thiorphan has been researched along with Acute Confusional Senile Dementia in 6 studies
Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A central question in Alzheimer's disease (AD) research is what role β-amyloid peptide (Aβ) plays in synaptic dysfunction." | 1.37 | Impaired β-amyloid secretion in Alzheimer's disease pathogenesis. ( Capetillo-Zarate, E; Gouras, GK; Lin, MT; Rahman, N; Tampellini, D, 2011) |
| "Studies on the pathogenesis of Alzheimer's disease (AD) suggest overproduction of amyloid beta (Abeta) may not be the only pathogenic route to AD." | 1.32 | Thiorphan-induced neprilysin inhibition raises amyloid beta levels in rabbit cortex and cerebrospinal fluid. ( Beach, TG; Newell, AJ; Potter, PE; Rauschkolb, PK; Scott, S; Sue, LI; Walker, DG, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abramov, E | 1 |
| Dolev, I | 1 |
| Fogel, H | 1 |
| Ciccotosto, GD | 1 |
| Ruff, E | 1 |
| Slutsky, I | 1 |
| Li, W | 1 |
| Wu, Y | 1 |
| Min, F | 1 |
| Li, Z | 1 |
| Huang, J | 1 |
| Huang, R | 1 |
| Miners, JS | 1 |
| Barua, N | 1 |
| Kehoe, PG | 1 |
| Gill, S | 1 |
| Love, S | 1 |
| Tampellini, D | 1 |
| Rahman, N | 1 |
| Lin, MT | 1 |
| Capetillo-Zarate, E | 1 |
| Gouras, GK | 1 |
| Newell, AJ | 1 |
| Sue, LI | 1 |
| Scott, S | 1 |
| Rauschkolb, PK | 1 |
| Walker, DG | 1 |
| Potter, PE | 1 |
| Beach, TG | 1 |
| Shalova, IN | 1 |
| Cechalova, K | 1 |
| Rehakova, Z | 1 |
| Dimitrova, P | 1 |
| Ognibene, E | 1 |
| Caprioli, A | 1 |
| Schmalhausen, EV | 1 |
| Muronetz, VI | 1 |
| Saso, L | 1 |
1 review available for thiorphan and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Aβ-degrading enzymes: potential for treatment of Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Genetic Therapy; Glycopep | 2011 |
5 other studies available for thiorphan and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; CA1 Region, Hippocampal; Excitatory Postsynaptic | 2009 |
A nonhuman primate model of Alzheimer's disease generated by intracranial injection of amyloid-β42 and thiorphan.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Craniotomy; Disease Models, Animal; Infusion Pump | 2010 |
Impaired β-amyloid secretion in Alzheimer's disease pathogenesis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Calcium-Calmoduli | 2011 |
Thiorphan-induced neprilysin inhibition raises amyloid beta levels in rabbit cortex and cerebrospinal fluid.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain Chemistry; Cerebral Cortex; Enzyme-Linked I | 2003 |
Decrease of dehydrogenase activity of cerebral glyceraldehyde-3-phosphate dehydrogenase in different animal models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Enzyme Inhibitors; Glycer | 2007 |