thiosemicarbazide and Stomach-Ulcer

thiosemicarbazide has been researched along with Stomach-Ulcer* in 1 studies

Other Studies

1 other study(ies) available for thiosemicarbazide and Stomach-Ulcer

Article	Year
Design, synthesis and pharmacological evaluation of novel azole derivatives of aryl acetic acid as anti-inflammatory and analgesic agents. Journal of enzyme inhibition and medicinal chemistry, 2011, Volume: 26, Issue:1 A series of substituted azole derivatives (3a-e, 4a-e and 5a-e) were synthesised by the cyclisation of N(1)(diphenylethanoyl)-N(4)-substituted phenyl thiosemicarbazides under various reaction conditions. These compounds were tested in vivo for their anti-inflammatory activity. The compounds which showed activity comparable to the standard drug ibuprofen, were screened for their analgesic, ulcerogenic and lipid peroxidation activities. The compounds 5-(diphenylmethyl)-N-(4-fluorophenyl)-1,3,4-oxadiazol-2-amine (3b) and 5-(diphenylmethyl)-N-(3-chloro-4-fluorophenyl)-1,3,4-oxadiazol-2-amine (3c) emerged as the most active compounds of the series, and were moderately more potent than the standard drug, ibuprofen. (This abstract was published in Inflammation Research, Supplement 2, Volume 56, page A101, 2008.). Topics: Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Drug Design; Gastric Mucosa; Ibuprofen; Inflammation; Lipid Peroxidation; Mice; Models, Animal; Oxadiazoles; Pyrazoles; Rats; Rats, Wistar; Semicarbazides; Severity of Illness Index; Stomach Ulcer	2011

Article

Year

Design, synthesis and pharmacological evaluation of novel azole derivatives of aryl acetic acid as anti-inflammatory and analgesic agents.

Journal of enzyme inhibition and medicinal chemistry, 2011, Volume: 26, Issue:1

A series of substituted azole derivatives (3a-e, 4a-e and 5a-e) were synthesised by the cyclisation of N(1)(diphenylethanoyl)-N(4)-substituted phenyl thiosemicarbazides under various reaction conditions. These compounds were tested in vivo for their anti-inflammatory activity. The compounds which showed activity comparable to the standard drug ibuprofen, were screened for their analgesic, ulcerogenic and lipid peroxidation activities. The compounds 5-(diphenylmethyl)-N-(4-fluorophenyl)-1,3,4-oxadiazol-2-amine (3b) and 5-(diphenylmethyl)-N-(3-chloro-4-fluorophenyl)-1,3,4-oxadiazol-2-amine (3c) emerged as the most active compounds of the series, and were moderately more potent than the standard drug, ibuprofen. (This abstract was published in Inflammation Research, Supplement 2, Volume 56, page A101, 2008.).

Topics: Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Drug Design; Gastric Mucosa; Ibuprofen; Inflammation; Lipid Peroxidation; Mice; Models, Animal; Oxadiazoles; Pyrazoles; Rats; Rats, Wistar; Semicarbazides; Severity of Illness Index; Stomach Ulcer

2011