thiorphan has been researched along with Acute Disease in 27 studies
Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
Acute Disease: Disease having a short and relatively severe course.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In our study group, the use of racecadotril did not improve the symptoms of diarrhea compared with standard rehydration therapy." | 9.14 | Use of racecadotril as outpatient treatment for acute gastroenteritis: a prospective, randomized, parallel study. ( Marañón, R; Miguez, C; Sánchez, C; Santos, M; Vázquez, P, 2009) |
| " Loperamide is an effective anti-diarrheal agent, but it usually induces constipation." | 9.11 | A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults. ( Liao, KF; Shieh, MJ; Wang, HH, 2005) |
| "We conducted the study to determine the role of racecadotril as an adjunct to the standard treatment of cholera in adults." | 9.10 | Efficacy and tolerability of racecadotril in the treatment of cholera in adults: a double blind, randomised, controlled clinical trial. ( Alam, NH; Ashraf, H; Fuchs, GJ; Karim, MM; Khan, WA, 2003) |
| "Racecadotril (acetorphan), an enkephalinase inhibitor with antisecretory and antidiarrheal actions, is an effective and safe treatment for acute diarrhea in adults and children." | 9.09 | Racecadotril in the treatment of acute watery diarrhea in children. ( Chea-Woo, E; Gutierrez, M; Salazar-Lindo, E; Santisteban-Ponce, J, 2000) |
| "This study demonstrates the efficacy (up to 50% reduction in stool output) and tolerability of racecadotril as adjuvant therapy to oral rehydration solution in the treatment of severe diarrhea in infants and children." | 9.09 | Efficacy and tolerability of racecadotril in acute diarrhea in children. ( Audrain, S; Bellaiche, M; Cézard, JP; Duhamel, JF; Ginies, JL; Girardet, JP; Lamireau, T; Lecomte, JM; Maurage, C; Meyer, M; Morali, A; Olives, JP; Pharaon, I; Poujol, A; Sarles, J; Vaillant, JM; Whately-Smith, C, 2001) |
| "Racecadotril is a guideline-recommended option for the treatment of acute diarrhea in children but existing guidelines and previous reviews of the field are based on a small fraction of published evidence." | 8.98 | Racecadotril in the treatment of acute diarrhea in children: a systematic, comprehensive review and meta-analysis of randomized controlled trials. ( Chen, M; Däbritz, J; Eberlin, M; Mueck, T, 2018) |
| "Racecadotril has been shown to reduce the stools output during acute diarrhoea." | 6.70 | [Effect of racecadotril in the management of acute diarrhea in infants and children]. ( Bocquet, N; Boursiquot, C; Chéron, G; Cojocaru, B; Garel, D; Marcombes, F; Sannier, N; Timsit, S; Wille, C, 2002) |
| "In our study group, the use of racecadotril did not improve the symptoms of diarrhea compared with standard rehydration therapy." | 5.14 | Use of racecadotril as outpatient treatment for acute gastroenteritis: a prospective, randomized, parallel study. ( Marañón, R; Miguez, C; Sánchez, C; Santos, M; Vázquez, P, 2009) |
| " Loperamide is an effective anti-diarrheal agent, but it usually induces constipation." | 5.11 | A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults. ( Liao, KF; Shieh, MJ; Wang, HH, 2005) |
| "We conducted the study to determine the role of racecadotril as an adjunct to the standard treatment of cholera in adults." | 5.10 | Efficacy and tolerability of racecadotril in the treatment of cholera in adults: a double blind, randomised, controlled clinical trial. ( Alam, NH; Ashraf, H; Fuchs, GJ; Karim, MM; Khan, WA, 2003) |
| "Racecadotril (acetorphan), an enkephalinase inhibitor with antisecretory and antidiarrheal actions, is an effective and safe treatment for acute diarrhea in adults and children." | 5.09 | Racecadotril in the treatment of acute watery diarrhea in children. ( Chea-Woo, E; Gutierrez, M; Salazar-Lindo, E; Santisteban-Ponce, J, 2000) |
| "This study demonstrates the efficacy (up to 50% reduction in stool output) and tolerability of racecadotril as adjuvant therapy to oral rehydration solution in the treatment of severe diarrhea in infants and children." | 5.09 | Efficacy and tolerability of racecadotril in acute diarrhea in children. ( Audrain, S; Bellaiche, M; Cézard, JP; Duhamel, JF; Ginies, JL; Girardet, JP; Lamireau, T; Lecomte, JM; Maurage, C; Meyer, M; Morali, A; Olives, JP; Pharaon, I; Poujol, A; Sarles, J; Vaillant, JM; Whately-Smith, C, 2001) |
| "Racecadotril is a guideline-recommended option for the treatment of acute diarrhea in children but existing guidelines and previous reviews of the field are based on a small fraction of published evidence." | 4.98 | Racecadotril in the treatment of acute diarrhea in children: a systematic, comprehensive review and meta-analysis of randomized controlled trials. ( Chen, M; Däbritz, J; Eberlin, M; Mueck, T, 2018) |
| "To summarize studies testing the efficacy and safety of racecadotril for treating children with acute gastroenteritis." | 4.84 | Systematic review: racecadotril in the treatment of acute diarrhoea in children. ( Chmielewska, A; Ruszczyński, M; Szajewska, H; Wieczorek, J, 2007) |
| "Racecadotril (acetorphan) is an orally active, potent inhibitor of enkephalinase, which exerts an antihypersecretory effect without increasing intestinal transit time." | 2.70 | A multinational comparison of racecadotril and loperamide in the treatment of acute watery diarrhoea in adults. ( Prado, D, 2002) |
| "Racecadotril has been shown to reduce the stools output during acute diarrhoea." | 2.70 | [Effect of racecadotril in the management of acute diarrhea in infants and children]. ( Bocquet, N; Boursiquot, C; Chéron, G; Cojocaru, B; Garel, D; Marcombes, F; Sannier, N; Timsit, S; Wille, C, 2002) |
| "Racecadotril and placebo were equally well tolerated, and the frequency of symptoms and signs was similar in both groups after 4 days of treatment." | 2.69 | Racecadotril versus placebo in the treatment of acute diarrhoea in adults. ( Baumer, P; Ben Khalifa, H; Berard, H; Hamza, H; Lecomte, JM, 1999) |
| "Racecadotril is an antisecretory agent that can prevent fluid/electrolyte depletion from the bowel as a result of acute diarrhoea without affecting intestinal motility." | 2.53 | Racecadotril for acute diarrhoea in children: systematic review and meta-analyses. ( Akobeng, A; Gordon, M, 2016) |
| "Nitazoxanide has high efficacy against Cryptosporodial diarrhea only." | 1.33 | Current status of anti-diarrheal and anti-secretory drugs in the management of acute childhood diarrhea. ( Alam, S; Bhatnagar, S, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (25.93) | 18.2507 |
| 2000's | 17 (62.96) | 29.6817 |
| 2010's | 3 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eberlin, M | 1 |
| Chen, M | 1 |
| Mueck, T | 1 |
| Däbritz, J | 1 |
| Gordon, M | 1 |
| Akobeng, A | 1 |
| Sáez, J | 2 |
| Cifuentes, L | 2 |
| Emparanza Knörr, JI | 1 |
| Ozcoidi Erro, I | 1 |
| Martínez Andueza, MC | 1 |
| Callén Blecua, MT | 1 |
| Alústiza Martínez, E | 1 |
| Aseguinolaza Iparraguirre, I | 1 |
| Guarino, A | 1 |
| Buccigrossi, V | 1 |
| Armellino, C | 1 |
| Santos, M | 1 |
| Marañón, R | 1 |
| Miguez, C | 1 |
| Vázquez, P | 1 |
| Sánchez, C | 1 |
| Prado, D | 1 |
| Cojocaru, B | 1 |
| Bocquet, N | 1 |
| Timsit, S | 1 |
| Wille, C | 1 |
| Boursiquot, C | 1 |
| Marcombes, F | 1 |
| Garel, D | 1 |
| Sannier, N | 1 |
| Chéron, G | 1 |
| Rao, SG | 1 |
| Alam, NH | 1 |
| Ashraf, H | 1 |
| Khan, WA | 1 |
| Karim, MM | 1 |
| Fuchs, GJ | 1 |
| Wang, HH | 1 |
| Shieh, MJ | 1 |
| Liao, KF | 1 |
| Cezard, JP | 2 |
| Salazar-Lindo, E | 3 |
| Alam, S | 1 |
| Bhatnagar, S | 1 |
| Turck, D | 2 |
| Szajewska, H | 1 |
| Ruszczyński, M | 1 |
| Chmielewska, A | 1 |
| Wieczorek, J | 1 |
| Tormo, R | 1 |
| Polanco, I | 1 |
| Goulet, O | 1 |
| Dorval, ED | 1 |
| Regimbeau, C | 1 |
| Gamelin, E | 1 |
| Picon, L | 1 |
| Bérard, H | 5 |
| Roge, J | 1 |
| Baumer, P | 2 |
| Schwartz, JC | 1 |
| Lecomte, JM | 5 |
| Grasemann, H | 1 |
| Lu, B | 1 |
| Jiao, A | 1 |
| Boudreau, J | 1 |
| Gerard, NP | 1 |
| De Sanctis, GT | 1 |
| Farthing, MJ | 1 |
| Vetel, JM | 1 |
| Fretault, N | 2 |
| Hamza, H | 1 |
| Ben Khalifa, H | 1 |
| Stanović, S | 1 |
| Boranić, M | 1 |
| Petrovecki, M | 1 |
| Batinić, D | 1 |
| Skodlar, J | 1 |
| Nemet, D | 1 |
| Labar, B | 1 |
| Santisteban-Ponce, J | 1 |
| Chea-Woo, E | 1 |
| Gutierrez, M | 1 |
| Capasso, G | 1 |
| Unwin, R | 1 |
| Ciani, F | 1 |
| Rizzo, A | 1 |
| Russo, F | 1 |
| Pica, A | 1 |
| De Santo, NG | 1 |
| Duhamel, JF | 1 |
| Meyer, M | 1 |
| Pharaon, I | 1 |
| Bellaiche, M | 1 |
| Maurage, C | 1 |
| Ginies, JL | 1 |
| Vaillant, JM | 1 |
| Girardet, JP | 1 |
| Lamireau, T | 1 |
| Poujol, A | 1 |
| Morali, A | 1 |
| Sarles, J | 1 |
| Olives, JP | 1 |
| Whately-Smith, C | 1 |
| Audrain, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy, Safety and Cost-effectiveness Analysis of Impact of Racecadotril as an Adjunct in the Treatment of Acute Diarrhea in Mexican Children[NCT01153854] | Phase 3 | 454 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for thiorphan and Acute Disease
| Article | Year |
|---|---|
Racecadotril in the treatment of acute diarrhea in children: a systematic, comprehensive review and meta-analysis of randomized controlled trials.
Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Humans; Randomized Controlled Trials as Topic; Thior | 2018 |
Racecadotril for acute diarrhoea in children: systematic review and meta-analyses.
Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Humans; Thiorphan; Treatment Outcome | 2016 |
Is racecadotril effective for acute diarrhea in children? -First update.
Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Gastroenteritis; Humans; Randomized Controlled Trial | 2015 |
Is racecadotril effective for acute diarrhea in children? -First update.
Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Gastroenteritis; Humans; Randomized Controlled Trial | 2015 |
Is racecadotril effective for acute diarrhea in children? -First update.
Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Gastroenteritis; Humans; Randomized Controlled Trial | 2015 |
Is racecadotril effective for acute diarrhea in children? -First update.
Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Gastroenteritis; Humans; Randomized Controlled Trial | 2015 |
[Systematic review of the efficacy of racecadotril in the treatment of acute diarrhoea].
Topics: Acute Disease; Antidiarrheals; Child, Preschool; Diarrhea, Infantile; Humans; Infant; Randomized Con | 2008 |
[Prevention and treatment of acute diarrhea in infants].
Topics: Acute Disease; Antidiarrheals; Breast Feeding; Dehydration; Diarrhea, Infantile; Fluid Therapy; Huma | 2007 |
Systematic review: racecadotril in the treatment of acute diarrhoea in children.
Topics: Acute Disease; Antidiarrheals; Child, Preschool; Diarrhea; Female; Gastroenteritis; Humans; Infant; | 2007 |
Acute infectious diarrhoea in children: new insights in antisecretory treatment with racecadotril.
Topics: Acute Disease; Antidiarrheals; Bacterial Infections; Breast Feeding; Child; Dehydration; Diarrhea; F | 2008 |
12 trials available for thiorphan and Acute Disease
| Article | Year |
|---|---|
Use of racecadotril as outpatient treatment for acute gastroenteritis: a prospective, randomized, parallel study.
Topics: Acute Disease; Ambulatory Care; Antidiarrheals; Dehydration; Diarrhea; Drug Therapy, Combination; Em | 2009 |
A multinational comparison of racecadotril and loperamide in the treatment of acute watery diarrhoea in adults.
Topics: Acute Disease; Administration, Oral; Adult; Antidiarrheals; Diarrhea; Dose-Response Relationship, Dr | 2002 |
[Effect of racecadotril in the management of acute diarrhea in infants and children].
Topics: Acute Disease; Antidiarrheals; Child, Preschool; Dehydration; Diarrhea; Emergency Medical Services; | 2002 |
Efficacy and tolerability of racecadotril in the treatment of cholera in adults: a double blind, randomised, controlled clinical trial.
Topics: Acute Disease; Adolescent; Adult; Antidiarrheals; Chemotherapy, Adjuvant; Chi-Square Distribution; C | 2003 |
A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults.
Topics: Acute Disease; Adult; Antidiarrheals; Constipation; Diarrhea; Female; Humans; Loperamide; Male; Midd | 2005 |
[Treatment of acute chemically induced diarrhea by inhibition of enkephalinase. Results of a pilot study].
Topics: Acute Disease; Adenocarcinoma; Adult; Aged; Colorectal Neoplasms; Combined Modality Therapy; Diarrhe | 1995 |
The enkephalinase inhibitor, acetorphan, in acute diarrhoea. A double-blind, controlled clinical trial versus loperamide.
Topics: Acute Disease; Adult; Diarrhea; Double-Blind Method; Female; Humans; Loperamide; Male; Neprilysin; T | 1993 |
Comparison of racecadotril and loperamide in adults with acute diarrhoea.
Topics: Acute Disease; Adult; Diarrhea; Double-Blind Method; Female; Humans; Loperamide; Male; Neprilysin; P | 1999 |
Racecadotril versus placebo in the treatment of acute diarrhoea in adults.
Topics: Acute Disease; Adult; Antidiarrheals; Diarrhea; Double-Blind Method; Female; Humans; Male; Middle Ag | 1999 |
Comparison of racecadotril and loperamide in children with acute diarrhoea.
Topics: Acute Disease; Antidiarrheals; Child; Child, Preschool; Diarrhea; Double-Blind Method; Female; Human | 1999 |
Racecadotril in the treatment of acute watery diarrhea in children.
Topics: Acute Disease; Antidiarrheals; Child, Preschool; Combined Modality Therapy; Developing Countries; Di | 2000 |
Efficacy and tolerability of racecadotril in acute diarrhea in children.
Topics: Acute Disease; Antidiarrheals; Child, Preschool; Defecation; Diarrhea; Double-Blind Method; Female; | 2001 |
8 other studies available for thiorphan and Acute Disease
| Article | Year |
|---|---|
Colon in acute intestinal infection.
Topics: Acute Disease; Antidiarrheals; Caco-2 Cells; Colon; Diarrhea; Drug Evaluation, Preclinical; Gastroen | 2009 |
Racecadotril (acetorphan) in the treatment of acute watery diarrhoea in children.
Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Fluid Therapy; Humans; Thiorphan | 2002 |
Racecadotril in acute diarrhea.
Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Drug Evaluation; Female; Humans; Male; Research Desi | 2005 |
Current status of anti-diarrheal and anti-secretory drugs in the management of acute childhood diarrhea.
Topics: Acute Disease; Antidiarrheals; Antiparasitic Agents; Child; Child, Preschool; Cholera; Diarrhea; Dis | 2006 |
Targeted deletion of the neutral endopeptidase gene alters ventilatory responses to acute hypoxia in mice.
Topics: Acute Disease; Animals; Gene Deletion; Gene Targeting; Hypoxia; Male; Mice; Mice, Inbred C57BL; Mice | 1999 |
Introduction. Enkephalinase inhibition: a rational approach to antisecretory therapy for acute diarrhoea.
Topics: Acute Disease; Antidiarrheals; Diarrhea; Humans; Neprilysin; Protease Inhibitors; Thiorphan | 1999 |
Thiorphan, an inhibitor of neutral endopeptidase/enkephalinase (CD10/CALLA) enhances cell proliferation in bone marrow cultures of patients with acute leukemia in remission.
Topics: Acute Disease; Anemia, Refractory, with Excess of Blasts; Angiotensin-Converting Enzyme Inhibitors; | 2000 |
Inhibition of neutral endopeptidase potentiates the effects of atrial natriuretic peptide on acute cyclosporin-induced nephrotoxicity.
Topics: Acute Disease; Animals; Atrial Natriuretic Factor; Cyclosporine; Drug Synergism; Glomerular Filtrati | 2000 |