thiorphan has been researched along with Disease Models, Animal in 18 studies
Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Adjuvant arthritis was induced in rats by intradermal inoculation of mycobacterium butyricum and the effects of intraventricular met-enk+thiorphan (enkephalinase inhibitor) were studied." | 3.70 | Intracerebroventricular met-enkephalin administration modulates adjuvant arthritis. ( Adem, A; Elhassan, AM; Gad, A; Lindgren, JU; Papadogiannakis, N; Suliman, I, 2000) |
| "A central question in Alzheimer's disease (AD) research is what role β-amyloid peptide (Aβ) plays in synaptic dysfunction." | 1.37 | Impaired β-amyloid secretion in Alzheimer's disease pathogenesis. ( Capetillo-Zarate, E; Gouras, GK; Lin, MT; Rahman, N; Tampellini, D, 2011) |
| "However, cardiac hypertrophy itself poses a serious risk to patients with heart failure." | 1.30 | Effect of ecadotril, a neutral endopeptidase inhibitor, on myocardial hypertrophy in the rat aortic insufficiency model. ( Kimura, M; Nakashima, M; Ohashi, K; Umemura, K, 1998) |
| " Airway hyperresponsiveness was evidenced by significant shifts to the left of dose-response curves for intravenous acetylcholine (ACh) without a change in maximum responses to ACh." | 1.29 | The tachykinin NK2 receptor antagonist SR 48968 inhibits citric acid-induced airway hyperresponsiveness in guinea pigs. ( Advenier, C; Emonds-Alt, X; Girard, V; Yavo, JC, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.56) | 18.7374 |
| 1990's | 7 (38.89) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 2 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Baliga, RS | 1 |
| Zhao, L | 1 |
| Madhani, M | 1 |
| Lopez-Torondel, B | 1 |
| Visintin, C | 1 |
| Selwood, D | 1 |
| Wilkins, MR | 2 |
| MacAllister, RJ | 1 |
| Hobbs, AJ | 1 |
| Wu, Y | 1 |
| Min, F | 1 |
| Li, Z | 1 |
| Huang, J | 1 |
| Huang, R | 1 |
| Miners, JS | 1 |
| Barua, N | 1 |
| Kehoe, PG | 1 |
| Gill, S | 1 |
| Love, S | 1 |
| Tampellini, D | 1 |
| Rahman, N | 1 |
| Lin, MT | 1 |
| Capetillo-Zarate, E | 1 |
| Gouras, GK | 1 |
| Burssens, P | 1 |
| Steyaert, A | 1 |
| Forsyth, R | 1 |
| van Ovost, EJ | 1 |
| Depaepe, Y | 1 |
| De Paepe, Y | 1 |
| Verdonk, R | 1 |
| Shalova, IN | 1 |
| Cechalova, K | 1 |
| Rehakova, Z | 1 |
| Dimitrova, P | 1 |
| Ognibene, E | 1 |
| Caprioli, A | 1 |
| Schmalhausen, EV | 1 |
| Muronetz, VI | 1 |
| Saso, L | 1 |
| Maeshiro, K | 1 |
| Takamori, S | 1 |
| Mifune, H | 1 |
| Matsuo, T | 1 |
| Kimura, NY | 1 |
| Honda, J | 1 |
| Shirouzu, K | 1 |
| Rónai, AZ | 1 |
| Fehér, E | 1 |
| Botyánszki, J | 1 |
| Hepp, J | 1 |
| Magyar, A | 1 |
| Medzihradszky, K | 1 |
| Girard, V | 1 |
| Yavo, JC | 1 |
| Emonds-Alt, X | 1 |
| Advenier, C | 1 |
| Wegner, M | 2 |
| Hirth-Dietrich, C | 1 |
| Stasch, JP | 2 |
| Ganten, D | 1 |
| Kimura, M | 1 |
| Umemura, K | 1 |
| Ohashi, K | 1 |
| Nakashima, M | 1 |
| Elhassan, AM | 1 |
| Papadogiannakis, N | 1 |
| Adem, A | 1 |
| Suliman, I | 1 |
| Gad, A | 1 |
| Lindgren, JU | 1 |
| Anderson, JA | 1 |
| Hernandez, E | 1 |
| Duzman, E | 1 |
| Malfroy, B | 1 |
| Settle, SL | 1 |
| Stockmann, PT | 1 |
| Needleman, P | 1 |
| Jacoby, DB | 1 |
| Tamaoki, J | 1 |
| Borson, DB | 1 |
| Nadel, JA | 1 |
1 review available for thiorphan and Disease Models, Animal
| Article | Year |
|---|---|
Aβ-degrading enzymes: potential for treatment of Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Genetic Therapy; Glycopep | 2011 |
17 other studies available for thiorphan and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Synergy between natriuretic peptides and phosphodiesterase 5 inhibitors ameliorates pulmonary arterial hypertension.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Atrial Natriuretic Factor; Disease Models, Animal; Dru | 2008 |
A nonhuman primate model of Alzheimer's disease generated by intracranial injection of amyloid-β42 and thiorphan.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Craniotomy; Disease Models, Animal; Infusion Pump | 2010 |
Impaired β-amyloid secretion in Alzheimer's disease pathogenesis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Calcium-Calmoduli | 2011 |
Exogenously administered substance P and neutral endopeptidase inhibitors stimulate fibroblast proliferation, angiogenesis and collagen organization during Achilles tendon healing.
Topics: Achilles Tendon; Animals; Captopril; Cell Proliferation; Collagen; Disease Models, Animal; Drug Comb | 2005 |
Decrease of dehydrogenase activity of cerebral glyceraldehyde-3-phosphate dehydrogenase in different animal models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Enzyme Inhibitors; Glycer | 2007 |
Changes in A-type natriuretic peptide and its receptors induced by a neutral endopeptidase inhibitor in a rat model of sepsis.
Topics: Animals; Atrial Natriuretic Factor; Disease Models, Animal; Lung; Male; Protease Inhibitors; Rats; R | 2008 |
Substrate- and inhibitor-specificity of a non-endothelial enzyme which forms [Met5]-enkephalin from [Met5]-enkephalin-Arg6,Phe7 in isolated rabbit ear artery: pharmacological characterization.
Topics: Amino Acid Sequence; Angiotensin I; Animals; Arteries; Bradykinin; Captopril; Disease Models, Animal | 1995 |
The tachykinin NK2 receptor antagonist SR 48968 inhibits citric acid-induced airway hyperresponsiveness in guinea pigs.
Topics: Acetylcholine; Aerosols; Animals; Benzamides; Bronchial Hyperreactivity; Bronchoconstriction; Capsai | 1996 |
Role of neutral endopeptidase 24.11 in AV fistular rat model of heart failure.
Topics: Angiotensin I; Animals; Aorta; Arteriovenous Fistula; Atrial Natriuretic Factor; Disease Models, Ani | 1996 |
Neutral endopeptidase inhibition potentiates the effects of natriuretic peptides in renin transgenic rats.
Topics: Animals; Animals, Genetically Modified; Atrial Natriuretic Factor; Blood Pressure; Cyclic GMP; Disea | 1996 |
Effect of ecadotril, a neutral endopeptidase inhibitor, on myocardial hypertrophy in the rat aortic insufficiency model.
Topics: Angiotensin II; Animals; Aortic Diseases; Blood Pressure; Cardiomegaly; Disease Models, Animal; Guan | 1998 |
Intracerebroventricular met-enkephalin administration modulates adjuvant arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cerebral Ventricles; Dise | 2000 |
Recombinant enkephalinase effectively inhibits substance P-induced miosis in the rabbit eye cup model.
Topics: Animals; Atropine; Disease Models, Animal; Female; Humans; Iris; Miosis; Neprilysin; Rabbits; Recomb | 1990 |
Maximizing the natriuretic effect of endogenous atriopeptin in a rat model of heart failure.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Antibodies, Monoclonal; Atrial Natriuretic Factor; Blo | 1990 |
Influenza infection causes airway hyperresponsiveness by decreasing enkephalinase.
Topics: Animals; Captopril; Disease Models, Animal; Ferrets; In Vitro Techniques; Influenza A virus; Leucine | 1988 |