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thiorphan and Ache

thiorphan has been researched along with Ache in 18 studies

Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.

Research Excerpts

ExcerptRelevanceReference
" In rats with hindpaw inflammation, inhibitors of aminopeptidase N (APN; bestatin) or neutral endopeptidase (NEP; thiorphan), and a dual inhibitor, NH(2)-CH-Ph-P(O)(OH)CH(2)-CH-CH(2)Ph(p-Ph)-CONH-CH-CH(3)-COOH (P8B), were applied to injured paws."3.78Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue. ( Fournie-Zaluski, MC; Gore, C; Labuz, D; Machelska, H; Roques, BP; Schreiter, A; Stein, C, 2012)
"5 mg/kg of GB 52, a highly potent derivative of the enkephalinase inhibitor, thiorphan, were studied on the threshold of both the nociceptive reflex (Tr) and sensation of pain (Tp) as well as on the thresholds of both recruitment of the maximal nociceptive reflex response (Tmr) and tolerable pain (Tip), elicited by electrical stimulation of the sural nerve in normal and relaxed volunteers."3.67The enkephalinase inhibitor, GB 52, does not affect nociceptive flexion reflexes nor pain sensation in humans. ( Ernst, M; Roby, A; Willer, JC, 1986)
"To confirm that endogenous opioid-peptidergic systems and monoaminergic systems participate in the regulation of pain, the effects of a narcotic antagonist naloxone, inhibitors of enkephalin-degrading enzymes and monoaminergic blockers on persistent pain induced by formalin were investigated."3.67Involvement of medullary opioid-peptidergic and spinal noradrenergic systems in the regulation of formalin-induced persistent pain. ( Kuraishi, Y; Satoh, M; Sugimoto, M; Takagi, H, 1986)
"The effect of the inhibition of aminopeptidase and enkephalinase A on the pain threshold of mice and rats was investigated, using bestatin and thiorphan as selective peptidase inhibitors."3.66Effect of inhibition of neuropeptidases on the pain threshold of mice and rats. ( Carenzi, A; Della Bella, D; Frigeni, V; Reggiani, A, 1983)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-199014 (77.78)18.7374
1990's2 (11.11)18.2507
2000's1 (5.56)29.6817
2010's1 (5.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Schreiter, A1
Gore, C1
Labuz, D1
Fournie-Zaluski, MC4
Roques, BP4
Stein, C1
Machelska, H1
Rougeot, C1
Messaoudi, M1
Hermitte, V1
Rigault, AG1
Blisnick, T1
Dugave, C1
Desor, D1
Rougeon, F1
Chaillet, P1
Coulaud, A1
Gacel, G1
Costentin, J2
Guilbaud, G2
Kayser, V2
Benoist, JM1
Gautron, M1
Carenzi, A1
Frigeni, V1
Reggiani, A1
Della Bella, D1
Nichols, ML1
Bian, D1
Ossipov, MH1
Malan, TP1
Porreca, F1
Zhou, Y1
Luo, F1
Han, J1
Yu, Z1
Williams, PS2
Smith, HJ2
Sewell, RD2
Patel, A1
Gonzalez, JP2
Malin, DH1
Lake, JR1
Hamilton, RF1
Skolnick, MH1
Michael-Titus, A1
Dourmap, N1
Caline, H1
Schwartz, JC1
Villanueva, L1
Cadden, S1
Chitour, D1
Le Bars, D2
Willer, JC1
Roby, A1
Ernst, M1
Bourgoin, S1
Cesselin, F1
Hamon, M1
Dickenson, AH2
Hill, RG1
Hughes, J1
Pittaway, KM1
Sugimoto, M1
Kuraishi, Y1
Satoh, M1
Takagi, H1
Sullivan, AF1

Other Studies

18 other studies available for thiorphan and Ache

ArticleYear
Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2012, Volume: 26, Issue:12

    Topics: Alanine; Amino Acid Sequence; Animals; Antibodies; CD13 Antigens; Dose-Response Relationship, Drug;

2012
Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Jul-08, Volume: 100, Issue:14

    Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, Methionine; Formaldehyde; Glycopeptides; Kidne

2003
Pain control by endogenous enkephalins is mediated by mu opioid receptors.
    Life sciences, 1983, Volume: 33 Suppl 1

    Topics: Amino Acids, Sulfur; Analgesia; Animals; Enkephalin, Methionine; Enkephalins; Leucine; Male; Mice; P

1983
Depressive effects of morphine and of an enkephalinase inhibitor on responses of ventro-basal thalamic neurones to noxious stimuli.
    Life sciences, 1983, Volume: 33 Suppl 1

    Topics: Amino Acids, Sulfur; Animals; Morphine; Neprilysin; Neurons; Nociceptors; Pain; Protease Inhibitors;

1983
Effect of inhibition of neuropeptidases on the pain threshold of mice and rats.
    Neuropharmacology, 1983, Volume: 22, Issue:11

    Topics: Aminopeptidases; Animals; Endopeptidases; Enkephalin, Leucine; Leucine; Male; Mice; Neprilysin; Pain

1983
The analgesic effects of morphine, but not those of the enkephalinase inhibitor thiorphan, are enhanced in arthritic rats.
    Brain research, 1983, May-09, Volume: 267, Issue:1

    Topics: Amino Acids, Sulfur; Analgesia; Animals; Arthritis; Arthritis, Experimental; Male; Morphine; Naloxon

1983
Antiallodynic effects of a CCKB antagonist in rats with nerve ligation injury: role of endogenous enkephalins.
    Neuroscience letters, 1996, Sep-13, Volume: 215, Issue:3

    Topics: Animals; Male; Naltrexone; Narcotic Antagonists; Pain; Peripheral Nervous System; Rats; Rats, Spragu

1996
[Enkephelinase inhibitors acetorphan and SCH34826 potentiate the analgesic effect of low frequency electroacupuncture in rats].
    Zhen ci yan jiu = Acupuncture research, 1990, Volume: 15, Issue:4

    Topics: Acupuncture Analgesia; Animals; Dioxolanes; Dipeptides; Electroacupuncture; Female; Male; Neprilysin

1990
Novel inhibitors of enkephalin-degrading enzymes. II: N5'-substituted-4-thioxohydantoic acids as aminopeptidase inhibitors.
    Journal of enzyme inhibition, 1989, Volume: 3, Issue:2

    Topics: Aminopeptidases; Analgesics; Animals; Glycine; Indicators and Reagents; Leucine; Mice; Naloxone; Nep

1989
Novel inhibitors of enkephalin-degrading enzymes. I: Inhibitors of enkephalinase by penicillins.
    Journal of enzyme inhibition, 1989, Volume: 3, Issue:2

    Topics: Analgesics; Animals; Brain; Enkephalin, Leucine-2-Alanine; Isoenzymes; Male; Mice; Mice, Inbred Stra

1989
Augmented analgesic effects of enkephalinase inhibitors combined with transcranial electrostimulation.
    Life sciences, 1989, Volume: 44, Issue:19

    Topics: Analgesia; Analgesics; Animals; Brain; Cerebral Ventricles; Electric Stimulation; Injections, Intrav

1989
Role of endogenous enkephalins in locomotion and nociception studied with peptidase inhibitors in two inbred strains of mice (C57BL/6J and DBA/2J).
    Neuropharmacology, 1989, Volume: 28, Issue:2

    Topics: Analgesics; Animals; Cerebral Ventricles; Enkephalins; Injections, Intraventricular; Leucine; Male;

1989
Failure of ES 52, a highly potent enkephalinase inhibitor, to affect nociceptive transmission by rat dorsal horn convergent neurones.
    Brain research, 1985, Apr-29, Volume: 333, Issue:1

    Topics: Amino Acids, Sulfur; Animals; Enkephalins; Male; Nociceptors; Pain; Rats; Spinal Cord; Synaptic Tran

1985
The enkephalinase inhibitor, GB 52, does not affect nociceptive flexion reflexes nor pain sensation in humans.
    Neuropharmacology, 1986, Volume: 25, Issue:8

    Topics: Adult; Amino Acids, Sulfur; Electric Stimulation; Endopeptidases; Enkephalins; Female; Humans; Male;

1986
Increase in met-enkephalin level and antinociceptive effects induced by kelatorphan in the rat spinal cord.
    NIDA research monograph, 1986, Volume: 75

    Topics: Analgesics; Animals; Dipeptides; Enkephalin, Methionine; In Vitro Techniques; Leucine; Neurons; Pain

1986
Antinociceptive action of cholecystokinin octapeptide (CCK 8) and related peptides in rats and mice: effects of naloxone and peptidase inhibitors.
    Neuropharmacology, 1987, Volume: 26, Issue:4

    Topics: Animals; Captopril; FMRFamide; Gastrins; Leucine; Male; Mice; Naloxone; Neuropeptides; Pain; Proteas

1987
Involvement of medullary opioid-peptidergic and spinal noradrenergic systems in the regulation of formalin-induced persistent pain.
    Neuropharmacology, 1986, Volume: 25, Issue:5

    Topics: Animals; Endorphins; Formaldehyde; Injections, Spinal; Leucine; Male; Medulla Oblongata; Naloxone; N

1986
Prevention of degradation of endogenous enkephalins produces inhibition of nociceptive neurones in rat spinal cord.
    Brain research, 1987, Apr-07, Volume: 408, Issue:1-2

    Topics: Action Potentials; Animals; Dipeptides; Enkephalins; Leucine; Male; Naloxone; Nerve Fibers; Neural I

1987