thioridazine has been researched along with Breast Neoplasms in 13 studies
Thioridazine: A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.
thioridazine : A phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position.
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Most breast cancers (BCs) express estrogen receptor α (ERα) and are treated with the endocrine therapy (ET) drugs 4OH-tamoxifen (Tam) and fulvestrant (ICI 182,780; ICI)." | 7.88 | In silico screening for ERα down modulators identifies thioridazine as an anti-proliferative agent in primary, 4OH-tamoxifen-resistant and Y537S ERα-expressing breast cancer cells. ( Acconcia, F; Bianchi, F; Busonero, C; Leone, S, 2018) |
| " The present study investigated the effect of the dopamine receptor antagonist thioridazine on murine breast cancer." | 7.81 | Dopamine receptor antagonist thioridazine inhibits tumor growth in a murine breast cancer model. ( Guo, F; He, S; Shen, G; Wang, Y; Ye, T; Yin, T, 2015) |
| "We also show that all breast cancer cell lines tested express DRD2 mRNA and protein, regardless of thioridazine sensitivity." | 5.51 | Selective Effects of Thioridazine on Self-Renewal of Basal-Like Breast Cancer Cells. ( Baldwin, AS; Fan, C; Tegowski, M, 2019) |
| "Thioridazine is an antipsychotic that has been shown to induce cell death and inhibit self-renewal in a broad spectrum of cancer cells." | 5.48 | Thioridazine inhibits self-renewal in breast cancer cells via DRD2-dependent STAT3 inhibition, but induces a G ( Baldwin, AS; Fan, C; Tegowski, M, 2018) |
| "Estrogen receptor (ER)-negative human breast cancer cell lines (MDA-MB-231 and MDA-MB-435) and ER-positive derivatives of the MCF-7 cell line selected for growth in the presence of antiestrogens (LY2 and RR) were used as in vitro models of tamoxifen-resistant human breast cancer in this study." | 5.28 | Tamoxifen-resistant human breast cancer cell growth: inhibition by thioridazine, pimozide and the calmodulin antagonist, W-13. ( Peterson, VA; Strobl, JS, 1992) |
| "The effects of pimozide on breast cancer cell growth were not limited to the MCF-7 cell line." | 5.28 | Inhibition of human breast cancer cell proliferation in tissue culture by the neuroleptic agents pimozide and thioridazine. ( Kirkwood, KL; Lantz, TK; Lewine, MA; Peterson, VA; Strobl, JS; Worley, JF, 1990) |
| " We demonstrated the combinations of doxorubicin (DOX) + artesunate, DOX + chloroquine, paclitaxel (PTX) + fluoxetine, PTX + fluphenazine, and PTX + benztropine induce significant cytotoxicity in Michigan Cancer Foundation-7 (MCF-7) breast cancer cells." | 4.12 | Combination of Antimalarial and CNS Drugs with Antineoplastic Agents in MCF-7 Breast and HT-29 Colon Cancer Cells: Biosafety Evaluation and Mechanism of Action. ( Duarte, D; Nunes, M; Ricardo, S; Vale, N, 2022) |
| "Most breast cancers (BCs) express estrogen receptor α (ERα) and are treated with the endocrine therapy (ET) drugs 4OH-tamoxifen (Tam) and fulvestrant (ICI 182,780; ICI)." | 3.88 | In silico screening for ERα down modulators identifies thioridazine as an anti-proliferative agent in primary, 4OH-tamoxifen-resistant and Y537S ERα-expressing breast cancer cells. ( Acconcia, F; Bianchi, F; Busonero, C; Leone, S, 2018) |
| " The present study investigated the effect of the dopamine receptor antagonist thioridazine on murine breast cancer." | 3.81 | Dopamine receptor antagonist thioridazine inhibits tumor growth in a murine breast cancer model. ( Guo, F; He, S; Shen, G; Wang, Y; Ye, T; Yin, T, 2015) |
| "Among the 48 human ABC proteins, the breast cancer resistance protein (BCRP/ABCG2) has been described as a pivotal player in cancer resistance." | 2.82 | Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators. ( Delabio, LC; Dutra, JP; Hembecker, M; Kita, DH; Moure, VR; Pereira, GDS; Scheiffer, G; Valdameri, G; Zattoni, IF, 2022) |
| "We also show that all breast cancer cell lines tested express DRD2 mRNA and protein, regardless of thioridazine sensitivity." | 1.51 | Selective Effects of Thioridazine on Self-Renewal of Basal-Like Breast Cancer Cells. ( Baldwin, AS; Fan, C; Tegowski, M, 2019) |
| "Metastatic breast cancer may be resistant to chemo-immunotherapy due to the existence of cancer stem cells (CSC)." | 1.51 | Cocktail Strategy Based on Spatio-Temporally Controlled Nano Device Improves Therapy of Breast Cancer. ( Lang, T; Li, Y; Liu, Y; Ran, W; Yin, Q; Zhai, Y; Zhang, P; Zheng, Z, 2019) |
| "Thioridazine is an antipsychotic that has been shown to induce cell death and inhibit self-renewal in a broad spectrum of cancer cells." | 1.48 | Thioridazine inhibits self-renewal in breast cancer cells via DRD2-dependent STAT3 inhibition, but induces a G ( Baldwin, AS; Fan, C; Tegowski, M, 2018) |
| "Thioridazine has been known as an antipsychotic agent, but it also has anticancer activity." | 1.40 | Antipsychotic agent thioridazine sensitizes renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated inhibition of Akt signaling and downregulation of Mcl-1 and c-FLIP(L). ( Bae, YC; Kwon, TK; Min, KJ; Seo, BR; Yoo, YH, 2014) |
| "Estrogen receptor (ER)-negative human breast cancer cell lines (MDA-MB-231 and MDA-MB-435) and ER-positive derivatives of the MCF-7 cell line selected for growth in the presence of antiestrogens (LY2 and RR) were used as in vitro models of tamoxifen-resistant human breast cancer in this study." | 1.28 | Tamoxifen-resistant human breast cancer cell growth: inhibition by thioridazine, pimozide and the calmodulin antagonist, W-13. ( Peterson, VA; Strobl, JS, 1992) |
| "The effects of pimozide on breast cancer cell growth were not limited to the MCF-7 cell line." | 1.28 | Inhibition of human breast cancer cell proliferation in tissue culture by the neuroleptic agents pimozide and thioridazine. ( Kirkwood, KL; Lantz, TK; Lewine, MA; Peterson, VA; Strobl, JS; Worley, JF, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (61.54) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Zattoni, IF | 1 |
| Delabio, LC | 1 |
| Dutra, JP | 1 |
| Kita, DH | 1 |
| Scheiffer, G | 1 |
| Hembecker, M | 1 |
| Pereira, GDS | 1 |
| Moure, VR | 1 |
| Valdameri, G | 1 |
| Duarte, D | 1 |
| Nunes, M | 1 |
| Ricardo, S | 1 |
| Vale, N | 1 |
| Tegowski, M | 2 |
| Fan, C | 2 |
| Baldwin, AS | 2 |
| Busonero, C | 1 |
| Leone, S | 1 |
| Bianchi, F | 1 |
| Acconcia, F | 1 |
| Lang, T | 1 |
| Liu, Y | 1 |
| Zheng, Z | 1 |
| Ran, W | 1 |
| Zhai, Y | 1 |
| Yin, Q | 1 |
| Zhang, P | 1 |
| Li, Y | 1 |
| Ke, XY | 1 |
| Lin Ng, VW | 1 |
| Gao, SJ | 1 |
| Tong, YW | 1 |
| Hedrick, JL | 1 |
| Yang, YY | 1 |
| Min, KJ | 2 |
| Seo, BR | 1 |
| Bae, YC | 1 |
| Yoo, YH | 1 |
| Kwon, TK | 2 |
| Yin, T | 1 |
| He, S | 1 |
| Shen, G | 1 |
| Ye, T | 1 |
| Guo, F | 1 |
| Wang, Y | 1 |
| Seo, SU | 1 |
| Cho, HK | 1 |
| Woo, SM | 1 |
| Kim, S | 1 |
| Park, JW | 1 |
| Kim, SH | 1 |
| Choi, YH | 1 |
| Keum, YS | 1 |
| Hyun, JW | 1 |
| Park, HH | 1 |
| Lee, SH | 1 |
| Kim, DE | 1 |
| Wilson, RG | 1 |
| Hamilton, JR | 1 |
| Boyd, WD | 1 |
| Forrest, AP | 1 |
| Cole, EN | 1 |
| Boyns, AR | 1 |
| Griffiths, K | 1 |
| Strobl, JS | 2 |
| Peterson, VA | 2 |
| Kirkwood, KL | 1 |
| Lantz, TK | 1 |
| Lewine, MA | 1 |
| Worley, JF | 1 |
1 review available for thioridazine and Breast Neoplasms
| Article | Year |
|---|---|
Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Dr | 2022 |
12 other studies available for thioridazine and Breast Neoplasms
| Article | Year |
|---|---|
Combination of Antimalarial and CNS Drugs with Antineoplastic Agents in MCF-7 Breast and HT-29 Colon Cancer Cells: Biosafety Evaluation and Mechanism of Action.
Topics: Adenosine Diphosphate; Antimalarials; Antineoplastic Agents; Artesunate; ATP Binding Cassette Transp | 2022 |
Selective Effects of Thioridazine on Self-Renewal of Basal-Like Breast Cancer Cells.
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; | 2019 |
Thioridazine inhibits self-renewal in breast cancer cells via DRD2-dependent STAT3 inhibition, but induces a G
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Self Renewal; Cell Survival; | 2018 |
In silico screening for ERα down modulators identifies thioridazine as an anti-proliferative agent in primary, 4OH-tamoxifen-resistant and Y537S ERα-expressing breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Computer Simulation; Down-Regulation; D | 2018 |
Cocktail Strategy Based on Spatio-Temporally Controlled Nano Device Improves Therapy of Breast Cancer.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Survival; Drug Carriers; Drug Therapy, Combin | 2019 |
Co-delivery of thioridazine and doxorubicin using polymeric micelles for targeting both cancer cells and cancer stem cells.
Topics: Animals; Antibiotics, Antineoplastic; Breast; Breast Neoplasms; Cell Line, Tumor; Dopamine Antagonis | 2014 |
Antipsychotic agent thioridazine sensitizes renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated inhibition of Akt signaling and downregulation of Mcl-1 and c-FLIP(L).
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antipsychotic Agents; Apoptos | 2014 |
Dopamine receptor antagonist thioridazine inhibits tumor growth in a murine breast cancer model.
Topics: Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; | 2015 |
Thioridazine enhances sensitivity to carboplatin in human head and neck cancer cells through downregulation of c-FLIP and Mcl-1 expression.
Topics: Breast Neoplasms; Carboplatin; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line; Cell Lin | 2017 |
The effect of long term phenothiazine therapy on plasma prolactin.
Topics: Aged; Antipsychotic Agents; Breast; Breast Neoplasms; Chlorpromazine; Female; Galactorrhea; Growth H | 1975 |
Tamoxifen-resistant human breast cancer cell growth: inhibition by thioridazine, pimozide and the calmodulin antagonist, W-13.
Topics: Breast Neoplasms; Calmodulin; Cell Cycle; Cell Division; Drug Resistance; Flow Cytometry; Humans; Pi | 1992 |
Inhibition of human breast cancer cell proliferation in tissue culture by the neuroleptic agents pimozide and thioridazine.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line; DNA Replication; Estradiol; Femal | 1990 |