 participants (Actual)Interventional2009-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

13 reviews available for thiosulfates and Kidney Diseases

ArticleYear
Calciphylaxis.
    The New England journal of medicine, 2018, May-03, Volume: 378, Issue:18

    Topics: Age of Onset; Calciphylaxis; Debridement; Diagnosis, Differential; Humans; Kidney Diseases; Microves

2018
Calcific uraemic arteriolopathy: an update.
    Current opinion in nephrology and hypertension, 2008, Volume: 17, Issue:6

    Topics: Calciphylaxis; Calcium; Chelating Agents; Chronic Disease; Humans; Hyperbaric Oxygenation; Kidney Di

2008
Treatment of vascular calcification.
    Kidney international, 2008, Volume: 74, Issue:11

    Topics: Animals; Calcinosis; Humans; Kidney Diseases; Renal Circulation; Thiosulfates; Vascular Diseases

2008
Recent progress in the treatment of vascular calcification.
    Kidney international, 2010, Volume: 78, Issue:12

    Topics: Animals; Calcinosis; Diphosphonates; Disease Models, Animal; Humans; Kidney Diseases; Thiosulfates;

2010
Vascular ossification-calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis-calcific uremic arteriolopathy: the emerging role of sodium thiosulfate.
    Cardiovascular diabetology, 2005, Mar-18, Volume: 4

    Topics: Animals; Antioxidants; Arteries; Atherosclerosis; Calcinosis; Calciphylaxis; Chelating Agents; Chron

2005
Strategies to prevent nephrotoxicity of anticancer drugs.
    Current opinion in oncology, 1995, Volume: 7, Issue:4

    Topics: Adult; Antineoplastic Agents; Cell Line; Chelating Agents; Child; Child, Preschool; Cisplatin; Human

1995
Newer insights into cisplatin nephrotoxicity.
    The Annals of pharmacotherapy, 1993, Volume: 27, Issue:12

    Topics: Amifostine; Animals; Cisplatin; Furosemide; Glutathione; Humans; Kidney Diseases; Male; Mannitol; So

1993
[Can cisplatin renal toxicity be prevented?].
    Nephrologie, 1991, Volume: 12, Issue:3

    Topics: Calcium Channel Blockers; Cisplatin; Diuretics; Humans; Kidney Diseases; Neoplasms; Thiosulfates

1991
[New treatments for urogenital toxicity of anti-neoplastic chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:4 Pt 2

    Topics: Antidotes; Antineoplastic Agents; Cisplatin; Humans; Ifosfamide; Kidney Diseases; Mesna; Thiosulfate

1990
Pharmacological interventions to reduce platinum-induced toxicity.
    Cancer treatment reviews, 1990, Volume: 17, Issue:2-3

    Topics: Adrenocorticotropic Hormone; Amifostine; Cisplatin; Ditiocarb; Fluid Therapy; Glutathione; Hematolog

1990
Cisplatin rescue therapy: experience with sodium thiosulfate, WR2721, and diethyldithiocarbamate.
    Critical reviews in oncology/hematology, 1990, Volume: 10, Issue:4

    Topics: Amifostine; Antidotes; Cisplatin; Ditiocarb; Drug Therapy, Combination; Humans; Kidney Diseases; Thi

1990
[Effect of sodium thiosulfate on the anti-tumor effect and nephrotoxicity of CDDP in human gastric cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:4 Pt 2

    Topics: Antidotes; Cisplatin; Humans; Kidney Diseases; Stomach Neoplasms; Thiosulfates

1990
Some procedures to reduce cis-platinum toxicity reduce antitumour activity.
    Cancer treatment reviews, 1987, Volume: 14, Issue:3-4

    Topics: Animals; Cisplatin; Kidney Diseases; Mice; Neoplasms, Experimental; Saline Solution, Hypertonic; Sod

1987

Trials

7 trials available for thiosulfates and Kidney Diseases

ArticleYear
Effect of sodium thiosulfate on cisplatin removal after intra-arterial embolization with a lipiodol-platinum suspension for hepatocellular carcinoma.
    Acta radiologica (Stockholm, Sweden : 1987), 2010, Volume: 51, Issue:4

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Hepatocellular; Chelating Agents; Chemoem

2010
Sodium thiosulfate pharmacokinetics in hemodialysis patients and healthy volunteers.
    Clinical journal of the American Society of Nephrology : CJASN, 2011, Volume: 6, Issue:6

    Topics: Administration, Oral; Adult; Aged; Biological Availability; Biotransformation; Cardiovascular Agents

2011
Phase II trial for intraperitoneal cisplatin plus intravenous sodium thiosulphate in advanced ovarian carcinoma patients with minimal residual disease after cisplatin-based chemotherapy--a phase II study of the EORTC Gynaecological Cancer Cooperative Grou
    European journal of cancer (Oxford, England : 1990), 1994, Volume: 30A, Issue:1

    Topics: Aged; Catheterization, Peripheral; Cisplatin; Female; Humans; Infusions, Parenteral; Kidney Diseases

1994
Dose intensification of cisplatin chemotherapy through biweekly administration.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1993, Volume: 4, Issue:3

    Topics: Adult; Aged; Bone Marrow Diseases; Cisplatin; Drug Administration Schedule; Female; Hearing Disorder

1993
Serum cystatin C reliably detects renal dysfunction in patients with various renal diseases.
    Nephron, 2002, Volume: 91, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Creatine; Cystatin C; Cystatins; Female; Glo

2002
Phase II trial of high-dose cisplatin with sodium thiosulfate nephroprotection in patients with advanced carcinoma of the uterine cervix previously untreated with chemotherapy.
    Gynecologic oncology, 1991, Volume: 43, Issue:2

    Topics: Adult; Carcinoma; Cisplatin; Dose-Response Relationship, Drug; Drug Evaluation; Female; Hearing Diso

1991
[Combination effects of cis-dichlorodiammineplatinum (II) and sodium thiosulfate on renal dysfunction].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:10

    Topics: Blood Urea Nitrogen; Cisplatin; Creatinine; Drug Therapy, Combination; Female; Glomerular Filtration

1987

Other Studies

26 other studies available for thiosulfates and Kidney Diseases

ArticleYear
Sodium thiosulphate treatment of uraemic tumoral calcinosis.
    Rheumatology (Oxford, England), 2014, Volume: 53, Issue:3

    Topics: Aged; Calcinosis; Comorbidity; Female; Humans; Hypertension; Incidence; Kidney Diseases; Kidney Fail

2014
Sodium thiosulfate prevents vascular calcifications in uremic rats.
    Kidney international, 2008, Volume: 74, Issue:11

    Topics: Animals; Aortic Diseases; Bone and Bones; Calcinosis; Calcium; Kidney Diseases; Rats; Renal Circulat

2008
Quantification of sodium thiosulphate protection on cisplatin-induced toxicities.
    The Journal of otolaryngology, 2003, Volume: 32, Issue:3

    Topics: Animals; Antidotes; Antineoplastic Agents; Cisplatin; Disease Models, Animal; Dose-Response Relation

2003
[Sodium thiosulfate & sodium hyposulfite in liver & kidney diseases].
    Prensa medica argentina, 1958, Mar-07, Volume: 45, Issue:10

    Topics: Dithionite; Humans; Kidney; Kidney Diseases; Liver Diseases; Sodium; Sulfites; Thiosulfates

1958
[The urinary elimination of the dextran molecule as index of glomerular permeability. Relation between the clearance of dextran and the clearance of sodium hyposulfite].
    Archivio per le scienze mediche, 1959, Volume: 108

    Topics: Dextrans; Dithionite; Humans; Kidney Diseases; Kidney Function Tests; Kidney Glomerulus; Permeabilit

1959
[Determination of renal filtration with the aid of thiosulfate and the maximum glomerular reabsorption of glucose].
    Klinicheskaia meditsina, 1951, Volume: 29, Issue:5

    Topics: Glucose; Humans; Kidney; Kidney Diseases; Thiosulfates

1951
Effect of sodium thiosulphate and cis-diamminedichloroplatinum on FADU tumour cells in nude mice.
    The Journal of otolaryngology, 2005, Volume: 34, Issue:6

    Topics: Animals; Antineoplastic Agents; Antioxidants; Carcinoma, Squamous Cell; Cisplatin; Disease Models, A

2005
Sodium thiosulphate: a new way of treatment for calciphylaxis?
    Dermatology (Basel, Switzerland), 2007, Volume: 214, Issue:4

    Topics: Antioxidants; Calciphylaxis; Chelating Agents; Humans; Kidney Diseases; Thiosulfates

2007
Sodium thiosulfate as first-line treatment for calciphylaxis.
    Archives of dermatology, 2007, Volume: 143, Issue:10

    Topics: Calciphylaxis; Diabetes Complications; Female; Humans; Kidney Diseases; Kidney Transplantation; Leg

2007
Calciphylaxis and the cardiometabolic syndrome: the emerging role of sodium thiosulfate as a novel treatment option.
    Journal of the cardiometabolic syndrome, 2008,Winter, Volume: 3, Issue:1

    Topics: Antioxidants; Arteries; Calciphylaxis; Humans; Kidney Diseases; Metabolic Syndrome; Renal Dialysis;

2008
Effects of sodium thiosulfate on the pharmacokinetics of unchanged cisplatin and on the distribution of platinum species in rat kidney: protective mechanism against cisplatin nephrotoxicity.
    Cancer chemotherapy and pharmacology, 1995, Volume: 36, Issue:5

    Topics: Analysis of Variance; Animals; Cisplatin; Glomerular Filtration Rate; Kidney; Kidney Diseases; Male;

1995
Laparoscopic cholecystectomy and time-course changes in renal function. The effect of the retraction method on renal function.
    Surgical endoscopy, 1997, Volume: 11, Issue:8

    Topics: Adult; Cholecystectomy, Laparoscopic; Female; Glomerular Filtration Rate; Hemodynamics; Humans; Kidn

1997
1-Piperidinocyclohexanecarbonitrile, a toxic precursor of phencyclidine.
    The Journal of pharmacy and pharmacology, 1976, Volume: 28, Issue:9

    Topics: Animals; Chemical and Drug Induced Liver Injury; Kidney Diseases; Lethal Dose 50; Male; Mice; Nitril

1976
[Clinical significance of the sodium thiosulfate clearance test].
    Nihon rinsho. Japanese journal of clinical medicine, 1989, Volume: 48 Suppl

    Topics: Female; Glomerular Filtration Rate; Humans; Kidney Diseases; Male; Pregnancy; Reference Values; Thio

1989
Hypomagnesemia following high-dose intracavitary cisplatin with systemically administered sodium thiosulfate.
    American journal of clinical oncology, 1986, Volume: 9, Issue:5

    Topics: Adult; Aged; Carcinoma; Cisplatin; Dose-Response Relationship, Drug; Female; Humans; Kidney Diseases

1986
Prevention of cisplatin nephrotoxicity.
    European journal of cancer & clinical oncology, 1986, Volume: 22, Issue:9

    Topics: Cisplatin; Humans; Kidney Diseases; Thiosulfates

1986
High-dose cisplatin with sodium thiosulfate protection.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1985, Volume: 3, Issue:2

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Interaction

1985
Experimental and clinical results with intraperitoneal cisplatin.
    Seminars in oncology, 1985, Volume: 12, Issue:3 Suppl 4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Catheterization; Catheters, Indwelling; Cisplatin; F

1985
Fibrinolytic activity in renal disease.
    Clinica chimica acta; international journal of clinical chemistry, 1972, Volume: 36, Issue:1

    Topics: Cholesterol; Chronic Disease; Creatinine; Female; Fibrinogen; Fibrinolysin; Fibrinolysis; Glomerulon

1972
Measurement of extracellular fluid volume with 169Yb-diethylenetriaminepentaacetate.
    The Journal of laboratory and clinical medicine, 1971, Volume: 77, Issue:4

    Topics: Animals; Carbon Isotopes; Dogs; Extracellular Space; Half-Life; Humans; Inulin; Kidney Diseases; Met

1971
[Comparative studies on the renal clearance of Na-Cr2Cr51 ethylenediaminetetraacetate, inulin and sodium thiosulfate in humans].
    Klinische Wochenschrift, 1969, Apr-15, Volume: 47, Issue:8

    Topics: Chromium Isotopes; Edetic Acid; Glomerular Filtration Rate; Humans; Inulin; Kidney; Kidney Diseases;

1969
[Estimation of glomerular filtration using 51 Cr E.D.T.A].
    Nephron, 1971, Volume: 8, Issue:2

    Topics: Adolescent; Adult; Chromium Isotopes; Edetic Acid; Female; Glomerular Filtration Rate; Humans; Kidne

1971
169 Ytterbium diethylenetriaminepentaacetic acid ( 169 YB DTPA)--a versatile radiopharmaceutical.
    Journal of the Canadian Association of Radiologists, 1971, Volume: 22, Issue:2

    Topics: Body Weight; Brain Diseases; Extracellular Space; Glomerular Filtration Rate; Humans; Injections, In

1971
[Current methods of study in determination of renal clearances with saluresis and waterdiuresis].
    Medicina interna, 1970, Volume: 22, Issue:8

    Topics: Aminohippuric Acids; Blood Flow Velocity; Diuresis; Glomerular Filtration Rate; Humans; Hypertension

1970
[Blood levels, excretion and dosage of N-pyrrolidino-methyl-tetracycline (PMT, Reverin) in kidney patients].
    Klinische Wochenschrift, 1967, Feb-01, Volume: 45, Issue:3

    Topics: Creatine; Creatinine; Glomerular Filtration Rate; Humans; Injections, Intravenous; Inulin; Kidney; K

1967
Stop-flow analysis in man.
    Metabolism: clinical and experimental, 1966, Volume: 15, Issue:12

    Topics: Aminohippuric Acids; Chlorides; Female; Furosemide; Humans; Inulin; Kidney Diseases; Kidney Function

1966