thiorphan has been researched along with Leucocythaemia in 2 studies
Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "NALM-1 cells (a cell line derived from human pre-B leukemia) were exposed to the opioid pentapeptide methionine-enkephalin (Met-enkephalin) and/or to thiorphan, an inhibitor of the enzyme that degrades the enkephalins (membrane endopeptidase EC 3." | 3.72 | Methionine enkephalin suppresses metabolic activity of a leukemic cell line (NALM-1) and enhances CD10 expression. ( Boranić, M; Gabrilovac, J; Kusec, R; Martin-Kleiner, I, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Martin-Kleiner, I | 1 |
| Gabrilovac, J | 1 |
| Kusec, R | 1 |
| Boranić, M | 2 |
| Stanović, S | 1 |
| Petrovecki, M | 1 |
| Batinić, D | 1 |
| Skodlar, J | 1 |
| Nemet, D | 1 |
| Labar, B | 1 |
2 other studies available for thiorphan and Leucocythaemia
| Article | Year |
|---|---|
Methionine enkephalin suppresses metabolic activity of a leukemic cell line (NALM-1) and enhances CD10 expression.
Topics: Cell Line, Tumor; DNA, Complementary; Enkephalin, Methionine; Humans; Leukemia; Neprilysin; Protease | 2003 |
Thiorphan, an inhibitor of neutral endopeptidase/enkephalinase (CD10/CALLA) enhances cell proliferation in bone marrow cultures of patients with acute leukemia in remission.
Topics: Acute Disease; Anemia, Refractory, with Excess of Blasts; Angiotensin-Converting Enzyme Inhibitors; | 2000 |