thiorphan has been researched along with Leukemia in 2 studies
Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "NALM-1 cells (a cell line derived from human pre-B leukemia) were exposed to the opioid pentapeptide methionine-enkephalin (Met-enkephalin) and/or to thiorphan, an inhibitor of the enzyme that degrades the enkephalins (membrane endopeptidase EC 3." | 3.72 | Methionine enkephalin suppresses metabolic activity of a leukemic cell line (NALM-1) and enhances CD10 expression. ( Boranić, M; Gabrilovac, J; Kusec, R; Martin-Kleiner, I, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Martin-Kleiner, I | 1 |
| Gabrilovac, J | 1 |
| Kusec, R | 1 |
| Boranić, M | 2 |
| Stanović, S | 1 |
| Petrovecki, M | 1 |
| Batinić, D | 1 |
| Skodlar, J | 1 |
| Nemet, D | 1 |
| Labar, B | 1 |
2 other studies available for thiorphan and Leukemia
| Article | Year |
|---|---|
Methionine enkephalin suppresses metabolic activity of a leukemic cell line (NALM-1) and enhances CD10 expression.
Topics: Cell Line, Tumor; DNA, Complementary; Enkephalin, Methionine; Humans; Leukemia; Neprilysin; Protease | 2003 |
Thiorphan, an inhibitor of neutral endopeptidase/enkephalinase (CD10/CALLA) enhances cell proliferation in bone marrow cultures of patients with acute leukemia in remission.
Topics: Acute Disease; Anemia, Refractory, with Excess of Blasts; Angiotensin-Converting Enzyme Inhibitors; | 2000 |