thiosulfates and Calciphylaxes studies

Thiosulfates: Inorganic salts of thiosulfuric acid possessing the general formula R2S2O3.
thiosulfate(2-) : A divalent inorganic anion obtained by removal of both protons from thiosulfuric acid.

Research Excerpts

Excerpt	Relevance	Reference
"Calciphylaxis is associated with medial arteriolar vascular calcification and results in ischemic subcutaneous necrosis with vulnerable skin ulcerations and high mortality."	6.43	Vascular ossification-calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis-calcific uremic arteriolopathy: the emerging role of sodium thiosulfate. ( Hayden, MR; Khanna, R; Kolb, L; Sowers, JR; Tyagi, SC, 2005)
"Calciphylaxis is a potencially disorder in patients with hyperphosphatemic familial tumoral calcinosis (HFTC)."	5.72	Therapeutic success of sodium thiosulfate in treating cutaneous calciphylaxis in a patient with hyperphosphataemic familial tumoral calcinosis. ( Gómez, C; Morales, P; Requena, S; Santos-Juanes, J, 2022)
" Sodium thiosulfate (STS) can be used in hemodialysis patients but therapy is often limited by the development of high anion gap metabolic acidosis."	3.96	Sodium-Thiosulfate Induced Life-Threatening Metabolic Acidosis Limiting Treatment of Calciphylaxis. ( George, T; Sohal, R, 2020)
" The skin ulcers drastically improved within 6 months after the initiation of hemodialysis, aggressive wound care, the control of a mineral and bone disorder, and the administration of sodium thiosulfate and hyperbaric oxygen therapy."	3.83	The Successful Treatment of Calciphylaxis with Sodium Thiosulfate and Hyperbaric Oxygen in a Non-dialyzed Patient with Chronic Kidney Disease. ( Aihara, S; Arase, H; Higashi, H; Kitazono, T; Nakano, T; Taniguchi, M; Tsuchimoto, A; Tsuruya, K; Uchida, Y; Yamada, S, 2016)
"We describe the case of a 42-year-old woman who developed encapsulating peritoneal sclerosis (EPS) after 7 years on peritoneal dialysis, with clinical relief by enterolysis associated to treatment with tamoxifen, corticosteroids and parenteral nutrition in haemodialysis."	3.80	Discovering implicit associations in a case of encapsulating peritoneal sclerosis complicated by severe mineral imbalance. ( Neves, P; Pinho, A; Pinto, I; Sampaio, S, 2014)
" We report a case of calciphylaxis in a patient with normal renal function and hypoparathyroidism, who responded to treatment with sodium thiosulfate."	3.75	Calciphylaxis in a patient with normal renal function: response to treatment with sodium thiosulfate. ( Hackett, BC; McAleer, MA; O'Donnell, BF; Powell, FC; Sheehan, G, 2009)
"Sodium thiosulfate was used to treat penile calciphylaxis in 23."	3.01	Risk factors, treatment modalities, and clinical outcomes of penile calciphylaxis: systematic review. ( Susantitaphong, P; Takkavatakarn, K; Wipattanakitcharoen, A, 2023)
"Calciphylaxis is a rare and devastating condition with important systemic ramifications."	2.82	Calciphylaxis: Treatment and outlook-CME part II. ( Chand, S; Kroshinsky, D; Micheletti, R; Ortega-Loayza, AG; Pasieka, HB; Rick, J; Rrapi, R; Shinohara, MM; Strowd, L, 2022)
"A 51-year-old man with ESRD on peritoneal dialysis presented with a right calf biopsy-proven calciphylaxis lesion measuring 3."	2.61	Successful Treatment of Single Infected Calciphylaxis Lesion With Intralesional Injection of Sodium Thiosulfate at High Concentration. ( Al-Talib, K; Zuhaili, B, 2019)
"Calciphylaxis is a rare disorder of poor prognosis that can lead to intense, painful lesions involving the skin and subcutaneous tissue."	2.61	Calciphylaxis: Approach to Diagnosis and Management. ( Noureddine, L; Seethapathy, H, 2019)
"Calciphylaxis is an uncommon life-threatening systemic disease, mostly occurring in patients with chronic kidney disease and other risk factors."	2.61	Successful treatment of extensive uremic calciphylaxis with intravenous sodium thiosulfate and its potential in treating various diseases of pathologic calcification. ( Breznik, V; Burja, S; Ekart, R; Jovic, A; Miljkovic, J; Piko, N, 2019)
"Calciphylaxis is a cutaneous ischemic infarct caused by total occlusion of blood vessels initiated by vascular calcification."	2.61	Calciphylaxis: Diagnosis, Pathogenesis, and Treatment. ( Chang, JJ, 2019)
"The diagnosis and treatment of calciphylaxis presents significant challenges."	2.61	Revisiting therapeutic options for calciphylaxis. ( Nigwekar, SU; Seethapathy, H, 2019)
"Calciphylaxis is a severe complication of advanced chronic kidney disease (CKD)."	2.58	Systematic review of sodium thiosulfate in treating calciphylaxis in chronic kidney disease patients. ( Hong, D; Jun, M; Li, G; Peng, T; Wang, L; Wang, Y; Zhuo, L, 2018)
"Calciphylaxis is defined as calcification of the media of small- and medium-sized blood vessels in the dermis and subcutaneous tissue."	2.52	Calcinosis Cutis and Calciphylaxis. ( Jiménez-Gallo, D; Linares-Barrios, M; Ossorio-García, L, 2015)
"Calciphylaxis is a rare but devastating condition that has continued to challenge the medical community since its early descriptions in the scientific literature many decades ago."	2.52	Calciphylaxis: risk factors, diagnosis, and treatment. ( Goverman, J; Jackson, VA; Kamdar, MM; Kroshinsky, D; Malhotra, R; Nazarian, RM; Nigwekar, SU; Steele, DJ; Thadhani, RI, 2015)
"Cases of nonuremic calciphylaxis have also been reported, but data on this rare condition are mainly empirical."	2.50	Successful treatment of calciphylaxis with intravenous sodium thiosulfate in a nonuremic patient: case report and review of therapy side effects. ( Fernandes, C; Hanna, D; Maynard, B, 2014)
"Calciphylaxis is a relatively rare disease, observed mainly in patients on dialysis, associated with high mortality rates, and characterized by painful skin ulceration."	2.49	Calciphylaxis: diagnosis and clinical features. ( Hayashi, M, 2013)
"Calciphylaxis is a rare disease primarily affecting patients dependent on dialysis."	2.47	[Sodium thiosulfate--new hope for the treatment of calciphylaxis]. ( Heiro, M; Hohenthal, U; Koivuviita, N; Mäkelä, L; Manner, I; Metsärinne, K; Tertti, R, 2011)
"Cutaneous calciphylaxis is a potentially fatal condition characterized by calcium deposition in dermal arterioles and the subsequent development of livedo reticularis, plaques, and extremely painful ulcers."	2.47	Treatment of cutaneous calciphylaxis with sodium thiosulfate: two case reports and a review of the literature. ( Amerio, P; Auriemma, M; Bonomini, M; Caponio, C; Carbone, A; Cupaiolo, A; De Simone, C; Di Liberato, L; Tulli, A, 2011)
"Calciphylaxis is associated with medial arteriolar vascular calcification and results in ischemic subcutaneous necrosis with vulnerable skin ulcerations and high mortality."	2.43	Vascular ossification-calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis-calcific uremic arteriolopathy: the emerging role of sodium thiosulfate. ( Hayden, MR; Khanna, R; Kolb, L; Sowers, JR; Tyagi, SC, 2005)
"Calciphylaxis is a very uncommon and severe disease which mainly appears in patients with chronic renal insufficiency."	2.43	Calciphylaxis: no therapeutic concepts for a poorly understood syndrome? ( Gille, J; Kaufmann, R; Meissner, M, 2006)
"Calciphylaxis is a rare disease characterized by calcification of the middle layer of small arteries and arterioles, causing secondary cuta-neous ischemia."	1.91	Intralesional Sodium Thiosulfate as Adjuvant Therapy in Severe Calciphylaxis. ( Ana, T; Anamá, DP; Carolina, V; Denys, P; Guido, MC; Luis, M; María, D; Paula, E, 2023)
"Our experience suggests that the treatment of calciphylaxis requires timely and multi-angle intervention."	1.72	Success of small-dose fractionated sodium thiosulfate in the treatment of calciphylaxis in a peritoneal dialysis patient. ( Lu, Y; Shen, L; Xu, D; Zhou, L, 2022)
"Calciphylaxis is a potencially disorder in patients with hyperphosphatemic familial tumoral calcinosis (HFTC)."	1.72	Therapeutic success of sodium thiosulfate in treating cutaneous calciphylaxis in a patient with hyperphosphataemic familial tumoral calcinosis. ( Gómez, C; Morales, P; Requena, S; Santos-Juanes, J, 2022)
"Calciphylaxis has poor prognosis which often results in amputation and high mortality."	1.62	Potential effect of sodium thiosulfate in calciphylaxis: remission of intractable pain. ( Li, X; Liu, H; Liu, Y; Ni, H; Yang, C; Zhang, X, 2021)
"Calciphylaxis is a serious condition that often occurs in patients with end-stage renal failure undergoing hemodialysis, with potential comorbidities of hyperparathyroidism and chronic kidney disease (CKD)."	1.56	Calciphylaxis in Stage 3 Chronic Kidney Disease on Apixaban Successfully Treated With Sodium Thiosulfate: A Case Report. ( Ali, F; Friedman, BJ; Gordon Spratt, E; Matharu, T; Nagesh, RV, 2020)
"Sodium thiosulfate therapy has proven to be effective and tolerated."	1.51	Multifaceted approach to a rare clinical case of calciphylaxis in a renal transplant recipient. ( Bellasi, A; Feriozzi, S; Gomes, V; Massimetti, C; Modoni, A, 2019)
"Non-uremic calciphylaxis is a rare, life-threatening condition characterized clinically by cutaneous necrosis and histologically by calcium deposition in small vessel walls."	1.51	Non-uremic calciphylaxis in a patient with multiple rheumatologic diseases. ( Cotter, D; Hinds, B; Kusari, A; Paravar, T, 2019)
"A 66-year-old man with renal failure due to diabetic nephropathy was on peritoneal dialysis alone for 1 year, followed by peritoneal dialysis combined with hemodialysis for 3 years."	1.48	Penile calciphylaxis in a patient on combined peritoneal dialysis and hemodialysis. ( Fujii, K; Itoh, H; Kasai, T; Morimoto, K; Muraoka, H; Shinozuka, K; Tokuyama, H; Uchiyama, K; Wakino, S; Washida, N, 2018)
"Calciphylaxis is an infrequent disease that almost exclusively affects patients with chronic kidney disease, although cases have been observed in patients without renal function impairment."	1.48	Sodium thiosulfate and pamidronate for treatment of calciphylaxis: case report. ( Alvarez, CL; Estifan Ksabji, J; Fernández Cañabate, S; Ortega Valin, L, 2018)
"Sodium thiosulfate therapy was given to 4 Caucasian patients (3 females and 1 male aged 49 to 91 years) with CUA."	1.43	Sodium thiosulfate is effective in calcific uremic arteriolopathy complicating chronic hemodialysis. ( Bardin, T; Ea, HK; Malbos, S; Ureña-Torres, P, 2016)
"Calciphylaxis is a rare disorder predominantly seen in patients with chronic kidney disease."	1.43	Sodium thiosulfate as a treatment for calciphylaxis: A case series. ( Bourgeois, P; De Haes, P, 2016)
"Calciphylaxis is associated with a high mortality rate."	1.43	Survival, Risk Factors, and Effect of Treatment in 101 Patients With Calciphylaxis. ( Albright, RC; Bridges, AD; Claus, PL; Davis, MD; Dillon, JJ; El-Azhary, RA; El-Zoghby, ZM; Hickson, LJ; Kumar, R; McBane, RD; McCarthy, JT; McCarthy-Fruin, KA; McEvoy, MT; Patzelt, MT; Pittelkow, MR; Weaver, AL; Wetter, DA; Williams, AW, 2016)
"Calciphylaxis is a small vessel vasculopathy, characterized by medial wall calcification that develops in a few patients with chronic renal failure."	1.43	Successful Treatment of Lung Calciphylaxis With Sodium Thiosulfate in a Patient With Sickle Cell Disease: A Case Report. ( Adedjouma, A; Arrestier, R; Audard, V; Bartolucci, P; Bentaarit, B; Boulahia, G; Colin, C; Deux, JF; Dudreuilh, C; Dufresne, R; Grimbert, P; Kofman, T; Lang, P; Leibler, C; Maitre, B; Matignon, M; Remy, P; Sahali, D; Tran Van Nhieu, J, 2016)
"Calciphylaxis is dangerous by its fast progression into tissue necrosis, difficult healing process and a great risk of secondary infection which is the most common cause of death in this condition."	1.42	[Calcific uremic arteriolopathy - treatment with sodium thiosulfate]. ( Blaštíková, J; Dvořáková, G; Souček, M; Svojanovský, J; Vyskočilová, M, 2015)
"Calciphylaxis is a rare disease in which the treatment is basically supportive."	1.42	Penile and generalised calciphylaxis in peritoneal dialysis. ( Sarkis, E, 2015)
"Calciphylaxis is a rare and severe disease with an annual incidence of around 1 % in dialysis patients."	1.40	[Incidence and characteristics of calciphylaxis in Martinique (2006-2012)]. ( Aoun, A; Banydeen, R; Baubion, E; Derancourt, C; Djiconkpode, I; Dueymes, JM; Ekindi, N; Quist, D; Riaux, A; Sadreux, T; Ureña-Torres, P, 2014)
"Sodium thiosulfate (STS) is used to treat calciphylaxis and cyanide poisoning, but can lead to a serious anion-gap acidosis."	1.40	Falsely increased chloride and missed anion gap elevation during treatment with sodium thiosulfate. ( Bachmann, LM; Boyd, JC; Bruns, DE; Haverstick, DM; Heady, TN; Scott, MG; Wendroth, SM, 2014)
"Calciphylaxis is a rare, yet life-threatening disease mainly occurring in dialysis patients."	1.39	Multi-modal treatment of calciphylaxis with sodium-thiosulfate, cinacalcet and sevelamer including long-term data. ( Berr, F; Fend, F; Franzen, M; Hauser-Kronberger, C; Heemann, U; Hitzl, W; Koller, J; Kreymann, B; Salmhofer, H; Schmaderer, C, 2013)
"Calciphylaxis is a metastatic calcification-induced vasculopathy that results in the occlusion of small blood vessels."	1.39	Sodium thiosulfate in the treatment of non-uremic calciphylaxis. ( Castellanos, EH; Dahir, KM; McGirt, LY; Ning, MS, 2013)
" Although many recent case reports have shown exceptional results and healing with the use of sodium thiosulphate, we did not experience any change in the poor prognosis of our patients with the use of this drug, at a dosage of 5 g thrice weekly endovenously."	1.39	Calciphylaxis in dialysis patients, a severe disease poorly responding to therapies: report of 4 cases. ( Aldi, M; Cantelli, S; Gaddoni, G; Misciali, C; Odorici, G; Patrizi, A; Savoia, F; Tampieri, E; Tampieri, G, 2013)
"Calciphylaxis is a rare cutaneous disorder, characterized by vascular calcification and progressive skin necrosis, not yet described in cats."	1.39	Nonuraemic nonfatal idiopathic calciphylaxis in a kitten. ( Er, E; Reinacher, M; Thom, N, 2013)
"Calciphylaxis is a potentially fatal disorder of abnormal calcium deposition."	1.39	Intralesional sodium thiosulfate for the treatment of calciphylaxis. ( Bis, S; Kroshinsky, D; Nigwekar, SU; Sise, M; Smith, GP; Steele, D; Strazzula, L; Tsiaras, W, 2013)
" Dosage adjustment and close follow-up of patients' acid-base status after STS initiation is necessary."	1.39	Severe anion gap acidosis associated with intravenous sodium thiosulfate administration. ( Albright, R; Kashani, K; Lee, S; Mao, M; Qian, Q, 2013)
"Calciphylaxis is a life-threatening complication in patients with end-stage renal disease (ESRD)."	1.39	Use of sodium thiosulphate in a multi-interventional setting for the treatment of calciphylaxis in dialysis patients. ( Auinger, M; König, M; Lhotta, K; Lingenhel, G; Rudnicki, M; Salmhofer, H; Schilcher, G; Vychytil, A; Wallner, M; Zitt, E, 2013)
"Calciphylaxis is a rare life-threatening form of skin necrosis."	1.39	Warfarin-induced calciphylaxis successfully treated with sodium thiosulphate. ( Brais, R; Deegan, P; Hafiji, J; Norris, P, 2013)
"Calciphylaxis is an uncommon and often under diagnosed condition affecting patients undergoing chronic dialysis."	1.39	Calciphylaxis and sodium thiosulphate: a glimmer of hope in desperate situation. ( Burnie, R; Javaid, MM; Smail, S, 2013)
"Calciphylaxis is a rare and potentially life-threatening condition."	1.38	Calciphylaxis with normal renal function: treated with intravenous sodium thiosulfate. ( Merchant, W; Oliphant, T; Shareef, M; Smith, VM; Wilkinson, SM, 2012)
"Penile calciphylaxis is very rare but has a mortality rate of 69% within 6 months."	1.38	Penile calciphylaxis: a life-threatening condition successfully treated with sodium thiosulfate. ( Djebali, D; Gini, MB; Ranade, A; Sandhu, G; Smith, S, 2012)
"Calciphylaxis is a severe "vascular ossification-calcification," associated with a very high mortality rate that involves arterial wall, venular wall, and nerves resulting in ischemia and necrosis of skin, subcutaneous fat, visceral organs, and skeletal muscles."	1.37	Sodium thiosulfate not always resolves calciphylaxis: an ambiguous response. ( Di Raimondo, D; La Placa, S; Li Vecchi, M; Licata, G; Miceli, S; Milio, G; Pinto, A; Tuttolomondo, A, 2011)
" Lack of rigorous pharmacokinetic studies makes it problematic for determining proper STS dosing given the expanding range of dialysis prescriptions and intensities."	1.37	Simulation-based sodium thiosulfate dosing strategies for the treatment of calciphylaxis. ( Derendorf, H; Ross, EA; Singh, RP, 2011)
"Calciphylaxis is a rare condition with dismal prognosis that affects patients with ESRD."	1.37	Efficacy of sodium thiosulfate for the treatment for calciphylaxis. ( Landis, M; Moe, SM; Noureddine, L; Patel, N, 2011)
"Treatment with sodium thiosulfate resulted in dramatic scintigraphic improvement."	1.35	Bone scan findings in metastatic calcification from calciphylaxis. ( Leslie, WD; Soni, S, 2008)
"Sodium thiosulfate has been shown to produce clinical improvement of calciphylaxis lesions."	1.35	Sodium thiosulfate, bisphosphonates, and cinacalcet for treatment of calciphylaxis. ( Raymond, CB; Wazny, LD, 2008)
"As the treatment of calciphylaxis is mainly empirical and controversial, we decided to administer cinacalcet with paricalcitol for the control of hyperparathyroidism and sodium thiosulfate to improve the calcification of the arterioles."	1.35	Combination of sodium thiosulphate, cinacalcet, and paricalcitol in the treatment of calciphylaxis with hyperparathyroidism. ( Agroyannis, B; Agroyannis, I; Gombou, A; Griveas, I; Kyritsis, I; Retsa, K, 2008)
"Calciphylaxis is an infrequent but severe entity found in chronic dialysis patients."	1.35	Use of sodium thiosulfate in the treatment of calciphylaxis. ( Algranati, L; Enz, P; Galimberti, R; Garfi, L; Gelman, R; Giuseppe, LD; Kowalczuk, A; Lizarraga, A; Musso, CG; Vidal, F, 2009)
"There has been no recurrence of lesions in the 18 months since the cessation of sodium thiosulfate."	1.35	Complete resolution of recurrent calciphylaxis with long-term intravenous sodium thiosulfate. ( Saker, B; Sinniah, R; Subramaniam, K; Wallace, H, 2008)
" STS dosage was 25 g/1."	1.33	Sodium thiosulfate treatment for calcific uremic arteriolopathy in children and young adults. ( Araya, CE; Dharnidharka, VR; Fennell, RS; Neiberger, RE, 2006)
"Calciphylaxis is a dreaded complication of renal failure characterized by nodular subcutaneous calcification and painful tissue necrosis often leading to ulceration, secondary infection, and high mortality rates."	1.32	Successful treatment of calciphylaxis with intravenous sodium thiosulfate. ( Cicone, JS; Embert, CD; Petronis, JB; Spector, DA, 2004)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	23 (18.70)	29.6817
2010's	85 (69.11)	24.3611
2020's	15 (12.20)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Effects of Human Amniotic Mesenchymal Stem Cells (hAMSCs) on Wound Healing in Uremic Calciphylaxis Patients: an Open Label Single Arm Study[NCT04592640]		7 participants (Anticipated)	Interventional	2018-09-17	Active, not recruiting
National Follow-up of Dialysis Patients With Sodium Thiosufate-treated Calciphylaxis Under Temporary Use Authorization[NCT03146793]		600 participants (Anticipated)	Observational	2017-05-01	Recruiting
Evaluation of Vitamin K Supplementation for Calcific Uremic Arteriolopathy[NCT02278692]		26 participants (Actual)	Interventional	2015-03-31	Completed
Partners Calciphylaxis Biobank and Patient Registry[NCT03032835]		300 participants (Anticipated)	Observational [Patient Registry]	2017-01-31	Recruiting
Randomized Placebo-controlled Trial of the Safety and Efficacy of Topical Sodium Metabisulfite for the Treatment of Calcinosis in Patients With Systemic Sclerosis.[NCT06155578]	Phase 1/Phase 2	20 participants (Anticipated)	Interventional	2024-01-02	Not yet recruiting
The Treatment Effect of Intravenous Sodium Thiosulfate on Coronary Calcification in Patients on Hemodialysis[NCT00720772]	Phase 2	50 participants (Anticipated)	Interventional	2008-07-31	Completed
European Calciphylaxis Registry Network[NCT02635373]		1,000 participants (Anticipated)	Observational [Patient Registry]	2015-12-31	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Calciphylaxis: Treatment and outlook-CME part II. Journal of the American Academy of Dermatology, 2022, Volume: 86, Issue:5 Topics: Calciphylaxis; Female; Humans; Kidney Failure, Chronic; Male; Thiosulfates	2022
Risk factors, treatment modalities, and clinical outcomes of penile calciphylaxis: systematic review. World journal of urology, 2023, Volume: 41, Issue:11 Topics: Calciphylaxis; Humans; Kidney Failure, Chronic; Male; Penis; Risk Factors; Thiosulfates	2023
Successful Treatment of Single Infected Calciphylaxis Lesion With Intralesional Injection of Sodium Thiosulfate at High Concentration. Wounds : a compendium of clinical research and practice, 2019, Volume: 31, Issue:8 Topics: Anti-Bacterial Agents; Calciphylaxis; Chelating Agents; Diabetic Nephropathies; Humans; Injections,	2019
Calciphylaxis: Approach to Diagnosis and Management. Advances in chronic kidney disease, 2019, Volume: 26, Issue:6 Topics: Calciphylaxis; Chelating Agents; Humans; Kidney Failure, Chronic; Microvessels; Pain Management; Ren	2019
Systematic review of sodium thiosulfate in treating calciphylaxis in chronic kidney disease patients. Nephrology (Carlton, Vic.), 2018, Volume: 23, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Calciphylaxis; Calcium Chelating Agents; Female; Human	2018
Calciphylaxis. The New England journal of medicine, 2018, May-03, Volume: 378, Issue:18 Topics: Age of Onset; Calciphylaxis; Debridement; Diagnosis, Differential; Humans; Kidney Diseases; Microves	2018
Successful treatment of extensive uremic calciphylaxis with intravenous sodium thiosulfate and its potential in treating various diseases of pathologic calcification. Acta dermatovenerologica Alpina, Pannonica, et Adriatica, 2019, Volume: 28, Issue:1 Topics: Aged; Calciphylaxis; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Kidney Failure, Chro	2019
Calciphylaxis: Diagnosis, Pathogenesis, and Treatment. Advances in skin & wound care, 2019, Volume: 32, Issue:5 Topics: Calciphylaxis; Chelating Agents; Humans; Kidney Failure, Chronic; Kidney Transplantation; Pain Manag	2019
Revisiting therapeutic options for calciphylaxis. Current opinion in nephrology and hypertension, 2019, Volume: 28, Issue:5 Topics: Anticoagulants; Calciphylaxis; Cinacalcet; Clinical Trials as Topic; Humans; Pain Management; Parath	2019
Calciphylaxis: diagnosis and clinical features. Clinical and experimental nephrology, 2013, Volume: 17, Issue:4 Topics: Calciphylaxis; Debridement; Humans; Japan; Male; Middle Aged; Prevalence; Renal Dialysis; Thiosulfat	2013
Successful treatment of calciphylaxis with intravenous sodium thiosulfate in a nonuremic patient: case report and review of therapy side effects. Journal of cutaneous medicine and surgery, 2014, Volume: 18, Issue:5 Topics: Administration, Intravenous; Calciphylaxis; Chelating Agents; Female; Humans; Leg Ulcer; Middle Aged	2014
Calcific uremic arteriolopathy: a call for action. Seminars in nephrology, 2014, Volume: 34, Issue:6 Topics: Antioxidants; Biomedical Research; Calciphylaxis; Cinacalcet; Diphosphonates; Humans; Kidney Failure	2014
Calciphylaxis: risk factors, diagnosis, and treatment. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2015, Volume: 66, Issue:1 Topics: Animals; Arterioles; Biopsy; Calciphylaxis; Case-Control Studies; Chronic Kidney Disease-Mineral and	2015
Multidisciplinary approach to calcific uremic arteriolopathy. Current opinion in nephrology and hypertension, 2015, Volume: 24, Issue:6 Topics: Calciphylaxis; Chelating Agents; Humans; Kidney Failure, Chronic; Risk Factors; Thiosulfates; Uremia	2015
Calcinosis Cutis and Calciphylaxis. Actas dermo-sifiliograficas, 2015, Volume: 106, Issue:10 Topics: Autoimmune Diseases; Calcinosis; Calciphylaxis; Calcium; Collagen Diseases; Diagnostic Imaging; Huma	2015
Calcific uraemic arteriolopathy: an update. Current opinion in nephrology and hypertension, 2008, Volume: 17, Issue:6 Topics: Calciphylaxis; Calcium; Chelating Agents; Chronic Disease; Humans; Hyperbaric Oxygenation; Kidney Di	2008
Sodium thiosulfate in the treatment of calcific uremic arteriolopathy. Nature reviews. Nephrology, 2009, Volume: 5, Issue:9 Topics: Aged; Calciphylaxis; Chelating Agents; Female; Humans; Prevalence; Risk Factors; Thiosulfates; Uremi	2009
[Cutaneous calciphylaxis]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2010, Volume: 61, Issue:12 Topics: Biopsy; Bone Density Conservation Agents; Calciphylaxis; Chelating Agents; Combined Modality Therapy	2010
Calciphylaxis: a systematic review of existing and emerging therapies. Journal of the American Academy of Dermatology, 2012, Volume: 67, Issue:6 Topics: Antioxidants; Calciphylaxis; Cinacalcet; Diphosphonates; Humans; Naphthalenes; Parathyroidectomy; Sk	2012
Treatment of cutaneous calciphylaxis with sodium thiosulfate: two case reports and a review of the literature. American journal of clinical dermatology, 2011, Oct-01, Volume: 12, Issue:5 Topics: Adult; Calciphylaxis; Calcium; Calcium Phosphates; Chelating Agents; Female; Humans; Male; Middle Ag	2011
[Sodium thiosulfate--new hope for the treatment of calciphylaxis]. Duodecim; laaketieteellinen aikakauskirja, 2011, Volume: 127, Issue:16 Topics: Calciphylaxis; Chelating Agents; Humans; Renal Dialysis; Thiosulfates	2011
Vascular ossification-calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis-calcific uremic arteriolopathy: the emerging role of sodium thiosulfate. Cardiovascular diabetology, 2005, Mar-18, Volume: 4 Topics: Animals; Antioxidants; Arteries; Atherosclerosis; Calcinosis; Calciphylaxis; Chelating Agents; Chron	2005
Calciphylaxis: no therapeutic concepts for a poorly understood syndrome? Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2006, Volume: 4, Issue:12 Topics: Age Factors; Calciphylaxis; Calcium; Cinacalcet; Diabetes Mellitus, Type 2; Female; Humans; Hyperbar	2006
Calciphylaxis: calcific uremic arteriolopathy and the emerging role of sodium thiosulfate. International urology and nephrology, 2008, Volume: 40, Issue:2 Topics: Antioxidants; Calciphylaxis; Chelating Agents; Endothelium, Vascular; Humans; Syndrome; Thiosulfates	2008

Article	Year
Therapeutic success of sodium thiosulfate in treating cutaneous calciphylaxis in a patient with hyperphosphataemic familial tumoral calcinosis. The Australasian journal of dermatology, 2022, Volume: 63, Issue:1 Topics: Aged; Antioxidants; Calcinosis; Calciphylaxis; Humans; Hyperostosis, Cortical, Congenital; Hyperphos	2022
Success of small-dose fractionated sodium thiosulfate in the treatment of calciphylaxis in a peritoneal dialysis patient. BMC nephrology, 2022, 01-03, Volume: 23, Issue:1 Topics: Adult; Calciphylaxis; Chelating Agents; Humans; Kidney Failure, Chronic; Male; Peritoneal Dialysis;	2022
Potential effect of sodium thiosulfate in calciphylaxis: remission of intractable pain. JPMA. The Journal of the Pakistan Medical Association, 2021, Volume: 71, Issue:1(B) Topics: Calciphylaxis; Humans; Kidney Failure, Chronic; Male; Middle Aged; Pain, Intractable; Renal Insuffic	2021
Use of the optimized sodium thiosulfate regimen for the treatment of calciphylaxis in Chinese patients. Renal failure, 2022, Volume: 44, Issue:1 Topics: Calciphylaxis; Chelating Agents; China; Humans; Retrospective Studies; Thiosulfates	2022
Therapeutic evaluation of calciphylaxis by transcutaneous oxygen tension measurement in a case treated with a combined regimen including sodium thiosulphate European journal of dermatology : EJD, 2022, 11-01, Volume: 32, Issue:6 Topics: Calciphylaxis; Humans; Oxygen; Thiosulfates	2022
Intralesional Sodium Thiosulfate as Adjuvant Therapy in Severe Calciphylaxis. Journal of drugs in dermatology : JDD, 2023, Dec-01, Volume: 22, Issue:12 Topics: Calciphylaxis; Female; Humans; Kidney Failure, Chronic; Renal Dialysis; Thiosulfates	2023
Multifaceted approach to a rare clinical case of calciphylaxis in a renal transplant recipient. Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia, 2019, Sep-24, Volume: 36, Issue:5 Topics: Aged; Anticoagulants; Bone Density Conservation Agents; Calciphylaxis; Chelating Agents; Combined Mo	2019
[Primary hyperoxaluria: case report and therapeutic perspectives]. Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia, 2020, Feb-12, Volume: 37, Issue:1 Topics: Calciphylaxis; Calcium Compounds; Female; Glyoxylates; Hemodiafiltration; Humans; Hyperoxaluria, Pri	2020
Sodium-Thiosulfate Induced Life-Threatening Metabolic Acidosis Limiting Treatment of Calciphylaxis. The American journal of case reports, 2020, Apr-27, Volume: 21 Topics: Acidosis; Calciphylaxis; Chelating Agents; Comorbidity; Fatal Outcome; Humans; Kidney Failure, Chron	2020
Assessment of outcomes of calciphylaxis lesions treated with intralesional sodium thiosulfate. Journal of the American Academy of Dermatology, 2021, Volume: 85, Issue:3 Topics: Calciphylaxis; Chelating Agents; Humans; Kidney Failure, Chronic; Thiosulfates	2021
Clinical Characteristics and Outcomes of Patients with Calciphylaxis. The American journal of the medical sciences, 2021, Volume: 361, Issue:1 Topics: Calciphylaxis; Female; Humans; Infusions, Intravenous; Male; Middle Aged; New York; Peritoneal Dialy	2021
Calciphylaxis in Stage 3 Chronic Kidney Disease on Apixaban Successfully Treated With Sodium Thiosulfate: A Case Report. Wounds : a compendium of clinical research and practice, 2020, Volume: 32, Issue:9 Topics: Aged; Antioxidants; Calciphylaxis; Diabetes Mellitus, Type 2; Factor Xa Inhibitors; Female; Humans;	2020
Nonuraemic calciphylaxis: A case series. Annales de dermatologie et de venereologie, 2021, Volume: 148, Issue:2 Topics: Calciphylaxis; Humans; Thiosulfates	2021
Successful treatment of calciphylaxis in a renal transplant recipient with combination of intralesional sodium thiosulphate, intravenous sodium thiosulphate and fish skin graft. The Australasian journal of dermatology, 2021, Volume: 62, Issue:2 Topics: Acellular Dermis; Adult; Anti-Bacterial Agents; Antioxidants; Calciphylaxis; Debridement; Female; Hu	2021
Benefits of intralesional injections of sodium thiosulfate in the treatment of calciphylaxis. International wound journal, 2017, Volume: 14, Issue:6 Topics: Aged; Aged, 80 and over; Antidotes; Calciphylaxis; Female; Humans; Injections, Intralesional; Leg Ul	2017
Fractures in calciphylaxis patients following intravenous sodium thiosulfate therapy. Journal of the European Academy of Dermatology and Venereology : JEADV, 2017, Volume: 31, Issue:10 Topics: Adult; Calciphylaxis; Chelating Agents; Female; Fractures, Bone; Humans; Male; Middle Aged; Polyphar	2017
[Sodium thiosulfate for the treatment of acenocumarol-induced calciphylaxis in a patient with preserved kidney function]. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria, 2017, May-01, Volume: 41, Issue:3 Topics: Acenocoumarol; Aged, 80 and over; Anticoagulants; Antidotes; Calciphylaxis; Female; Humans; Kidney;	2017
Cirrhosis Presenting as Cutaneous Calciphylaxis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2017, Volume: 15, Issue:10 Topics: Aged; Antioxidants; Calciphylaxis; Chelating Agents; Female; Humans; Liver Cirrhosis; Skin Diseases;	2017
The Signs Aligned: Nonuremic Calciphylaxis. The American journal of medicine, 2017, Volume: 130, Issue:9 Topics: Adult; Aged; Antioxidants; Calciphylaxis; Comorbidity; Diagnosis, Differential; Fatal Outcome; Femal	2017
[Sodium thiosulfate in the treatment of calcific uremic arteriolopathy (calciphylaxis)]. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria, 2017, Sep-01, Volume: 41, Issue:5 Topics: Calciphylaxis; Female; Humans; Kidney Failure, Chronic; Thiosulfates; Uricosuric Agents	2017
Sodium Thiosulfate in the Treatment of Lung and Breast Calciphylaxis: CT and Bone Scintigraphy Findings. Clinical nuclear medicine, 2017, Volume: 42, Issue:11 Topics: Bone and Bones; Breast Diseases; Calciphylaxis; Female; Humans; Lung Diseases; Radionuclide Imaging;	2017
Clinical characteristics and risk factors associated with mortality in calcific uremic arteriolopathy. International urology and nephrology, 2017, Volume: 49, Issue:12 Topics: Aged; Anticoagulants; Arterioles; Calciphylaxis; Cardiovascular Diseases; Chelating Agents; Debridem	2017
Recalcitrant ulcer on the lower leg. Cutis, 2017, Volume: 100, Issue:3 Topics: Administration, Intravenous; Aged, 80 and over; Antioxidants; Biopsy; Calciphylaxis; Diagnosis, Diff	2017
[Calciphylaxis in hemodialysis patients: 8 cases treated with sodium thiosulfate]. Annales de dermatologie et de venereologie, 2018, Volume: 145, Issue:4 Topics: Aged; Aged, 80 and over; Calciphylaxis; Combined Modality Therapy; Diabetes Mellitus, Type 2; Diabet	2018
Penile calciphylaxis in a patient on combined peritoneal dialysis and hemodialysis. CEN case reports, 2018, Volume: 7, Issue:2 Topics: Aged; Buffers; Calciphylaxis; Dialysis Solutions; Humans; Lactates; Male; Penile Diseases; Penis; Pe	2018
[Hyperthyroidism-induced calciphylaxis: A case report]. Nephrologie & therapeutique, 2018, Volume: 14, Issue:7 Topics: Aged; Bone Density Conservation Agents; Calciphylaxis; Denosumab; Female; Humans; Hyperbaric Oxygena	2018
Classic Lesion, Not-So-Classic Cause. The American journal of medicine, 2019, Volume: 132, Issue:2 Topics: Adenoma; Aged; Calciphylaxis; Chelating Agents; Female; Humans; Parathyroid Neoplasms; Thiosulfates	2019
Demographics, Comorbid Conditions, and Outcomes of Patients With Nonuremic Calciphylaxis. JAMA dermatology, 2019, Feb-01, Volume: 155, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Biopsy, Needle; Calciphylaxis; Disease Progression; Drug Therapy, Co	2019
The Effectiveness of Topical Cerium Nitrate-Silver Sulfadiazine Application on Overall Outcome in Patients with Calciphylaxis. Dermatology (Basel, Switzerland), 2019, Volume: 235, Issue:2 Topics: Administration, Cutaneous; Aged; Anti-Infective Agents, Local; Calciphylaxis; Cerium; Chelating Agen	2019
Calciphylaxis and nephrogenic fibrosing dermopathy with pseudoxanthoma elasticum-like changes: Successful treatment with sodium thiosulfate. The Journal of dermatology, 2019, Volume: 46, Issue:7 Topics: Aged; Calciphylaxis; Chelating Agents; Humans; Kidney Failure, Chronic; Male; Microscopy, Electron;	2019
Sodium thiosulfate and pamidronate for treatment of calciphylaxis: case report. Colombia medica (Cali, Colombia), 2018, Dec-30, Volume: 49, Issue:4 Topics: Administration, Intravenous; Aged; Calciphylaxis; Chelating Agents; Drug Therapy, Combination; Femal	2018
Non-uremic calciphylaxis in a patient with multiple rheumatologic diseases. Dermatology online journal, 2019, Feb-15, Volume: 25, Issue:2 Topics: Calciphylaxis; Chelating Agents; Female; Humans; Kidney; Leg Ulcer; Lupus Erythematosus, Systemic; M	2019
Hypercalcemia associated with sodium thiosulfate treatment in a patient with calciphylaxis. Polish archives of internal medicine, 2019, 09-30, Volume: 129, Issue:9 Topics: Adolescent; Breast Diseases; Calciphylaxis; Chelating Agents; Female; Humans; Hypercalcemia; Kidney	2019
[Efficacy of sodium thiosulphate in a case of calciphylaxis in a chronic nephropathic ninety-year-old patient on conservative therapy]. Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia, 2019, Jun-11, Volume: 36, Issue:3 Topics: Aged, 80 and over; Calciphylaxis; Conservative Treatment; Female; Humans; Kidney Failure, Chronic; T	2019
Sodium thiosulfate therapy for calcific uremic arteriolopathy. Clinical journal of the American Society of Nephrology : CJASN, 2013, Volume: 8, Issue:7 Topics: Administration, Intravenous; Adult; Aged; Calciphylaxis; Chi-Square Distribution; Female; Humans; Ma	2013
Sodium thiosulfate therapy for calcific uremic arteriolopathy. Clinical journal of the American Society of Nephrology : CJASN, 2013, Volume: 8, Issue:7 Topics: Administration, Intravenous; Adult; Aged; Calciphylaxis; Chi-Square Distribution; Female; Humans; Ma	2013
Sodium thiosulfate therapy for calcific uremic arteriolopathy. Clinical journal of the American Society of Nephrology : CJASN, 2013, Volume: 8, Issue:7 Topics: Administration, Intravenous; Adult; Aged; Calciphylaxis; Chi-Square Distribution; Female; Humans; Ma	2013
Sodium thiosulfate therapy for calcific uremic arteriolopathy. Clinical journal of the American Society of Nephrology : CJASN, 2013, Volume: 8, Issue:7 Topics: Administration, Intravenous; Adult; Aged; Calciphylaxis; Chi-Square Distribution; Female; Humans; Ma	2013
Calciphylaxis and sodium thiosulphate: a glimmer of hope in desperate situation. Journal of renal care, 2013, Volume: 39, Issue:2 Topics: Aged; Calciphylaxis; Chelating Agents; Female; Humans; Renal Dialysis; Skin Diseases, Vascular; Thio	2013
Warfarin-induced calciphylaxis successfully treated with sodium thiosulphate. The Australasian journal of dermatology, 2013, Volume: 54, Issue:2 Topics: Anticoagulants; Antioxidants; Calciphylaxis; Drug Eruptions; Humans; Male; Middle Aged; Skin Ulcer;	2013
Severe anion gap acidosis associated with intravenous sodium thiosulfate administration. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2013, Volume: 9, Issue:3 Topics: Acidosis, Renal Tubular; Aged; Antioxidants; Calciphylaxis; Critical Care; Female; Heart Arrest; Hos	2013
Sodium thiosulfate in the treatment of non-uremic calciphylaxis. The Journal of dermatology, 2013, Volume: 40, Issue:8 Topics: Adult; Antidotes; Calciphylaxis; Female; Humans; Thiosulfates	2013
Sodium thiosulfate: mythical treatment for a mysterious disease? Clinical journal of the American Society of Nephrology : CJASN, 2013, Volume: 8, Issue:7 Topics: Calciphylaxis; Female; Humans; Male; Thiosulfates	2013
Intralesional sodium thiosulfate for the treatment of calciphylaxis. JAMA dermatology, 2013, Volume: 149, Issue:8 Topics: Aged; Calciphylaxis; Chelating Agents; Female; Follow-Up Studies; Humans; Injections, Intralesional;	2013
Nonuraemic nonfatal idiopathic calciphylaxis in a kitten. Veterinary dermatology, 2013, Volume: 24, Issue:5 Topics: Animals; Antifibrinolytic Agents; Calciphylaxis; Cat Diseases; Cats; Chelating Agents; Lanthanum; Ma	2013
Calciphylaxis in dialysis patients, a severe disease poorly responding to therapies: report of 4 cases. Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 2013, Volume: 148, Issue:5 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Biopsy; Calciphylaxis; Cinacalcet; Combined Modality	2013
Calciphylaxis treated with sodium thiosulfate: report of two cases. Dermatology online journal, 2013, Sep-14, Volume: 19, Issue:9 Topics: Acenocoumarol; Aged; Aged, 80 and over; Atrial Fibrillation; Calciphylaxis; Comorbidity; Diabetes Me	2013
Multi-modal treatment of calciphylaxis with sodium-thiosulfate, cinacalcet and sevelamer including long-term data. Kidney & blood pressure research, 2013, Volume: 37, Issue:4-5 Topics: Aged; Calciphylaxis; Cinacalcet; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Napht	2013
Falsely increased chloride and missed anion gap elevation during treatment with sodium thiosulfate. Clinica chimica acta; international journal of clinical chemistry, 2014, Apr-20, Volume: 431 Topics: Acid-Base Equilibrium; Adult; Calciphylaxis; Chlorides; Electrodes; False Positive Reactions; Female	2014
Fetuin-A-containing calciprotein particle levels can be reduced by dialysis, sodium thiosulphate and plasma exchange. Potential therapeutic implications for calciphylaxis? Nephrology (Carlton, Vic.), 2013, Volume: 18, Issue:11 Topics: Adult; alpha-2-HS-Glycoprotein; Calciphylaxis; Female; Humans; Middle Aged; Plasma Exchange; Renal D	2013
Non-uraemic calciphylaxis with acral necrosis. The lancet. Diabetes & endocrinology, 2014, Volume: 2, Issue:1 Topics: Amputation, Surgical; Calciphylaxis; Chelating Agents; Diabetic Nephropathies; Humans; Male; Necrosi	2014
Nonuraemic calciphylaxis and pancreatic cancer: a previously unreported association. The British journal of dermatology, 2014, Volume: 171, Issue:5 Topics: Adenocarcinoma; Administration, Oral; Aged; Calciphylaxis; Chelating Agents; Fatal Outcome; Humans;	2014
Discovering implicit associations in a case of encapsulating peritoneal sclerosis complicated by severe mineral imbalance. BMJ case reports, 2014, Nov-03, Volume: 2014 Topics: Adult; Calciphylaxis; Fatal Outcome; Female; Glucocorticoids; Humans; Hyperparathyroidism; Parathyro	2014
[Incidence and characteristics of calciphylaxis in Martinique (2006-2012)]. Annales de dermatologie et de venereologie, 2014, Volume: 141, Issue:12 Topics: Amputation, Surgical; Calciphylaxis; Female; Humans; Hyperparathyroidism, Secondary; Incidence; Kidn	2014
[Calcific uremic arteriolopathy - treatment with sodium thiosulfate]. Vnitrni lekarstvi, 2015, Volume: 61, Issue:2 Topics: Calciphylaxis; Chelating Agents; Humans; Hyperparathyroidism, Secondary; Kidney Failure, Chronic; Ma	2015
Penile and generalised calciphylaxis in peritoneal dialysis. BMJ case reports, 2015, Apr-16, Volume: 2015 Topics: Anti-Bacterial Agents; Calciphylaxis; Debridement; Humans; Kidney Failure, Chronic; Male; Middle Age	2015
[Calcific uremic arteriolopathy]. Vnitrni lekarstvi, 2015, Volume: 61, Issue:2 Topics: Calciphylaxis; Chelating Agents; Humans; Kidney Failure, Chronic; Male; Renal Dialysis; Thiosulfates	2015
Widespread calciphylaxis and normal renal function: no improvement with sodium thiosulfate. Dermatology online journal, 2015, May-18, Volume: 21, Issue:5 Topics: Adult; Biopsy; Calciphylaxis; Chelating Agents; Delayed Graft Function; Female; Follow-Up Studies; G	2015
Calcific uraemic arteriolopathy. BMJ case reports, 2015, Aug-27, Volume: 2015 Topics: Adult; Arterioles; Calciphylaxis; Calcium; Chelating Agents; Female; Humans; Kidney Failure, Chronic	2015
Sodium thiosulfate is effective in calcific uremic arteriolopathy complicating chronic hemodialysis. Joint bone spine, 2016, Volume: 83, Issue:1 Topics: Aged; Aged, 80 and over; Antioxidants; Arterioles; Calciphylaxis; Female; Humans; Kidney Failure, Ch	2016
Intralesional Sodium Thiosulfate to Treat Calciphylaxis. Actas dermo-sifiliograficas, 2016, Volume: 107, Issue:4 Topics: Antioxidants; Calciphylaxis; Female; Humans; Middle Aged; Skin Diseases, Vascular; Thiosulfates; Vas	2016
Successful Treatment of Lung Calciphylaxis With Sodium Thiosulfate in a Patient With Sickle Cell Disease: A Case Report. Medicine, 2016, Volume: 95, Issue:6 Topics: Anemia, Sickle Cell; Antioxidants; Calciphylaxis; Female; Humans; Lung Diseases; Middle Aged; Remiss	2016
Sodium Thiosulfate and the Anion Gap in Patients Treated by Hemodialysis. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2016, Volume: 68, Issue:3 Topics: Acid-Base Equilibrium; Acid-Base Imbalance; Adult; Aged; Calciphylaxis; Chelating Agents; Databases,	2016
Sodium thiosulfate as a treatment for calciphylaxis: A case series. The Journal of dermatological treatment, 2016, Volume: 27, Issue:6 Topics: Calciphylaxis; Chelating Agents; Female; Humans; Male; Middle Aged; Retrospective Studies; Thiosulfa	2016
Multimodal Treatment of Calciphylaxis With Sodium Thiosulfate, Alprostadil, and Hyperbaric Oxygen Therapy. Actas dermo-sifiliograficas, 2016, Volume: 107, Issue:8 Topics: Alprostadil; Calciphylaxis; Combined Modality Therapy; Female; Humans; Hyperbaric Oxygenation; Hyper	2016
The Successful Treatment of Calciphylaxis with Sodium Thiosulfate and Hyperbaric Oxygen in a Non-dialyzed Patient with Chronic Kidney Disease. Internal medicine (Tokyo, Japan), 2016, Volume: 55, Issue:14 Topics: alpha-2-HS-Glycoprotein; C-Reactive Protein; Calciphylaxis; Female; Humans; Hyperbaric Oxygenation;	2016
Survival, Risk Factors, and Effect of Treatment in 101 Patients With Calciphylaxis. Mayo Clinic proceedings, 2016, Volume: 91, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Calciphylaxis; Debridement; Diabetes Mellitus; Female; Glomerular Fi	2016
Bone scan findings in metastatic calcification from calciphylaxis. Clinical nuclear medicine, 2008, Volume: 33, Issue:7 Topics: Bone and Bones; Calcinosis; Calciphylaxis; Female; Humans; Ischemia; Kidney Failure, Chronic; Middle	2008
Calciphylaxis in a patient with normal renal function: response to treatment with sodium thiosulfate. Clinical and experimental dermatology, 2009, Volume: 34, Issue:1 Topics: Abdominal Wall; Adult; Anticoagulants; Calciphylaxis; Calcium; Chelating Agents; Female; Humans; Hyp	2009
Sodium thiosulfate, bisphosphonates, and cinacalcet for treatment of calciphylaxis. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2008, Aug-01, Volume: 65, Issue:15 Topics: Adult; Aged; Calciphylaxis; Cinacalcet; Diphosphonates; Female; Humans; Kidney Failure, Chronic; Mal	2008
Oral sodium thiosulfate solution as a secondary preventive treatment for calciphylaxis in dialysis patients. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2008, Volume: 19, Issue:5 Topics: Administration, Oral; Antioxidants; Calciphylaxis; Humans; Renal Dialysis; Thiosulfates	2008
Combination of sodium thiosulphate, cinacalcet, and paricalcitol in the treatment of calciphylaxis with hyperparathyroidism. The International journal of artificial organs, 2008, Volume: 31, Issue:8 Topics: Aged; Calciphylaxis; Chelating Agents; Cinacalcet; Drug Therapy, Combination; Ergocalciferols; Femal	2008
Use of sodium thiosulfate in the treatment of calciphylaxis. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2009, Volume: 20, Issue:6 Topics: Calciphylaxis; Chelating Agents; Female; Humans; Infusions, Intravenous; Kidney Failure, Chronic; Mi	2009
Calciphylaxis (calcific uremic arteriolopathy) in a patient with chronic kidney disease. Journal of hospital medicine, 2010, Volume: 5, Issue:7 Topics: Aged; Anti-Bacterial Agents; Calciphylaxis; Chelating Agents; Dialysis Solutions; Fatal Outcome; Fem	2010
Penile calciphylaxis: a life-threatening condition successfully treated with sodium thiosulfate. American journal of therapeutics, 2012, Volume: 19, Issue:1 Topics: Calciphylaxis; Calcium; Chelating Agents; Combined Modality Therapy; Humans; Male; Middle Aged; Peni	2012
Sodium thiosulfate-based treatment in calcific uremic arteriolopathy: a consecutive case series. Clinical nephrology, 2011, Volume: 75, Issue:1 Topics: Adult; Arterial Occlusive Diseases; Calciphylaxis; Female; Humans; Kidney Failure, Chronic; Male; Ma	2011
Sodium thiosulfate not always resolves calciphylaxis: an ambiguous response. Renal failure, 2011, Volume: 33, Issue:1 Topics: Antioxidants; Calciphylaxis; Chelating Agents; Fatal Outcome; Female; Humans; Middle Aged; Severity	2011
Simulation-based sodium thiosulfate dosing strategies for the treatment of calciphylaxis. Clinical journal of the American Society of Nephrology : CJASN, 2011, Volume: 6, Issue:5 Topics: Calciphylaxis; Chelating Agents; Computer Simulation; Dose-Response Relationship, Drug; Humans; Kidn	2011
Normo-renal calciphylaxis: response to sodium thiosulfate. Journal of the American Academy of Dermatology, 2011, Volume: 64, Issue:5 Topics: Aged; Calciphylaxis; Chelating Agents; Disease Progression; Female; Humans; Kidney; Leg Ulcer; Thios	2011
Calciphylaxis, occurring 10 weeks after hypercalcaemia, in a patient with multiple myeloma. British journal of haematology, 2011, Volume: 155, Issue:2 Topics: Antineoplastic Combined Chemotherapy Protocols; Arterioles; Calciphylaxis; Chelation Therapy; Cyclop	2011
Efficacy of sodium thiosulfate for the treatment for calciphylaxis. Clinical nephrology, 2011, Volume: 75, Issue:6 Topics: Adult; Aged; Calciphylaxis; Chelating Agents; Female; Humans; Male; Middle Aged; Pain Measurement; R	2011
Successful treatment with sodium thiosulfate for calcific uraemic arteriolopathy. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2011, Volume: 31, Issue:3 Topics: Aged; Calciphylaxis; Humans; Kidney Failure, Chronic; Male; Remission Induction; Thiosulfates; Uremi	2011
Calciphylaxis: a severe complication of renal disease. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2011, Nov-08, Volume: 183, Issue:16 Topics: Adrenal Cortex Hormones; Calciphylaxis; Chelating Agents; Cinacalcet; Humans; Ischemia; Kidney Failu	2011
Multi-intervention management of calciphylaxis: a report of 7 cases. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2011, Volume: 58, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Arterioles; Calciphylaxis; Chelating Agents; Cinacalcet; Combined Mo	2011
Complete clearance of calciphylaxis following combined treatment with cinacalcet and sodium thiosulfate. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2011, Volume: 9, Issue:12 Topics: Calciphylaxis; Cinacalcet; Drug Therapy, Combination; Female; Humans; Middle Aged; Naphthalenes; Ski	2011
Multidisciplinary treatment. A therapeutic option to treat calciphylaxis. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2011, Volume: 31, Issue:5 Topics: Anti-Bacterial Agents; Antiphospholipid Syndrome; Calciphylaxis; Carcinoma, Renal Cell; Cardiovascul	2011
Calciphylaxis with normal renal function: treated with intravenous sodium thiosulfate. Clinical and experimental dermatology, 2012, Volume: 37, Issue:8 Topics: Antioxidants; Calciphylaxis; Chelating Agents; Humans; Injections, Intravenous; Kidney; Leg; Male; M	2012
Three cases of penile calciphylaxis: diagnosis, treatment strategies, and the role of sodium thiosulfate. Urology, 2012, Volume: 80, Issue:1 Topics: Aged; Calciphylaxis; Chelating Agents; Humans; Male; Middle Aged; Penile Diseases; Thiosulfates	2012
Use of sodium thiosulphate in a multi-interventional setting for the treatment of calciphylaxis in dialysis patients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2013, Volume: 28, Issue:5 Topics: Aged; Calciphylaxis; Chelating Agents; Female; Follow-Up Studies; Humans; Kidney Failure, Chronic; M	2013
Successful treatment of calciphylaxis with intravenous sodium thiosulfate. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2004, Volume: 43, Issue:6 Topics: Aged; Calciphylaxis; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Thiosulfa	2004
Rapid resolution of calciphylaxis with intravenous sodium thiosulfate and continuous venovenous haemofiltration using low calcium replacement fluid: case report. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2005, Volume: 20, Issue:6 Topics: Calciphylaxis; Calcium; Calcium Chloride; Female; Hemofiltration; Humans; Kidney Failure, Chronic; M	2005
Sodium thiosulphate as a promising therapeutic option to treat calciphylaxis. Dermatology (Basel, Switzerland), 2006, Volume: 212, Issue:4 Topics: Abdomen; Adult; Biopsy; Buttocks; Calciphylaxis; Chelating Agents; Female; Humans; Kidney Failure, C	2006
Intraperitoneal sodium thiosulfate for the treatment of calciphylaxis. Renal failure, 2006, Volume: 28, Issue:4 Topics: Adolescent; Calciphylaxis; Chelating Agents; Female; Glomerulosclerosis, Focal Segmental; Humans; Hy	2006
Successful management of critical limb ischemia with intravenous sodium thiosulfate in a chronic hemodialysis patient. Clinical nephrology, 2006, Volume: 66, Issue:2 Topics: Calcinosis; Calciphylaxis; Fingers; Humans; Infusions, Intravenous; Ischemia; Male; Middle Aged; Ren	2006
Calciphylaxis responding to sodium thiosulfate therapy. Archives of dermatology, 2007, Volume: 143, Issue:2 Topics: Aged; Calciphylaxis; Chelating Agents; Female; Humans; Leg Ulcer; Thiosulfates	2007
[Reader's letter on Marcus Meissner, Jens, Gille, Roland Kaufmann. Calciphylaxis: no therapeutic concepts for a poorly understood syndrome?]. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2007, Volume: 5, Issue:5 Topics: Age Factors; Calciphylaxis; Calcium; Cinacalcet; Diabetes Mellitus, Type 2; Female; Humans; Hyperbar	2007
Sodium thiosulphate: a new way of treatment for calciphylaxis? Dermatology (Basel, Switzerland), 2007, Volume: 214, Issue:4 Topics: Antioxidants; Calciphylaxis; Chelating Agents; Humans; Kidney Diseases; Thiosulfates	2007
Sodium thiosulfate treatment for calcific uremic arteriolopathy in children and young adults. Clinical journal of the American Society of Nephrology : CJASN, 2006, Volume: 1, Issue:6 Topics: Adult; Antioxidants; Arteriosclerosis; Calciphylaxis; Child; Female; Humans; Male; Thiosulfates; Ure	2006
Sodium thiosulfate as first-line treatment for calciphylaxis. Archives of dermatology, 2007, Volume: 143, Issue:10 Topics: Calciphylaxis; Diabetes Complications; Female; Humans; Kidney Diseases; Kidney Transplantation; Leg	2007
Complete resolution of recurrent calciphylaxis with long-term intravenous sodium thiosulfate. The Australasian journal of dermatology, 2008, Volume: 49, Issue:1 Topics: Antioxidants; Calciphylaxis; Chelating Agents; Female; Humans; Infusions, Intravenous; Kidney Failur	2008
Calciphylaxis and the cardiometabolic syndrome: the emerging role of sodium thiosulfate as a novel treatment option. Journal of the cardiometabolic syndrome, 2008,Winter, Volume: 3, Issue:1 Topics: Antioxidants; Arteries; Calciphylaxis; Humans; Kidney Diseases; Metabolic Syndrome; Renal Dialysis;	2008

thiosulfates and Calciphylaxes

Research Excerpts

Research

Studies (123)

Authors

Clinical Trials (7)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Requena, S	1
Santos-Juanes, J	1
Morales, P	1
Gómez, C	1
Lu, Y	1
Shen, L	1
Zhou, L	1
Xu, D	1
Yang, C	1
Liu, Y	2
Ni, H	1
Li, X	2
Liu, H	1
Zhang, X	2
Rick, J	1
Rrapi, R	1
Chand, S	1
Shinohara, MM	1
Strowd, L	1
Pasieka, HB	1
Micheletti, R	1
Kroshinsky, D	5
Ortega-Loayza, AG	1
Yang, X	1
Xie, X	1
Shi, W	1
Si, J	1
Liu, B	2
Nishihara, K	1
Shiraishi, K	1
Utsunomiya, R	1
Tohyama, M	1
Sayama, K	1
Wipattanakitcharoen, A	1
Takkavatakarn, K	1
Susantitaphong, P	1
Paula, E	1
Denys, P	1
Anamá, DP	1
María, D	1
Carolina, V	1
Ana, T	1
Luis, M	1
Guido, MC	1
Zuhaili, B	1
Al-Talib, K	1
Massimetti, C	1
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