thiorphan has been researched along with Diarrhea in 49 studies
Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with racecadotril did not reduce diarrheal duration, stool volume or the requirement for fluid replacement in children with acute gastroenteritis, both with and without rotavirus infection." | 9.22 | Racecadotril in the Management of Rotavirus and Non-rotavirus Diarrhea in Under-five Children: Two Randomized, Double-blind, Placebo-controlled Trials. ( Anbu, D; Bose, A; Kang, G; Parez, N; Sarkar, R; Sindhu, K; Srinivasan, R; Subashini, B; Svensson, L; Thuppal, SV; Venugopal, S, 2016) |
| " The study included 189 patients, ages 3 to 36 months, with acute gastroenteritis: 94 were administered an oral rehydration solution (OR), 94 received oral rehydration solution plus racecadotril (OR + R)." | 9.14 | Use of racecadotril as outpatient treatment for acute gastroenteritis: a prospective, randomized, parallel study. ( Marañón, R; Miguez, C; Sánchez, C; Santos, M; Vázquez, P, 2009) |
| "Our aim was to compare the efficacy and tolerability of loperamide and racecadotril in elderly patients with acute diarrhea." | 9.14 | Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes. ( Colosimo, M; Cucchiara, S; Curto, LS; De Sarro, G; Falcone, D; Gallelli, L; Luberto, L; Marigliano, NM; Mazzei, F; Rende, P; Tolotta, GA, 2010) |
| " Loperamide is an effective anti-diarrheal agent, but it usually induces constipation." | 9.11 | A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults. ( Liao, KF; Shieh, MJ; Wang, HH, 2005) |
| "This study demonstrates the efficacy (up to 50% reduction in stool output) and tolerability of racecadotril as adjuvant therapy to oral rehydration solution in the treatment of severe diarrhea in infants and children." | 9.09 | Efficacy and tolerability of racecadotril in acute diarrhea in children. ( Audrain, S; Bellaiche, M; Cézard, JP; Duhamel, JF; Ginies, JL; Girardet, JP; Lamireau, T; Lecomte, JM; Maurage, C; Meyer, M; Morali, A; Olives, JP; Pharaon, I; Poujol, A; Sarles, J; Vaillant, JM; Whately-Smith, C, 2001) |
| "In young boys with acute watery diarrhea, racecadotril is an effective and safe treatment." | 9.09 | Racecadotril in the treatment of acute watery diarrhea in children. ( Chea-Woo, E; Gutierrez, M; Salazar-Lindo, E; Santisteban-Ponce, J, 2000) |
| "Irinotecan (CPT-11), a camptothecin derivative, has shown efficacy against colorectal cancer." | 9.08 | Pathophysiology and therapy of irinotecan-induced delayed-onset diarrhea in patients with advanced colorectal cancer: a prospective assessment. ( Bastian, G; Bonnay, M; Cote, C; Cvitkovic, E; Hagipantelli, R; Herait, P; Mahjoubi, M; Mignard, D; Misset, JL; Saliba, F; Vassal, G, 1998) |
| "Racecadotril is a guideline-recommended option for the treatment of acute diarrhea in children but existing guidelines and previous reviews of the field are based on a small fraction of published evidence." | 8.98 | Racecadotril in the treatment of acute diarrhea in children: a systematic, comprehensive review and meta-analysis of randomized controlled trials. ( Chen, M; Däbritz, J; Eberlin, M; Mueck, T, 2018) |
| "To assess racecadotril efficacy as an adjunct to oral rehydration solution, against oral rehydration solution alone or with placebo in childhood acute gastroenteritis." | 8.87 | Racecadotril for childhood gastroenteritis: an individual patient data meta-analysis. ( Calatayud, GA; Castrellón, PG; Cézard, JP; Chéron, G; Garcia, JM; Lehert, P; Santos, M; Savitha, MR, 2011) |
| "Racecadotril is an enkephalinase inhibitor, presented as a purely antisecretory agent with advantages over the opiate-receptor agonist loperamide in the treatment of diarrhea." | 8.82 | Racecadotril versus loperamide: antidiarrheal research revisited. ( Awouters, F; Huighebaert, S; Tytgat, GN, 2003) |
| "Racecadotril has been shown to reduce the stools output during acute diarrhoea." | 6.70 | [Effect of racecadotril in the management of acute diarrhea in infants and children]. ( Bocquet, N; Boursiquot, C; Chéron, G; Cojocaru, B; Garel, D; Marcombes, F; Sannier, N; Timsit, S; Wille, C, 2002) |
| "In patients with AIDS, it is a more common problem than for other entities (e." | 6.49 | [Treatment of diarrhea with loperamide in palliative medicine. A systematic review]. ( Meißner, W; Pastrana, T, 2013) |
| "Treatment with racecadotril did not reduce diarrheal duration, stool volume or the requirement for fluid replacement in children with acute gastroenteritis, both with and without rotavirus infection." | 5.22 | Racecadotril in the Management of Rotavirus and Non-rotavirus Diarrhea in Under-five Children: Two Randomized, Double-blind, Placebo-controlled Trials. ( Anbu, D; Bose, A; Kang, G; Parez, N; Sarkar, R; Sindhu, K; Srinivasan, R; Subashini, B; Svensson, L; Thuppal, SV; Venugopal, S, 2016) |
| "To assess the efficacy of single dose of octreotide and compare it with another antisecretory agent racecadotril in the management of acute infective diarrhea." | 5.16 | A comparative study of racecadotril and single dose octreotide as an anti-secretory agent in acute infective diarrhoea. ( Jain, VK; Khandelwal, PD; Mehta, S; Sihag, M, 2012) |
| "Our aim was to compare the efficacy and tolerability of loperamide and racecadotril in elderly patients with acute diarrhea." | 5.14 | Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes. ( Colosimo, M; Cucchiara, S; Curto, LS; De Sarro, G; Falcone, D; Gallelli, L; Luberto, L; Marigliano, NM; Mazzei, F; Rende, P; Tolotta, GA, 2010) |
| " The study included 189 patients, ages 3 to 36 months, with acute gastroenteritis: 94 were administered an oral rehydration solution (OR), 94 received oral rehydration solution plus racecadotril (OR + R)." | 5.14 | Use of racecadotril as outpatient treatment for acute gastroenteritis: a prospective, randomized, parallel study. ( Marañón, R; Miguez, C; Sánchez, C; Santos, M; Vázquez, P, 2009) |
| " Loperamide is an effective anti-diarrheal agent, but it usually induces constipation." | 5.11 | A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults. ( Liao, KF; Shieh, MJ; Wang, HH, 2005) |
| "In young boys with acute watery diarrhea, racecadotril is an effective and safe treatment." | 5.09 | Racecadotril in the treatment of acute watery diarrhea in children. ( Chea-Woo, E; Gutierrez, M; Salazar-Lindo, E; Santisteban-Ponce, J, 2000) |
| "This study demonstrates the efficacy (up to 50% reduction in stool output) and tolerability of racecadotril as adjuvant therapy to oral rehydration solution in the treatment of severe diarrhea in infants and children." | 5.09 | Efficacy and tolerability of racecadotril in acute diarrhea in children. ( Audrain, S; Bellaiche, M; Cézard, JP; Duhamel, JF; Ginies, JL; Girardet, JP; Lamireau, T; Lecomte, JM; Maurage, C; Meyer, M; Morali, A; Olives, JP; Pharaon, I; Poujol, A; Sarles, J; Vaillant, JM; Whately-Smith, C, 2001) |
| "Irinotecan (CPT-11), a camptothecin derivative, has shown efficacy against colorectal cancer." | 5.08 | Pathophysiology and therapy of irinotecan-induced delayed-onset diarrhea in patients with advanced colorectal cancer: a prospective assessment. ( Bastian, G; Bonnay, M; Cote, C; Cvitkovic, E; Hagipantelli, R; Herait, P; Mahjoubi, M; Mignard, D; Misset, JL; Saliba, F; Vassal, G, 1998) |
| "Racecadotril is a guideline-recommended option for the treatment of acute diarrhea in children but existing guidelines and previous reviews of the field are based on a small fraction of published evidence." | 4.98 | Racecadotril in the treatment of acute diarrhea in children: a systematic, comprehensive review and meta-analysis of randomized controlled trials. ( Chen, M; Däbritz, J; Eberlin, M; Mueck, T, 2018) |
| "Racecadotril has sufficient proven efficacy in the treatment of acute diarrhea in children." | 4.89 | [The treatment of acute diarrhea]. ( Leemans, L, 2013) |
| "To assess racecadotril efficacy as an adjunct to oral rehydration solution, against oral rehydration solution alone or with placebo in childhood acute gastroenteritis." | 4.87 | Racecadotril for childhood gastroenteritis: an individual patient data meta-analysis. ( Calatayud, GA; Castrellón, PG; Cézard, JP; Chéron, G; Garcia, JM; Lehert, P; Santos, M; Savitha, MR, 2011) |
| "The small number of included trials provided some evidence in favour of the use of racecadotril over placebo or no intervention, to reduce the stool output and duration of diarrhoea in children with acute gastroenteritis." | 4.84 | Systematic review: racecadotril in the treatment of acute diarrhoea in children. ( Chmielewska, A; Ruszczyński, M; Szajewska, H; Wieczorek, J, 2007) |
| "Racecadotril is an enkephalinase inhibitor, presented as a purely antisecretory agent with advantages over the opiate-receptor agonist loperamide in the treatment of diarrhea." | 4.82 | Racecadotril versus loperamide: antidiarrheal research revisited. ( Awouters, F; Huighebaert, S; Tytgat, GN, 2003) |
| "For the treatment of acute uncomplicated traveler's diarrhea - more than 90 % of all cases - the secretion inhibitor racecadotril is considered first choice, based on our evaluation criteria." | 3.85 | [Consensus paper treatment of acute traveler's diarrhea. Practice recommendation for travel advice]. ( Haditsch, M; Jelinek, T; Nothdurft, HD; Weinke, T, 2017) |
| "Racecadotril (acetorphan) is a neutral endopeptidase (NEP) inhibitor with known antidiarrheal activity in animals and humans; however, in humans, it suffers from shortcomings that might be improved with newer drugs in this class that have progressed to the clinic for nonenteric disease indications." | 3.83 | Pharmacologic Comparison of Clinical Neutral Endopeptidase Inhibitors in a Rat Model of Acute Secretory Diarrhea. ( Arnett, SD; Bond, BR; Campbell, MA; Choy, RK; de Hostos, E; Griggs, DW; Ji, Y; Meyers, MJ; Neckermann, G; Oliva, J; Prinsen, MJ; Ruminski, PG; Tajfirouz, D; Yu, Y, 2016) |
| "Racecadotril (acetorphan) is an orally active, potent inhibitor of enkephalinase, which exerts an antihypersecretory effect without increasing intestinal transit time." | 2.70 | A multinational comparison of racecadotril and loperamide in the treatment of acute watery diarrhoea in adults. ( Prado, D, 2002) |
| "Racecadotril has been shown to reduce the stools output during acute diarrhoea." | 2.70 | [Effect of racecadotril in the management of acute diarrhea in infants and children]. ( Bocquet, N; Boursiquot, C; Chéron, G; Cojocaru, B; Garel, D; Marcombes, F; Sannier, N; Timsit, S; Wille, C, 2002) |
| "Racecadotril and placebo were equally well tolerated, and the frequency of symptoms and signs was similar in both groups after 4 days of treatment." | 2.69 | Racecadotril versus placebo in the treatment of acute diarrhoea in adults. ( Baumer, P; Ben Khalifa, H; Berard, H; Hamza, H; Lecomte, JM, 1999) |
| "Racecadotril is an anti-secretory drug that has been used for acute diarrhoea in children as an adjunct to oral rehydration therapy." | 2.61 | Racecadotril for acute diarrhoea in children. ( Gordon, M; Liang, Y; Wen, J; Zeng, L; Zhang, L, 2019) |
| "Racecadotril is an antisecretory agent that can prevent fluid/electrolyte depletion from the bowel as a result of acute diarrhoea without affecting intestinal motility." | 2.53 | Racecadotril for acute diarrhoea in children: systematic review and meta-analyses. ( Akobeng, A; Gordon, M, 2016) |
| "In patients with AIDS, it is a more common problem than for other entities (e." | 2.49 | [Treatment of diarrhea with loperamide in palliative medicine. A systematic review]. ( Meißner, W; Pastrana, T, 2013) |
| "Chronic diarrhea is a frequent and challenging problem in clinical medicine." | 2.48 | Functional diarrhea. ( Tack, J, 2012) |
| "Racecadotril is an antisecretory drug recommended as an adjuvant antidiarrhoeal treatment." | 1.56 | Drugs in Focus: The Use of Racecadotril in Paediatric Gastrointestinal Disease. ( Benninga, MA; Broekaert, IJ; Dolinsek, J; Mas, E; Miele, E; Orel, R; Pienar, C; Ribes-Koninckx, C; Thapar, N; Thomassen, RA; Thomson, M; Tzivinikos, C, 2020) |
| "Nitazoxanide has high efficacy against Cryptosporodial diarrhea only." | 1.33 | Current status of anti-diarrheal and anti-secretory drugs in the management of acute childhood diarrhea. ( Alam, S; Bhatnagar, S, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.04) | 18.7374 |
| 1990's | 9 (18.37) | 18.2507 |
| 2000's | 17 (34.69) | 29.6817 |
| 2010's | 20 (40.82) | 24.3611 |
| 2020's | 2 (4.08) | 2.80 |
| Authors | Studies |
|---|---|
| Tras, B | 1 |
| Ok, M | 1 |
| Parlak, TM | 1 |
| Ider, M | 1 |
| Yildiz, R | 1 |
| Eser Faki, H | 1 |
| Ozdemir Kutahya, Z | 1 |
| Uney, K | 1 |
| Liang, Y | 1 |
| Zhang, L | 1 |
| Zeng, L | 1 |
| Gordon, M | 2 |
| Wen, J | 1 |
| Pienar, C | 1 |
| Benninga, MA | 1 |
| Broekaert, IJ | 1 |
| Dolinsek, J | 1 |
| Mas, E | 1 |
| Miele, E | 1 |
| Orel, R | 1 |
| Ribes-Koninckx, C | 1 |
| Thomassen, RA | 1 |
| Thomson, M | 1 |
| Tzivinikos, C | 1 |
| Thapar, N | 1 |
| Bui, T | 1 |
| Li, G | 1 |
| Kim, I | 1 |
| Wen, K | 1 |
| Twitchell, EL | 1 |
| Hualei, S | 1 |
| Ramesh, AK | 1 |
| Weiss, MD | 1 |
| Yang, X | 1 |
| Glark-Deener, SG | 1 |
| Choy, RK | 2 |
| Yuan, L | 1 |
| Eberlin, M | 1 |
| Chen, M | 1 |
| Mueck, T | 1 |
| Däbritz, J | 1 |
| Pastrana, T | 1 |
| Meißner, W | 1 |
| Mehta, S | 1 |
| Khandelwal, PD | 1 |
| Jain, VK | 1 |
| Sihag, M | 1 |
| Leemans, L | 1 |
| Heather, CS | 1 |
| Akobeng, A | 1 |
| Sáez, J | 2 |
| Cifuentes, L | 2 |
| Griggs, DW | 1 |
| Prinsen, MJ | 1 |
| Oliva, J | 1 |
| Campbell, MA | 1 |
| Arnett, SD | 1 |
| Tajfirouz, D | 1 |
| Ruminski, PG | 1 |
| Yu, Y | 1 |
| Bond, BR | 1 |
| Ji, Y | 1 |
| Neckermann, G | 1 |
| de Hostos, E | 1 |
| Meyers, MJ | 1 |
| Kang, G | 1 |
| Thuppal, SV | 1 |
| Srinivasan, R | 1 |
| Sarkar, R | 1 |
| Subashini, B | 1 |
| Venugopal, S | 1 |
| Sindhu, K | 1 |
| Anbu, D | 1 |
| Parez, N | 1 |
| Svensson, L | 1 |
| Bose, A | 1 |
| Tran, LC | 1 |
| Lazonby, G | 1 |
| Ellis, D | 1 |
| Goldthorpe, J | 1 |
| Iglesias, N | 1 |
| Steele, J | 1 |
| Zamvar, V | 1 |
| Puntis, JW | 1 |
| Vora, R | 1 |
| Jelinek, T | 1 |
| Nothdurft, HD | 1 |
| Haditsch, M | 1 |
| Weinke, T | 1 |
| Guarino, A | 1 |
| Buccigrossi, V | 1 |
| Armellino, C | 1 |
| Santos, M | 2 |
| Marañón, R | 1 |
| Miguez, C | 1 |
| Vázquez, P | 1 |
| Sánchez, C | 1 |
| Gallelli, L | 1 |
| Colosimo, M | 1 |
| Tolotta, GA | 1 |
| Falcone, D | 1 |
| Luberto, L | 1 |
| Curto, LS | 1 |
| Rende, P | 1 |
| Mazzei, F | 1 |
| Marigliano, NM | 1 |
| De Sarro, G | 1 |
| Cucchiara, S | 1 |
| Lehert, P | 1 |
| Chéron, G | 2 |
| Calatayud, GA | 1 |
| Cézard, JP | 3 |
| Castrellón, PG | 1 |
| Garcia, JM | 1 |
| Savitha, MR | 1 |
| Cuello García, CA | 1 |
| Pacheco Alvarado, KP | 1 |
| Pérez Gaxiola, G | 1 |
| López-Campos, JL | 1 |
| Gutiérrez, C | 1 |
| Calero, C | 1 |
| Tack, J | 1 |
| Duh, D | 1 |
| Tanret, I | 1 |
| Prado, D | 1 |
| Cojocaru, B | 1 |
| Bocquet, N | 1 |
| Timsit, S | 1 |
| Wille, C | 1 |
| Boursiquot, C | 1 |
| Marcombes, F | 1 |
| Garel, D | 1 |
| Sannier, N | 1 |
| Huighebaert, S | 1 |
| Awouters, F | 1 |
| Tytgat, GN | 1 |
| Rao, SG | 1 |
| Bhan, MK | 1 |
| Bhatnagar, S | 2 |
| Wang, HH | 1 |
| Shieh, MJ | 1 |
| Liao, KF | 1 |
| Salazar-Lindo, E | 3 |
| Alam, S | 1 |
| Szajewska, H | 1 |
| Ruszczyński, M | 1 |
| Chmielewska, A | 1 |
| Wieczorek, J | 1 |
| Tormo, R | 1 |
| Polanco, I | 1 |
| Goulet, O | 1 |
| Gonçalves, E | 1 |
| de Costa, L | 1 |
| Abigerges, D | 1 |
| Armand, JP | 1 |
| Dorval, ED | 1 |
| Regimbeau, C | 1 |
| Gamelin, E | 1 |
| Picon, L | 1 |
| Bérard, H | 5 |
| Roge, J | 1 |
| Baumer, P | 3 |
| Schwartz, JC | 4 |
| Lecomte, JM | 8 |
| Saliba, F | 1 |
| Hagipantelli, R | 1 |
| Misset, JL | 1 |
| Bastian, G | 1 |
| Vassal, G | 1 |
| Bonnay, M | 1 |
| Herait, P | 2 |
| Cote, C | 1 |
| Mahjoubi, M | 1 |
| Mignard, D | 2 |
| Cvitkovic, E | 1 |
| Farthing, MJ | 1 |
| Vetel, JM | 2 |
| Fretault, N | 2 |
| Hamza, H | 1 |
| Ben Khalifa, H | 1 |
| Turck, D | 1 |
| Santisteban-Ponce, J | 1 |
| Chea-Woo, E | 1 |
| Gutierrez, M | 1 |
| Freyer, G | 1 |
| Rougier, P | 1 |
| Bugat, R | 1 |
| Droz, JP | 1 |
| Marty, M | 1 |
| Bleiberg, H | 1 |
| Awad, L | 1 |
| Culine, S | 1 |
| Trillet-Lenoir, V | 1 |
| Duhamel, JF | 1 |
| Meyer, M | 1 |
| Pharaon, I | 1 |
| Bellaiche, M | 1 |
| Maurage, C | 1 |
| Ginies, JL | 1 |
| Vaillant, JM | 1 |
| Girardet, JP | 1 |
| Lamireau, T | 1 |
| Poujol, A | 1 |
| Morali, A | 1 |
| Sarles, J | 1 |
| Olives, JP | 1 |
| Whately-Smith, C | 1 |
| Audrain, S | 1 |
| Danquechin Dorval, E | 1 |
| Bertrand, J | 1 |
| Marçais-Collado, H | 1 |
| Uchida, G | 1 |
| Costentin, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Different Grading Systems to Grade Evidence and Recommendations in Clinical Practice Guidelines: Does it Influence the Clinicians´ Behavior?[NCT00940290] | 216 participants (Actual) | Interventional | 2009-08-31 | Completed | |||
| Efficacy, Safety and Cost-effectiveness Analysis of Impact of Racecadotril as an Adjunct in the Treatment of Acute Diarrhea in Mexican Children[NCT01153854] | Phase 3 | 454 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"A fictitious clinical case of a child with acute diarrhea was presented. The physician read the case and then answered the question would you recommend racecadotril to this patient? A zero to 10 visual-analog scale and a Likert scale were used to measure the decision of the physician related to the clinical case presented (from zero=definitely no to 10=definitely yes). Mean differences before-after and among groups were measured on the 10 centimeters scale." (NCT00940290)
Timeframe: One day
| Intervention | Mean change in centimeters (Mean) |
|---|---|
| GRADE System | 2.18 |
| SIGN Grading System | 0.31 |
| NICE Grading System | 0.04 |
| CEBM-Oxford | 0.08 |
15 reviews available for thiorphan and Diarrhea
| Article | Year |
|---|---|
Racecadotril for acute diarrhoea in children.
Topics: Child, Preschool; Diarrhea; Fluid Therapy; Humans; Infant; Length of Stay; Randomized Controlled Tri | 2019 |
Racecadotril in the treatment of acute diarrhea in children: a systematic, comprehensive review and meta-analysis of randomized controlled trials.
Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Humans; Randomized Controlled Trials as Topic; Thior | 2018 |
[Treatment of diarrhea with loperamide in palliative medicine. A systematic review].
Topics: Acquired Immunodeficiency Syndrome; Antidiarrheals; Controlled Clinical Trials as Topic; Diarrhea; D | 2013 |
What place for ▾racecadotril?
Topics: Antidiarrheals; Diarrhea; Humans; Neprilysin; Practice Guidelines as Topic; Randomized Controlled Tr | 2013 |
[The treatment of acute diarrhea].
Topics: Adult; Anti-Bacterial Agents; Antidiarrheals; Child; Diarrhea; Fluid Therapy; Humans; Loperamide; Pr | 2013 |
Travellers' diarrhoea.
Topics: Anti-Bacterial Agents; Antidiarrheals; Bismuth; Diarrhea; Diet; Fluid Therapy; Humans; Organometalli | 2015 |
Racecadotril for acute diarrhoea in children: systematic review and meta-analyses.
Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Humans; Thiorphan; Treatment Outcome | 2016 |
Is racecadotril effective for acute diarrhea in children? -First update.
Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Gastroenteritis; Humans; Randomized Controlled Trial | 2015 |
Is racecadotril effective for acute diarrhea in children? -First update.
Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Gastroenteritis; Humans; Randomized Controlled Trial | 2015 |
Is racecadotril effective for acute diarrhea in children? -First update.
Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Gastroenteritis; Humans; Randomized Controlled Trial | 2015 |
Is racecadotril effective for acute diarrhea in children? -First update.
Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Gastroenteritis; Humans; Randomized Controlled Trial | 2015 |
Racecadotril for childhood gastroenteritis: an individual patient data meta-analysis.
Topics: Adolescent; Adult; Antidiarrheals; Child; Combined Modality Therapy; Dehydration; Diarrhea; Feces; F | 2011 |
Functional diarrhea.
Topics: Antidepressive Agents, Tricyclic; Antidiarrheals; Bismuth; Carbon; Cholestyramine Resin; Chronic Dis | 2012 |
Racecadotril versus loperamide: antidiarrheal research revisited.
Topics: Adolescent; Adult; Antidiarrheals; Child; Child, Preschool; Controlled Clinical Trials as Topic; Dia | 2003 |
Systematic review: racecadotril in the treatment of acute diarrhoea in children.
Topics: Acute Disease; Antidiarrheals; Child, Preschool; Diarrhea; Female; Gastroenteritis; Humans; Infant; | 2007 |
Acute infectious diarrhoea in children: new insights in antisecretory treatment with racecadotril.
Topics: Acute Disease; Antidiarrheals; Bacterial Infections; Breast Feeding; Child; Dehydration; Diarrhea; F | 2008 |
Racecadotril: a new approach to the treatment of diarrhoea.
Topics: Animals; Antidiarrheals; Diarrhea; Dogs; Rats; Thiorphan | 2000 |
An overview of clinical studies with racecadotril in adults.
Topics: Adult; Antidiarrheals; Diarrhea; Double-Blind Method; Humans; Randomized Controlled Trials as Topic; | 2000 |
18 trials available for thiorphan and Diarrhea
| Article | Year |
|---|---|
A comparative study of racecadotril and single dose octreotide as an anti-secretory agent in acute infective diarrhoea.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Antidiarrheals; Diarrhea; Drug Therapy, Combination; Dysen | 2012 |
Racecadotril in the Management of Rotavirus and Non-rotavirus Diarrhea in Under-five Children: Two Randomized, Double-blind, Placebo-controlled Trials.
Topics: Antidiarrheals; Child, Preschool; Diarrhea; Female; Humans; Infant; Male; Rotavirus Infections; Thio | 2016 |
Use of racecadotril as outpatient treatment for acute gastroenteritis: a prospective, randomized, parallel study.
Topics: Acute Disease; Ambulatory Care; Antidiarrheals; Dehydration; Diarrhea; Drug Therapy, Combination; Em | 2009 |
Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes.
Topics: Abdominal Pain; Aged; Aged, 80 and over; Aging; Antidiarrheals; Cytochrome P-450 Enzyme System; Dehy | 2010 |
Grading recommendations in clinical practice guidelines: randomised experimental evaluation of four different systems.
Topics: Adult; Antidiarrheals; Attitude of Health Personnel; Child; Decision Making; Diarrhea; Evidence-Base | 2011 |
A multinational comparison of racecadotril and loperamide in the treatment of acute watery diarrhoea in adults.
Topics: Acute Disease; Administration, Oral; Adult; Antidiarrheals; Diarrhea; Dose-Response Relationship, Dr | 2002 |
[Effect of racecadotril in the management of acute diarrhea in infants and children].
Topics: Acute Disease; Antidiarrheals; Child, Preschool; Dehydration; Diarrhea; Emergency Medical Services; | 2002 |
A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults.
Topics: Acute Disease; Adult; Antidiarrheals; Constipation; Diarrhea; Female; Humans; Loperamide; Male; Midd | 2005 |
[Treatment of acute chemically induced diarrhea by inhibition of enkephalinase. Results of a pilot study].
Topics: Acute Disease; Adenocarcinoma; Adult; Aged; Colorectal Neoplasms; Combined Modality Therapy; Diarrhe | 1995 |
The enkephalinase inhibitor, acetorphan, in acute diarrhoea. A double-blind, controlled clinical trial versus loperamide.
Topics: Acute Disease; Adult; Diarrhea; Double-Blind Method; Female; Humans; Loperamide; Male; Neprilysin; T | 1993 |
Pathophysiology and therapy of irinotecan-induced delayed-onset diarrhea in patients with advanced colorectal cancer: a prospective assessment.
Topics: Adult; Aged; Antidiarrheals; Antineoplastic Agents, Phytogenic; Camptothecin; Colorectal Neoplasms; | 1998 |
Comparison of racecadotril and loperamide in adults with acute diarrhoea.
Topics: Acute Disease; Adult; Diarrhea; Double-Blind Method; Female; Humans; Loperamide; Male; Neprilysin; P | 1999 |
Racecadotril versus placebo in the treatment of acute diarrhoea in adults.
Topics: Acute Disease; Adult; Antidiarrheals; Diarrhea; Double-Blind Method; Female; Humans; Male; Middle Ag | 1999 |
Comparison of racecadotril and loperamide in children with acute diarrhoea.
Topics: Acute Disease; Antidiarrheals; Child; Child, Preschool; Diarrhea; Double-Blind Method; Female; Human | 1999 |
Racecadotril in the treatment of acute watery diarrhea in children.
Topics: Acute Disease; Antidiarrheals; Child, Preschool; Combined Modality Therapy; Developing Countries; Di | 2000 |
Prognostic factors for tumour response, progression-free survival and toxicity in metastatic colorectal cancer patients given irinotecan (CPT-11) as second-line chemotherapy after 5FU failure. CPT-11 F205, F220, F221 and V222 study groups.
Topics: Adult; Aged; Antidiarrheals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Cam | 2000 |
Efficacy and tolerability of racecadotril in acute diarrhea in children.
Topics: Acute Disease; Antidiarrheals; Child, Preschool; Defecation; Diarrhea; Double-Blind Method; Female; | 2001 |
Effects of acetorphan, an enkephalinase inhibitor, on experimental and acute diarrhoea.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Castor Oil; Diarrhea; Double-Blind Method; Female; Human | 1992 |
16 other studies available for thiorphan and Diarrhea
| Article | Year |
|---|---|
Can diarrhea affect the pharmacokinetics of racecadotril in neonatal calves?
Topics: Animals; Antidiarrheals; Cattle; Cattle Diseases; Cryptosporidiosis; Cryptosporidium; Diarrhea; Thio | 2022 |
Drugs in Focus: The Use of Racecadotril in Paediatric Gastrointestinal Disease.
Topics: Antidiarrheals; Child; Diarrhea; Gastrointestinal Diseases; Humans; Pharmaceutical Preparations; Thi | 2020 |
Effects of Racecadotril on Weight Loss and Diarrhea Due to Human Rotavirus in Neonatal Gnotobiotic Pigs (
Topics: Animals; Antidiarrheals; Diarrhea; Drug Evaluation, Preclinical; Rotavirus; Rotavirus Infections; Su | 2017 |
Pharmacologic Comparison of Clinical Neutral Endopeptidase Inhibitors in a Rat Model of Acute Secretory Diarrhea.
Topics: Animals; Antidiarrheals; Castor Oil; Charcoal; Diarrhea; Dose-Response Relationship, Drug; Endopepti | 2016 |
Racecadotril May Reduce Diarrhoea in Microvillous Inclusion Disease.
Topics: Antidiarrheals; Child, Preschool; Diarrhea; Humans; Malabsorption Syndromes; Male; Microvilli; Mucol | 2017 |
[Consensus paper treatment of acute traveler's diarrhea. Practice recommendation for travel advice].
Topics: Anti-Bacterial Agents; Antidiarrheals; Consensus; Diarrhea; Dysentery; Germany; Humans; Practice Gui | 2017 |
Colon in acute intestinal infection.
Topics: Acute Disease; Antidiarrheals; Caco-2 Cells; Colon; Diarrhea; Drug Evaluation, Preclinical; Gastroen | 2009 |
The potential role of racecadotril in the treatment of diarrhea associated with roflumilast.
Topics: Adrenergic beta-2 Receptor Agonists; Adult; Aminopyridines; Antidiarrheals; Benzamides; Child; Cycli | 2012 |
[Racecadotril (Tiorfix), oral].
Topics: Adult; Antidiarrheals; Child; Child, Preschool; Diarrhea; Drug Interactions; Humans; Infant; Infant, | 2012 |
Racecadotril (acetorphan) in the treatment of acute watery diarrhoea in children.
Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Fluid Therapy; Humans; Thiorphan | 2002 |
Racecadotril-is there enough evidence to recommend it for treatment of acute diarrhea?
Topics: Antidiarrheals; Diarrhea; Humans; Thiorphan; Treatment Outcome | 2004 |
Racecadotril in acute diarrhea.
Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Drug Evaluation; Female; Humans; Male; Research Desi | 2005 |
Current status of anti-diarrheal and anti-secretory drugs in the management of acute childhood diarrhea.
Topics: Acute Disease; Antidiarrheals; Antiparasitic Agents; Child; Child, Preschool; Cholera; Diarrhea; Dis | 2006 |
A new enkephalinase inhibitor as an alternative to loperamide in the prevention of diarrhea induced by CPT-11.
Topics: Adult; Antineoplastic Agents, Phytogenic; Camptothecin; Clinical Trials as Topic; Diarrhea; Female; | 1995 |
Introduction. Enkephalinase inhibition: a rational approach to antisecretory therapy for acute diarrhoea.
Topics: Acute Disease; Antidiarrheals; Diarrhea; Humans; Neprilysin; Protease Inhibitors; Thiorphan | 1999 |
Naloxone-reversible antidiarrheal effects of enkephalinase inhibitors.
Topics: Amino Acids, Sulfur; Animals; Castor Oil; Diarrhea; Drug Interactions; Gastrointestinal Transit; Lop | 1987 |