Compounds > thioridazine
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thioridazine and Arrhythmia

thioridazine has been researched along with Arrhythmia in 41 studies

Thioridazine: A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.
thioridazine : A phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position.

Research Excerpts

ExcerptRelevanceReference
"Thioridazine is an antipsychotic that can still be used for schizophrenia although it is associated with the cardiac arrhythmia, torsades de pointe."8.84Thioridazine for schizophrenia. ( Fenton, M; Rathbone, J; Reilly, J; Sultana, A, 2007)
"All cases of arrhythmias associated with thioridazine were reviewed (177 cases)."7.68Transient cardiac pacing is insufficiently used to treat arrhythmia associated with thioridazine. ( Donatini, B; Krupp, P; Le Blaye, I, 1992)
" Physostigmine only caused temporary improvement and the arrhythmias only resolved completely after additional administration of NaCl."7.66[Arrhythmias in poisoning with tricyclic antidepressive agents. Successful treatment with physostigmine and sodium]. ( Pallmert, N; Seitz, R; Wehr, M, 1982)
"No protection against drug-induced arrhythmia or death was afforded by this procedure."5.27Does chlorpromazine produce cardiac arrhythmia via the central nervous system? ( Lathers, CM; Lipka, LJ; Roberts, J, 1988)
"Thioridazine is an antipsychotic that can still be used for schizophrenia although it is associated with the cardiac arrhythmia, torsades de pointe."4.84Thioridazine for schizophrenia. ( Fenton, M; Rathbone, J; Reilly, J; Sultana, A, 2007)
"To compare the rate of ventricular arrhythmia, sudden death and unexplained or unattended death among users of thioridazine and haloperidol."3.72Comparative cardiac safety of low-dose thioridazine and low-dose haloperidol. ( Bilker, WB; Glasser, DB; Hennessy, S; Kimmel, SE; Knauss, JS; Margolis, DJ; Morrison, MF; Reynolds, RF; Strom, BL, 2004)
"Patients with schizophrenia treated with clozapine, haloperidol, risperidone, or thioridazine; a control group of patients with glaucoma; and a control group of patients with psoriasis."3.71Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using administrative data. ( Bilker, WB; Glasser, DB; Hennessy, S; Kimmel, SE; Knauss, JS; Margolis, DJ; Morrison, MF; Reynolds, RF; Strom, BL, 2002)
"All cases of arrhythmias associated with thioridazine were reviewed (177 cases)."3.68Transient cardiac pacing is insufficiently used to treat arrhythmia associated with thioridazine. ( Donatini, B; Krupp, P; Le Blaye, I, 1992)
" Physostigmine only caused temporary improvement and the arrhythmias only resolved completely after additional administration of NaCl."3.66[Arrhythmias in poisoning with tricyclic antidepressive agents. Successful treatment with physostigmine and sodium]. ( Pallmert, N; Seitz, R; Wehr, M, 1982)
" In 4 of the 11 patients, when thioridazine, diuretic drugs and antiarrhythmic agents were withdrawn and hypokalemia or hypocalcemia corrected, ventricular tachyarrhythmias did not recur."3.66Management of recurrent ventricular tachyarrhythmias associated with Q-T prolongation. ( Adgey, AA; Khan, MM; Logan, KR; McComb, JM, 1981)
"Treatment with thioridazine has been associated with electrocardiographic abnormalities, and there are individual case reports of fatal cardiac arrhythmias in patients taking thioridazine."3.66Electrocardiographic changes following intravenous administration of thioridazine to macaque monkeys. ( Moore, RH; Rainey, JM, 1982)
" The ventricular arrhythmias responded to intravenous administration of lidocaine and to direct current electric shock; ventricular pacing was required in some instances and intravenous administration of propranolol combined with ventricular pacing in one."3.65Electrocardiographic changes and cardiac arrhythmias in patients receiving psychotropic drugs. ( Chou, TC; Fowler, NO; Hanenson, IB; Holmes, JC; McCall, D, 1976)
"Torsades de pointes was originally seen in patients with pre-existing heart disease or with intoxication."2.42[Psychopharmaceuticals and arrhythmias]. ( Binggeli, C; Brunckhorst, C; Candinas, R, 2004)
"Arrhythmia was the most frequently reported serious toxic effect."1.29Acute overdosage with thioridazine: a review of the available clinical exposure. ( Donatini, B; Hall, M; Krupp, P; Le Blaye, I, 1993)
"Mild thioridazine poisoning was characterized by somnolence, tremor, ataxia and dysarthria."1.29[Acute poisoning with thioridazine]. ( Meier, PJ; Schürch, F; Wyss, PA, 1996)
"No protection against drug-induced arrhythmia or death was afforded by this procedure."1.27Does chlorpromazine produce cardiac arrhythmia via the central nervous system? ( Lathers, CM; Lipka, LJ; Roberts, J, 1988)

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-199028 (68.29)18.7374
1990's4 (9.76)18.2507
2000's9 (21.95)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jia, L1
Sun, H1
Hennessy, S2
Bilker, WB2
Knauss, JS2
Margolis, DJ2
Kimmel, SE2
Reynolds, RF2
Glasser, DB2
Morrison, MF2
Strom, BL2
KELLY, HG1
FAY, JE1
LAVERTY, SG1
Binggeli, C1
Candinas, R1
Brunckhorst, C1
Bateman, DN1
Fenton, M1
Rathbone, J1
Reilly, J1
Sultana, A1
Lingjaerde, O1
Seitz, R1
Wehr, M1
Pallmert, N1
Khan, MM1
Logan, KR1
McComb, JM1
Adgey, AA1
Gould, RJ1
Murphy, KM1
Reynolds, IJ1
Snyder, SH1
Moore, RH1
Rainey, JM1
Forycki, Z1
Swica, P1
Lipscomb, PA1
Le Blaye, I2
Donatini, B2
Hall, M1
Krupp, P2
Schürch, F1
Meier, PJ1
Wyss, PA1
Annane, D1
Girard, F1
Fabre, JE1
Raphael, JC1
Gajdos, P1
Timell, AM1
Dallaire, S1
Fowler, NO1
McCall, D1
Chou, TC1
Holmes, JC1
Hanenson, IB1
Levine, DF1
Marshall, AJ1
Yoon, MS1
Han, J1
Dersham, GH1
Jones, SA1
Thornton, WE2
Gelenberg, AJ1
Urbano Márquez, A1
Rubio, M1
Fernández-Huerta, JM1
Aranalde, JM1
Navarro López, F1
Pray, BJ1
Lipka, LJ1
Lathers, CM1
Roberts, J1
Vertrees, JE1
Siebel, G1
Flugelman, MY1
Tal, A1
Pollack, S1
Hefez, A1
Weisstub, EB1
Gotsman, MS1
Lewis, BS1
Hollow, VM1
Clarke, GM1
Weekes, JW1
Newton, RW1
Shamsi, MA1
Kulshrestha, VK1
Dhawan, KN1
Bhargava, KP1
Landmark, K1
Hollander, PB1
Cain, RM1
Kalbian, VV1
Burda, CD1
Tranum, BL1
Murphy, ML1
Fletcher, GF1
Kazamias, TM1
Schoonmaker, FW1
Osteen, RT1
Greenfield, JC1

Reviews

2 reviews available for thioridazine and Arrhythmia

ArticleYear
[Psychopharmaceuticals and arrhythmias].
    Therapeutische Umschau. Revue therapeutique, 2004, Volume: 61, Issue:4

    Topics: Antidepressive Agents, Tricyclic; Antipsychotic Agents; Arrhythmias, Cardiac; Dopamine Antagonists;

2004
Thioridazine for schizophrenia.
    The Cochrane database of systematic reviews, 2007, Jul-18, Issue:3

    Topics: Antipsychotic Agents; Arrhythmias, Cardiac; Humans; Outcome Assessment, Health Care; Randomized Cont

2007

Other Studies

39 other studies available for thioridazine and Arrhythmia

ArticleYear
Support vector machines classification of hERG liabilities based on atom types.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant

2008
Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using administrative data.
    BMJ (Clinical research ed.), 2002, Nov-09, Volume: 325, Issue:7372

    Topics: Adult; Aged; Antipsychotic Agents; Arrhythmias, Cardiac; Clozapine; Cohort Studies; Confidence Inter

2002
THIORIDAZINE HYDROCHLORIDE (MELLARIL): ITS EFFECT ON THE ELECTROCARDIOGRAM AND A REPORT OF TWO FATALITIES WITH ELECTROCARDIOGRAPHIC ABNORMALITIES.
    Canadian Medical Association journal, 1963, Sep-14, Volume: 89

    Topics: Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Electrocardiography; Hear

1963
Comparative cardiac safety of low-dose thioridazine and low-dose haloperidol.
    British journal of clinical pharmacology, 2004, Volume: 58, Issue:1

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Arrhythmias, Cardiac; Child; Child, Preschool; Cohort

2004
Clinical toxicology: clinical science to public health.
    Clinical and experimental pharmacology & physiology, 2005, Volume: 32, Issue:11

    Topics: Analgesics, Opioid; Antipsychotic Agents; Arrhythmias, Cardiac; Dextropropoxyphene; Drug Information

2005
[Electrocardiographic changes, disturbances of cardiac rhythm, and sudden deaths during treatment with phenothiazine drugs].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1967, Jan-15, Volume: 87, Issue:2

    Topics: Arrhythmias, Cardiac; Death, Sudden; Female; Heart Arrest; Humans; Middle Aged; Quinidine; Tachycard

1967
[Arrhythmias in poisoning with tricyclic antidepressive agents. Successful treatment with physostigmine and sodium].
    Deutsche medizinische Wochenschrift (1946), 1982, Jul-16, Volume: 107, Issue:28

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Dibenzazepines; Female; Human

1982
Management of recurrent ventricular tachyarrhythmias associated with Q-T prolongation.
    The American journal of cardiology, 1981, Volume: 47, Issue:6

    Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Gluconate; Cardiac Pacing, Artifi

1981
Calcium channel blockade: possible explanation for thioridazine's peripheral side effects.
    The American journal of psychiatry, 1984, Volume: 141, Issue:3

    Topics: Animals; Arrhythmias, Cardiac; Calcium Channel Blockers; Ejaculation; Female; Ion Channels; Male; Mu

1984
Electrocardiographic changes following intravenous administration of thioridazine to macaque monkeys.
    The Journal of clinical psychiatry, 1982, Volume: 43, Issue:5 Pt 2

    Topics: Animals; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Electrocardiography; Heart Conducti

1982
[Recurrent ventricular flutter after thioridazine poisoning].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1982, Jun-21, Volume: 37, Issue:18

    Topics: Adult; Arrhythmias, Cardiac; Female; Heart Ventricles; Humans; Recurrence; Thioridazine

1982
Cardiovascular side effects of phenothiazines and tricyclic antidepressants. A review with precautionary measures.
    Postgraduate medicine, 1980, Volume: 67, Issue:3

    Topics: Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Cardiovascular System; Death, Sudden; Drug I

1980
Acute overdosage with thioridazine: a review of the available clinical exposure.
    Veterinary and human toxicology, 1993, Volume: 35, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Child; Child, Preschool; Drug Over

1993
[Acute poisoning with thioridazine].
    Deutsche medizinische Wochenschrift (1946), 1996, Aug-16, Volume: 121, Issue:33

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Arrhythmias, Cardiac; Case-Control

1996
Near fatal case of self-poisoning with thioridazine.
    Intensive care medicine, 1996, Volume: 22, Issue:12

    Topics: Adult; Antipsychotic Agents; Arrhythmias, Cardiac; Coma; Electrocardiography; Female; Humans; Thiori

1996
Thioridazine: re-evaluating the risk/benefit equation.
    Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 2000, Volume: 12, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Arrhythmias, Cardiac; Cause of Death; Female;

2000
Thioridazine (Mellaril) and mesoridazine (Serentil): prolongation of the QTc interval.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2001, Jan-09, Volume: 164, Issue:1

    Topics: Antipsychotic Agents; Arrhythmias, Cardiac; Contraindications; Heart Conduction System; Humans; Long

2001
Thioridazine and severe cardiac arrhythmia.
    Prescrire international, 2001, Volume: 10, Issue:56

    Topics: Antipsychotic Agents; Arrhythmias, Cardiac; Contraindications; Drug Interactions; France; Schizophre

2001
Electrocardiographic changes and cardiac arrhythmias in patients receiving psychotropic drugs.
    The American journal of cardiology, 1976, Volume: 37, Issue:2

    Topics: Adrenergic Agonists; Adult; Aged; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Cardiovasc

1976
Letter: Cardiac arrhythmia induced by phenothiazine.
    Lancet (London, England), 1975, Nov-15, Volume: 2, Issue:7942

    Topics: Adult; Arrhythmias, Cardiac; Humans; Male; Thioridazine

1975
Effects of thioridazine (Mellaril) on ventricular electrophysiologic properties.
    The American journal of cardiology, 1979, Volume: 43, Issue:6

    Topics: Animals; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Dogs; Dose-Response Relationship, Drug; H

1979
Alcohol withdrawal and thioridazine.
    Diseases of the nervous system, 1977, Volume: 38, Issue:12

    Topics: Alcoholism; Arrhythmias, Cardiac; Humans; Substance Withdrawal Syndrome; Thioridazine

1977
Cardiac arrhythmias after psychotropic drugs.
    The American journal of cardiology, 1977, Volume: 40, Issue:2

    Topics: Arrhythmias, Cardiac; Humans; Psychotropic Drugs; Thioridazine

1977
[Electrocardiographic disorders induced by thioridazine poisoning. Apropos of 2 cases of acute poisoning].
    Revista clinica espanola, 1976, Oct-31, Volume: 143, Issue:2

    Topics: Acute Disease; Adult; Arrhythmias, Cardiac; Depression; Electrocardiography; Female; Humans; Middle

1976
Ventricular arrhythmia and thioridazine: a case report.
    The American journal of nursing, 1976, Volume: 76, Issue:2

    Topics: Adult; Arrhythmias, Cardiac; Female; Heart Ventricles; Humans; Hypokalemia; Thioridazine

1976
Transient cardiac pacing is insufficiently used to treat arrhythmia associated with thioridazine.
    Cardiology, 1992, Volume: 81, Issue:6

    Topics: Adult; Arrhythmias, Cardiac; Bundle-Branch Block; Cardiac Pacing, Artificial; Child; Dose-Response R

1992
Does chlorpromazine produce cardiac arrhythmia via the central nervous system?
    Journal of clinical pharmacology, 1988, Volume: 28, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Cats; Central Nervous System; Chlorpromazine; Decereb

1988
Rapid death resulting from mesoridazine overdose.
    Veterinary and human toxicology, 1987, Volume: 29, Issue:1

    Topics: Adult; Arrhythmias, Cardiac; Electrocardiography; Female; Humans; Male; Mesoridazine; Middle Aged; T

1987
Psychotropic drugs and long QT syndromes: case reports.
    The Journal of clinical psychiatry, 1985, Volume: 46, Issue:7

    Topics: Aged; Arrhythmias, Cardiac; Depressive Disorder; Electrocardiography; Female; Humans; Middle Aged; P

1985
Case report: thioridazine overdose.
    Anaesthesia and intensive care, 1974, Volume: 2, Issue:4

    Topics: Arrhythmias, Cardiac; Atropine; Electrocardiography; Female; Humans; Lidocaine; Middle Aged; Procain

1974
Letter: Ventricular dysrhythmias and thioridazine in alcohol withdrawal.
    British medical journal, 1973, Dec-22, Volume: 4, Issue:5894

    Topics: Alcoholism; Arrhythmias, Cardiac; Electrocardiography; Humans; Hypokalemia; Substance Withdrawal Syn

1973
Correlation of chemical structure of phenothiazines with their coronary dilator and antiarrhythmic activities.
    Japanese journal of pharmacology, 1971, Volume: 21, Issue:6

    Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chlorpromazine; Coronary Vessels;

1971
The action of promazine and thioridazine in isolated rat atria. 1. Effects on automaticity, mechanical performance, refractoriness and excitability.
    European journal of pharmacology, 1971, Volume: 16, Issue:1

    Topics: Animals; Arrhythmias, Cardiac; Atrial Fibrillation; Electric Stimulation; Female; Heart Arrest; Hear

1971
Effects of thioridazine on transmembrane potential and contractile characteristics of guinea pig hearts.
    European journal of pharmacology, 1971, Volume: 16, Issue:2

    Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Electric Stimulation; Electrophysiology; Guinea Pi

1971
Electrocardiogram of the month. Q-T prolongation associated with the use of thioridazine hydrochloride (Mellaril).
    The West Virginia medical journal, 1971, Volume: 67, Issue:10

    Topics: Arrhythmias, Cardiac; Electrocardiography; Humans; Male; Middle Aged; Schizophrenia; Thioridazine

1971
Electrocardiographic abnormalities induced by thioridazine (Mellaril).
    American heart journal, 1968, Volume: 76, Issue:2

    Topics: Arrhythmias, Cardiac; Child; Electrocardiography; Humans; Male; Suicide; Tachycardia; Thioridazine

1968
Case report: successful treatment of ventricular tachycardia associated with thioridazine (Mellaril).
    Southern medical journal, 1969, Volume: 62, Issue:3

    Topics: Arrhythmias, Cardiac; Aspartate Aminotransferases; Electric Countershock; Electrocardiography; Human

1969
Cardiotoxic effects of Mellaril: conduction disturbances and supraventricular arrhythmias.
    American heart journal, 1969, Volume: 78, Issue:1

    Topics: Adult; Arrhythmias, Cardiac; Electrocardiography; Female; Heart Conduction System; Humans; Male; Mid

1969
Thioridazine (mellaril)-induced ventricular tachycardia controlled with an artificial pacemaker.
    Annals of internal medicine, 1966, Volume: 65, Issue:5

    Topics: Arrhythmias, Cardiac; Electrocardiography; Humans; Male; Middle Aged; Pacemaker, Artificial; Thiorid

1966