thiorphan has been researched along with Cerebral Palsy in 1 studies
Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
Cerebral Palsy: A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life. The four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common. The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. Spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms. Pathologically, this condition may be associated with LEUKOMALACIA, PERIVENTRICULAR. (From Dev Med Child Neurol 1998 Aug;40(8):520-7)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thiorphan effects were mimicked by substance P (SP) and, in a less potent manner, by neurokinin A." | 1.33 | Thiorphan, a neutral endopeptidase inhibitor used for diarrhoea, is neuroprotective in newborn mice. ( Dournaud, P; Fontaine, RH; Gressens, P; Lebas, F; Lelièvre, V; Leroux, P; Medja, F; Ouimet, T; Rougeot, C; Saria, A, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Medja, F | 1 |
| Lelièvre, V | 1 |
| Fontaine, RH | 1 |
| Lebas, F | 1 |
| Leroux, P | 1 |
| Ouimet, T | 1 |
| Saria, A | 1 |
| Rougeot, C | 1 |
| Dournaud, P | 1 |
| Gressens, P | 1 |
1 other study available for thiorphan and Cerebral Palsy
| Article | Year |
|---|---|
Thiorphan, a neutral endopeptidase inhibitor used for diarrhoea, is neuroprotective in newborn mice.
Topics: Animals; Animals, Newborn; Caspase 3; Cell Death; Cells, Cultured; Cerebral Cortex; Cerebral Palsy; | 2006 |