thiostrepton and Colitis

thiostrepton has been researched along with Colitis* in 1 studies

Other Studies

1 other study(ies) available for thiostrepton and Colitis

ArticleYear
Thiostrepton alleviates experimental colitis by promoting RORγt ubiquitination and modulating dysbiosis.
    Cellular & molecular immunology, 2023, Volume: 20, Issue:11

    Thiostrepton (TST) is a natural antibiotic with pleiotropic properties. This study aimed to elucidate the therapeutic effect of TST on experimental colitis and identify its targets. The effect of TST on colon inflammation was evaluated in a dextran sulfate sodium (DSS)-induced colitis model and a T-cell transfer colitis model. The therapeutic targets of TST were investigated by cytokine profiling, immunophenotyping and biochemical approaches. The effect of TST on the gut microbiota and its contribution to colitis were evaluated in mice with DSS-induced colitis that were subjected to gut microbiota depletion and fecal microbiota transplantation (FMT). Alterations in the gut microbiota caused by TST were determined by 16S rDNA and metagenomic sequencing. Here, we showed that TST treatment significantly ameliorated colitis in the DSS-induced and T-cell transfer models. Specifically, TST targeted the retinoic acid-related orphan nuclear receptor RORγt to reduce the production of IL-17A by γδ T cells, type 3 innate lymphoid cells (ILC3s) and Th17 cells in mice with DSS-induced colitis. Similarly, TST selectively prevented the development of Th17 cells in the T-cell transfer colitis model and the differentiation of naïve CD4

    Topics: Animals; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Dysbiosis; Immunity, Innate; Inflammation; Interleukin-17; Lymphocytes; Mice; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group F, Member 3; Thiostrepton; Ubiquitination

2023