thioridazine has been researched along with Tuberculosis, Multidrug-Resistant in 15 studies
Thioridazine: A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.
thioridazine : A phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position.
Tuberculosis, Multidrug-Resistant: Tuberculosis resistant to chemotherapy with two or more ANTITUBERCULAR AGENTS, including at least ISONIAZID and RIFAMPICIN. The problem of resistance is particularly troublesome in tuberculous OPPORTUNISTIC INFECTIONS associated with HIV INFECTIONS. It requires the use of second line drugs which are more toxic than the first line regimens. TB with isolates that have developed further resistance to at least three of the six classes of second line drugs is defined as EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clarithromycin was not associated with excess SAEs in eight controlled trials in HIV-infected patients (RD 0." | 2.52 | Efficacy and safety of World Health Organization group 5 drugs for multidrug-resistant tuberculosis treatment. ( Butler-Laporte, G; Menzies, D; Winters, N, 2015) |
| "Thioridazine treatment resulted in a significant reduction of colony-forming-units of the susceptible (-4." | 1.36 | The antipsychotic thioridazine shows promising therapeutic activity in a mouse model of multidrug-resistant tuberculosis. ( Aguilar, D; Amaral, L; Boeree, MJ; Hernandez-Pando, R; Magis-Escurra, C; Orozco, H; van Ingen, J; van Soolingen, D, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 12 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amaral, L | 8 |
| Martins, A | 1 |
| Spengler, G | 1 |
| Hunyadi, A | 1 |
| Molnar, J | 2 |
| Koutsouki, E | 1 |
| Dutta, NK | 2 |
| Pinn, ML | 1 |
| Karakousis, PC | 2 |
| Winters, N | 1 |
| Butler-Laporte, G | 1 |
| Menzies, D | 1 |
| Kristiansen, JE | 4 |
| Dastidar, SG | 2 |
| Palchoudhuri, S | 1 |
| Roy, DS | 1 |
| Das, S | 1 |
| Hendricks, O | 1 |
| Christensen, JB | 1 |
| Martins, M | 2 |
| Viveiros, M | 4 |
| van Soolingen, D | 1 |
| Hernandez-Pando, R | 1 |
| Orozco, H | 1 |
| Aguilar, D | 1 |
| Magis-Escurra, C | 1 |
| van Ingen, J | 2 |
| Boeree, MJ | 2 |
| Mazumdar, K | 1 |
| Machado, D | 1 |
| Couto, I | 1 |
| Perdigão, J | 1 |
| Rodrigues, L | 1 |
| Portugal, I | 1 |
| Baptista, P | 1 |
| Veigas, B | 1 |
10 reviews available for thioridazine and Tuberculosis, Multidrug-Resistant
| Article | Year |
|---|---|
The mechanism by which the phenothiazine thioridazine contributes to cure problematic drug-resistant forms of pulmonary tuberculosis: recent patents for "new use".
Topics: Antitubercular Agents; Extensively Drug-Resistant Tuberculosis; Humans; Mycobacterium tuberculosis; | 2013 |
Efficacy and safety of World Health Organization group 5 drugs for multidrug-resistant tuberculosis treatment.
Topics: Amoxicillin; Antitubercular Agents; Azithromycin; Cilastatin; Clarithromycin; Clavulanic Acid; HIV I | 2015 |
Phenothiazines as a solution for multidrug resistant tuberculosis: From the origin to present.
Topics: Antipsychotic Agents; Antitubercular Agents; Chlorpromazine; Humans; Mycobacterium tuberculosis; Phe | 2015 |
Promising therapy of XDR-TB/MDR-TB with thioridazine an inhibitor of bacterial efflux pumps.
Topics: Antitubercular Agents; Bacterial Proteins; Drug Resistance, Multiple, Bacterial; Extensively Drug-Re | 2008 |
The broad-spectrum antimycobacterial activities of phenothiazines, InVitro: somewhere in all of this there may be patentable potentials.
Topics: Animals; Antitubercular Agents; Drug Discovery; Drug Resistance, Multiple, Bacterial; Drug Therapy, | 2011 |
New patentable use of an old neuroleptic compound thioridazine to combat tuberculosis: a gene regulation perspective.
Topics: Animals; Antitubercular Agents; Drug Discovery; Drug Resistance, Multiple, Bacterial; Drug Therapy, | 2011 |
Targeting the human macrophage with combinations of drugs and inhibitors of Ca2+ and K+ transport to enhance the killing of intracellular multi-drug resistant Mycobacterium tuberculosis (MDR-TB)--a novel, patentable approach to limit the emergence of XDR-
Topics: Animals; Antitubercular Agents; Calcium Signaling; Drug Discovery; Drug Resistance, Multiple, Bacter | 2011 |
Global clinical trials for the treatment of TB with thioridazine.
Topics: Antitubercular Agents; Clinical Trials as Topic; Drug Discovery; Drug Resistance, Multiple, Bacteria | 2011 |
"Non-Antibiotics": alternative therapy for the management of MDRTB and MRSA in economically disadvantaged countries.
Topics: Developing Countries; Humans; Methicillin Resistance; Staphylococcal Infections; Staphylococcus aure | 2006 |
Phenothiazines: potential alternatives for the management of antibiotic resistant infections of tuberculosis and malaria in developing countries.
Topics: Animals; Antimalarials; Antitubercular Agents; Developing Countries; Drug Resistance; Drug Resistanc | 2001 |
5 other studies available for thioridazine and Tuberculosis, Multidrug-Resistant
| Article | Year |
|---|---|
New US patent for potential treatment of multidrug-resistant tuberculosis.
Topics: Antitubercular Agents; Bacterial Proteins; Humans; Membrane Transport Proteins; Mycobacterium tuberc | 2014 |
Reduced emergence of isoniazid resistance with concurrent use of thioridazine against acute murine tuberculosis.
Topics: Animals; Antipsychotic Agents; Antitubercular Agents; Disease Models, Animal; Drug Repositioning; Dr | 2014 |
The antipsychotic thioridazine shows promising therapeutic activity in a mouse model of multidrug-resistant tuberculosis.
Topics: Animals; Antipsychotic Agents; Antitubercular Agents; Disease Models, Animal; Drug Resistance, Bacte | 2010 |
It is anticipated that as is usually the case, financial motivation will move TZ from its current status “potential anti-MDR/XDR agent,” to one that will cure MDR and XDR TB. Foreword.
Topics: Animals; Antitubercular Agents; Drug Discovery; Drug Resistance, Multiple, Bacterial; Drug Therapy, | 2011 |
Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis.
Topics: Antitubercular Agents; Bacterial Proteins; Biological Transport, Active; Carrier Proteins; Catalase; | 2012 |