thiorphan has been researched along with Dehydration in 8 studies
Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
Dehydration: The condition that results from excessive loss of water from a living organism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In our study group, the use of racecadotril did not improve the symptoms of diarrhea compared with standard rehydration therapy." | 9.14 | Use of racecadotril as outpatient treatment for acute gastroenteritis: a prospective, randomized, parallel study. ( Marañón, R; Miguez, C; Sánchez, C; Santos, M; Vázquez, P, 2009) |
| "Our aim was to compare the efficacy and tolerability of loperamide and racecadotril in elderly patients with acute diarrhea." | 9.14 | Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes. ( Colosimo, M; Cucchiara, S; Curto, LS; De Sarro, G; Falcone, D; Gallelli, L; Luberto, L; Marigliano, NM; Mazzei, F; Rende, P; Tolotta, GA, 2010) |
| "To assess racecadotril efficacy as an adjunct to oral rehydration solution, against oral rehydration solution alone or with placebo in childhood acute gastroenteritis." | 8.87 | Racecadotril for childhood gastroenteritis: an individual patient data meta-analysis. ( Calatayud, GA; Castrellón, PG; Cézard, JP; Chéron, G; Garcia, JM; Lehert, P; Santos, M; Savitha, MR, 2011) |
| "Racecadotril has been shown to reduce the stools output during acute diarrhoea." | 6.70 | [Effect of racecadotril in the management of acute diarrhea in infants and children]. ( Bocquet, N; Boursiquot, C; Chéron, G; Cojocaru, B; Garel, D; Marcombes, F; Sannier, N; Timsit, S; Wille, C, 2002) |
| "In our study group, the use of racecadotril did not improve the symptoms of diarrhea compared with standard rehydration therapy." | 5.14 | Use of racecadotril as outpatient treatment for acute gastroenteritis: a prospective, randomized, parallel study. ( Marañón, R; Miguez, C; Sánchez, C; Santos, M; Vázquez, P, 2009) |
| "Our aim was to compare the efficacy and tolerability of loperamide and racecadotril in elderly patients with acute diarrhea." | 5.14 | Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes. ( Colosimo, M; Cucchiara, S; Curto, LS; De Sarro, G; Falcone, D; Gallelli, L; Luberto, L; Marigliano, NM; Mazzei, F; Rende, P; Tolotta, GA, 2010) |
| "To assess racecadotril efficacy as an adjunct to oral rehydration solution, against oral rehydration solution alone or with placebo in childhood acute gastroenteritis." | 4.87 | Racecadotril for childhood gastroenteritis: an individual patient data meta-analysis. ( Calatayud, GA; Castrellón, PG; Cézard, JP; Chéron, G; Garcia, JM; Lehert, P; Santos, M; Savitha, MR, 2011) |
| "Racecadotril has been shown to reduce the stools output during acute diarrhoea." | 2.70 | [Effect of racecadotril in the management of acute diarrhea in infants and children]. ( Bocquet, N; Boursiquot, C; Chéron, G; Cojocaru, B; Garel, D; Marcombes, F; Sannier, N; Timsit, S; Wille, C, 2002) |
| "Racecadotril was more frequently used in France, and ondansetron was more frequently used in Switzerland." | 1.40 | Pediatric gastroenteritis in the emergency department: practice evaluation in Belgium, France, The Netherlands and Switzerland. ( Angoulvant, F; Gajdos, V; Julliand, S; Llor, J; Lorrot, M; Oostenbrink, R; Pelc, R; Redant, S, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pelc, R | 1 |
| Redant, S | 1 |
| Julliand, S | 1 |
| Llor, J | 1 |
| Lorrot, M | 1 |
| Oostenbrink, R | 1 |
| Gajdos, V | 1 |
| Angoulvant, F | 1 |
| Santos, M | 2 |
| Marañón, R | 1 |
| Miguez, C | 1 |
| Vázquez, P | 1 |
| Sánchez, C | 1 |
| Gallelli, L | 1 |
| Colosimo, M | 1 |
| Tolotta, GA | 1 |
| Falcone, D | 1 |
| Luberto, L | 1 |
| Curto, LS | 1 |
| Rende, P | 1 |
| Mazzei, F | 1 |
| Marigliano, NM | 1 |
| De Sarro, G | 1 |
| Cucchiara, S | 1 |
| Lehert, P | 1 |
| Chéron, G | 2 |
| Calatayud, GA | 1 |
| Cézard, JP | 1 |
| Castrellón, PG | 1 |
| Garcia, JM | 1 |
| Savitha, MR | 1 |
| Cojocaru, B | 1 |
| Bocquet, N | 1 |
| Timsit, S | 1 |
| Wille, C | 1 |
| Boursiquot, C | 1 |
| Marcombes, F | 1 |
| Garel, D | 1 |
| Sannier, N | 1 |
| Turck, D | 1 |
| Tormo, R | 1 |
| Polanco, I | 1 |
| Salazar-Lindo, E | 1 |
| Goulet, O | 1 |
| Sullivan, MJ | 1 |
| Johnson, AK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy, Safety and Cost-effectiveness Analysis of Impact of Racecadotril as an Adjunct in the Treatment of Acute Diarrhea in Mexican Children[NCT01153854] | Phase 3 | 454 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for thiorphan and Dehydration
| Article | Year |
|---|---|
Racecadotril for childhood gastroenteritis: an individual patient data meta-analysis.
Topics: Adolescent; Adult; Antidiarrheals; Child; Combined Modality Therapy; Dehydration; Diarrhea; Feces; F | 2011 |
[Prevention and treatment of acute diarrhea in infants].
Topics: Acute Disease; Antidiarrheals; Breast Feeding; Dehydration; Diarrhea, Infantile; Fluid Therapy; Huma | 2007 |
Acute infectious diarrhoea in children: new insights in antisecretory treatment with racecadotril.
Topics: Acute Disease; Antidiarrheals; Bacterial Infections; Breast Feeding; Child; Dehydration; Diarrhea; F | 2008 |
3 trials available for thiorphan and Dehydration
| Article | Year |
|---|---|
Use of racecadotril as outpatient treatment for acute gastroenteritis: a prospective, randomized, parallel study.
Topics: Acute Disease; Ambulatory Care; Antidiarrheals; Dehydration; Diarrhea; Drug Therapy, Combination; Em | 2009 |
Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes.
Topics: Abdominal Pain; Aged; Aged, 80 and over; Aging; Antidiarrheals; Cytochrome P-450 Enzyme System; Dehy | 2010 |
[Effect of racecadotril in the management of acute diarrhea in infants and children].
Topics: Acute Disease; Antidiarrheals; Child, Preschool; Dehydration; Diarrhea; Emergency Medical Services; | 2002 |
2 other studies available for thiorphan and Dehydration
| Article | Year |
|---|---|
Pediatric gastroenteritis in the emergency department: practice evaluation in Belgium, France, The Netherlands and Switzerland.
Topics: Abdomen; Antidiarrheals; Antiemetics; Belgium; Blood Cell Count; Blood Gas Analysis; C-Reactive Prot | 2014 |
Amastatin potentiates drinking elicited by osmotic stimuli: evidence for peptidergic mediation of intracellular dehydration-induced thirst.
Topics: Aminopeptidases; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anti-Bacterial Agents; D | 1992 |