thiorphan has been researched along with Cardiac Failure in 19 studies
Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Heart failure was induced by rapid ventricular pacing in conscious dogs." | 5.30 | Kinin-mediated coronary nitric oxide production contributes to the therapeutic action of angiotensin-converting enzyme and neutral endopeptidase inhibitors and amlodipine in the treatment in heart failure. ( Bernstein, R; Hintze, TH; Nasjletti, A; Recchia, FA; Xu, X; Zhang, X, 1999) |
| "Thiorphan was coinfused with Lys-des-Arg9-bradykinin (1 to 10 nmol/min), bradykinin (30 to 300 pmol/min), atrial natriuretic peptide (10 to 100 pmol/min), and sodium nitroprusside (2 to 8 mug/min)." | 2.71 | Neutral endopeptidase inhibition augments vascular actions of bradykinin in patients treated with angiotensin-converting enzyme inhibition. ( Cruden, NL; Fox, KA; Johnston, NR; Ludlam, CA; Newby, DE, 2004) |
| "No increases in deaths, serious adverse events, or dropouts from adverse events were observed for the ecadotril group compared with placebo." | 2.69 | A randomized trial of ecadotril versus placebo in patients with mild to moderate heart failure: the U.S. ecadotril pilot safety study. ( Burnett, JC; Cody, RJ; Elkayam, U; Gattis, WA; Gheorghiade, M; Gilbert, J; Goldstein, S; Granger, CB; Kasper, EK; Katz, SD; Massie, BM; McKenney, JM; Messineo, FC; O'Connor, CM, 1999) |
| "Heart failure was induced by repeated coronary embolization with latex microspheres." | 1.31 | Short-term effects of ecadotril in dogs with induced congestive heart failure. ( Beals, S; Hanson, B; Kutas, SM; Olivier, NB; Windram, S, 2000) |
| " There was no evidence of an effect accumulated over time, and reversibility of toxic effects was evident." | 1.31 | Acute, subchronic, and chronic toxicity of ecadotril in dogs. ( Goetze, L; Maertins, T; von Keutz, E, 2000) |
| "Heart failure was induced by rapid ventricular pacing in conscious dogs." | 1.30 | Kinin-mediated coronary nitric oxide production contributes to the therapeutic action of angiotensin-converting enzyme and neutral endopeptidase inhibitors and amlodipine in the treatment in heart failure. ( Bernstein, R; Hintze, TH; Nasjletti, A; Recchia, FA; Xu, X; Zhang, X, 1999) |
| "Treatment with thiorphan (10 mg/kg i." | 1.28 | Effect of endopeptidase 24.11 inhibition in conscious cardiomyopathic hamsters. ( Blaine, EB; McGraw, DE; Smits, GJ; Trapani, AJ, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (63.16) | 18.2507 |
| 2000's | 7 (36.84) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mishima, T | 1 |
| Tanimura, M | 1 |
| Suzuki, G | 1 |
| Todor, A | 1 |
| Sharov, VG | 1 |
| Tanhehco, EJ | 1 |
| Goldstein, S | 2 |
| Sabbah, HN | 1 |
| Berezin, AE | 1 |
| Cruden, NL | 1 |
| Fox, KA | 1 |
| Ludlam, CA | 1 |
| Johnston, NR | 1 |
| Newby, DE | 1 |
| Stasch, JP | 2 |
| Knorr, A | 1 |
| Wegner, M | 2 |
| Hirth-Dietrich, C | 2 |
| Wilkins, MR | 2 |
| Cleland, JG | 1 |
| Swedberg, K | 1 |
| Zhang, X | 1 |
| Recchia, FA | 1 |
| Bernstein, R | 1 |
| Xu, X | 1 |
| Nasjletti, A | 1 |
| Hintze, TH | 1 |
| O'Connor, CM | 1 |
| Gattis, WA | 1 |
| Gheorghiade, M | 1 |
| Granger, CB | 1 |
| Gilbert, J | 1 |
| McKenney, JM | 1 |
| Messineo, FC | 1 |
| Burnett, JC | 1 |
| Katz, SD | 1 |
| Elkayam, U | 1 |
| Kasper, EK | 1 |
| Cody, RJ | 1 |
| Massie, BM | 1 |
| Olivier, NB | 1 |
| Kutas, SM | 1 |
| Beals, S | 1 |
| Hanson, B | 1 |
| Windram, S | 1 |
| Maertins, T | 1 |
| von Keutz, E | 1 |
| Goetze, L | 2 |
| Solter, P | 1 |
| Sisson, D | 1 |
| Thomas, W | 1 |
| Petrie, MC | 1 |
| Hillier, C | 1 |
| Johnston, F | 1 |
| McMurray, JJ | 1 |
| Varin, J | 1 |
| Duboc, D | 2 |
| Weber, S | 1 |
| Fouchard, J | 1 |
| Schwartz, JC | 2 |
| Muffat-Joly, M | 1 |
| Guérin, F | 1 |
| Hirata, Y | 1 |
| Kahn, JC | 1 |
| Patey, M | 1 |
| Dubois-Rande, JL | 1 |
| Merlet, P | 1 |
| Castaigne, A | 1 |
| Lim-Alexandre, C | 1 |
| Lecomte, JM | 1 |
| Gros, C | 1 |
| Smits, GJ | 1 |
| McGraw, DE | 1 |
| Trapani, AJ | 1 |
| Blaine, EB | 1 |
| Settle, SL | 1 |
| Stockmann, PT | 1 |
| Needleman, P | 1 |
3 reviews available for thiorphan and Cardiac Failure
| Article | Year |
|---|---|
[The new class of drugs-- metalloprotease inhibitors -- in the treatment of heart failure].
Topics: Glycopeptides; Heart Failure; Hemodynamics; Humans; Indans; Metalloproteases; Propionates; Protease | 2004 |
Clinical potential of endopeptidase-24.11 inhibitors in cardiovascular disease.
Topics: Animals; Antihypertensive Agents; Cardiovascular Diseases; Cyclohexanecarboxylic Acids; Diuretics; D | 1993 |
[Effect of sinorphan, an endopeptidase inhibitor on severe congestive cardiac insufficiency].
Topics: Adult; Aged; Atrial Natriuretic Factor; Blood Pressure; Creatinine; Cyclic GMP; Diuresis; Female; He | 1991 |
5 trials available for thiorphan and Cardiac Failure
| Article | Year |
|---|---|
Neutral endopeptidase inhibition augments vascular actions of bradykinin in patients treated with angiotensin-converting enzyme inhibition.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Atrial Natriuretic Factor; Bradykinin; Cross-Over St | 2004 |
Lack of efficacy of neutral endopeptidase inhibitor ecadotril in heart failure. The International Ecadotril Multi-centre Dose-ranging Study Investigators.
Topics: Anemia, Aplastic; Dose-Response Relationship, Drug; Female; Heart Failure; Humans; Male; Middle Aged | 1998 |
A randomized trial of ecadotril versus placebo in patients with mild to moderate heart failure: the U.S. ecadotril pilot safety study.
Topics: Adolescent; Adult; Aged; Double-Blind Method; Female; Heart Failure; Humans; Male; Middle Aged; Pilo | 1999 |
[Effect of sinorphan, an endopeptidase inhibitor on severe congestive cardiac insufficiency].
Topics: Adult; Aged; Atrial Natriuretic Factor; Blood Pressure; Creatinine; Cyclic GMP; Diuresis; Female; He | 1991 |
Effect of sinorphan on plasma atrial natriuretic factor in congestive heart failure.
Topics: Administration, Oral; Atrial Natriuretic Factor; Clinical Trials as Topic; Drug Administration Sched | 1990 |
12 other studies available for thiorphan and Cardiac Failure
| Article | Year |
|---|---|
Effects of chronic neutral endopeptidase inhibition on the progression of left ventricular dysfunction and remodeling in dogs with moderate heart failure.
Topics: Animals; Chronic Disease; Coronary Angiography; Dogs; Heart Failure; Hemodynamics; Myocytes, Cardiac | 2002 |
Prolonged inhibition of neutral endopeptidase 24.11 by sinorphan in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Body Weight; Heart Failure; Hemodynamics; Kidney | 1995 |
Role of neutral endopeptidase 24.11 in AV fistular rat model of heart failure.
Topics: Angiotensin I; Animals; Aorta; Arteriovenous Fistula; Atrial Natriuretic Factor; Disease Models, Ani | 1996 |
Kinin-mediated coronary nitric oxide production contributes to the therapeutic action of angiotensin-converting enzyme and neutral endopeptidase inhibitors and amlodipine in the treatment in heart failure.
Topics: Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin Receptor Antagonists; Coro | 1999 |
Ecadotril. (S)-acetorphan, sinorphan.
Topics: Animals; Cardiovascular Diseases; Drugs, Investigational; Endopeptidases; Heart Failure; Humans; Hyp | 1999 |
Short-term effects of ecadotril in dogs with induced congestive heart failure.
Topics: Animals; Cyclic GMP; Dog Diseases; Dogs; Electrocardiography; Heart Failure; Hemodynamics; Male; Mic | 2000 |
Acute, subchronic, and chronic toxicity of ecadotril in dogs.
Topics: Animals; Dog Diseases; Dogs; Drug Administration Schedule; Heart Failure; Neprilysin; Prodrugs; Prot | 2000 |
Intrarenal effects of ecadotril during acute volume expansion in dogs with congestive heart failure.
Topics: Animals; Atrial Natriuretic Factor; Dogs; Glomerular Filtration Rate; Heart Failure; Kidney; Male; N | 2000 |
Effect of neutral endopeptidase inhibition on the actions of adrenomedullin and endothelin-1 in resistance arteries from patients with chronic heart failure.
Topics: Adrenomedullin; Antihypertensive Agents; Arteries; Chronic Disease; Dose-Response Relationship, Drug | 2001 |
[Clinical significance and therapeutic application of atrial natriuretic peptides].
Topics: Animals; Atrial Natriuretic Factor; Glycopeptides; Heart Atria; Heart Failure; Hemodynamics; Humans; | 1991 |
Effect of endopeptidase 24.11 inhibition in conscious cardiomyopathic hamsters.
Topics: Animals; Atrial Natriuretic Factor; Cardiomyopathies; Cricetinae; Heart Failure; Male; Neprilysin; S | 1990 |
Maximizing the natriuretic effect of endogenous atriopeptin in a rat model of heart failure.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Antibodies, Monoclonal; Atrial Natriuretic Factor; Blo | 1990 |