thioridazine has been researched along with Long QT Syndrome in 21 studies
Thioridazine: A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.
thioridazine : A phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Torsades de pointes was originally seen in patients with pre-existing heart disease or with intoxication." | 2.42 | [Psychopharmaceuticals and arrhythmias]. ( Binggeli, C; Brunckhorst, C; Candinas, R, 2004) |
| "There was 1 case of torsade de pointes in a thioridazine overdose." | 1.42 | Prolonged QT Risk Assessment in Antipsychotic Overdose Using the QT Nomogram. ( Berling, I; Isbister, GK, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 19 (90.48) | 29.6817 |
| 2010's | 2 (9.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kongsamut, S | 1 |
| Kang, J | 1 |
| Chen, XL | 1 |
| Roehr, J | 1 |
| Rampe, D | 2 |
| Cavalli, A | 1 |
| Poluzzi, E | 1 |
| De Ponti, F | 1 |
| Recanatini, M | 1 |
| Pearlstein, R | 1 |
| Vaz, R | 1 |
| Berling, I | 1 |
| Isbister, GK | 1 |
| Roman, M | 1 |
| Farmer, SY | 1 |
| Menkes, DB | 1 |
| Knight, JC | 1 |
| LLerena, A | 1 |
| Berecz, R | 1 |
| de la Rubia, A | 1 |
| Dorado, P | 1 |
| Laisalmi, M | 1 |
| Brahm, NC | 1 |
| Buswell, A | 1 |
| Christensen, D | 1 |
| Brown, RD | 1 |
| Zareba, W | 1 |
| Lin, DA | 1 |
| Timell, AM | 1 |
| Harrigan, EP | 1 |
| Miceli, JJ | 1 |
| Anziano, R | 1 |
| Watsky, E | 1 |
| Reeves, KR | 1 |
| Cutler, NR | 1 |
| Sramek, J | 1 |
| Shiovitz, T | 1 |
| Middle, M | 1 |
| Wright, NM | 1 |
| Roberts, AJ | 1 |
| Allgar, VL | 1 |
| Tompkins, CN | 1 |
| Greenwood, DC | 1 |
| Laurence, G | 1 |
| Binggeli, C | 1 |
| Candinas, R | 1 |
| Brunckhorst, C | 1 |
| Shiotani, M | 1 |
| Harada, T | 1 |
| Abe, J | 1 |
| Sawada, Y | 1 |
| Hashimoto, K | 1 |
| Hamada, Y | 1 |
| Horii, I | 1 |
| Salih, IS | 1 |
| Thanacoody, RH | 2 |
| McKay, GA | 1 |
| Thomas, SH | 2 |
| Daly, AK | 1 |
| Reilly, JG | 1 |
| Ferrier, IN | 1 |
| Hancox, JC | 1 |
| Witchel, HJ | 1 |
| Dallaire, S | 1 |
| Sachdev, P | 1 |
| Su, KP | 1 |
| Chang, HC | 1 |
| Shen, WW | 1 |
4 reviews available for thioridazine and Long QT Syndrome
| Article | Year |
|---|---|
Understanding the structure-activity relationship of the human ether-a-go-go-related gene cardiac K+ channel. A model for bad behavior.
Topics: Cation Transport Proteins; DNA-Binding Proteins; Drug-Related Side Effects and Adverse Reactions; ER | 2003 |
Cardiotoxicity and prescription of thioridazine in New Zealand.
Topics: Antipsychotic Agents; Dose-Response Relationship, Drug; Humans; Long QT Syndrome; New Zealand; Psych | 2002 |
Antipsychotic drugs and QT interval prolongation.
Topics: Age Factors; Algorithms; Antipsychotic Agents; Benzodiazepines; Death, Sudden, Cardiac; Dopamine Ant | 2003 |
[Psychopharmaceuticals and arrhythmias].
Topics: Antidepressive Agents, Tricyclic; Antipsychotic Agents; Arrhythmias, Cardiac; Dopamine Antagonists; | 2004 |
3 trials available for thioridazine and Long QT Syndrome
| Article | Year |
|---|---|
QTc interval lengthening is related to CYP2D6 hydroxylation capacity and plasma concentration of thioridazine in patients.
Topics: Adrenergic Agents; Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Biotransformation; Cytochro | 2002 |
A randomized evaluation of the effects of six antipsychotic agents on QTc, in the absence and presence of metabolic inhibition.
Topics: Adolescent; Adult; Antipsychotic Agents; Aryl Hydrocarbon Hydroxylases; Benzodiazepines; Biotransfor | 2004 |
Comparison of the effects of thioridazine and mesoridazine on the QT interval in healthy adults after single oral doses.
Topics: Administration, Oral; Adult; Antipsychotic Agents; Area Under Curve; Cross-Over Studies; Dopamine An | 2007 |
14 other studies available for thioridazine and Long QT Syndrome
| Article | Year |
|---|---|
A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Cation Transport Proteins; Cell Line; Clinical Trials as Topic; Crice | 2002 |
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go- | 2002 |
Prolonged QT Risk Assessment in Antipsychotic Overdose Using the QT Nomogram.
Topics: Adolescent; Adult; Aged; Amisulpride; Antipsychotic Agents; Drug Overdose; Electrocardiography; Fema | 2015 |
Antipsychotic medications and cardiac conduction risks.
Topics: Antipsychotic Agents; Comorbidity; Death, Sudden, Cardiac; Electrocardiography; Heart Conduction Sys | 2010 |
[Thioridazine and the warning about prolonged QT time].
Topics: Antipsychotic Agents; Humans; Long QT Syndrome; Psychotic Disorders; Thioridazine | 2002 |
Assessment of QTc prolongation following thioridazine withdrawal in a developmentally disabled population.
Topics: Adult; Child; Developmental Disabilities; Electrocardiography; Female; Humans; Long QT Syndrome; Mal | 2003 |
Re: Thioridazine: re-evaluating the risk/benefit equation.
Topics: Antipsychotic Agents; Data Collection; Death, Sudden; Electrocardiography; Female; Humans; Long QT S | 2003 |
Impact of the CSM advice on thioridazine on general practitioner prescribing behaviour in Leeds: time series analysis.
Topics: Antipsychotic Agents; Drug Approval; England; Family Practice; Humans; Long QT Syndrome; Practice Gu | 2004 |
Practical application of guinea pig telemetry system for QT evaluation.
Topics: Animals; Anti-Arrhythmia Agents; Antipsychotic Agents; Bepridil; Cisapride; Disease Models, Animal; | 2005 |
Factors affecting drug concentrations and QT interval during thioridazine therapy.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Alleles; Antipsychotic Agents; Aryl Hydrocarbon Hydroxy | 2007 |
Psychotropic drugs, HERG, and the heart.
Topics: Antipsychotic Agents; Cation Transport Proteins; DNA-Binding Proteins; ERG1 Potassium Channel; Ether | 2000 |
Thioridazine (Mellaril) and mesoridazine (Serentil): prolongation of the QTc interval.
Topics: Antipsychotic Agents; Arrhythmias, Cardiac; Contraindications; Heart Conduction System; Humans; Long | 2001 |
The prolongation of QTc-interval by thioridazine.
Topics: Antipsychotic Agents; Humans; Long QT Syndrome; Psychotic Disorders; Thioridazine | 2001 |
Prolongation of QTc interval and antipsychotics.
Topics: Antipsychotic Agents; Death, Sudden, Cardiac; Haloperidol; Humans; Long QT Syndrome; Thioridazine; T | 2002 |