Page last updated: 2024-10-26

thiorphan and Diarrhea

thiorphan has been researched along with Diarrhea in 49 studies

Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.

Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.

Research Excerpts

ExcerptRelevanceReference
"Treatment with racecadotril did not reduce diarrheal duration, stool volume or the requirement for fluid replacement in children with acute gastroenteritis, both with and without rotavirus infection."9.22Racecadotril in the Management of Rotavirus and Non-rotavirus Diarrhea in Under-five Children: Two Randomized, Double-blind, Placebo-controlled Trials. ( Anbu, D; Bose, A; Kang, G; Parez, N; Sarkar, R; Sindhu, K; Srinivasan, R; Subashini, B; Svensson, L; Thuppal, SV; Venugopal, S, 2016)
" The study included 189 patients, ages 3 to 36 months, with acute gastroenteritis: 94 were administered an oral rehydration solution (OR), 94 received oral rehydration solution plus racecadotril (OR + R)."9.14Use of racecadotril as outpatient treatment for acute gastroenteritis: a prospective, randomized, parallel study. ( Marañón, R; Miguez, C; Sánchez, C; Santos, M; Vázquez, P, 2009)
"Our aim was to compare the efficacy and tolerability of loperamide and racecadotril in elderly patients with acute diarrhea."9.14Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes. ( Colosimo, M; Cucchiara, S; Curto, LS; De Sarro, G; Falcone, D; Gallelli, L; Luberto, L; Marigliano, NM; Mazzei, F; Rende, P; Tolotta, GA, 2010)
" Loperamide is an effective anti-diarrheal agent, but it usually induces constipation."9.11A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults. ( Liao, KF; Shieh, MJ; Wang, HH, 2005)
"This study demonstrates the efficacy (up to 50% reduction in stool output) and tolerability of racecadotril as adjuvant therapy to oral rehydration solution in the treatment of severe diarrhea in infants and children."9.09Efficacy and tolerability of racecadotril in acute diarrhea in children. ( Audrain, S; Bellaiche, M; Cézard, JP; Duhamel, JF; Ginies, JL; Girardet, JP; Lamireau, T; Lecomte, JM; Maurage, C; Meyer, M; Morali, A; Olives, JP; Pharaon, I; Poujol, A; Sarles, J; Vaillant, JM; Whately-Smith, C, 2001)
"In young boys with acute watery diarrhea, racecadotril is an effective and safe treatment."9.09Racecadotril in the treatment of acute watery diarrhea in children. ( Chea-Woo, E; Gutierrez, M; Salazar-Lindo, E; Santisteban-Ponce, J, 2000)
"Irinotecan (CPT-11), a camptothecin derivative, has shown efficacy against colorectal cancer."9.08Pathophysiology and therapy of irinotecan-induced delayed-onset diarrhea in patients with advanced colorectal cancer: a prospective assessment. ( Bastian, G; Bonnay, M; Cote, C; Cvitkovic, E; Hagipantelli, R; Herait, P; Mahjoubi, M; Mignard, D; Misset, JL; Saliba, F; Vassal, G, 1998)
"Racecadotril is a guideline-recommended option for the treatment of acute diarrhea in children but existing guidelines and previous reviews of the field are based on a small fraction of published evidence."8.98Racecadotril in the treatment of acute diarrhea in children: a systematic, comprehensive review and meta-analysis of randomized controlled trials. ( Chen, M; Däbritz, J; Eberlin, M; Mueck, T, 2018)
"To assess racecadotril efficacy as an adjunct to oral rehydration solution, against oral rehydration solution alone or with placebo in childhood acute gastroenteritis."8.87Racecadotril for childhood gastroenteritis: an individual patient data meta-analysis. ( Calatayud, GA; Castrellón, PG; Cézard, JP; Chéron, G; Garcia, JM; Lehert, P; Santos, M; Savitha, MR, 2011)
"Racecadotril is an enkephalinase inhibitor, presented as a purely antisecretory agent with advantages over the opiate-receptor agonist loperamide in the treatment of diarrhea."8.82Racecadotril versus loperamide: antidiarrheal research revisited. ( Awouters, F; Huighebaert, S; Tytgat, GN, 2003)
"Racecadotril has been shown to reduce the stools output during acute diarrhoea."6.70[Effect of racecadotril in the management of acute diarrhea in infants and children]. ( Bocquet, N; Boursiquot, C; Chéron, G; Cojocaru, B; Garel, D; Marcombes, F; Sannier, N; Timsit, S; Wille, C, 2002)
"In patients with AIDS, it is a more common problem than for other entities (e."6.49[Treatment of diarrhea with loperamide in palliative medicine. A systematic review]. ( Meißner, W; Pastrana, T, 2013)
"Treatment with racecadotril did not reduce diarrheal duration, stool volume or the requirement for fluid replacement in children with acute gastroenteritis, both with and without rotavirus infection."5.22Racecadotril in the Management of Rotavirus and Non-rotavirus Diarrhea in Under-five Children: Two Randomized, Double-blind, Placebo-controlled Trials. ( Anbu, D; Bose, A; Kang, G; Parez, N; Sarkar, R; Sindhu, K; Srinivasan, R; Subashini, B; Svensson, L; Thuppal, SV; Venugopal, S, 2016)
"To assess the efficacy of single dose of octreotide and compare it with another antisecretory agent racecadotril in the management of acute infective diarrhea."5.16A comparative study of racecadotril and single dose octreotide as an anti-secretory agent in acute infective diarrhoea. ( Jain, VK; Khandelwal, PD; Mehta, S; Sihag, M, 2012)
"Our aim was to compare the efficacy and tolerability of loperamide and racecadotril in elderly patients with acute diarrhea."5.14Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes. ( Colosimo, M; Cucchiara, S; Curto, LS; De Sarro, G; Falcone, D; Gallelli, L; Luberto, L; Marigliano, NM; Mazzei, F; Rende, P; Tolotta, GA, 2010)
" The study included 189 patients, ages 3 to 36 months, with acute gastroenteritis: 94 were administered an oral rehydration solution (OR), 94 received oral rehydration solution plus racecadotril (OR + R)."5.14Use of racecadotril as outpatient treatment for acute gastroenteritis: a prospective, randomized, parallel study. ( Marañón, R; Miguez, C; Sánchez, C; Santos, M; Vázquez, P, 2009)
" Loperamide is an effective anti-diarrheal agent, but it usually induces constipation."5.11A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults. ( Liao, KF; Shieh, MJ; Wang, HH, 2005)
"In young boys with acute watery diarrhea, racecadotril is an effective and safe treatment."5.09Racecadotril in the treatment of acute watery diarrhea in children. ( Chea-Woo, E; Gutierrez, M; Salazar-Lindo, E; Santisteban-Ponce, J, 2000)
"This study demonstrates the efficacy (up to 50% reduction in stool output) and tolerability of racecadotril as adjuvant therapy to oral rehydration solution in the treatment of severe diarrhea in infants and children."5.09Efficacy and tolerability of racecadotril in acute diarrhea in children. ( Audrain, S; Bellaiche, M; Cézard, JP; Duhamel, JF; Ginies, JL; Girardet, JP; Lamireau, T; Lecomte, JM; Maurage, C; Meyer, M; Morali, A; Olives, JP; Pharaon, I; Poujol, A; Sarles, J; Vaillant, JM; Whately-Smith, C, 2001)
"Irinotecan (CPT-11), a camptothecin derivative, has shown efficacy against colorectal cancer."5.08Pathophysiology and therapy of irinotecan-induced delayed-onset diarrhea in patients with advanced colorectal cancer: a prospective assessment. ( Bastian, G; Bonnay, M; Cote, C; Cvitkovic, E; Hagipantelli, R; Herait, P; Mahjoubi, M; Mignard, D; Misset, JL; Saliba, F; Vassal, G, 1998)
"Racecadotril is a guideline-recommended option for the treatment of acute diarrhea in children but existing guidelines and previous reviews of the field are based on a small fraction of published evidence."4.98Racecadotril in the treatment of acute diarrhea in children: a systematic, comprehensive review and meta-analysis of randomized controlled trials. ( Chen, M; Däbritz, J; Eberlin, M; Mueck, T, 2018)
"Racecadotril has sufficient proven efficacy in the treatment of acute diarrhea in children."4.89[The treatment of acute diarrhea]. ( Leemans, L, 2013)
"To assess racecadotril efficacy as an adjunct to oral rehydration solution, against oral rehydration solution alone or with placebo in childhood acute gastroenteritis."4.87Racecadotril for childhood gastroenteritis: an individual patient data meta-analysis. ( Calatayud, GA; Castrellón, PG; Cézard, JP; Chéron, G; Garcia, JM; Lehert, P; Santos, M; Savitha, MR, 2011)
"The small number of included trials provided some evidence in favour of the use of racecadotril over placebo or no intervention, to reduce the stool output and duration of diarrhoea in children with acute gastroenteritis."4.84Systematic review: racecadotril in the treatment of acute diarrhoea in children. ( Chmielewska, A; Ruszczyński, M; Szajewska, H; Wieczorek, J, 2007)
"Racecadotril is an enkephalinase inhibitor, presented as a purely antisecretory agent with advantages over the opiate-receptor agonist loperamide in the treatment of diarrhea."4.82Racecadotril versus loperamide: antidiarrheal research revisited. ( Awouters, F; Huighebaert, S; Tytgat, GN, 2003)
"For the treatment of acute uncomplicated traveler's diarrhea - more than 90 % of all cases - the secretion inhibitor racecadotril is considered first choice, based on our evaluation criteria."3.85[Consensus paper treatment of acute traveler's diarrhea. Practice recommendation for travel advice]. ( Haditsch, M; Jelinek, T; Nothdurft, HD; Weinke, T, 2017)
"Racecadotril (acetorphan) is a neutral endopeptidase (NEP) inhibitor with known antidiarrheal activity in animals and humans; however, in humans, it suffers from shortcomings that might be improved with newer drugs in this class that have progressed to the clinic for nonenteric disease indications."3.83Pharmacologic Comparison of Clinical Neutral Endopeptidase Inhibitors in a Rat Model of Acute Secretory Diarrhea. ( Arnett, SD; Bond, BR; Campbell, MA; Choy, RK; de Hostos, E; Griggs, DW; Ji, Y; Meyers, MJ; Neckermann, G; Oliva, J; Prinsen, MJ; Ruminski, PG; Tajfirouz, D; Yu, Y, 2016)
"Racecadotril (acetorphan) is an orally active, potent inhibitor of enkephalinase, which exerts an antihypersecretory effect without increasing intestinal transit time."2.70A multinational comparison of racecadotril and loperamide in the treatment of acute watery diarrhoea in adults. ( Prado, D, 2002)
"Racecadotril has been shown to reduce the stools output during acute diarrhoea."2.70[Effect of racecadotril in the management of acute diarrhea in infants and children]. ( Bocquet, N; Boursiquot, C; Chéron, G; Cojocaru, B; Garel, D; Marcombes, F; Sannier, N; Timsit, S; Wille, C, 2002)
"Racecadotril and placebo were equally well tolerated, and the frequency of symptoms and signs was similar in both groups after 4 days of treatment."2.69Racecadotril versus placebo in the treatment of acute diarrhoea in adults. ( Baumer, P; Ben Khalifa, H; Berard, H; Hamza, H; Lecomte, JM, 1999)
"Racecadotril is an anti-secretory drug that has been used for acute diarrhoea in children as an adjunct to oral rehydration therapy."2.61Racecadotril for acute diarrhoea in children. ( Gordon, M; Liang, Y; Wen, J; Zeng, L; Zhang, L, 2019)
"Racecadotril is an antisecretory agent that can prevent fluid/electrolyte depletion from the bowel as a result of acute diarrhoea without affecting intestinal motility."2.53Racecadotril for acute diarrhoea in children: systematic review and meta-analyses. ( Akobeng, A; Gordon, M, 2016)
"In patients with AIDS, it is a more common problem than for other entities (e."2.49[Treatment of diarrhea with loperamide in palliative medicine. A systematic review]. ( Meißner, W; Pastrana, T, 2013)
"Chronic diarrhea is a frequent and challenging problem in clinical medicine."2.48Functional diarrhea. ( Tack, J, 2012)
"Racecadotril is an antisecretory drug recommended as an adjuvant antidiarrhoeal treatment."1.56Drugs in Focus: The Use of Racecadotril in Paediatric Gastrointestinal Disease. ( Benninga, MA; Broekaert, IJ; Dolinsek, J; Mas, E; Miele, E; Orel, R; Pienar, C; Ribes-Koninckx, C; Thapar, N; Thomassen, RA; Thomson, M; Tzivinikos, C, 2020)
"Nitazoxanide has high efficacy against Cryptosporodial diarrhea only."1.33Current status of anti-diarrheal and anti-secretory drugs in the management of acute childhood diarrhea. ( Alam, S; Bhatnagar, S, 2006)

Research

Studies (49)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.04)18.7374
1990's9 (18.37)18.2507
2000's17 (34.69)29.6817
2010's20 (40.82)24.3611
2020's2 (4.08)2.80

Authors

AuthorsStudies
Tras, B1
Ok, M1
Parlak, TM1
Ider, M1
Yildiz, R1
Eser Faki, H1
Ozdemir Kutahya, Z1
Uney, K1
Liang, Y1
Zhang, L1
Zeng, L1
Gordon, M2
Wen, J1
Pienar, C1
Benninga, MA1
Broekaert, IJ1
Dolinsek, J1
Mas, E1
Miele, E1
Orel, R1
Ribes-Koninckx, C1
Thomassen, RA1
Thomson, M1
Tzivinikos, C1
Thapar, N1
Bui, T1
Li, G1
Kim, I1
Wen, K1
Twitchell, EL1
Hualei, S1
Ramesh, AK1
Weiss, MD1
Yang, X1
Glark-Deener, SG1
Choy, RK2
Yuan, L1
Eberlin, M1
Chen, M1
Mueck, T1
Däbritz, J1
Pastrana, T1
Meißner, W1
Mehta, S1
Khandelwal, PD1
Jain, VK1
Sihag, M1
Leemans, L1
Heather, CS1
Akobeng, A1
Sáez, J2
Cifuentes, L2
Griggs, DW1
Prinsen, MJ1
Oliva, J1
Campbell, MA1
Arnett, SD1
Tajfirouz, D1
Ruminski, PG1
Yu, Y1
Bond, BR1
Ji, Y1
Neckermann, G1
de Hostos, E1
Meyers, MJ1
Kang, G1
Thuppal, SV1
Srinivasan, R1
Sarkar, R1
Subashini, B1
Venugopal, S1
Sindhu, K1
Anbu, D1
Parez, N1
Svensson, L1
Bose, A1
Tran, LC1
Lazonby, G1
Ellis, D1
Goldthorpe, J1
Iglesias, N1
Steele, J1
Zamvar, V1
Puntis, JW1
Vora, R1
Jelinek, T1
Nothdurft, HD1
Haditsch, M1
Weinke, T1
Guarino, A1
Buccigrossi, V1
Armellino, C1
Santos, M2
Marañón, R1
Miguez, C1
Vázquez, P1
Sánchez, C1
Gallelli, L1
Colosimo, M1
Tolotta, GA1
Falcone, D1
Luberto, L1
Curto, LS1
Rende, P1
Mazzei, F1
Marigliano, NM1
De Sarro, G1
Cucchiara, S1
Lehert, P1
Chéron, G2
Calatayud, GA1
Cézard, JP3
Castrellón, PG1
Garcia, JM1
Savitha, MR1
Cuello García, CA1
Pacheco Alvarado, KP1
Pérez Gaxiola, G1
López-Campos, JL1
Gutiérrez, C1
Calero, C1
Tack, J1
Duh, D1
Tanret, I1
Prado, D1
Cojocaru, B1
Bocquet, N1
Timsit, S1
Wille, C1
Boursiquot, C1
Marcombes, F1
Garel, D1
Sannier, N1
Huighebaert, S1
Awouters, F1
Tytgat, GN1
Rao, SG1
Bhan, MK1
Bhatnagar, S2
Wang, HH1
Shieh, MJ1
Liao, KF1
Salazar-Lindo, E3
Alam, S1
Szajewska, H1
Ruszczyński, M1
Chmielewska, A1
Wieczorek, J1
Tormo, R1
Polanco, I1
Goulet, O1
Gonçalves, E1
de Costa, L1
Abigerges, D1
Armand, JP1
Dorval, ED1
Regimbeau, C1
Gamelin, E1
Picon, L1
Bérard, H5
Roge, J1
Baumer, P3
Schwartz, JC4
Lecomte, JM8
Saliba, F1
Hagipantelli, R1
Misset, JL1
Bastian, G1
Vassal, G1
Bonnay, M1
Herait, P2
Cote, C1
Mahjoubi, M1
Mignard, D2
Cvitkovic, E1
Farthing, MJ1
Vetel, JM2
Fretault, N2
Hamza, H1
Ben Khalifa, H1
Turck, D1
Santisteban-Ponce, J1
Chea-Woo, E1
Gutierrez, M1
Freyer, G1
Rougier, P1
Bugat, R1
Droz, JP1
Marty, M1
Bleiberg, H1
Awad, L1
Culine, S1
Trillet-Lenoir, V1
Duhamel, JF1
Meyer, M1
Pharaon, I1
Bellaiche, M1
Maurage, C1
Ginies, JL1
Vaillant, JM1
Girardet, JP1
Lamireau, T1
Poujol, A1
Morali, A1
Sarles, J1
Olives, JP1
Whately-Smith, C1
Audrain, S1
Danquechin Dorval, E1
Bertrand, J1
Marçais-Collado, H1
Uchida, G1
Costentin, J1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Different Grading Systems to Grade Evidence and Recommendations in Clinical Practice Guidelines: Does it Influence the Clinicians´ Behavior?[NCT00940290]216 participants (Actual)Interventional2009-08-31Completed
Efficacy, Safety and Cost-effectiveness Analysis of Impact of Racecadotril as an Adjunct in the Treatment of Acute Diarrhea in Mexican Children[NCT01153854]Phase 3454 participants (Actual)Interventional2007-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Behavior in Physicians Attitude Towards a Decision to Give a Medication

"A fictitious clinical case of a child with acute diarrhea was presented. The physician read the case and then answered the question would you recommend racecadotril to this patient? A zero to 10 visual-analog scale and a Likert scale were used to measure the decision of the physician related to the clinical case presented (from zero=definitely no to 10=definitely yes). Mean differences before-after and among groups were measured on the 10 centimeters scale." (NCT00940290)
Timeframe: One day

InterventionMean change in centimeters (Mean)
GRADE System2.18
SIGN Grading System0.31
NICE Grading System0.04
CEBM-Oxford0.08

Reviews

15 reviews available for thiorphan and Diarrhea

ArticleYear
Racecadotril for acute diarrhoea in children.
    The Cochrane database of systematic reviews, 2019, 12-19, Volume: 12

    Topics: Child, Preschool; Diarrhea; Fluid Therapy; Humans; Infant; Length of Stay; Randomized Controlled Tri

2019
Racecadotril in the treatment of acute diarrhea in children: a systematic, comprehensive review and meta-analysis of randomized controlled trials.
    BMC pediatrics, 2018, 04-03, Volume: 18, Issue:1

    Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Humans; Randomized Controlled Trials as Topic; Thior

2018
[Treatment of diarrhea with loperamide in palliative medicine. A systematic review].
    Schmerz (Berlin, Germany), 2013, Volume: 27, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Antidiarrheals; Controlled Clinical Trials as Topic; Diarrhea; D

2013
What place for ▾racecadotril?
    Drug and therapeutics bulletin, 2013, Volume: 51, Issue:5

    Topics: Antidiarrheals; Diarrhea; Humans; Neprilysin; Practice Guidelines as Topic; Randomized Controlled Tr

2013
[The treatment of acute diarrhea].
    Journal de pharmacie de Belgique, 2013, Issue:3

    Topics: Adult; Anti-Bacterial Agents; Antidiarrheals; Child; Diarrhea; Fluid Therapy; Humans; Loperamide; Pr

2013
Travellers' diarrhoea.
    BMJ clinical evidence, 2015, Apr-30, Volume: 2015

    Topics: Anti-Bacterial Agents; Antidiarrheals; Bismuth; Diarrhea; Diet; Fluid Therapy; Humans; Organometalli

2015
Racecadotril for acute diarrhoea in children: systematic review and meta-analyses.
    Archives of disease in childhood, 2016, Volume: 101, Issue:3

    Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Humans; Thiorphan; Treatment Outcome

2016
Is racecadotril effective for acute diarrhea in children? -First update.
    Medwave, 2015, Dec-16, Volume: 15 Suppl 3

    Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Gastroenteritis; Humans; Randomized Controlled Trial

2015
Is racecadotril effective for acute diarrhea in children? -First update.
    Medwave, 2015, Dec-16, Volume: 15 Suppl 3

    Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Gastroenteritis; Humans; Randomized Controlled Trial

2015
Is racecadotril effective for acute diarrhea in children? -First update.
    Medwave, 2015, Dec-16, Volume: 15 Suppl 3

    Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Gastroenteritis; Humans; Randomized Controlled Trial

2015
Is racecadotril effective for acute diarrhea in children? -First update.
    Medwave, 2015, Dec-16, Volume: 15 Suppl 3

    Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Gastroenteritis; Humans; Randomized Controlled Trial

2015
Racecadotril for childhood gastroenteritis: an individual patient data meta-analysis.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2011, Volume: 43, Issue:9

    Topics: Adolescent; Adult; Antidiarrheals; Child; Combined Modality Therapy; Dehydration; Diarrhea; Feces; F

2011
Functional diarrhea.
    Gastroenterology clinics of North America, 2012, Volume: 41, Issue:3

    Topics: Antidepressive Agents, Tricyclic; Antidiarrheals; Bismuth; Carbon; Cholestyramine Resin; Chronic Dis

2012
Racecadotril versus loperamide: antidiarrheal research revisited.
    Digestive diseases and sciences, 2003, Volume: 48, Issue:2

    Topics: Adolescent; Adult; Antidiarrheals; Child; Child, Preschool; Controlled Clinical Trials as Topic; Dia

2003
Systematic review: racecadotril in the treatment of acute diarrhoea in children.
    Alimentary pharmacology & therapeutics, 2007, Sep-15, Volume: 26, Issue:6

    Topics: Acute Disease; Antidiarrheals; Child, Preschool; Diarrhea; Female; Gastroenteritis; Humans; Infant;

2007
Acute infectious diarrhoea in children: new insights in antisecretory treatment with racecadotril.
    Acta paediatrica (Oslo, Norway : 1992), 2008, Volume: 97, Issue:8

    Topics: Acute Disease; Antidiarrheals; Bacterial Infections; Breast Feeding; Child; Dehydration; Diarrhea; F

2008
Racecadotril: a new approach to the treatment of diarrhoea.
    International journal of antimicrobial agents, 2000, Volume: 14, Issue:1

    Topics: Animals; Antidiarrheals; Diarrhea; Dogs; Rats; Thiorphan

2000
An overview of clinical studies with racecadotril in adults.
    International journal of antimicrobial agents, 2000, Volume: 14, Issue:1

    Topics: Adult; Antidiarrheals; Diarrhea; Double-Blind Method; Humans; Randomized Controlled Trials as Topic;

2000

Trials

18 trials available for thiorphan and Diarrhea

ArticleYear
A comparative study of racecadotril and single dose octreotide as an anti-secretory agent in acute infective diarrhoea.
    The Journal of the Association of Physicians of India, 2012, Volume: 60

    Topics: Adolescent; Adult; Anti-Bacterial Agents; Antidiarrheals; Diarrhea; Drug Therapy, Combination; Dysen

2012
Racecadotril in the Management of Rotavirus and Non-rotavirus Diarrhea in Under-five Children: Two Randomized, Double-blind, Placebo-controlled Trials.
    Indian pediatrics, 2016, Jul-08, Volume: 53, Issue:7

    Topics: Antidiarrheals; Child, Preschool; Diarrhea; Female; Humans; Infant; Male; Rotavirus Infections; Thio

2016
Use of racecadotril as outpatient treatment for acute gastroenteritis: a prospective, randomized, parallel study.
    The Journal of pediatrics, 2009, Volume: 155, Issue:1

    Topics: Acute Disease; Ambulatory Care; Antidiarrheals; Dehydration; Diarrhea; Drug Therapy, Combination; Em

2009
Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes.
    European journal of clinical pharmacology, 2010, Volume: 66, Issue:2

    Topics: Abdominal Pain; Aged; Aged, 80 and over; Aging; Antidiarrheals; Cytochrome P-450 Enzyme System; Dehy

2010
Grading recommendations in clinical practice guidelines: randomised experimental evaluation of four different systems.
    Archives of disease in childhood, 2011, Volume: 96, Issue:8

    Topics: Adult; Antidiarrheals; Attitude of Health Personnel; Child; Decision Making; Diarrhea; Evidence-Base

2011
A multinational comparison of racecadotril and loperamide in the treatment of acute watery diarrhoea in adults.
    Scandinavian journal of gastroenterology, 2002, Volume: 37, Issue:6

    Topics: Acute Disease; Administration, Oral; Adult; Antidiarrheals; Diarrhea; Dose-Response Relationship, Dr

2002
[Effect of racecadotril in the management of acute diarrhea in infants and children].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2002, Volume: 9, Issue:8

    Topics: Acute Disease; Antidiarrheals; Child, Preschool; Dehydration; Diarrhea; Emergency Medical Services;

2002
A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults.
    World journal of gastroenterology, 2005, Mar-14, Volume: 11, Issue:10

    Topics: Acute Disease; Adult; Antidiarrheals; Constipation; Diarrhea; Female; Humans; Loperamide; Male; Midd

2005
[Treatment of acute chemically induced diarrhea by inhibition of enkephalinase. Results of a pilot study].
    Gastroenterologie clinique et biologique, 1995, Volume: 19, Issue:1

    Topics: Acute Disease; Adenocarcinoma; Adult; Aged; Colorectal Neoplasms; Combined Modality Therapy; Diarrhe

1995
The enkephalinase inhibitor, acetorphan, in acute diarrhoea. A double-blind, controlled clinical trial versus loperamide.
    Scandinavian journal of gastroenterology, 1993, Volume: 28, Issue:4

    Topics: Acute Disease; Adult; Diarrhea; Double-Blind Method; Female; Humans; Loperamide; Male; Neprilysin; T

1993
Pathophysiology and therapy of irinotecan-induced delayed-onset diarrhea in patients with advanced colorectal cancer: a prospective assessment.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:8

    Topics: Adult; Aged; Antidiarrheals; Antineoplastic Agents, Phytogenic; Camptothecin; Colorectal Neoplasms;

1998
Comparison of racecadotril and loperamide in adults with acute diarrhoea.
    Alimentary pharmacology & therapeutics, 1999, Volume: 13 Suppl 6

    Topics: Acute Disease; Adult; Diarrhea; Double-Blind Method; Female; Humans; Loperamide; Male; Neprilysin; P

1999
Racecadotril versus placebo in the treatment of acute diarrhoea in adults.
    Alimentary pharmacology & therapeutics, 1999, Volume: 13 Suppl 6

    Topics: Acute Disease; Adult; Antidiarrheals; Diarrhea; Double-Blind Method; Female; Humans; Male; Middle Ag

1999
Comparison of racecadotril and loperamide in children with acute diarrhoea.
    Alimentary pharmacology & therapeutics, 1999, Volume: 13 Suppl 6

    Topics: Acute Disease; Antidiarrheals; Child; Child, Preschool; Diarrhea; Double-Blind Method; Female; Human

1999
Racecadotril in the treatment of acute watery diarrhea in children.
    The New England journal of medicine, 2000, Aug-17, Volume: 343, Issue:7

    Topics: Acute Disease; Antidiarrheals; Child, Preschool; Combined Modality Therapy; Developing Countries; Di

2000
Prognostic factors for tumour response, progression-free survival and toxicity in metastatic colorectal cancer patients given irinotecan (CPT-11) as second-line chemotherapy after 5FU failure. CPT-11 F205, F220, F221 and V222 study groups.
    British journal of cancer, 2000, Volume: 83, Issue:4

    Topics: Adult; Aged; Antidiarrheals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Cam

2000
Efficacy and tolerability of racecadotril in acute diarrhea in children.
    Gastroenterology, 2001, Volume: 120, Issue:4

    Topics: Acute Disease; Antidiarrheals; Child, Preschool; Defecation; Diarrhea; Double-Blind Method; Female;

2001
Effects of acetorphan, an enkephalinase inhibitor, on experimental and acute diarrhoea.
    Gut, 1992, Volume: 33, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Castor Oil; Diarrhea; Double-Blind Method; Female; Human

1992

Other Studies

16 other studies available for thiorphan and Diarrhea

ArticleYear
Can diarrhea affect the pharmacokinetics of racecadotril in neonatal calves?
    Journal of veterinary pharmacology and therapeutics, 2022, Volume: 45, Issue:5

    Topics: Animals; Antidiarrheals; Cattle; Cattle Diseases; Cryptosporidiosis; Cryptosporidium; Diarrhea; Thio

2022
Drugs in Focus: The Use of Racecadotril in Paediatric Gastrointestinal Disease.
    Journal of pediatric gastroenterology and nutrition, 2020, Volume: 70, Issue:2

    Topics: Antidiarrheals; Child; Diarrhea; Gastrointestinal Diseases; Humans; Pharmaceutical Preparations; Thi

2020
Effects of Racecadotril on Weight Loss and Diarrhea Due to Human Rotavirus in Neonatal Gnotobiotic Pigs (
    Comparative medicine, 2017, Mar-01, Volume: 67, Issue:2

    Topics: Animals; Antidiarrheals; Diarrhea; Drug Evaluation, Preclinical; Rotavirus; Rotavirus Infections; Su

2017
Pharmacologic Comparison of Clinical Neutral Endopeptidase Inhibitors in a Rat Model of Acute Secretory Diarrhea.
    The Journal of pharmacology and experimental therapeutics, 2016, Volume: 357, Issue:2

    Topics: Animals; Antidiarrheals; Castor Oil; Charcoal; Diarrhea; Dose-Response Relationship, Drug; Endopepti

2016
Racecadotril May Reduce Diarrhoea in Microvillous Inclusion Disease.
    Journal of pediatric gastroenterology and nutrition, 2017, Volume: 64, Issue:1

    Topics: Antidiarrheals; Child, Preschool; Diarrhea; Humans; Malabsorption Syndromes; Male; Microvilli; Mucol

2017
[Consensus paper treatment of acute traveler's diarrhea. Practice recommendation for travel advice].
    MMW Fortschritte der Medizin, 2017, Volume: 159, Issue:Suppl 4

    Topics: Anti-Bacterial Agents; Antidiarrheals; Consensus; Diarrhea; Dysentery; Germany; Humans; Practice Gui

2017
Colon in acute intestinal infection.
    Journal of pediatric gastroenterology and nutrition, 2009, Volume: 48 Suppl 2

    Topics: Acute Disease; Antidiarrheals; Caco-2 Cells; Colon; Diarrhea; Drug Evaluation, Preclinical; Gastroen

2009
The potential role of racecadotril in the treatment of diarrhea associated with roflumilast.
    Archivos de bronconeumologia, 2012, Volume: 48, Issue:11

    Topics: Adrenergic beta-2 Receptor Agonists; Adult; Aminopyridines; Antidiarrheals; Benzamides; Child; Cycli

2012
[Racecadotril (Tiorfix), oral].
    Journal de pharmacie de Belgique, 2012, Issue:4

    Topics: Adult; Antidiarrheals; Child; Child, Preschool; Diarrhea; Drug Interactions; Humans; Infant; Infant,

2012
Racecadotril (acetorphan) in the treatment of acute watery diarrhoea in children.
    Journal of the Indian Medical Association, 2002, Volume: 100, Issue:8

    Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Fluid Therapy; Humans; Thiorphan

2002
Racecadotril-is there enough evidence to recommend it for treatment of acute diarrhea?
    Indian pediatrics, 2004, Volume: 41, Issue:12

    Topics: Antidiarrheals; Diarrhea; Humans; Thiorphan; Treatment Outcome

2004
Racecadotril in acute diarrhea.
    Indian pediatrics, 2005, Volume: 42, Issue:5

    Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Drug Evaluation; Female; Humans; Male; Research Desi

2005
Current status of anti-diarrheal and anti-secretory drugs in the management of acute childhood diarrhea.
    Indian journal of pediatrics, 2006, Volume: 73, Issue:8

    Topics: Acute Disease; Antidiarrheals; Antiparasitic Agents; Child; Child, Preschool; Cholera; Diarrhea; Dis

2006
A new enkephalinase inhibitor as an alternative to loperamide in the prevention of diarrhea induced by CPT-11.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:8

    Topics: Adult; Antineoplastic Agents, Phytogenic; Camptothecin; Clinical Trials as Topic; Diarrhea; Female;

1995
Introduction. Enkephalinase inhibition: a rational approach to antisecretory therapy for acute diarrhoea.
    Alimentary pharmacology & therapeutics, 1999, Volume: 13 Suppl 6

    Topics: Acute Disease; Antidiarrheals; Diarrhea; Humans; Neprilysin; Protease Inhibitors; Thiorphan

1999
Naloxone-reversible antidiarrheal effects of enkephalinase inhibitors.
    European journal of pharmacology, 1987, Dec-01, Volume: 144, Issue:2

    Topics: Amino Acids, Sulfur; Animals; Castor Oil; Diarrhea; Drug Interactions; Gastrointestinal Transit; Lop

1987