thiorphan has been researched along with Cough in 1 studies
Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To study the roles of substance P and endogenous neutral endopeptidase in mediating cough, we measured cough responses in awake guinea pigs in response to exogenous substance P and capsaicin aerosols in the presence and absence of the neutral endopeptidase inhibitors leucine-thiorphan and phosphoramidon." | 7.67 | Neutral endopeptidase inhibitors potentiate substance P- and capsaicin-induced cough in awake guinea pigs. ( Borson, DB; Graf, PD; Kohrogi, H; Nadel, JA; Sekizawa, K, 1988) |
| "To study the roles of substance P and endogenous neutral endopeptidase in mediating cough, we measured cough responses in awake guinea pigs in response to exogenous substance P and capsaicin aerosols in the presence and absence of the neutral endopeptidase inhibitors leucine-thiorphan and phosphoramidon." | 3.67 | Neutral endopeptidase inhibitors potentiate substance P- and capsaicin-induced cough in awake guinea pigs. ( Borson, DB; Graf, PD; Kohrogi, H; Nadel, JA; Sekizawa, K, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kohrogi, H | 1 |
| Graf, PD | 1 |
| Sekizawa, K | 1 |
| Borson, DB | 1 |
| Nadel, JA | 1 |
1 other study available for thiorphan and Cough
| Article | Year |
|---|---|
Neutral endopeptidase inhibitors potentiate substance P- and capsaicin-induced cough in awake guinea pigs.
Topics: Animals; Capsaicin; Cough; Drug Synergism; Glycopeptides; Guinea Pigs; Male; Neprilysin; Substance P | 1988 |