thioridazine has been researched along with Extensively Drug-Resistant Tuberculosis in 18 studies
Thioridazine: A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.
thioridazine : A phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position.
Extensively Drug-Resistant Tuberculosis: Tuberculosis resistant to ISONIAZID and RIFAMPIN and at least three of the six main classes of second-line drugs (AMINOGLYCOSIDES; polypeptide agents; FLUOROQUINOLONES; THIOAMIDES; CYCLOSERINE; and PARA-AMINOSALICYLIC ACID) as defined by the CDC.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thioridazine (TDZ) has been shown to have in vitro activity against multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis, to promote the killing of intracellular MDR and XDR strains and to cure the mouse of antibiotic-susceptible and -resistant pulmonary tuberculosis (TB) infections." | 6.46 | Thioridazine cures extensively drug-resistant tuberculosis (XDR-TB) and the need for global trials is now! ( Amaral, L; Boeree, MJ; Gillespie, SH; Udwadia, ZF; van Soolingen, D, 2010) |
| "Linezolid was included in the drug regimens of all patients; moxifloxacin and/or thioridazine were included in the regimens of 14 patients." | 5.38 | Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina with a combination of linezolid, moxifloxacin and thioridazine. ( Abbate, E; Ambroggi, M; Cufré, M; García, A; Gonzalez Montaner, P; Natiello, M; Ritacco, V; van Soolingen, D; Vescovo, M, 2012) |
| "Thioridazine (TDZ) in combination with antibiotics to which extensively drug-resistant Mycobacterium tuberculosis (XDR-TB) is initially resistant yields a cure." | 2.48 | Why thioridazine in combination with antibiotics cures extensively drug-resistant Mycobacterium tuberculosis infections. ( Amaral, L; Viveiros, M, 2012) |
| "Thioridazine is a phenothiazine drug which has previously been extensively used for its antipsychotic properties as it is associated with a low risk of extra-pyramidal side-effects." | 2.47 | Thioridazine: the good and the bad. ( Thanacoody, RH, 2011) |
| "Linezolid was included in the drug regimens of all patients; moxifloxacin and/or thioridazine were included in the regimens of 14 patients." | 1.38 | Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina with a combination of linezolid, moxifloxacin and thioridazine. ( Abbate, E; Ambroggi, M; Cufré, M; García, A; Gonzalez Montaner, P; Natiello, M; Ritacco, V; van Soolingen, D; Vescovo, M, 2012) |
| "Over a period of 14 years, the authors have studied thioridazine, an old neuroleptic, that has been shown to have in vitro activity against intracellular Mycobacterium tuberculosis, regardless of its antibiotic resistance status, thioridazine cures infected mice of antibiotic-susceptible and multidrug-resistant tuberculosis (TB) infections and, when used in combination with antibiotics used for therapy of TB, renders the organism significantly more susceptible." | 1.38 | Why and how thioridazine in combination with antibiotics to which the infective strain is resistant will cure totally drug-resistant tuberculosis. ( Amaral, L; Molnar, J, 2012) |
| "Thioridazine has proven anti tuberculous effects in vitro and in vivo mouse models and we used this drug as salvage therapy in 4 Indian patients with XDR (near total drug resistance) with advanced disease." | 1.37 | Safety and efficacy of thioridazine as salvage therapy in Indian patients with XDR-TB. ( Pinto, LM; Sen, T; Udwadia, ZF, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 16 (88.89) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Dixit, PP | 2 |
| Thore, SN | 1 |
| Perveen, S | 1 |
| Kumari, D | 1 |
| Singh, K | 2 |
| Sharma, R | 1 |
| Amaral, L | 9 |
| Martins, A | 1 |
| Spengler, G | 1 |
| Hunyadi, A | 1 |
| Molnar, J | 5 |
| Martins, M | 2 |
| Viveiros, M | 3 |
| Kristiansen, JE | 2 |
| Boeree, MJ | 2 |
| Gillespie, SH | 2 |
| Udwadia, ZF | 2 |
| van Soolingen, D | 2 |
| van Ingen, J | 1 |
| Dutta, NK | 1 |
| Mazumdar, K | 1 |
| Dastidar, SG | 1 |
| Karakousis, PC | 1 |
| Thanacoody, RH | 1 |
| Sen, T | 1 |
| Pinto, LM | 1 |
| Abbate, E | 1 |
| Vescovo, M | 1 |
| Natiello, M | 1 |
| Cufré, M | 1 |
| García, A | 1 |
| Gonzalez Montaner, P | 1 |
| Ambroggi, M | 1 |
| Ritacco, V | 1 |
12 reviews available for thioridazine and Extensively Drug-Resistant Tuberculosis
| Article | Year |
|---|---|
Tuberculosis drug discovery: Progression and future interventions in the wake of emerging resistance.
Topics: Antitubercular Agents; Diarylquinolines; Drug Therapy, Combination; Ethambutol; Extensively Drug-Res | 2022 |
The mechanism by which the phenothiazine thioridazine contributes to cure problematic drug-resistant forms of pulmonary tuberculosis: recent patents for "new use".
Topics: Antitubercular Agents; Extensively Drug-Resistant Tuberculosis; Humans; Mycobacterium tuberculosis; | 2013 |
Promising therapy of XDR-TB/MDR-TB with thioridazine an inhibitor of bacterial efflux pumps.
Topics: Antitubercular Agents; Bacterial Proteins; Drug Resistance, Multiple, Bacterial; Extensively Drug-Re | 2008 |
Thioridazine cures extensively drug-resistant tuberculosis (XDR-TB) and the need for global trials is now!
Topics: Animals; Antitubercular Agents; Argentina; Clinical Trials as Topic; Extensively Drug-Resistant Tube | 2010 |
The broad-spectrum antimycobacterial activities of phenothiazines, InVitro: somewhere in all of this there may be patentable potentials.
Topics: Animals; Antitubercular Agents; Drug Discovery; Drug Resistance, Multiple, Bacterial; Drug Therapy, | 2011 |
New patentable use of an old neuroleptic compound thioridazine to combat tuberculosis: a gene regulation perspective.
Topics: Animals; Antitubercular Agents; Drug Discovery; Drug Resistance, Multiple, Bacterial; Drug Therapy, | 2011 |
Targeting the human macrophage with combinations of drugs and inhibitors of Ca2+ and K+ transport to enhance the killing of intracellular multi-drug resistant Mycobacterium tuberculosis (MDR-TB)--a novel, patentable approach to limit the emergence of XDR-
Topics: Animals; Antitubercular Agents; Calcium Signaling; Drug Discovery; Drug Resistance, Multiple, Bacter | 2011 |
Thioridazine: the good and the bad.
Topics: Animals; Antitubercular Agents; Drug Discovery; Drug Resistance, Multiple, Bacterial; Drug Therapy, | 2011 |
Effective therapy with the neuroleptic thioridazine as an adjunct to second line of defence drugs, and the potential that thioridazine offers for new patents that cover a variety of "new uses".
Topics: Animals; Antitubercular Agents; Drug Discovery; Drug Resistance, Multiple, Bacterial; Drug Therapy, | 2011 |
Global clinical trials for the treatment of TB with thioridazine.
Topics: Antitubercular Agents; Clinical Trials as Topic; Drug Discovery; Drug Resistance, Multiple, Bacteria | 2011 |
XDR-TB, what is it; how is it treated; and why is therapeutic failure so high?
Topics: Animals; Antitubercular Agents; Drug Discovery; Drug Resistance, Multiple, Bacterial; Drug Therapy, | 2011 |
Why thioridazine in combination with antibiotics cures extensively drug-resistant Mycobacterium tuberculosis infections.
Topics: Anti-Bacterial Agents; Antitubercular Agents; Biological Transport, Active; Drug Resistance, Multipl | 2012 |
6 other studies available for thioridazine and Extensively Drug-Resistant Tuberculosis
| Article | Year |
|---|---|
Hybrid triazoles: Design and synthesis as potential dual inhibitor of growth and efflux inhibition in tuberculosis.
Topics: Antitubercular Agents; Cells, Cultured; Chemistry Techniques, Synthetic; Drug Design; Drug Evaluatio | 2016 |
Therapy Of XDR TB with thioridazine a drug beyond patent protection but eligible for patent "as new use".
Topics: Adjuvants, Pharmaceutic; Animals; Antitubercular Agents; Compassionate Use Trials; Drug Resistance, | 2010 |
Safety and efficacy of thioridazine as salvage therapy in Indian patients with XDR-TB.
Topics: Adolescent; Adult; Antitubercular Agents; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combin | 2011 |
It is anticipated that as is usually the case, financial motivation will move TZ from its current status “potential anti-MDR/XDR agent,” to one that will cure MDR and XDR TB. Foreword.
Topics: Animals; Antitubercular Agents; Drug Discovery; Drug Resistance, Multiple, Bacterial; Drug Therapy, | 2011 |
Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina with a combination of linezolid, moxifloxacin and thioridazine.
Topics: Acetamides; Adult; Antitubercular Agents; Argentina; Aza Compounds; Compassionate Use Trials; Drug R | 2012 |
Why and how thioridazine in combination with antibiotics to which the infective strain is resistant will cure totally drug-resistant tuberculosis.
Topics: Animals; Antibiotics, Antitubercular; Chlorpromazine; Drug Evaluation; Drug Resistance, Multiple, Ba | 2012 |