thioridazine has been researched along with Tuberculosis in 11 studies
Thioridazine: A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.
thioridazine : A phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position.
Tuberculosis: Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thioridazine is an orally administered antipsychotic drug with potential for treatment of drug-resistant tuberculosis (TB)." | 7.83 | In vitro evaluation of novel inhalable dry powders consisting of thioridazine and rifapentine for rapid tuberculosis treatment. ( Britton, WJ; Chan, HK; Chan, JG; Pang, A; Parumasivam, T; Quan, DH; Triccas, JA, 2016) |
| " in a recent issue of this Journal address one of the current debates regarding the potential role of thioridazine in the treatment of tuberculosis." | 7.80 | Thioridazine for treatment of tuberculosis: promises and pitfalls. ( Dutta, NK; Karakousis, PC, 2014) |
| "Assessment of the activity of thioridazine towards Mycobacterium tuberculosis (Mtb), in vitro and in vivo as a single drug and in combination with tuberculosis (TB) drugs." | 7.80 | Enhancement of in vitro activity of tuberculosis drugs by addition of thioridazine is not reflected by improved in vivo therapeutic efficacy. ( Aarnoutse, R; Bakker-Woudenberg, IA; Boeree, MJ; de Knegt, GJ; de Steenwinkel, JE; ten Kate, MT; van Soolingen, D, 2014) |
| "The antipsychotic drug thioridazine is active in the murine model of tuberculosis infection, which is predominantly intracellular in nature." | 7.79 | Thioridazine lacks bactericidal activity in an animal model of extracellular tuberculosis. ( Dutta, NK; Karakousis, PC; Pinn, ML; Rudek, MA; Zhao, M, 2013) |
| "Thioridazine is an orally administered antipsychotic drug with potential for treatment of drug-resistant tuberculosis (TB)." | 3.83 | In vitro evaluation of novel inhalable dry powders consisting of thioridazine and rifapentine for rapid tuberculosis treatment. ( Britton, WJ; Chan, HK; Chan, JG; Pang, A; Parumasivam, T; Quan, DH; Triccas, JA, 2016) |
| " in a recent issue of this Journal address one of the current debates regarding the potential role of thioridazine in the treatment of tuberculosis." | 3.80 | Thioridazine for treatment of tuberculosis: promises and pitfalls. ( Dutta, NK; Karakousis, PC, 2014) |
| "Assessment of the activity of thioridazine towards Mycobacterium tuberculosis (Mtb), in vitro and in vivo as a single drug and in combination with tuberculosis (TB) drugs." | 3.80 | Enhancement of in vitro activity of tuberculosis drugs by addition of thioridazine is not reflected by improved in vivo therapeutic efficacy. ( Aarnoutse, R; Bakker-Woudenberg, IA; Boeree, MJ; de Knegt, GJ; de Steenwinkel, JE; ten Kate, MT; van Soolingen, D, 2014) |
| "The antipsychotic drug thioridazine is active in the murine model of tuberculosis infection, which is predominantly intracellular in nature." | 3.79 | Thioridazine lacks bactericidal activity in an animal model of extracellular tuberculosis. ( Dutta, NK; Karakousis, PC; Pinn, ML; Rudek, MA; Zhao, M, 2013) |
| " Whereas free thioridazine was highly toxic in both cells and zebrafish embryos, after encapsulation in nanoparticles no toxicity was detected." | 1.43 | Thioridazine in PLGA nanoparticles reduces toxicity and improves rifampicin therapy against mycobacterial infection in zebrafish. ( Anes, E; Bogoeva, V; Fenaroli, F; Griffiths, G; Hildahl, J; Kalluru, R; Pires, D; Speth, M; Vibe, CB; Wilson, SR, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Saito, K | 1 |
| Warrier, T | 1 |
| Somersan-Karakaya, S | 1 |
| Kaminski, L | 1 |
| Mi, J | 1 |
| Jiang, X | 1 |
| Park, S | 1 |
| Shigyo, K | 1 |
| Gold, B | 1 |
| Roberts, J | 1 |
| Weber, E | 1 |
| Jacobs, WR | 1 |
| Nathan, CF | 1 |
| Dutta, NK | 2 |
| Pinn, ML | 1 |
| Zhao, M | 1 |
| Rudek, MA | 1 |
| Karakousis, PC | 2 |
| de Knegt, GJ | 1 |
| ten Kate, MT | 1 |
| van Soolingen, D | 1 |
| Aarnoutse, R | 1 |
| Boeree, MJ | 1 |
| Bakker-Woudenberg, IA | 1 |
| de Steenwinkel, JE | 1 |
| Vibe, CB | 1 |
| Fenaroli, F | 1 |
| Pires, D | 1 |
| Wilson, SR | 1 |
| Bogoeva, V | 1 |
| Kalluru, R | 1 |
| Speth, M | 1 |
| Anes, E | 1 |
| Griffiths, G | 1 |
| Hildahl, J | 1 |
| Parumasivam, T | 1 |
| Chan, JG | 1 |
| Pang, A | 1 |
| Quan, DH | 1 |
| Triccas, JA | 1 |
| Britton, WJ | 1 |
| Chan, HK | 1 |
| GOVER, DM | 1 |
| REYSS-BRION, R | 1 |
| MEYER, L | 1 |
| Amaral, L | 2 |
| Kristiansen, JE | 2 |
| Abebe, LS | 1 |
| Millett, W | 1 |
2 reviews available for thioridazine and Tuberculosis
| Article | Year |
|---|---|
Thioridazine.
Topics: Animals; Antitubercular Agents; Humans; Thioridazine; Treatment Outcome; Tuberculosis | 2008 |
Phenothiazines: an alternative to conventional therapy for the initial management of suspected multidrug resistant tuberculosis. A call for studies.
Topics: Antitubercular Agents; Chemotherapy, Adjuvant; Chlorpromazine; Drug Resistance, Multiple; Humans; My | 2000 |
9 other studies available for thioridazine and Tuberculosis
| Article | Year |
|---|---|
Rifamycin action on RNA polymerase in antibiotic-tolerant
Topics: Antibiotics, Antitubercular; Antitubercular Agents; Bacterial Proteins; DNA-Directed RNA Polymerases | 2017 |
Thioridazine lacks bactericidal activity in an animal model of extracellular tuberculosis.
Topics: Aerosols; Animals; Antipsychotic Agents; Area Under Curve; Dose-Response Relationship, Drug; Endpoin | 2013 |
Thioridazine for treatment of tuberculosis: promises and pitfalls.
Topics: Animals; Antitubercular Agents; Female; Isoniazid; Mycobacterium tuberculosis; Pyrazinamide; Rifampi | 2014 |
Enhancement of in vitro activity of tuberculosis drugs by addition of thioridazine is not reflected by improved in vivo therapeutic efficacy.
Topics: Animals; Antitubercular Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combi | 2014 |
Thioridazine in PLGA nanoparticles reduces toxicity and improves rifampicin therapy against mycobacterial infection in zebrafish.
Topics: Animals; Antitubercular Agents; Cell Survival; Cells, Cultured; Disease Models, Animal; Drug Therapy | 2016 |
In vitro evaluation of novel inhalable dry powders consisting of thioridazine and rifapentine for rapid tuberculosis treatment.
Topics: Administration, Inhalation; Antitubercular Agents; Humans; In Vitro Techniques; Powder Diffraction; | 2016 |
Thioridazine and chlorprothixene in the management of anxiety in tuberculous patients.
Topics: Antidepressive Agents; Anxiety; Anxiety Disorders; Chlorprothixene; Thioridazine; Tranquilizing Agen | 1962 |
[ATTEMPTED PSYCHOSOMATIC APPROACH TO THE NEUROTOXICITY OF CYCLOSERINE].
Topics: Adolescent; Chlorpromazine; Cycloserine; Geriatrics; Meprobamate; Neurologic Manifestations; Prometh | 1963 |
Inhibition of the respiration of multi-drug resistant clinical isolates of Mycobacterium tuberculosis by thioridazine: potential use for initial therapy of freshly diagnosed tuberculosis.
Topics: Antipsychotic Agents; Antitubercular Agents; Chlorpromazine; Drug Resistance, Microbial; Drug Resist | 1996 |