thiosulfates has been researched along with Head and Neck Neoplasms in 22 studies
Thiosulfates: Inorganic salts of thiosulfuric acid possessing the general formula R2S2O3.
thiosulfate(2-) : A divalent inorganic anion obtained by removal of both protons from thiosulfuric acid.
Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We aimed to compare the incidence of hearing loss between patients treated with intra-arterial high-dose cisplatin chemoradiation with sodium thiosulfate (CRT-IA) and intravenous high-dose cisplatin chemoradiation without sodium thiosulfate (CRT-IV)." | 5.12 | Ototoxicity in a randomized phase III trial of intra-arterial compared with intravenous cisplatin chemoradiation in patients with locally advanced head and neck cancer. ( Balm, AJ; Dreschler, WA; Hart, AA; Lansdaal, PE; Rasch, CR; Schornagel, JH; Simis, YJ; Zuur, CL, 2007) |
| "Our trial suggests that STS deposited on the round window was safe for the middle and inner ears." | 2.90 | A randomized controlled trial to test the efficacy of trans-tympanic injections of a sodium thiosulfate gel to prevent cisplatin-induced ototoxicity in patients with head and neck cancer. ( Bairati, I; Bussières, R; Côté, M; Guitton, MJ; Leclerc, M; Meyer, F; Philippon, D; Rolland, V, 2019) |
| "Ninety-seven patients with advanced head and neck cancers were treated by superselective intra-arterial chemotherapy using CDDP and sodium thiosulfate (STS) from 1995 to 2000." | 2.41 | [Present role and future prospect of superselective intra-arterial infusion chemotherapy for head and neck cancer]. ( Yokoyama, J, 2002) |
| "Fifty-one patients with advanced squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx were included in this prospective study." | 1.34 | Intra-arterial chemotherapy less intensive than RADPLAT with concurrent radiotherapy for resectable advanced head and neck squamous cell carcinoma: a prospective study. ( Furukawa, M; Kondo, S; Matsui, O; Murono, S; Sanada, J; Shimizu, Y; Takanaka, T; Terayama, N; Wakisaka, N; Yoshizaki, T, 2007) |
| "Organ-preservation programs in head and neck cancer result in improved QOL and swallowing 6 months after treatment." | 1.30 | Acute and chronic changes in swallowing and quality of life following intraarterial chemoradiation for organ preservation in patients with advanced head and neck cancer. ( Madasu, R; Martin, A; Murry, T; Robbins, KT, 1998) |
| " Plasma total CDDP level declined with two peaks, the half-life of the alpha phase being 3." | 1.27 | [Pharmacokinetics of cisplatin and the effect of sodium thiosulfate]. ( Esaki, S; Hayata, S; Hirano, M; Hitoshi, T; Kiyokawa, K; Mihashi, S, 1984) |
| "45 micrograms/ml and the half-life was 53 minutes." | 1.27 | [Pharmacokinetic study of cisplatin and sodium thiosulfate in two-route-infusion chemotherapy]. ( Ikeda, K, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (9.09) | 18.7374 |
| 1990's | 6 (27.27) | 18.2507 |
| 2000's | 11 (50.00) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rolland, V | 1 |
| Meyer, F | 1 |
| Guitton, MJ | 1 |
| Bussières, R | 1 |
| Philippon, D | 1 |
| Bairati, I | 1 |
| Leclerc, M | 1 |
| Côté, M | 1 |
| Ishikawa, E | 1 |
| Sugimoto, H | 1 |
| Hatano, M | 1 |
| Nakanishi, Y | 1 |
| Tsuji, A | 1 |
| Endo, K | 1 |
| Kondo, S | 2 |
| Wakisaka, N | 2 |
| Murono, S | 2 |
| Ito, M | 1 |
| Yoshizaki, T | 2 |
| Homma, A | 1 |
| Onimaru, R | 1 |
| Matsuura, K | 1 |
| Robbins, KT | 9 |
| Fujii, M | 1 |
| Blakley, BW | 1 |
| Cohen, JI | 1 |
| Doolittle, ND | 1 |
| Muldoon, LL | 1 |
| Campbell, KC | 1 |
| Dickey, DT | 1 |
| Neuwelt, EA | 1 |
| Yokoyama, J | 2 |
| Doweck, I | 1 |
| Samant, S | 1 |
| Vieira, F | 2 |
| Kumar, P | 3 |
| Kovács, AF | 1 |
| Mose, S | 1 |
| Böttcher, HD | 1 |
| Bitter, K | 1 |
| Spring, PM | 1 |
| Valentino, J | 1 |
| Arnold, SM | 1 |
| Sloan, D | 1 |
| Kenady, D | 1 |
| Kudrimoti, M | 1 |
| Haydon, RC | 1 |
| Lee, C | 1 |
| Given, C | 1 |
| Mohiuddin, M | 1 |
| Regine, WF | 1 |
| Viallet, NR | 1 |
| Blakley, BB | 1 |
| Begleiter, A | 1 |
| Leith, MK | 1 |
| Zuur, CL | 2 |
| Simis, YJ | 2 |
| Lansdaal, PE | 2 |
| Hart, AA | 2 |
| Rasch, CR | 2 |
| Schornagel, JH | 2 |
| Dreschler, WA | 2 |
| Balm, AJ | 2 |
| Shimizu, Y | 1 |
| Takanaka, T | 1 |
| Sanada, J | 1 |
| Terayama, N | 1 |
| Matsui, O | 1 |
| Furukawa, M | 1 |
| Hayata, S | 1 |
| Hitoshi, T | 1 |
| Kiyokawa, K | 1 |
| Esaki, S | 1 |
| Mihashi, S | 1 |
| Hirano, M | 1 |
| Storniolo, AM | 1 |
| Kerber, C | 2 |
| Vicario, D | 2 |
| Seagren, S | 2 |
| Shea, M | 1 |
| Hanchett, C | 2 |
| Los, G | 2 |
| Howell, SB | 4 |
| Weisman, R | 1 |
| Pellitteri, P | 1 |
| Orloff, L | 1 |
| Madasu, R | 2 |
| Ruckenstein, MJ | 1 |
| Leake, F | 1 |
| Steere, E | 1 |
| Denys, D | 1 |
| Wong, FS | 2 |
| Newman, LA | 1 |
| Murry, T | 2 |
| Martin, A | 1 |
| Kerber, CW | 1 |
| Wong, WH | 1 |
| Hanchett, K | 1 |
| Hartsell, WF | 1 |
| Flick, P | 1 |
| Palmer, R | 1 |
| Weir, AB | 1 |
| Neill, HB | 1 |
| Ferguson, R | 1 |
| Bush, A | 1 |
| Ikeda, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Prophylactic Swallowing Exercises on Head and Neck Cancer Patients[NCT01349309] | 26 participants (Actual) | Interventional | 2007-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for thiosulfates and Head and Neck Neoplasms
| Article | Year |
|---|---|
Intra-arterial chemoradiotherapy for head and neck cancer.
Topics: Chemoradiotherapy; Cisplatin; Clinical Trials as Topic; Head and Neck Neoplasms; Humans; Infusions, | 2016 |
[Present role and future prospect of superselective intra-arterial infusion chemotherapy for head and neck cancer].
Topics: Adult; Aged; Antidotes; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carci | 2002 |
7 trials available for thiosulfates and Head and Neck Neoplasms
| Article | Year |
|---|---|
A randomized controlled trial to test the efficacy of trans-tympanic injections of a sodium thiosulfate gel to prevent cisplatin-induced ototoxicity in patients with head and neck cancer.
Topics: Aged; Antineoplastic Agents; Antioxidants; Carcinoma, Squamous Cell; Cisplatin; Female; Head and Nec | 2019 |
Multimodality treatment including postoperative radiation and concurrent chemotherapy with weekly docetaxel is feasible and effective in patients with oral and oropharyngeal cancer.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Carcinoma, Squamous Cell; Cis | 2005 |
Ototoxicity in a randomized phase III trial of intra-arterial compared with intravenous cisplatin chemoradiation in patients with locally advanced head and neck cancer.
Topics: Antineoplastic Agents; Auditory Threshold; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Th | 2007 |
Phase I study of highly selective supradose cisplatin infusions for advanced head and neck cancer.
Topics: Adult; Aged; Analysis of Variance; Anemia; Cisplatin; Drug Administration Schedule; Female; Follow-U | 1994 |
A targeted supradose cisplatin chemoradiation protocol for advanced head and neck cancer.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Chelating Agents; Cisplatin; Combined Moda | 1994 |
An organ-preserving selective arterial chemotherapy strategy for head and neck cancer.
Topics: Antineoplastic Agents; Cerebral Angiography; Cisplatin; Cohort Studies; Combined Modality Therapy; D | 1998 |
Targeted chemoradiation for advanced head and neck cancer: analysis of 213 patients.
Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; | 2000 |
13 other studies available for thiosulfates and Head and Neck Neoplasms
| Article | Year |
|---|---|
Protective effects of sodium thiosulfate for cisplatin-mediated ototoxicity in patients with head and neck cancer.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Squamous Cell; Chelating Agents; Chemorad | 2015 |
Strategies for prevention of toxicity caused by platinum-based chemotherapy: review and summary of the annual meeting of the Blood-Brain Barrier Disruption Program, Gleneden Beach, Oregon, March 10, 2001.
Topics: Animals; Antineoplastic Agents; Antioxidants; Blood-Brain Barrier; Carboplatin; Cisplatin; Head and | 2002 |
[Usefulness of CT-angiography for superselective intra-arterial chemotherapy for advanced head and neck cancers].
Topics: Adult; Aged; Aged, 80 and over; Angiography; Antineoplastic Combined Chemotherapy Protocols; Cisplat | 2002 |
Factors predictive of local disease control after intra-arterial concomitant chemoradiation (RADPLAT).
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous | 2004 |
Long-term results of hyperfractionated radiation and high-dose intraarterial cisplatin for unresectable oropharyngeal carcinoma.
Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; | 2005 |
Sodium thiosulphate impairs the cytotoxic effects of cisplatin on FADU cells in culture.
Topics: Antineoplastic Agents; Antioxidants; Carcinoma, Squamous Cell; Cell Line, Tumor; Cisplatin; Dose-Res | 2006 |
Risk factors of ototoxicity after cisplatin-based chemo-irradiation in patients with locally advanced head-and-neck cancer: a multivariate analysis.
Topics: Age Factors; Antidotes; Antineoplastic Agents; Carcinoma, Squamous Cell; Cisplatin; Combined Modalit | 2007 |
Intra-arterial chemotherapy less intensive than RADPLAT with concurrent radiotherapy for resectable advanced head and neck squamous cell carcinoma: a prospective study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Carcinoma, Squamous Cell; Cisplatin; D | 2007 |
[Pharmacokinetics of cisplatin and the effect of sodium thiosulfate].
Topics: Cisplatin; Drug Administration Schedule; Head and Neck Neoplasms; Humans; Infusions, Parenteral; Kin | 1984 |
Ototoxic effects of supradose cisplatin with sodium thiosulfate neutralization in patients with head and neck cancer.
Topics: Adult; Antidotes; Antineoplastic Agents; Audiometry, Pure-Tone; Auditory Threshold; Carcinoma, Squam | 1997 |
The predictive value of tumor regression rates during chemoradiation therapy in patients with advanced head and neck squamous cell carcinoma.
Topics: Antidotes; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Dose Fractionation, Radia | 1997 |
Acute and chronic changes in swallowing and quality of life following intraarterial chemoradiation for organ preservation in patients with advanced head and neck cancer.
Topics: Acute Disease; Antidotes; Antineoplastic Agents; Chronic Disease; Cisplatin; Combined Modality Thera | 1998 |
[Pharmacokinetic study of cisplatin and sodium thiosulfate in two-route-infusion chemotherapy].
Topics: Cisplatin; Head and Neck Neoplasms; Humans; Infusions, Intra-Arterial; Infusions, Parenteral; Kineti | 1986 |