thiorphan has been researched along with Innate Inflammatory Response in 8 studies
Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Renoprotective potential of thiorphan (NEPi)/telmisartan (ARB) and thiorphan/Dize (ACE2 activator) combination therapies against the development of DN is primarily attributed to normalisation of RAS and NPS components and inhibition of pathological signalling related to inflammation, fibrosis, and apoptosis." | 3.91 | Concurrent neprilysin inhibition and renin-angiotensin system modulations prevented diabetic nephropathy. ( Gaikwad, AB; Malek, V; Sankrityayan, H; Sharma, N, 2019) |
| " In rats with hindpaw inflammation, inhibitors of aminopeptidase N (APN; bestatin) or neutral endopeptidase (NEP; thiorphan), and a dual inhibitor, NH(2)-CH-Ph-P(O)(OH)CH(2)-CH-CH(2)Ph(p-Ph)-CONH-CH-CH(3)-COOH (P8B), were applied to injured paws." | 3.78 | Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue. ( Fournie-Zaluski, MC; Gore, C; Labuz, D; Machelska, H; Roques, BP; Schreiter, A; Stein, C, 2012) |
| " Adjuvant arthritis was induced in rats by intradermal inoculation of mycobacterium butyricum and the effects of intraventricular met-enk+thiorphan (enkephalinase inhibitor) were studied." | 3.70 | Intracerebroventricular met-enkephalin administration modulates adjuvant arthritis. ( Adem, A; Elhassan, AM; Gad, A; Lindgren, JU; Papadogiannakis, N; Suliman, I, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Malek, V | 1 |
| Sharma, N | 1 |
| Sankrityayan, H | 1 |
| Gaikwad, AB | 1 |
| Schreiter, A | 1 |
| Gore, C | 1 |
| Labuz, D | 1 |
| Fournie-Zaluski, MC | 1 |
| Roques, BP | 1 |
| Stein, C | 1 |
| Machelska, H | 1 |
| Elhassan, AM | 1 |
| Papadogiannakis, N | 1 |
| Adem, A | 1 |
| Suliman, I | 1 |
| Gad, A | 1 |
| Lindgren, JU | 1 |
| Yong, T | 1 |
| Gao, XP | 1 |
| Koizumi, S | 1 |
| Conlon, JM | 1 |
| Rennard, SI | 1 |
| Mayhan, WG | 1 |
| Rubinstein, I | 1 |
| Norris, AA | 1 |
| Leeson, ME | 1 |
| Jackson, DM | 1 |
| Holroyde, MC | 1 |
| Parsons, CG | 1 |
| Herz, A | 1 |
8 other studies available for thiorphan and Innate Inflammatory Response
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Concurrent neprilysin inhibition and renin-angiotensin system modulations prevented diabetic nephropathy.
Topics: Angiotensin-Converting Enzyme 2; Animals; Apoptosis; Diabetes Mellitus, Experimental; Diabetic Nephr | 2019 |
[Just Checking].
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; CD13 Antigens; Endorphins; Hum | 2013 |
Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue.
Topics: Alanine; Amino Acid Sequence; Animals; Antibodies; CD13 Antigens; Dose-Response Relationship, Drug; | 2012 |
Intracerebroventricular met-enkephalin administration modulates adjuvant arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cerebral Ventricles; Dise | 2000 |
Role of peptidases in bradykinin-induced increase in vascular permeability in vivo.
Topics: Animals; Bradykinin; Capillary Permeability; Captopril; Cheek; Cricetinae; Glycopeptides; Inflammati | 1992 |
Modulation of neurogenic inflammation in rat trachea.
Topics: Albuterol; Animals; Cromolyn Sodium; Dexamethasone; Electric Stimulation; Inflammation; Male; Methys | 1990 |
Peripheral opioid receptors mediating antinociception in inflammation. Evidence for activation by enkephalin-like opioid peptides after cold water swim stress.
Topics: Analgesia; Animals; Dioxolanes; Dipeptides; Enkephalins; Inflammation; Leucine; Male; Naloxone; Nalt | 1990 |