thiorphan has been researched along with Asthma in 9 studies
Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We hypothesized that NEP-inhibition by inhaled thiorphan (TH) would increase allergen-induced early (EAR) and late (LAR) asthmatic responses, and allergen-induced airway hyperresponsiveness to histamine in asthmatic subjects in vivo." | 9.08 | The effect of inhaled thiorphan on allergen-induced airway responses in asthmatic subjects. ( Bakker, PF; Diamant, Z; Kuijpers, EA; Sterk, PJ; Van der Veen, H, 1996) |
| "Thiorphan or placebo were aerosolized and administered in two 0." | 6.67 | Effect of an inhaled neutral endopeptidase inhibitor, thiorphan, on airway responsiveness to leukotriene D4 in normal and asthmatic subjects. ( Booms, P; Diamant, Z; Sont, JK; Sterk, PJ; Timmers, MC; van der Veen, H, 1994) |
| " Dose-response curves to inhaled NKA (1 to 125 micrograms/ml, 0." | 5.29 | Neutral endopeptidase activity and airway hyperresponsiveness to neurokinin A in asthmatic subjects in vivo. ( Cheung, D; den Hartigh, J; Dijkman, JH; Sterk, PJ; Timmers, MC; Zwinderman, AH, 1993) |
| " To test this hypothesis, we have examined the effect of thiorphan, an NEP inhibitor, on the protection afforded by inhaled ANP against histamine-induced bronchoconstriction in 10 mildly asthmatic patients." | 5.08 | Effect of inhaled atrial natriuretic peptide and a neutral endopeptidase inhibitor on histamine-induced bronchoconstriction. ( Angus, RM; Chalmers, GW; Millar, EA; Thomson, NC, 1995) |
| "We hypothesized that NEP-inhibition by inhaled thiorphan (TH) would increase allergen-induced early (EAR) and late (LAR) asthmatic responses, and allergen-induced airway hyperresponsiveness to histamine in asthmatic subjects in vivo." | 5.08 | The effect of inhaled thiorphan on allergen-induced airway responses in asthmatic subjects. ( Bakker, PF; Diamant, Z; Kuijpers, EA; Sterk, PJ; Van der Veen, H, 1996) |
| "Neuropeptides such as neurokinin A (NKA) have been proposed as important mediators of bronchoconstriction and airway hyperresponsiveness in asthma." | 5.07 | The effect of an inhaled neutral endopeptidase inhibitor, thiorphan, on airway responses to neurokinin A in normal humans in vivo. ( Bel, EH; Cheung, D; Den Hartigh, J; Dijkman, JH; Sterk, PJ, 1992) |
| "We determined the effect of an inhibitor of neutral endopeptidase, acetorphan, on the skin responses to substance P and on the bronchostrictor effects of sodium metabisulphite aerosol in asthmatic subjects." | 5.07 | Effect of neutral endopeptidase inhibitor on airway function and bronchial responsiveness in asthmatic subjects. ( Barnes, PJ; Chung, KF; Lecomte, JM; Nichol, GM; O'Connor, BJ, 1992) |
| "Sodium metabisulfite (MBS) is a food preservative that can trigger bronchoconstriction in asthmatic subjects." | 3.68 | Mechanisms of metabisulfite-induced bronchoconstriction: evidence for bradykinin B2-receptor stimulation. ( Abraham, WM; Ahmed, A; Burch, RM; Caplan, J; Cortes, A; Mansour, E, 1992) |
| "Thiorphan or placebo were aerosolized and administered in two 0." | 2.67 | Effect of an inhaled neutral endopeptidase inhibitor, thiorphan, on airway responsiveness to leukotriene D4 in normal and asthmatic subjects. ( Booms, P; Diamant, Z; Sont, JK; Sterk, PJ; Timmers, MC; van der Veen, H, 1994) |
| " Dose-response curves to inhaled NKA (1 to 125 micrograms/ml, 0." | 1.29 | Neutral endopeptidase activity and airway hyperresponsiveness to neurokinin A in asthmatic subjects in vivo. ( Cheung, D; den Hartigh, J; Dijkman, JH; Sterk, PJ; Timmers, MC; Zwinderman, AH, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Angus, RM | 2 |
| Millar, EA | 2 |
| Chalmers, GW | 2 |
| Thomson, NC | 2 |
| Diamant, Z | 2 |
| Timmers, MC | 2 |
| van der Veen, H | 2 |
| Booms, P | 1 |
| Sont, JK | 1 |
| Sterk, PJ | 4 |
| Cheung, D | 2 |
| Zwinderman, AH | 1 |
| den Hartigh, J | 2 |
| Dijkman, JH | 2 |
| Kuijpers, EA | 1 |
| Bakker, PF | 1 |
| Bel, EH | 1 |
| Mansour, E | 1 |
| Ahmed, A | 1 |
| Cortes, A | 1 |
| Caplan, J | 1 |
| Burch, RM | 1 |
| Abraham, WM | 1 |
| Nichol, GM | 1 |
| O'Connor, BJ | 1 |
| Lecomte, JM | 1 |
| Chung, KF | 1 |
| Barnes, PJ | 1 |
| Patterson, R | 1 |
| Harris, KE | 1 |
6 trials available for thiorphan and Asthma
| Article | Year |
|---|---|
Effect of inhaled atrial natriuretic peptide and a neutral endopeptidase inhibitor on histamine-induced bronchoconstriction.
Topics: Administration, Inhalation; Adult; Asthma; Atrial Natriuretic Factor; Bronchial Provocation Tests; B | 1995 |
Effect of an inhaled neutral endopeptidase inhibitor, thiorphan, on airway responsiveness to leukotriene D4 in normal and asthmatic subjects.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; D | 1994 |
Effect of inhaled thiorphan, a neutral endopeptidase inhibitor, on the bronchodilator response to inhaled atrial natriuretic peptide (ANP).
Topics: Administration, Inhalation; Adult; Albuterol; Asthma; Atrial Natriuretic Factor; Bronchodilator Agen | 1996 |
The effect of inhaled thiorphan on allergen-induced airway responses in asthmatic subjects.
Topics: Administration, Inhalation; Adult; Allergens; Asthma; Bronchial Hyperreactivity; Cross-Over Studies; | 1996 |
The effect of an inhaled neutral endopeptidase inhibitor, thiorphan, on airway responses to neurokinin A in normal humans in vivo.
Topics: Adult; Aerosols; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Double-Blind Method | 1992 |
Effect of neutral endopeptidase inhibitor on airway function and bronchial responsiveness in asthmatic subjects.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Double-Blind Method; Female; Forced | 1992 |
3 other studies available for thiorphan and Asthma
| Article | Year |
|---|---|
Neutral endopeptidase activity and airway hyperresponsiveness to neurokinin A in asthmatic subjects in vivo.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Dose-Response Relationship, D | 1993 |
Mechanisms of metabisulfite-induced bronchoconstriction: evidence for bradykinin B2-receptor stimulation.
Topics: Animals; Asthma; Bradykinin; Bronchoconstriction; Food Preservatives; Receptors, Bradykinin; Recepto | 1992 |
Rhesus monkey airway responses to substance P.
Topics: Administration, Inhalation; Airway Obstruction; Animals; Antigens, Helminth; Ascaris; Asthma; Female | 1990 |