thiostrepton and Otitis-Externa

A topical preparation containing miconazole, polymyxin and prednisolone was shown to be more effective in the treatment of otitis externa in 167 dogs than 2 other ear preparations containing antibiotics, an antimycotic and a corticosteroid. With miconazole, polymyxin and prednisolone, the recurrence rate was 26.7% compared with 72.6% and 54.3% when the other products were used. The mean duration of treatment required to achieve resolution of clinical signs was 9.6 days, compared with 12.2 days and 13.0 days and no cases failed to respond to treatment, compared with 17.7% and 14.3%. Malassezia canis alone (71%) or in association with bacteria (18%) was recovered from 44 of 49 ears cultured.

Topics: Administration, Topical; Animals; Betamethasone; Disulfiram; Dog Diseases; Dogs; Drug Combinations; Miconazole; Neomycin; Nystatin; Otitis Externa; Polymyxin B; Prednisolone; Recurrence; Thiostrepton; Triamcinolone

Budding yeasts were present in the majority of cases of otitis externa examined. A reddish-brown, dry, waxy discharge was the typical exudate. A successful treatment of yeast-infected ears was multiple otic lavages using a combination of an aqueous solution of poloxamer-iodine and application of an antifungal-antibiotic-corticosteroids ointment.

Topics: Animals; Antifungal Agents; Candida; Candidiasis; Dog Diseases; Dogs; Drug Combinations; Iodine; Malassezia; Neomycin; Nystatin; Otitis Externa; Poloxalene; Thiostrepton; Tinea Versicolor; Triamcinolone