thiorphan has been researched along with Heart Failure in 19 studies
Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Heart failure was induced by rapid ventricular pacing in conscious dogs." | 5.30 | Kinin-mediated coronary nitric oxide production contributes to the therapeutic action of angiotensin-converting enzyme and neutral endopeptidase inhibitors and amlodipine in the treatment in heart failure. ( Bernstein, R; Hintze, TH; Nasjletti, A; Recchia, FA; Xu, X; Zhang, X, 1999) |
| "Thiorphan was coinfused with Lys-des-Arg9-bradykinin (1 to 10 nmol/min), bradykinin (30 to 300 pmol/min), atrial natriuretic peptide (10 to 100 pmol/min), and sodium nitroprusside (2 to 8 mug/min)." | 2.71 | Neutral endopeptidase inhibition augments vascular actions of bradykinin in patients treated with angiotensin-converting enzyme inhibition. ( Cruden, NL; Fox, KA; Johnston, NR; Ludlam, CA; Newby, DE, 2004) |
| "No increases in deaths, serious adverse events, or dropouts from adverse events were observed for the ecadotril group compared with placebo." | 2.69 | A randomized trial of ecadotril versus placebo in patients with mild to moderate heart failure: the U.S. ecadotril pilot safety study. ( Burnett, JC; Cody, RJ; Elkayam, U; Gattis, WA; Gheorghiade, M; Gilbert, J; Goldstein, S; Granger, CB; Kasper, EK; Katz, SD; Massie, BM; McKenney, JM; Messineo, FC; O'Connor, CM, 1999) |
| "Heart failure was induced by repeated coronary embolization with latex microspheres." | 1.31 | Short-term effects of ecadotril in dogs with induced congestive heart failure. ( Beals, S; Hanson, B; Kutas, SM; Olivier, NB; Windram, S, 2000) |
| " There was no evidence of an effect accumulated over time, and reversibility of toxic effects was evident." | 1.31 | Acute, subchronic, and chronic toxicity of ecadotril in dogs. ( Goetze, L; Maertins, T; von Keutz, E, 2000) |
| "Heart failure was induced by rapid ventricular pacing in conscious dogs." | 1.30 | Kinin-mediated coronary nitric oxide production contributes to the therapeutic action of angiotensin-converting enzyme and neutral endopeptidase inhibitors and amlodipine in the treatment in heart failure. ( Bernstein, R; Hintze, TH; Nasjletti, A; Recchia, FA; Xu, X; Zhang, X, 1999) |
| "Treatment with thiorphan (10 mg/kg i." | 1.28 | Effect of endopeptidase 24.11 inhibition in conscious cardiomyopathic hamsters. ( Blaine, EB; McGraw, DE; Smits, GJ; Trapani, AJ, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (63.16) | 18.2507 |
| 2000's | 7 (36.84) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mishima, T | 1 |
| Tanimura, M | 1 |
| Suzuki, G | 1 |
| Todor, A | 1 |
| Sharov, VG | 1 |
| Tanhehco, EJ | 1 |
| Goldstein, S | 2 |
| Sabbah, HN | 1 |
| Berezin, AE | 1 |
| Cruden, NL | 1 |
| Fox, KA | 1 |
| Ludlam, CA | 1 |
| Johnston, NR | 1 |
| Newby, DE | 1 |
| Stasch, JP | 2 |
| Knorr, A | 1 |
| Wegner, M | 2 |
| Hirth-Dietrich, C | 2 |
| Wilkins, MR | 2 |
| Cleland, JG | 1 |
| Swedberg, K | 1 |
| Zhang, X | 1 |
| Recchia, FA | 1 |
| Bernstein, R | 1 |
| Xu, X | 1 |
| Nasjletti, A | 1 |
| Hintze, TH | 1 |
| O'Connor, CM | 1 |
| Gattis, WA | 1 |
| Gheorghiade, M | 1 |
| Granger, CB | 1 |
| Gilbert, J | 1 |
| McKenney, JM | 1 |
| Messineo, FC | 1 |
| Burnett, JC | 1 |
| Katz, SD | 1 |
| Elkayam, U | 1 |
| Kasper, EK | 1 |
| Cody, RJ | 1 |
| Massie, BM | 1 |
| Olivier, NB | 1 |
| Kutas, SM | 1 |
| Beals, S | 1 |
| Hanson, B | 1 |
| Windram, S | 1 |
| Maertins, T | 1 |
| von Keutz, E | 1 |
| Goetze, L | 2 |
| Solter, P | 1 |
| Sisson, D | 1 |
| Thomas, W | 1 |
| Petrie, MC | 1 |
| Hillier, C | 1 |
| Johnston, F | 1 |
| McMurray, JJ | 1 |
| Varin, J | 1 |
| Duboc, D | 2 |
| Weber, S | 1 |
| Fouchard, J | 1 |
| Schwartz, JC | 2 |
| Muffat-Joly, M | 1 |
| Guérin, F | 1 |
| Hirata, Y | 1 |
| Kahn, JC | 1 |
| Patey, M | 1 |
| Dubois-Rande, JL | 1 |
| Merlet, P | 1 |
| Castaigne, A | 1 |
| Lim-Alexandre, C | 1 |
| Lecomte, JM | 1 |
| Gros, C | 1 |
| Smits, GJ | 1 |
| McGraw, DE | 1 |
| Trapani, AJ | 1 |
| Blaine, EB | 1 |
| Settle, SL | 1 |
| Stockmann, PT | 1 |
| Needleman, P | 1 |
3 reviews available for thiorphan and Heart Failure
| Article | Year |
|---|---|
[The new class of drugs-- metalloprotease inhibitors -- in the treatment of heart failure].
Topics: Glycopeptides; Heart Failure; Hemodynamics; Humans; Indans; Metalloproteases; Propionates; Protease | 2004 |
Clinical potential of endopeptidase-24.11 inhibitors in cardiovascular disease.
Topics: Animals; Antihypertensive Agents; Cardiovascular Diseases; Cyclohexanecarboxylic Acids; Diuretics; D | 1993 |
[Effect of sinorphan, an endopeptidase inhibitor on severe congestive cardiac insufficiency].
Topics: Adult; Aged; Atrial Natriuretic Factor; Blood Pressure; Creatinine; Cyclic GMP; Diuresis; Female; He | 1991 |
5 trials available for thiorphan and Heart Failure
| Article | Year |
|---|---|
Neutral endopeptidase inhibition augments vascular actions of bradykinin in patients treated with angiotensin-converting enzyme inhibition.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Atrial Natriuretic Factor; Bradykinin; Cross-Over St | 2004 |
Lack of efficacy of neutral endopeptidase inhibitor ecadotril in heart failure. The International Ecadotril Multi-centre Dose-ranging Study Investigators.
Topics: Anemia, Aplastic; Dose-Response Relationship, Drug; Female; Heart Failure; Humans; Male; Middle Aged | 1998 |
A randomized trial of ecadotril versus placebo in patients with mild to moderate heart failure: the U.S. ecadotril pilot safety study.
Topics: Adolescent; Adult; Aged; Double-Blind Method; Female; Heart Failure; Humans; Male; Middle Aged; Pilo | 1999 |
[Effect of sinorphan, an endopeptidase inhibitor on severe congestive cardiac insufficiency].
Topics: Adult; Aged; Atrial Natriuretic Factor; Blood Pressure; Creatinine; Cyclic GMP; Diuresis; Female; He | 1991 |
Effect of sinorphan on plasma atrial natriuretic factor in congestive heart failure.
Topics: Administration, Oral; Atrial Natriuretic Factor; Clinical Trials as Topic; Drug Administration Sched | 1990 |
12 other studies available for thiorphan and Heart Failure
| Article | Year |
|---|---|
Effects of chronic neutral endopeptidase inhibition on the progression of left ventricular dysfunction and remodeling in dogs with moderate heart failure.
Topics: Animals; Chronic Disease; Coronary Angiography; Dogs; Heart Failure; Hemodynamics; Myocytes, Cardiac | 2002 |
Prolonged inhibition of neutral endopeptidase 24.11 by sinorphan in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Body Weight; Heart Failure; Hemodynamics; Kidney | 1995 |
Role of neutral endopeptidase 24.11 in AV fistular rat model of heart failure.
Topics: Angiotensin I; Animals; Aorta; Arteriovenous Fistula; Atrial Natriuretic Factor; Disease Models, Ani | 1996 |
Kinin-mediated coronary nitric oxide production contributes to the therapeutic action of angiotensin-converting enzyme and neutral endopeptidase inhibitors and amlodipine in the treatment in heart failure.
Topics: Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin Receptor Antagonists; Coro | 1999 |
Ecadotril. (S)-acetorphan, sinorphan.
Topics: Animals; Cardiovascular Diseases; Drugs, Investigational; Endopeptidases; Heart Failure; Humans; Hyp | 1999 |
Short-term effects of ecadotril in dogs with induced congestive heart failure.
Topics: Animals; Cyclic GMP; Dog Diseases; Dogs; Electrocardiography; Heart Failure; Hemodynamics; Male; Mic | 2000 |
Acute, subchronic, and chronic toxicity of ecadotril in dogs.
Topics: Animals; Dog Diseases; Dogs; Drug Administration Schedule; Heart Failure; Neprilysin; Prodrugs; Prot | 2000 |
Intrarenal effects of ecadotril during acute volume expansion in dogs with congestive heart failure.
Topics: Animals; Atrial Natriuretic Factor; Dogs; Glomerular Filtration Rate; Heart Failure; Kidney; Male; N | 2000 |
Effect of neutral endopeptidase inhibition on the actions of adrenomedullin and endothelin-1 in resistance arteries from patients with chronic heart failure.
Topics: Adrenomedullin; Antihypertensive Agents; Arteries; Chronic Disease; Dose-Response Relationship, Drug | 2001 |
[Clinical significance and therapeutic application of atrial natriuretic peptides].
Topics: Animals; Atrial Natriuretic Factor; Glycopeptides; Heart Atria; Heart Failure; Hemodynamics; Humans; | 1991 |
Effect of endopeptidase 24.11 inhibition in conscious cardiomyopathic hamsters.
Topics: Animals; Atrial Natriuretic Factor; Cardiomyopathies; Cricetinae; Heart Failure; Male; Neprilysin; S | 1990 |
Maximizing the natriuretic effect of endogenous atriopeptin in a rat model of heart failure.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Antibodies, Monoclonal; Atrial Natriuretic Factor; Blo | 1990 |