thiorphan has been researched along with Drug Withdrawal Symptoms in 12 studies
Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Similarly, chronic dosing with acetorphan after withdrawal produced no significant effect on body weight." | 1.27 | Amelioration of naloxone-precipitated opioid withdrawal symptoms by peripheral administration of the enkephalinase inhibitor acetorphan. ( Livingston, SJ; Rooney, KF; Sewell, RD; Smith, HJ, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (58.33) | 18.7374 |
| 1990's | 5 (41.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bean, AJ | 1 |
| Vaught, JL | 1 |
| Bourin, M | 1 |
| Malinge, M | 1 |
| Colombel, MC | 1 |
| Vasar, E | 1 |
| Dzoljic, MR | 5 |
| Bokszanska, A | 1 |
| Korenhof, AM | 1 |
| Kaplan, CD | 1 |
| Dzoljic, M | 1 |
| Rupreht, J | 2 |
| Zijlstra, FJ | 1 |
| Brinkman, EC | 1 |
| Cappendijk, SL | 1 |
| Maldonado, R | 2 |
| Fournié-Zaluski, MC | 2 |
| Roques, BP | 2 |
| Ukponmwan, OE | 1 |
| Baas, AA | 1 |
| van den Berg, DJ | 1 |
| Dzoljic, MM | 1 |
| Hartmann, F | 1 |
| Poirier, MF | 1 |
| Bourdel, MC | 1 |
| Loo, H | 1 |
| Lecomte, JM | 1 |
| Schwartz, JC | 1 |
| Knisely, JS | 1 |
| Beardsley, PM | 1 |
| Aceto, MD | 1 |
| Balster, RL | 1 |
| Harris, LS | 1 |
| Daugé, V | 1 |
| Callebert, J | 1 |
| Villette, JM | 1 |
| Feger, J | 1 |
| Haffmans, J | 2 |
| Walsum, MV | 1 |
| van Amsterdam, JC | 1 |
| Livingston, SJ | 1 |
| Sewell, RD | 1 |
| Rooney, KF | 1 |
| Smith, HJ | 1 |
1 trial available for thiorphan and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Comparison of acetorphan with clonidine for opiate withdrawal symptoms.
Topics: Adolescent; Adult; Clonidine; Double-Blind Method; Female; Heroin; Humans; Male; Narcotics; Neprilys | 1991 |
11 other studies available for thiorphan and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Physical dependence produced by chronic intracerebroventricular infusion of [D-Arg]kyotorphin or thiorphan to rats.
Topics: Amino Acids, Sulfur; Analgesics; Animals; Cerebral Ventricles; Endorphins; Humans; Male; Morphine; N | 1984 |
Cholecystokinin receptor agonists block the jumping behaviour precipitated in morphine-dependent mice by naloxone.
Topics: Animals; Ceruletide; Devazepide; Dose-Response Relationship, Drug; Hormone Antagonists; Male; Mice; | 1999 |
The effects of orally active enkephalinase inhibitors on morphine withdrawal syndrome.
Topics: Administration, Oral; Analgesics; Animals; Dioxolanes; Dipeptides; Dose-Response Relationship, Drug; | 1992 |
Attenuation of the morphine withdrawal syndrome by inhibition of catabolism of endogenous enkephalins in the periaqueductal gray matter.
Topics: Analgesics; Animals; Behavior, Animal; Body Temperature; Body Weight; Corticosterone; Dipeptides; En | 1992 |
Suppressive effects of enkephalins and REM sleep deprivation on seizures.
Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Electroencephalography; Electroshock; En | 1991 |
Assessment of the abuse potential of acetorphan, an enkephalinase inhibitor.
Topics: Animals; Cocaine; Discrimination, Psychological; Female; Macaca mulatta; Male; Morphine Dependence; | 1989 |
Comparison of selective and complete inhibitors of enkephalin-degrading enzymes on morphine withdrawal syndrome.
Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Corticosterone; Dipeptides; Hydroxamic Aci | 1989 |
Phelorphan, an inhibitor of enzymes involved in the biodegradation of enkephalins, affected the withdrawal symptoms in chronic morphine-dependent rats.
Topics: Aminopeptidases; Animals; Brain; CD13 Antigens; Dipeptides; Dipeptidyl-Peptidases and Tripeptidyl-Pe | 1987 |
Enkephalinase inhibitors attenuate naloxone-precipitated withdrawal syndrome.
Topics: Amino Acids, Sulfur; Animals; Cerebral Ventricles; Cerebrospinal Fluid; Dipeptides; Glycopeptides; M | 1986 |
Amelioration of naloxone-precipitated opioid withdrawal symptoms by peripheral administration of the enkephalinase inhibitor acetorphan.
Topics: Amino Acids, Sulfur; Analgesics; Animals; Body Temperature; Body Weight; Male; Metalloendopeptidases | 1988 |
Inhibition of enkephalinase activity attenuates naloxone-precipitated withdrawal symptoms.
Topics: Amino Acids, Sulfur; Animals; Behavior, Animal; Endopeptidases; Injections; Injections, Intraventric | 1987 |