thioridazine has been researched along with Glioma in 5 studies
Thioridazine: A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.
thioridazine : A phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| " screen phenothiazines for cytotoxic activity in glioma, neuroblastoma, and primary mouse brain tissue; and (2)." | 7.72 | Characterization of phenothiazine-induced apoptosis in neuroblastoma and glioma cell lines: clinical relevance and possible application for brain-derived tumors. ( Dayag, M; Gil-Ad, I; Levkovitz, Y; Shtaif, B; Weizman, A; Zeldich, E, 2004) |
| "Thioridazine (THD) is a common phenothiazine antipsychotic drug reported to suppress growth in several types of cancer cells." | 5.51 | Thioridazine Enhances P62-Mediated Autophagy and Apoptosis Through Wnt/β-Catenin Signaling Pathway in Glioma Cells. ( Cheng, HW; Cheng, JT; Cheng, TS; Chiou, SJ; Chou, CH; Chu, CW; Hong, YR; Huang, CF; Ko, HJ; Lai, YL; Liang, YH; Lin, CY; Loh, JK; Su, CL; Wang, C, 2019) |
| " screen phenothiazines for cytotoxic activity in glioma, neuroblastoma, and primary mouse brain tissue; and (2)." | 3.72 | Characterization of phenothiazine-induced apoptosis in neuroblastoma and glioma cell lines: clinical relevance and possible application for brain-derived tumors. ( Dayag, M; Gil-Ad, I; Levkovitz, Y; Shtaif, B; Weizman, A; Zeldich, E, 2004) |
| "Thioridazine (THD) is a common phenothiazine antipsychotic drug reported to suppress growth in several types of cancer cells." | 1.51 | Thioridazine Enhances P62-Mediated Autophagy and Apoptosis Through Wnt/β-Catenin Signaling Pathway in Glioma Cells. ( Cheng, HW; Cheng, JT; Cheng, TS; Chiou, SJ; Chou, CH; Chu, CW; Hong, YR; Huang, CF; Ko, HJ; Lai, YL; Liang, YH; Lin, CY; Loh, JK; Su, CL; Wang, C, 2019) |
| "Thioridazine has been known as an antipsychotic agent, but it also has anticancer activity." | 1.40 | Antipsychotic agent thioridazine sensitizes renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated inhibition of Akt signaling and downregulation of Mcl-1 and c-FLIP(L). ( Bae, YC; Kwon, TK; Min, KJ; Seo, BR; Yoo, YH, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chu, CW | 1 |
| Ko, HJ | 1 |
| Chou, CH | 1 |
| Cheng, TS | 1 |
| Cheng, HW | 1 |
| Liang, YH | 1 |
| Lai, YL | 1 |
| Lin, CY | 1 |
| Wang, C | 1 |
| Loh, JK | 1 |
| Cheng, JT | 1 |
| Chiou, SJ | 1 |
| Su, CL | 1 |
| Huang, CF | 1 |
| Hong, YR | 1 |
| Min, KJ | 2 |
| Seo, BR | 1 |
| Bae, YC | 1 |
| Yoo, YH | 1 |
| Kwon, TK | 2 |
| Seo, SU | 1 |
| Cho, HK | 1 |
| Woo, SM | 1 |
| Kim, S | 1 |
| Park, JW | 1 |
| Kim, SH | 1 |
| Choi, YH | 1 |
| Keum, YS | 1 |
| Hyun, JW | 1 |
| Park, HH | 1 |
| Lee, SH | 1 |
| Kim, DE | 1 |
| Gil-Ad, I | 1 |
| Shtaif, B | 1 |
| Levkovitz, Y | 1 |
| Dayag, M | 1 |
| Zeldich, E | 1 |
| Weizman, A | 1 |
| Sundberg, AL | 1 |
| Steffen, AC | 1 |
5 other studies available for thioridazine and Glioma
| Article | Year |
|---|---|
Thioridazine Enhances P62-Mediated Autophagy and Apoptosis Through Wnt/β-Catenin Signaling Pathway in Glioma Cells.
Topics: Apoptosis; Autophagy; Beclin-1; Blotting, Western; Catenins; Cell Cycle; Cell Line, Tumor; Cell Surv | 2019 |
Antipsychotic agent thioridazine sensitizes renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated inhibition of Akt signaling and downregulation of Mcl-1 and c-FLIP(L).
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antipsychotic Agents; Apoptos | 2014 |
Thioridazine enhances sensitivity to carboplatin in human head and neck cancer cells through downregulation of c-FLIP and Mcl-1 expression.
Topics: Breast Neoplasms; Carboplatin; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line; Cell Lin | 2017 |
Characterization of phenothiazine-induced apoptosis in neuroblastoma and glioma cell lines: clinical relevance and possible application for brain-derived tumors.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Calmodulin; Caspase 3; Caspases; Cell Di | 2004 |
Enhancing the effect of radionuclide tumor targeting, using lysosomotropic weak bases.
Topics: Amantadine; Ammonium Chloride; Antimalarials; Antipsychotic Agents; Antiviral Agents; Astatine; Carc | 2007 |