thioridazine has been researched along with Glioblastoma in 2 studies
Thioridazine: A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.
thioridazine : A phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Glioblastoma multiforme (GBM) has a poor prognosis with an overall survival of 14-15 months after surgery, radiation and chemotherapy using temozolomide (TMZ)." | 7.91 | Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide. ( Bjerkvig, R; Denisova, O; Grudic, A; Hasan-Olive, MM; Janji, B; Johannessen, TC; Latif, MA; Lund-Johansen, M; Nordal, A; Prestegarden, L; Røsland, GV; Saed, H; Simonsen, A; Sundstrøm, T; Tronstad, KJ; Varughese, JK; Wang, J; Westermarck, J; Yang, N; Zhu, H, 2019) |
| "Glioblastoma multiforme (GBM) has a poor prognosis with an overall survival of 14-15 months after surgery, radiation and chemotherapy using temozolomide (TMZ)." | 3.91 | Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide. ( Bjerkvig, R; Denisova, O; Grudic, A; Hasan-Olive, MM; Janji, B; Johannessen, TC; Latif, MA; Lund-Johansen, M; Nordal, A; Prestegarden, L; Røsland, GV; Saed, H; Simonsen, A; Sundstrøm, T; Tronstad, KJ; Varughese, JK; Wang, J; Westermarck, J; Yang, N; Zhu, H, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Johannessen, TC | 1 |
| Hasan-Olive, MM | 1 |
| Zhu, H | 1 |
| Denisova, O | 1 |
| Grudic, A | 1 |
| Latif, MA | 1 |
| Saed, H | 1 |
| Varughese, JK | 1 |
| Røsland, GV | 1 |
| Yang, N | 1 |
| Sundstrøm, T | 1 |
| Nordal, A | 1 |
| Tronstad, KJ | 1 |
| Wang, J | 1 |
| Lund-Johansen, M | 1 |
| Simonsen, A | 1 |
| Janji, B | 1 |
| Westermarck, J | 1 |
| Bjerkvig, R | 1 |
| Prestegarden, L | 1 |
| Cheng, HW | 1 |
| Liang, YH | 1 |
| Kuo, YL | 1 |
| Chuu, CP | 1 |
| Lin, CY | 1 |
| Lee, MH | 1 |
| Wu, AT | 1 |
| Yeh, CT | 1 |
| Chen, EI | 1 |
| Whang-Peng, J | 1 |
| Su, CL | 1 |
| Huang, CY | 1 |
2 other studies available for thioridazine and Glioblastoma
| Article | Year |
|---|---|
Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Autophagosomes; Autophagy; Brain Neoplasms; | 2019 |
Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data.
Topics: Animals; Antipsychotic Agents; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Drug Scr | 2015 |