thiorphan has been researched along with Bronchial Hyperreactivity in 6 studies
Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
Bronchial Hyperreactivity: Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We hypothesized that NEP-inhibition by inhaled thiorphan (TH) would increase allergen-induced early (EAR) and late (LAR) asthmatic responses, and allergen-induced airway hyperresponsiveness to histamine in asthmatic subjects in vivo." | 9.08 | The effect of inhaled thiorphan on allergen-induced airway responses in asthmatic subjects. ( Bakker, PF; Diamant, Z; Kuijpers, EA; Sterk, PJ; Van der Veen, H, 1996) |
| "Thiorphan or placebo were aerosolized and administered in two 0." | 6.67 | Effect of an inhaled neutral endopeptidase inhibitor, thiorphan, on airway responsiveness to leukotriene D4 in normal and asthmatic subjects. ( Booms, P; Diamant, Z; Sont, JK; Sterk, PJ; Timmers, MC; van der Veen, H, 1994) |
| " Dose-response curves to inhaled NKA (1 to 125 micrograms/ml, 0." | 5.29 | Neutral endopeptidase activity and airway hyperresponsiveness to neurokinin A in asthmatic subjects in vivo. ( Cheung, D; den Hartigh, J; Dijkman, JH; Sterk, PJ; Timmers, MC; Zwinderman, AH, 1993) |
| "We hypothesized that NEP-inhibition by inhaled thiorphan (TH) would increase allergen-induced early (EAR) and late (LAR) asthmatic responses, and allergen-induced airway hyperresponsiveness to histamine in asthmatic subjects in vivo." | 5.08 | The effect of inhaled thiorphan on allergen-induced airway responses in asthmatic subjects. ( Bakker, PF; Diamant, Z; Kuijpers, EA; Sterk, PJ; Van der Veen, H, 1996) |
| "Neuropeptides such as neurokinin A (NKA) have been proposed as important mediators of bronchoconstriction and airway hyperresponsiveness in asthma." | 5.07 | The effect of an inhaled neutral endopeptidase inhibitor, thiorphan, on airway responses to neurokinin A in normal humans in vivo. ( Bel, EH; Cheung, D; Den Hartigh, J; Dijkman, JH; Sterk, PJ, 1992) |
| "Thiorphan or placebo were aerosolized and administered in two 0." | 2.67 | Effect of an inhaled neutral endopeptidase inhibitor, thiorphan, on airway responsiveness to leukotriene D4 in normal and asthmatic subjects. ( Booms, P; Diamant, Z; Sont, JK; Sterk, PJ; Timmers, MC; van der Veen, H, 1994) |
| " Dose-response curves to inhaled NKA (1 to 125 micrograms/ml, 0." | 1.29 | Neutral endopeptidase activity and airway hyperresponsiveness to neurokinin A in asthmatic subjects in vivo. ( Cheung, D; den Hartigh, J; Dijkman, JH; Sterk, PJ; Timmers, MC; Zwinderman, AH, 1993) |
| " Airway hyperresponsiveness was evidenced by significant shifts to the left of dose-response curves for intravenous acetylcholine (ACh) without a change in maximum responses to ACh." | 1.29 | The tachykinin NK2 receptor antagonist SR 48968 inhibits citric acid-induced airway hyperresponsiveness in guinea pigs. ( Advenier, C; Emonds-Alt, X; Girard, V; Yavo, JC, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stengel, PW | 1 |
| Bendele, AM | 1 |
| Cockerham, SL | 1 |
| Silbaugh, SA | 1 |
| Diamant, Z | 2 |
| Timmers, MC | 2 |
| van der Veen, H | 2 |
| Booms, P | 1 |
| Sont, JK | 1 |
| Sterk, PJ | 4 |
| Cheung, D | 2 |
| Zwinderman, AH | 1 |
| den Hartigh, J | 2 |
| Dijkman, JH | 2 |
| Girard, V | 1 |
| Yavo, JC | 1 |
| Emonds-Alt, X | 1 |
| Advenier, C | 1 |
| Kuijpers, EA | 1 |
| Bakker, PF | 1 |
| Bel, EH | 1 |
3 trials available for thiorphan and Bronchial Hyperreactivity
| Article | Year |
|---|---|
Effect of an inhaled neutral endopeptidase inhibitor, thiorphan, on airway responsiveness to leukotriene D4 in normal and asthmatic subjects.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; D | 1994 |
The effect of inhaled thiorphan on allergen-induced airway responses in asthmatic subjects.
Topics: Administration, Inhalation; Adult; Allergens; Asthma; Bronchial Hyperreactivity; Cross-Over Studies; | 1996 |
The effect of an inhaled neutral endopeptidase inhibitor, thiorphan, on airway responses to neurokinin A in normal humans in vivo.
Topics: Adult; Aerosols; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Double-Blind Method | 1992 |
3 other studies available for thiorphan and Bronchial Hyperreactivity
| Article | Year |
|---|---|
Sulfuric acid induces airway hyperresponsiveness to substance P in the guinea pig.
Topics: Administration, Inhalation; Animals; Bronchial Hyperreactivity; Dose-Response Relationship, Drug; Gu | 1993 |
Neutral endopeptidase activity and airway hyperresponsiveness to neurokinin A in asthmatic subjects in vivo.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Dose-Response Relationship, D | 1993 |
The tachykinin NK2 receptor antagonist SR 48968 inhibits citric acid-induced airway hyperresponsiveness in guinea pigs.
Topics: Acetylcholine; Aerosols; Animals; Benzamides; Bronchial Hyperreactivity; Bronchoconstriction; Capsai | 1996 |