thiorphan has been researched along with Muscle Contraction in 46 studies
Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "), shifted the dose-response relationships to the right for each of the antidepressant agents (dothiepin, amitriptyline, sibutramine, (+)-oxaprotiline and paroxetine)." | 1.30 | The involvement of the opioidergic system in the antinociceptive mechanism of action of antidepressant compounds. ( Gray, AM; Sewell, RD; Spencer, PS, 1998) |
| "Phosphoramidon tended to increase the potency and delayed the termination of post-tetanic twitch inhibition." | 1.29 | Effect of some peptidase inhibitors on exogenous and endogenous opioid actions in guinea-pig ileum. ( Kishioka, S; Masuda, Y; Miyamoto, Y; Ozaki, M; Yamamoto, H, 1994) |
| "Bradykinin pretreatment reduced the resiniferatoxin response by about 50%; resiniferatoxin pretreatment completely abolished the response to bradykinin." | 1.28 | Effect of resiniferatoxin on the isolated rabbit iris sphincter muscle: comparison with capsaicin and bradykinin. ( Håkanson, R; Wang, ZY, 1992) |
| "3." | 1.28 | Multiple mechanisms in the motor responses of the guinea-pig isolated urinary bladder to bradykinin. ( Cecconi, R; Geppetti, P; Giuliani, S; Maggi, CA; Meli, A; Patacchini, R; Santicioli, P, 1989) |
| " Leucine-thiorphan shifted, in concentration-dependent fashions, the dose-response curves to all tachykinins to lower concentrations." | 1.27 | Enkephalinase inhibitor potentiates mammalian tachykinin-induced contraction in ferret trachea. ( Basbaum, CB; Borson, DB; Graf, PD; Nadel, JA; Sekizawa, K; Tamaoki, J, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (39.13) | 18.7374 |
| 1990's | 25 (54.35) | 18.2507 |
| 2000's | 3 (6.52) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Godoy, MA | 1 |
| de Oliveira, AM | 1 |
| Rattan, S | 1 |
| Chaillet, P | 1 |
| Coulaud, A | 1 |
| Zajac, JM | 1 |
| Fournie-Zaluski, MC | 1 |
| Costentin, J | 1 |
| Roques, BP | 1 |
| Geary, LE | 1 |
| Wiley, KS | 1 |
| Scott, WL | 1 |
| Cohen, ML | 1 |
| Amano, H | 1 |
| Morimoto, Y | 1 |
| Kaneko, S | 1 |
| Takagi, H | 1 |
| Coburn, RF | 1 |
| Mitchell, H | 1 |
| Dey, RD | 1 |
| Alkon, J | 1 |
| Da Silva, A | 2 |
| Bertrand, C | 2 |
| Landry, Y | 2 |
| Maggi, CA | 8 |
| Giuliani, S | 3 |
| Hancock, DL | 1 |
| Coupar, IM | 2 |
| Battistini, B | 1 |
| Brown, M | 1 |
| Vane, JR | 1 |
| Farmer, SG | 1 |
| Broom, T | 1 |
| DeSiato, MA | 1 |
| Trapani, AJ | 1 |
| Balwierczak, JL | 1 |
| Lappe, RW | 1 |
| Stanton, JL | 1 |
| Graybill, SC | 1 |
| Hopkins, MF | 1 |
| Savage, P | 1 |
| Sperbeck, DM | 1 |
| Jeng, AY | 1 |
| Ozaki, M | 1 |
| Miyamoto, Y | 1 |
| Kishioka, S | 1 |
| Masuda, Y | 1 |
| Yamamoto, H | 1 |
| Kohrogi, H | 1 |
| Yamaguchi, T | 1 |
| Kawano, O | 1 |
| Honda, I | 1 |
| Ando, M | 1 |
| Cibulsky, SM | 1 |
| Thompson, DC | 1 |
| Vatter, H | 1 |
| Schilling, L | 1 |
| Schmiedek, P | 1 |
| Ehrenreich, H | 1 |
| Gray, AM | 1 |
| Spencer, PS | 1 |
| Sewell, RD | 1 |
| Kerr, KP | 1 |
| Thai, B | 1 |
| Craib, SJ | 1 |
| Ellington, HC | 1 |
| Pertwee, RG | 1 |
| Ross, RA | 1 |
| Dhuy, J | 1 |
| Waeldelé, F | 1 |
| Wang, ZY | 1 |
| Håkanson, R | 1 |
| Di Maria, GU | 1 |
| Katayama, M | 1 |
| Borson, DB | 6 |
| Nadel, JA | 6 |
| Anderson, JA | 1 |
| Malfroy, B | 1 |
| Richard, NR | 1 |
| Kullerstrand, L | 1 |
| Lucas, C | 1 |
| Binder, PS | 1 |
| Frossard, N | 1 |
| Barnes, J | 1 |
| Takubo, T | 1 |
| Banks, K | 1 |
| Martin, JG | 1 |
| Smits, GJ | 1 |
| Lefebvre, RA | 1 |
| Candenas, ML | 1 |
| Naline, E | 1 |
| Puybasset, L | 1 |
| Devillier, P | 1 |
| Advenier, C | 1 |
| Horii, S | 2 |
| Tamaoki, J | 4 |
| Kanemura, T | 2 |
| Yamawaki, I | 1 |
| Takizawa, T | 2 |
| Sakai, N | 1 |
| Kobayashi, K | 1 |
| Isono, K | 1 |
| Takeuchi, S | 1 |
| Patacchini, R | 6 |
| Santicioli, P | 5 |
| Giachetti, A | 2 |
| Meli, A | 7 |
| Astolfi, M | 1 |
| Tramontana, M | 1 |
| Leoncini, G | 1 |
| Geppetti, P | 2 |
| Undem, BJ | 1 |
| Myers, AC | 1 |
| Barthlow, H | 1 |
| Weinreich, D | 1 |
| Stimler-Gerard, NP | 1 |
| Sekizawa, K | 4 |
| Graf, PD | 3 |
| Basbaum, CB | 1 |
| Djokic, TD | 2 |
| Dusser, DJ | 2 |
| Renzi, D | 1 |
| Regoli, D | 2 |
| Rovero, P | 4 |
| Drapeau, G | 2 |
| Surrenti, C | 1 |
| Cecconi, R | 1 |
| Turini, D | 1 |
| Barbanti, G | 1 |
| Beneforti, P | 1 |
| Aoki, K | 1 |
| Kajiwara, M | 1 |
| Oka, T | 1 |
| Buéno, L | 1 |
| Fioramonti, J | 1 |
| Jacoby, DB | 1 |
| van Amsterdam, JG | 1 |
| van Buuren, KJ | 1 |
| Krielaart, MJ | 1 |
| Zuiderveld, OP | 1 |
| Tijms, RP | 1 |
| Anadón, A | 1 |
| Martinez-Larrañaga, MR | 1 |
2 reviews available for thiorphan and Muscle Contraction
| Article | Year |
|---|---|
Release of tachykinins and its metabolism in the airway.
Topics: Animals; Anti-Bacterial Agents; Bronchi; Glycopeptides; Guinea Pigs; Humans; In Vitro Techniques; Le | 1993 |
Enkephalins, other endogenous opioids and colonic motility in dog and man.
Topics: Animals; Central Nervous System; Colon; Dogs; Endorphins; Enkephalins; Gastrointestinal Motility; Hu | 1987 |
44 other studies available for thiorphan and Muscle Contraction
| Article | Year |
|---|---|
Angiotensin II-induced relaxation of anococcygeus smooth muscle via desensitization of AT1 receptor, and activation of AT2 receptor associated with nitric-oxide synthase pathway.
Topics: Adenine; Angiotensin II; Animals; Blotting, Western; CD13 Antigens; Drug Interactions; Glutamyl Amin | 2004 |
The mu rather than the delta subtype of opioid receptors appears to be involved in enkephalin-induced analgesia.
Topics: Analgesics; Animals; Enkephalin, Leucine; Enkephalins; Guinea Pigs; In Vitro Techniques; Leucine; Ma | 1984 |
Degradation of exogenous enkephalin in the guinea-pig ileum: relative importance of aminopeptidase, enkephalinase and angiotensin converting enzyme activity.
Topics: Aminopeptidases; Angiotensin I; Animals; Bradykinin; Endopeptidases; Endorphins; Enkephalin, Leucine | 1982 |
Opioid activity of enkephalin analogues containing the kyotorphin-related structure in the N-terminus.
Topics: Analgesics; Animals; Brain; Cell Membrane; Endorphins; Enkephalins; Guinea Pigs; Ileum; In Vitro Tec | 1984 |
Capsaicin-sensitive stretch responses in ferret trachealis muscle.
Topics: Animals; Capsaicin; Female; Ferrets; In Vitro Techniques; Membrane Potentials; Muscle Contraction; M | 1994 |
Epithelium modulates the kinetics of the response to substance P and its intrinsic activity in the guinea-pig trachea.
Topics: Animals; Carbachol; Epithelium; Guinea Pigs; Histamine; In Vitro Techniques; Kinetics; Male; Muscle | 1994 |
A thiorphan-sensitive mechanism regulates the action of both exogenous and endogenous calcitonin gene-related peptide (CGRP) in the guinea-pig ureter.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1994 |
Evidence for peptidase activity in the rat intestine.
Topics: Amino Acid Sequence; Animals; Drug Tolerance; Enkephalin, Methionine; Female; In Vitro Techniques; I | 1995 |
Selective proteolitic activation and degradation of ETs and big ETs in parenchymal strips of the guinea-pig lung.
Topics: Animals; Captopril; Endopeptidases; Endothelin-1; Endothelins; Glycopeptides; Guinea Pigs; Humans; I | 1995 |
Effects of bradykinin receptor agonists, and captopril and thiorphan in ferret isolated trachea: evidence for bradykinin generation in vitro.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Captopril; Ferrets; In Vitro Techniques; Male; | 1994 |
Effects of metalloprotease inhibitors on the conversion of proendothelin-1 to endothelin-1.
Topics: Animals; Aspartic Acid Endopeptidases; Benzazepines; Blood Pressure; Coronary Vessels; Dose-Response | 1993 |
Effect of some peptidase inhibitors on exogenous and endogenous opioid actions in guinea-pig ileum.
Topics: Aminopeptidases; Animals; Bacitracin; Captopril; Dose-Response Relationship, Drug; Electric Stimulat | 1994 |
Absence of tachykinin involvement in leukotriene D4 and antigen-induced contraction of guinea pig isolated bronchus.
Topics: Animals; Antigens; Bronchi; Guinea Pigs; In Vitro Techniques; Leukotriene D4; Lisinopril; Male; Musc | 1997 |
Evidence for functional endothelin-converting enzyme activity in isolated rat basilar artery: effect of inhibitors.
Topics: Animals; Aspartic Acid Endopeptidases; Basilar Artery; Endothelin-Converting Enzymes; Glycopeptides; | 1998 |
The involvement of the opioidergic system in the antinociceptive mechanism of action of antidepressant compounds.
Topics: Abdominal Muscles; Acetic Acid; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Cyclobuta | 1998 |
Tachykinin-induced contraction of the guinea-pig isolated oesophageal mucosa is mediated by NK(2) receptors.
Topics: Animals; Benzamides; Captopril; Dose-Response Relationship, Drug; Esophagus; Guinea Pigs; In Vitro T | 2000 |
A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acids; Bronchi; Calcium Channel Blockers; Caps | 2001 |
Endopeptidase 24.15 modulates bradykinin-induced contraction in guinea-pig trachea.
Topics: Amino Acid Sequence; Animals; Bradykinin; Dose-Response Relationship, Drug; Guinea Pigs; Male; Metal | 1992 |
Effect of resiniferatoxin on the isolated rabbit iris sphincter muscle: comparison with capsaicin and bradykinin.
Topics: Animals; Bradykinin; Capsaicin; Captopril; Diterpenes; Electric Stimulation; Female; Iris; Male; Mus | 1992 |
Neutral endopeptidase modulates endothelin-1-induced airway smooth muscle contraction in guinea-pig trachea.
Topics: Animals; Drug Interactions; Endothelins; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; | 1992 |
Substance P contracts the human iris sphincter: possible modulation by endogenous enkephalinase.
Topics: Aged; Aged, 80 and over; Carbachol; Female; Humans; Immunoenzyme Techniques; In Vitro Techniques; Ir | 1990 |
Effect of tachykinins in small human airways.
Topics: Bronchi; Bronchoconstriction; Carbachol; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Sm | 1991 |
Epithelium modulates the potency of vasoactive intestinal peptide in the guinea pig.
Topics: Animals; Electric Stimulation; Epithelium; Female; Glycopeptides; Guinea Pigs; In Vitro Techniques; | 1991 |
Influence of thiorphan and phosphoramidon on the relaxant effect of vasoactive intestinal polypeptide and non-adrenergic non-cholinergic neurone stimulation in the rat gastric fundus.
Topics: Animals; Electric Stimulation; Female; Gallbladder; Gastric Fundus; Glycopeptides; Guinea Pigs; Male | 1991 |
Effect of atrial natriuretic peptide and on atriopeptins on the human isolated bronchus. Comparison with the reactivity of the guinea-pig isolated trachea.
Topics: Amino Acid Sequence; Animals; Atrial Natriuretic Factor; Bronchi; Drug Synergism; Epithelium; Guinea | 1991 |
Effects of beta-endorphin and dynorphin A on cholinergic neurotransmission in canine airway smooth muscle.
Topics: Animals; beta-Endorphin; Bronchi; Captopril; Dogs; Dynorphins; Electric Stimulation; In Vitro Techni | 1990 |
Calcitonin gene-related peptide augments parasympathetic contraction of rabbit tracheal smooth muscle in vitro.
Topics: Acetylcholine; Animals; Atropine; Calcitonin Gene-Related Peptide; Electric Stimulation; Muscle Cont | 1990 |
Further studies on the response of the guinea-pig isolated bronchus to endothelins and sarafotoxin S6b.
Topics: Animals; Aorta, Thoracic; Bronchi; Captopril; Endothelins; Epithelium; Guinea Pigs; In Vitro Techniq | 1990 |
Effect of thiorphan on the response of guinea-pig isolated urinary bladder to exogenous and endogenous tachykinins.
Topics: Animals; Drug Synergism; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth; Neprilysin; Tachykin | 1990 |
Vagal innervation of guinea pig bronchial smooth muscle.
Topics: Animals; Bronchi; Electric Stimulation; Electrophysiology; Ganglia, Parasympathetic; Guinea Pigs; In | 1990 |
Neutral endopeptidase-like enzyme controls the contractile activity of substance P in guinea pig lung.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Complement C3; Complement C3a; Complem | 1987 |
Enkephalinase inhibitor potentiates mammalian tachykinin-induced contraction in ferret trachea.
Topics: Animals; Atropine; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Epitheliu | 1987 |
Neutral endopeptidase inhibitors potentiate substance P-induced contraction in gut smooth muscle.
Topics: Animals; Drug Synergism; Duodenum; Endopeptidases; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanin | 1989 |
Inhibitors of neutral endopeptidase potentiate electrically and capsaicin-induced noncholinergic contraction in guinea pig bronchi.
Topics: Animals; Bronchi; Capsaicin; Electric Stimulation; Glycopeptides; Guinea Pigs; In Vitro Techniques; | 1989 |
Effect of thiorphan on response of the guinea-pig gallbladder to tachykinins.
Topics: Animals; Captopril; Gallbladder; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, | 1989 |
The hamster isolated trachea: a new preparation for studying NK-2 receptors.
Topics: Animals; Atropine; Cricetinae; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, | 1989 |
Multiple mechanisms in the motor responses of the guinea-pig isolated urinary bladder to bradykinin.
Topics: Animals; Apamin; Bradykinin; Calcitonin Gene-Related Peptide; Capsaicin; Dibenz(b,f)(1,4)oxazepine-1 | 1989 |
Further studies on the motor response of the human isolated urinary bladder to tachykinins, capsaicin and electrical field stimulation.
Topics: Adult; Aged; Autonomic Nervous System; Calcitonin Gene-Related Peptide; Capsaicin; Dimethylphenylpip | 1989 |
Effect of thiorphan on tachykinin-induced potentiation of nerve-mediated contractions of the rat isolated vas deferens.
Topics: Animals; In Vitro Techniques; Male; Muscle Contraction; Rats; Rats, Inbred Strains; Receptors, Neuro | 1989 |
The inactivation of [Met5]-enkephalin by bestatin-sensitive aminopeptidase, captopril-sensitive peptidyl dipeptidase A and thiorphan-sensitive endopeptidase-24.11 in mouse vas deferens.
Topics: Amino Acids, Sulfur; Aminopeptidases; Animals; Captopril; Dipeptides; Dose-Response Relationship, Dr | 1986 |
Influenza infection causes airway hyperresponsiveness by decreasing enkephalinase.
Topics: Animals; Captopril; Disease Models, Animal; Ferrets; In Vitro Techniques; Influenza A virus; Leucine | 1988 |
Effect of inhibitors of enkephalin degradation in the isolated guinea-pig ileum.
Topics: Animals; Buffers; Dipeptides; Enkephalin, Methionine; Guinea Pigs; Ileum; In Vitro Techniques; Leuci | 1988 |
Neutral endopeptidase and angiotensin converting enzyme inhibitors potentiate kinin-induced contraction of ferret trachea.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Dose-Response Relationship, Drug; Drug | 1988 |
An inhibitory action of tetracyclines on guinea-pig myenteric plexus.
Topics: Animals; Captopril; Drug Interactions; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Leuci | 1987 |