thioridazine and Dementia studies

Thioridazine: A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.
thioridazine : A phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position.

Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.

Research Excerpts

Excerpt	Relevance	Reference
"The efficacy and safety of risperidone, haloperidol, and thioridazine for treating dementia-associated behavioral disturbances were evaluated in a retrospective study of 186 patients aged 65 years or older with DSM-III-R or DSM-IV diagnoses of Alzheimer's dementia, senile dementia NOS, or organic brain syndrome."	9.08	Clinical experience with risperidone, haloperidol, and thioridazine for dementia-associated behavioral disturbances. ( Frenchman, IB; Prince, T, 1997)
"The efficacy and safety of risperidone, haloperidol, and thioridazine for treating dementia-associated behavioral disturbances were evaluated in a retrospective study of 186 patients aged 65 years or older with DSM-III-R or DSM-IV diagnoses of Alzheimer's dementia, senile dementia NOS, or organic brain syndrome."	5.08	Clinical experience with risperidone, haloperidol, and thioridazine for dementia-associated behavioral disturbances. ( Frenchman, IB; Prince, T, 1997)
"This study compared the therapeutic efficacy of thioridazine, loxapine, and a placebo in the treatment of behavioral disturbances in nursing home patients with dementia."	3.66	Efficacy of antipsychotic medications in behaviorally disturbed dementia patients. ( Barnes, R; Gumbrecht, G; Okimoto, J; Raskind, M; Veith, R, 1982)
" Both drugs were given in a dosage range of 50-200 mg/day."	2.67	Remoxipride versus thioridazine in elderly psychotic patients. ( Link, C; Phanjoo, AL, 1990)
"Chlormethiazole treatment also resulted in significant reductions in physical disability as assessed by the Clifton Behaviour Rating Scale."	2.66	A comparison of chlormethiazole and thioridazine in agitated confusional states of the elderly. ( Ather, SA; Shaw, SH; Stoker, MJ, 1986)
"Thioridazine was compared with placebo or diazepam or both in 610 elderly, nonpsychotic inpatients in geriatric wards of state hospitals or nursing homes."	2.65	Multicenter study comparing thioridazine with diazepam and placebo in elderly, nonpsychotic patients with emotional and behavioral disorders. ( Stotsky, B, 1984)
"Acute anticholinergic delirium has been reported to occur following ingestion of antidepressants, neuroleptics and antiparkinsonian drugs in toxic and therapeutic doses."	1.27	Chronic central anticholinergic toxicity in manic depressive illness mimicking dementia. ( Banno, V; Jones, BD; Moreau, A, 1986)

Timeframe	Studies, this research(%)	All Research%
pre-1990	41 (85.42)	18.7374
1990's	5 (10.42)	18.2507
2000's	2 (4.17)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
JUDAH, L	1
MURPHREE, O	1
SEAGER, L	1
KRAL, VA	1
RICHERT, J	1
MANS, J	1
SENES, M	1
AJZENBERG, D	1
VALLET, R	1
RIVEST, R	1
Fleischl, H	1
Massone, A	1
Mantellini, M	1
Bonavita, S	1
Reedy, WJ	1
Allen, RM	1
Stotsky, B	1
Tyler, KL	1
Tyler, HR	1
Reisberg, B	2
Ferris, SH	1
Gershon, S	1
Barnes, R	1
Veith, R	1
Okimoto, J	1
Raskind, M	1
Gumbrecht, G	1
Devanand, DP	1
Auer, SR	1
Monteiro, IM	1
Frenchman, IB	1
Prince, T	1
MacLennan, WJ	1
Kirchner, V	2
Kelly C, A	1
Harvey, RJ	2
Kelly, CA	1
Gallien, M	1
Schnetzler, JP	1
Morin, J	1
Yesavage, J	1
Cowley, LM	1
Glen, RS	1
Kamen, S	1
Covington, JS	1
Phanjoo, AL	1
Link, C	1
Tibilova, AU	1
Alimova, RA	1
Raskind, MA	1
Risse, SC	1
Lampe, TH	1
Ather, SA	1
Shaw, SH	1
Stoker, MJ	1
Moreau, A	1
Jones, BD	1
Banno, V	1
Chin, CN	1
Cole, JO	2
Stotsky, BA	2
Gol'dovskaia, IL	1
Asnes, DP	1
Lehmann, HE	4
Ban, TA	4
Saxena, BM	4
Altman, H	1
Mehta, D	1
Evenson, RC	1
Sletten, IW	1
Fraiberg, PL	1
Tewfik, GI	1
Jain, VK	1
Harcup, M	1
Magowan, S	1
Tsuang, MM	1
Lu, LM	1
Deutsch, M	1
Ananth, JV	1
Boiullat, JE	1
Ahmed, A	1
Post, F	1
Zapletálek, M	1
Komenda, S	1
Barone, P	1
Carrozza, G	1
Inferrera, C	1
Tigano, F	1
Felger, HL	1

Article	Year
Pharmacotherapy of senile dementia. Proceedings of the annual meeting of the American Psychopathological Association, 1980, Volume: 69 Topics: Adult; Age Factors; Aged; Alzheimer Disease; Amphetamine; Antidepressive Agents, Tricyclic; Dementia	1980
Confusion: the cause is the key. The Practitioner, 1999, Volume: 243, Issue:1596 Topics: Aged; Confusion; Dementia; Haloperidol; Humans; Hypnotics and Sedatives; Thioridazine	1999
Thioridazine for dementia. The Cochrane database of systematic reviews, 2000, Issue:2 Topics: Antipsychotic Agents; Dementia; Humans; Thioridazine	2000
Thioridazine for dementia. The Cochrane database of systematic reviews, 2001, Issue:3 Topics: Antipsychotic Agents; Dementia; Humans; Thioridazine	2001

Article	Year
Multicenter study comparing thioridazine with diazepam and placebo in elderly, nonpsychotic patients with emotional and behavioral disorders. Clinical therapeutics, 1984, Volume: 6, Issue:4 Topics: Affective Symptoms; Aged; Clinical Trials as Topic; Dementia; Diazepam; Double-Blind Method; Humans;	1984
Behavioral symptoms in dementia: community-based research. International psychogeriatrics, 1996, Volume: 8 Suppl 3 Topics: Aged; Alzheimer Disease; Ambulatory Care; Antipsychotic Agents; Dementia; Double-Blind Method; Femal	1996
Clinical experience with risperidone, haloperidol, and thioridazine for dementia-associated behavioral disturbances. International psychogeriatrics, 1997, Volume: 9, Issue:4 Topics: Aged; Antipsychotic Agents; Chi-Square Distribution; Dementia; Haloperidol; Humans; Retrospective St	1997
Double-blind study of thioridazine and haloperidol in geriatric patients with a psychosis associated with organic brain syndrome. The Journal of clinical psychiatry, 1979, Volume: 40, Issue:10 Topics: Aged; Blood Pressure; Dementia; Double-Blind Method; Female; Haloperidol; Humans; Male; Middle Aged;	1979
Alleviating agitation, apprehension, and related symptoms in geriatric patients: A double-blind comparison of a phenothiazine and a benzodiazepien. Southern medical journal, 1975, Volume: 68, Issue:6 Topics: Aged; Anxiety; Clinical Trials as Topic; Dementia; Depression; Diazepam; Drug Evaluation; Female; Hu	1975
Remoxipride versus thioridazine in elderly psychotic patients. Acta psychiatrica Scandinavica. Supplementum, 1990, Volume: 358 Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Benzamides; Dementia; Dose-Response Relationship, Dru	1990
Dementia and antipsychotic drugs. The Journal of clinical psychiatry, 1987, Volume: 48 Suppl Topics: Aged; Alzheimer Disease; Antipsychotic Agents; Clinical Trials as Topic; Cognition Disorders; Dement	1987
A comparison of chlormethiazole and thioridazine in agitated confusional states of the elderly. Acta psychiatrica Scandinavica. Supplementum, 1986, Volume: 329 Topics: Aged; Alzheimer Disease; Chlormethiazole; Clinical Trials as Topic; Cognition Disorders; Confusion;	1986
Nicotinic acid, thioridazine, fluoxymesterone and their combinations in hospitalized geriatric patients: a systematic clinical study. Canadian Psychiatric Association journal, 1972, Volume: 17, Issue:4 Topics: Aged; Clinical Trials as Topic; Dementia; Drug Synergism; Female; Fluoxymesterone; Humans; Male; Nic	1972
Behavioral effects of drug therapy on psychogeriatric inpatients. I. Chlorpromazine and thioridazine. Journal of the American Geriatrics Society, 1973, Volume: 21, Issue:6 Topics: Administration, Oral; Aged; Behavior; Chlorpromazine; Clinical Trials as Topic; Dementia; Evaluation	1973
Control of behavioral symptoms in patients with long-term illness. Diseases of the nervous system, 1972, Volume: 33, Issue:3 Topics: Adult; Aged; Cardiovascular Diseases; Cerebrovascular Disorders; Chronic Disease; Clinical Trials as	1972
Effectiveness of various tranquilisers in the management of senile restlessness. Gerontologia clinica, 1970, Volume: 12, Issue:6 Topics: Aged; Carbamates; Chlorpromazine; Clinical Trials as Topic; Dementia; Female; Haloperidol; Humans; H	1970
Haloperidol versus thioridazine for hospitalized psychogeriatric patients: double-blind study. Journal of the American Geriatrics Society, 1971, Volume: 19, Issue:7 Topics: Activities of Daily Living; Aged; Clinical Trials as Topic; Dementia; Electrocardiography; Female; H	1971
Combined administration of thioridazine and nicotinic acid in the treatment of geriatric patients. Current therapeutic research, clinical and experimental, 1971, Volume: 13, Issue:3 Topics: Aged; Clinical Trials as Topic; Dementia; Female; Humans; Nicotinic Acids; Psychiatric Status Rating	1971
Combined administration of thioridazine, nicotinic acid, and fluoxymesterone in the treatment of geriatric patients. Current therapeutic research, clinical and experimental, 1971, Volume: 13, Issue:8 Topics: Aged; Clinical Trials as Topic; Dementia; Evaluation Studies as Topic; Female; Fluoxymesterone; Huma	1971

Article	Year
Psychiatric response of geriatric-psychiatric patients to mellaril (TP-21 Sandoz). The American journal of psychiatry, 1959, Volume: 115, Issue:12 Topics: Dementia; Humans; Phenothiazines; Psychotic Disorders; Thioridazine	1959
The use of thioridazine (Mellaril) in aged people. Canadian Medical Association journal, 1961, Jan-21, Volume: 84 Topics: Aged; Aged, 80 and over; Dementia; Mental Disorders; Psychotic Disorders; Thioridazine; Tranquilizin	1961
[On the indications for thioridazine in neurological practice]. Die Medizinische Welt, 1963, Apr-27, Volume: 17 Topics: Bipolar Disorder; Dementia; Humans; Intracranial Arteriosclerosis; Mental Disorders; Psychotic Disor	1963
[ON THE SUBJECT OF A YEAR OF APPLICATION OF THIORIDAZINE IN A PSYCHIATRIC MILIEU. (APROPOS OF 300 CASES)]. L'Encephale, 1964, Volume: 53 Topics: Delirium; Dementia; Humans; Intellectual Disability; Mental Disorders; Pharmacology; Psychoses, Alco	1964
[TREATMENT OF PSYCHIC DISORDERS OF CEREBRAL ATHEROSCLEROSIS. DIAGNOSTIC, NOSOLOGIC AND PATHOGENIC ASPECTS]. Annales medico-psychologiques, 1964, Volume: 122 Topics: Blood Glucose; Brain Ischemia; Cerebrovascular Circulation; Cholesterol; Dementia; Depression; Drug	1964
[THIORIDAZINE (MELLARIL) IN THE TREATMENT OF AGED SUBJECTS]. L'union medicale du Canada, 1965, Volume: 94 Topics: Dementia; Drug Therapy; Geriatrics; Humans; Mental Disorders; Psychotic Disorders; Thioridazine	1965
Effects of thioridazine on chronically regressed patients. Journal of the American Geriatrics Society, 1967, Volume: 15, Issue:1 Topics: Aged; Antisocial Personality Disorder; Brain Diseases; Dementia; Female; Humans; Intellectual Disabi	1967
[The role of old age homes in the resolution of the geriatric psychologic assistance problem]. Minerva medica, 1967, Feb-03, Volume: 58, Issue:10 Topics: Aged; Dementia; Female; Homes for the Aged; Humans; Italy; Male; Middle Aged; Neurotic Disorders; Th	1967
An internist's observations on thioridazine in the very elderly. Journal of the American Geriatrics Society, 1967, Volume: 15, Issue:6 Topics: Aged; Anxiety Disorders; Arteriosclerosis; Brain Diseases; Dementia; Female; Heart Diseases; Humans;	1967
Palliative treatment of tardive dyskinesia with combination of amantadine-neuroleptic administration. Biological psychiatry, 1982, Volume: 17, Issue:6 Topics: Adult; Aged; Amantadine; Antipsychotic Agents; Dementia; Dose-Response Relationship, Drug; Drug Ther	1982
Differentiating organic dementia. Geriatrics, 1984, Volume: 39, Issue:3 Topics: Adult; Aged; Aging; Alzheimer Disease; Dementia; Diagnosis, Differential; Female; Humans; Male; Meta	1984
Efficacy of antipsychotic medications in behaviorally disturbed dementia patients. The American journal of psychiatry, 1982, Volume: 139, Issue:9 Topics: Aged; Basal Ganglia Diseases; Dementia; Dibenzoxazepines; Double-Blind Method; Female; Humans; Hypot	1982
Antipsychotic treatment in outpatients with dementia. International psychogeriatrics, 1996, Volume: 8 Suppl 3 Topics: Aged; Alzheimer Disease; Ambulatory Care; Antipsychotic Agents; Chlorpromazine; Dementia; Dose-Respo	1996
[Antinuclear antibodies and lupus due to phenothiazines in 600 hospitalized patients]. Annales medico-psychologiques, 1975, Volume: 1, Issue:2 Topics: Adult; Aged; Antibodies, Antinuclear; Antipsychotic Agents; Chlorpromazine; Dementia; Female; Fluphe	1975
Dementia: differential diagnosis and treatment. Geriatrics, 1979, Volume: 34, Issue:9 Topics: Antidepressive Agents, Tricyclic; Dementia; Depression; Diagnosis, Differential; Dihydroergotoxine;	1979
Tardive dyskinesia. A significant syndrome for geriatric dentistry. Oral surgery, oral medicine, and oral pathology, 1975, Volume: 39, Issue:1 Topics: Aged; Arteriosclerosis; Bruxism; Chlorpromazine; Dementia; Denture, Complete; Depression; Depressive	1975
Serentil for chronic brain syndrome. The Medical letter on drugs and therapeutics, 1975, Aug-01, Volume: 17, Issue:16 Topics: Aged; Dementia; Drug Evaluation; Humans; Mesoridazine; Neurocognitive Disorders; Thioridazine	1975
[Problem of transient dementias of old age (clinico-diagnostic aspect)]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1985, Volume: 85, Issue:9 Topics: Aged; Amphetamine; Anxiety; Central Nervous System Stimulants; Dementia; Depressive Disorder; Diagno	1985
Chronic central anticholinergic toxicity in manic depressive illness mimicking dementia. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1986, Volume: 31, Issue:4 Topics: Aged; Amitriptyline; Benztropine; Bipolar Disorder; Central Nervous System Diseases; Dementia; Diagn	1986
Neuroleptic malignant syndrome: a case report. The Medical journal of Malaysia, 1986, Volume: 41, Issue:2 Topics: Aged; Dementia; Drug Therapy, Combination; Female; Humans; Neuroleptic Malignant Syndrome; Thioridaz	1986
Improving psychiatric drug therapy. A matter of dosage and choice. Geriatrics, 1974, Volume: 29, Issue:6 Topics: Adrenal Cortex Hormones; Adult; Aged; Anticoagulants; Antidepressive Agents; Antiparkinson Agents; B	1974
[The possibilities and limitations of psychotropic drug therapy for patients with glaucoma]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1974, Volume: 74, Issue:9 Topics: Aged; Alcoholism; Amitriptyline; Antidepressive Agents; Bipolar Disorder; Chronic Disease; Dementia;	1974
Psychopharmacology in the aged. Use of major psychotropic medications in treatment of the elderly: case examples. Journal of geriatric psychiatry, 1974, Volume: 7, Issue:2 Topics: Adjustment Disorders; Aged; Alzheimer Disease; Amitriptyline; Benztropine; Bipolar Disorder; Cataton	1974
Combined administration of thioridazine and fluoxymesterone in the treatment of geriatric patients. Current therapeutic research, clinical and experimental, 1970, Volume: 12, Issue:12 Topics: Aged; Dementia; Female; Fluoxymesterone; Humans; Male; Nicotinic Acids; Psychiatric Status Rating Sc	1970
Thioridazine in the management of geriatric patients. Journal of the American Geriatrics Society, 1968, Volume: 16, Issue:8 Topics: Anxiety; Arteriosclerosis; Attention; Dementia; Humans; Thioridazine	1968
Management of senile psychiatric disorders. British medical journal, 1968, Dec-07, Volume: 4, Issue:5631 Topics: Adjustment Disorders; Affective Symptoms; Aged; Alcoholism; Amitriptyline; Dementia; Depressive Diso	1968
[The influence of thioridazine on the catalase activity in the serum of oligophrenics and in gerontopsychiatric patients]. Psychiatrie, Neurologie, und medizinische Psychologie, 1965, Volume: 17, Issue:2 Topics: Adult; Aged; Blood Chemical Analysis; Catalase; Dementia; Female; Humans; Intellectual Disability; M	1965
[Ball-like edema of the sinusoidal pole of human hepatocytes. Jaundice during treatment with thioridazine]. Archivio "de Vecchi" per l'anatomia patologica e la medicina clinica, 1965, Volume: 46, Issue:2 Topics: Aged; Dementia; Humans; Jaundice; Liver Diseases; Male; Thioridazine	1965
Thioridazine (mellaril) in the geriatric patient. Diseases of the nervous system, 1966, Volume: 27, Issue:8 Topics: Aged; Chlorpromazine; Dementia; Humans; Orientation; Thioridazine	1966

thioridazine and Dementia

Research Excerpts

Research

Studies (48)

Authors

Reviews

Trials

Other Studies