thiorphan has been researched along with Cardiac Hypertrophy in 2 studies
Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
Cardiac Hypertrophy: Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Given that NEP and ACE metabolize angiotensin (Ang) and bradykinin (BK) peptides, we investigated the effects of NEP inhibition and combined NEP and ACE inhibition on Ang and BK levels in rats with myocardial infarction." | 7.70 | Interaction between neutral endopeptidase and angiotensin converting enzyme inhibition in rats with myocardial infarction: effects on cardiac hypertrophy and angiotensin and bradykinin peptide levels. ( Anastasopoulos, F; Briscoe, TA; Campbell, DJ; Duncan, AM; James, GM; Kladis, A, 1999) |
| " Given that NEP and ACE metabolize angiotensin (Ang) and bradykinin (BK) peptides, we investigated the effects of NEP inhibition and combined NEP and ACE inhibition on Ang and BK levels in rats with myocardial infarction." | 3.70 | Interaction between neutral endopeptidase and angiotensin converting enzyme inhibition in rats with myocardial infarction: effects on cardiac hypertrophy and angiotensin and bradykinin peptide levels. ( Anastasopoulos, F; Briscoe, TA; Campbell, DJ; Duncan, AM; James, GM; Kladis, A, 1999) |
| "However, cardiac hypertrophy itself poses a serious risk to patients with heart failure." | 1.30 | Effect of ecadotril, a neutral endopeptidase inhibitor, on myocardial hypertrophy in the rat aortic insufficiency model. ( Kimura, M; Nakashima, M; Ohashi, K; Umemura, K, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kimura, M | 1 |
| Umemura, K | 1 |
| Ohashi, K | 1 |
| Nakashima, M | 1 |
| Duncan, AM | 1 |
| James, GM | 1 |
| Anastasopoulos, F | 1 |
| Kladis, A | 1 |
| Briscoe, TA | 1 |
| Campbell, DJ | 1 |
2 other studies available for thiorphan and Cardiac Hypertrophy
| Article | Year |
|---|---|
Effect of ecadotril, a neutral endopeptidase inhibitor, on myocardial hypertrophy in the rat aortic insufficiency model.
Topics: Angiotensin II; Animals; Aortic Diseases; Blood Pressure; Cardiomegaly; Disease Models, Animal; Guan | 1998 |
Interaction between neutral endopeptidase and angiotensin converting enzyme inhibition in rats with myocardial infarction: effects on cardiac hypertrophy and angiotensin and bradykinin peptide levels.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Body Weight; Bradykinin; Cardiome | 1999 |